A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure

Liver International

Volumn 31, Issue 8, 2011, Pages 1209-1221

  Jambekar, Amruta A ^a   Palma, Elena ^b   Nicolosi, Luca ^b   Rasola, Andrea ^b   Petronilli, Valeria ^b   Chiara, Federica ^b   Bernardi, Paolo ^b   Needleman, Richard ^a   Brusilow, William S A ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Immune response; Inflammation; Lipopolysaccharide; Methionine sulfoximine; TNF

Indexed keywords

CYTOKINE; ENDOTOXIN; GALACTOSAMINE; GAMMA INTERFERON; GLUTAMATE AMMONIA LIGASE; GLUTAMATE CYSTEINE LIGASE; LIPOPOLYSACCHARIDE; METHIONINE SULFOXIMINE; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LIVER FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN EDEMA; CONTROLLED STUDY; CYTOKINE RELEASE; EX VIVO STUDY; FEMALE; HYPERAMMONEMIA; IN VIVO STUDY; INFLAMMATION; LIVER CELL; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; SURVIVAL;

ANIMALS; APOPTOSIS; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GALACTOSAMINE; GLUTAMATE-AMMONIA LIGASE; INFLAMMATION MEDIATORS; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; LIVER; LIVER FAILURE, ACUTE; MACROPHAGES, PERITONEAL; MALE; METHIONINE SULFOXIMINE; MICE; STAT1 TRANSCRIPTION FACTOR; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79961208830     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2011.02553.x     Document Type: Article

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