메뉴 건너뛰기




Volumn 24, Issue 1, 2009, Pages 69-80

Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy

Author keywords

GABA; Glutamate; Hepatic encephalopathy; Hyperammonemia; Hypokinesia; Motor function; Neuronal circuits

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ACETYLCHOLINE; ACETYLCHOLINESTERASE; AMMONIA; CYCLIC GMP; GLUTAMATE RECEPTOR; GLUTAMIC ACID; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1 ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROSTEROID; NITRIC OXIDE; TETRAHYDRODEOXYCORTICOSTERONE; UNCLASSIFIED DRUG;

EID: 60449084556     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11011-008-9115-4     Document Type: Review
Times cited : (128)

References (52)
  • 3
    • 33746336003 scopus 로고    scopus 로고
    • Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma
    • S Ahboucha G Pomier-Layrargues O Mamer RF Butterworth 2006 Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma Neurochem Int 49 372 378
    • (2006) Neurochem Int , vol.49 , pp. 372-378
    • Ahboucha, S.1    Pomier-Layrargues, G.2    Mamer, O.3    Butterworth, R.F.4
  • 4
    • 0342470611 scopus 로고    scopus 로고
    • Chronic moderate hyperammonemia impairs active and passive avoidance behavior and conditional discrimination learning in rats
    • MA Aguilar J Miñarro V Felipo 2000 Chronic moderate hyperammonemia impairs active and passive avoidance behavior and conditional discrimination learning in rats Experimental Neurol 161 704 713
    • (2000) Experimental Neurol , vol.161 , pp. 704-713
    • Aguilar, M.A.1    Miñarro, J.2    Felipo, V.3
  • 6
    • 0030758721 scopus 로고    scopus 로고
    • Further evidence for the involvement of a hippocampal cGMP/cGMP-dependent protein kinase cascade in memory consolidation
    • R Bernabeu N Schroder J Quevedo M Cammarota I Izquierdo JH Medina 1997 Further evidence for the involvement of a hippocampal cGMP/cGMP-dependent protein kinase cascade in memory consolidation Neuroreport 8 2221 2224
    • (1997) Neuroreport , vol.8 , pp. 2221-2224
    • Bernabeu, R.1    Schroder, N.2    Quevedo, J.3    Cammarota, M.4    Izquierdo, I.5    Medina, J.H.6
  • 7
    • 0346848900 scopus 로고    scopus 로고
    • Chronic hyperammonemia alters motor and neurochemical responses to activation of group i metabotropic glutamate receptors in the nucleus accumbens in rats in vivo
    • JJ Canales A Elayadi M Errami M Llansola O Cauli V Felipo 2003 Chronic hyperammonemia alters motor and neurochemical responses to activation of group I metabotropic glutamate receptors in the nucleus accumbens in rats in vivo Neurobiol Dis 143 380 390
    • (2003) Neurobiol Dis , vol.143 , pp. 380-390
    • Canales, J.J.1    Elayadi, A.2    Errami, M.3    Llansola, M.4    Cauli, O.5    Felipo, V.6
  • 8
    • 33749044194 scopus 로고    scopus 로고
    • Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra
    • O Cauli M Llansola S Erceg V Felipo 2006 Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra J Hepatol 45 654 661
    • (2006) J Hepatol , vol.45 , pp. 654-661
    • Cauli, O.1    Llansola, M.2    Erceg, S.3    Felipo, V.4
  • 9
    • 34548361564 scopus 로고    scopus 로고
    • Inflammation and hepatic encephalopathy: Ibuprofen restores learning ability in rats with porto-caval shunts
    • O Cauli R Rodrigo B Piedrafita V Boix J Felipo 2007 Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with porto-caval shunts Hepatology 46 514 519
    • (2007) Hepatology , vol.46 , pp. 514-519
    • Cauli, O.1    Rodrigo, R.2    Piedrafita, B.3    Boix Felipo J, V.4
  • 10
    • 34548607777 scopus 로고    scopus 로고
    • Hyperammonemia alters the mechanisms by which metabotropic glutamate receptors in nucleus accumbens modulate motor function
    • O Cauli N Mlili R Rodrigo V Felipo 2007 Hyperammonemia alters the mechanisms by which metabotropic glutamate receptors in nucleus accumbens modulate motor function J Neurochem 103 38 46
    • (2007) J Neurochem , vol.103 , pp. 38-46
    • Cauli, O.1    Mlili, N.2    Rodrigo, R.3    Felipo, V.4
  • 11
    • 34147215959 scopus 로고    scopus 로고
    • Motor activity is modulated via different neuronal circuits in rats with chronic liver failure than in normal rats
    • O Cauli N Mlili M Llansola V Felipo 2007 Motor activity is modulated via different neuronal circuits in rats with chronic liver failure than in normal rats Eur J Neurosci 25 2112 2122
    • (2007) Eur J Neurosci , vol.25 , pp. 2112-2122
    • Cauli, O.1    Mlili, N.2    Llansola, M.3    Felipo, V.4
  • 12
    • 35448962385 scopus 로고    scopus 로고
    • Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of NMDA receptors
    • 4
    • O Cauli P López-Larrubia TB Rodrigues S Cerdán V Felipo 2007 Magnetic resonance analysis of the effects of acute ammonia intoxication on rat brain. Role of NMDA receptors J Neurochem 103 4 1334 1343
    • (2007) J Neurochem , vol.103 , pp. 1334-1343
    • Cauli, O.1    López-Larrubia, P.2    Rodrigues, T.B.3    Cerdán, S.4    Felipo, V.5
  • 13
    • 0036829813 scopus 로고    scopus 로고
    • Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients
    • R Corbalán N Chatauret S Behrends RF Butterworth V Felipo 2002 Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients Hepatology 36 1155 1162
    • (2002) Hepatology , vol.36 , pp. 1155-1162
    • Corbalán, R.1    Chatauret, N.2    Behrends, S.3    Butterworth, R.F.4    Felipo, V.5
  • 14
    • 12844262177 scopus 로고    scopus 로고
    • Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts
    • S Erceg P Monfort M Hernández-Viadel R Rodrigo C Montoliu V Felipo 2005 Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts Hepatology 41 299 306
    • (2005) Hepatology , vol.41 , pp. 299-306
    • Erceg, S.1    Monfort, P.2    Hernández-Viadel, M.3    Rodrigo, R.4    Montoliu, C.5    Felipo, V.6
  • 15
    • 13844296393 scopus 로고    scopus 로고
    • Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain
    • S Erceg P Monfort M Hernandez-Viadel M Llansola C Montoliu V Felipo 2005 Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain Brain Res 1036 115 121
    • (2005) Brain Res , vol.1036 , pp. 115-121
    • Erceg, S.1    Monfort, P.2    Hernandez-Viadel, M.3    Llansola, M.4    Montoliu, C.5    Felipo, V.6
  • 16
    • 33846192274 scopus 로고    scopus 로고
    • Contribution of altered signal transduction associated to glutamate receptors in brain to the neurological alterations of hepatic encephalopathy
    • V Felipo 2006 Contribution of altered signal transduction associated to glutamate receptors in brain to the neurological alterations of hepatic encephalopathy World J Gastroenterol 12 7737 7743
    • (2006) World J Gastroenterol , vol.12 , pp. 7737-7743
    • Felipo, V.1
  • 17
    • 60449097440 scopus 로고    scopus 로고
    • 3 Kluwer Academic/Plenum USA
    • Felipo V (2008a) Hyperammonemia. handbook of neurochemistry and molecular neurobiology, vol. 24, 3rd edn. Kluwer Academic/Plenum, USA, pp 1-27
    • (2008) , pp. 1-27
    • Felipo, V.1
  • 20
    • 0023711180 scopus 로고
    • Long term ingestion of ammonium increases acetylglutamate and urea levels without affecting the amount of carbamyl phosphate synthase
    • V Felipo MD Minana S Grisolía 1988 Long term ingestion of ammonium increases acetylglutamate and urea levels without affecting the amount of carbamyl phosphate synthase Eur J Biochem 176 567 571
    • (1988) Eur J Biochem , vol.176 , pp. 567-571
    • Felipo, V.1    Minana, M.D.2    Grisolía, S.3
  • 22
    • 0030003924 scopus 로고    scopus 로고
    • A receptor complex by ammonia: Implications for the pathogenesis of hyperammonemic syndromes
    • A receptor complex by ammonia: implications for the pathogenesis of hyperammonemic syndromes Brain Res 720 35 44
    • (1996) Brain Res , vol.720 , pp. 35-44
    • Ha, J.H.1    Basile, A.S.2
  • 24
    • 0032430914 scopus 로고    scopus 로고
    • Chronic hyperammonemia impairs glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo
    • C Hermenegildo C Montoliu M Llansola MD Muñoz JM Gaztelu MD Miñana V Felipo 1998 Chronic hyperammonemia impairs glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in the rat in vivo Eur J Neurosci 10 3201 3209
    • (1998) Eur J Neurosci , vol.10 , pp. 3201-3209
    • Hermenegildo, C.1    Montoliu, C.2    Llansola, M.3    Muñoz, M.D.4    Gaztelu, J.M.5    Miñana, M.D.6    Felipo, V.7
  • 25
    • 0033993867 scopus 로고    scopus 로고
    • Activation of NMDA receptors in rat brain in vivo following acute ammonia intoxication. Characterization by in vivo brain microdialysis
    • C Hermenegildo P Monfort V Felipo 2000 Activation of NMDA receptors in rat brain in vivo following acute ammonia intoxication. Characterization by in vivo brain microdialysis Hepatology 31 709 715
    • (2000) Hepatology , vol.31 , pp. 709-715
    • Hermenegildo, C.1    Monfort, P.2    Felipo, V.3
  • 26
    • 0029562295 scopus 로고
    • Acute liver failure and hyperammonemia increase peripheral-type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain
    • Y Itzhak A Roig-Cantisano RS Dombro MD Norenberg 1995 Acute liver failure and hyperammonemia increase peripheral-type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain Brain Res 705 345 348
    • (1995) Brain Res , vol.705 , pp. 345-348
    • Itzhak, Y.1    Roig-Cantisano, A.2    Dombro, R.S.3    Norenberg, M.D.4
  • 28
    • 0026074879 scopus 로고
    • Ammonium ingestion prevents depletion of hepatic energy metabolites induced by acute ammonium intoxication
    • E Kosenko V Felipo MD Miñana E Grau S Grisolía 1991 Ammonium ingestion prevents depletion of hepatic energy metabolites induced by acute ammonium intoxication Arch Biochem Biophys 290 484 488
    • (1991) Arch Biochem Biophys , vol.290 , pp. 484-488
    • Kosenko, E.1    Felipo, V.2    Miñana, M.D.3    Grau, E.4    Grisolía, S.5
  • 29
    • 0027500453 scopus 로고
    • Chronic hyperammonemia prevents changes in brain energy and ammonia metabolites induced by acute ammonium intoxication
    • E Kosenko YG Kaminsky V Felipo MD Miñana S Grisolía 1993 Chronic hyperammonemia prevents changes in brain energy and ammonia metabolites induced by acute ammonium intoxication Biochim Biophys Acta 1180 321 326
    • (1993) Biochim Biophys Acta , vol.1180 , pp. 321-326
    • Kosenko, E.1    Kaminsky, Y.G.2    Felipo, V.3    Miñana, M.D.4    Grisolía, S.5
  • 30
    • 0027988722 scopus 로고
    • Brain ATP depletion induced by acute ammonia intoxication in rats is mediated by activation of the NMDA receptor and of Na/K ATPase
    • E Kosenko Y Kaminsky E Grau MD Miñana G Marcaida S Grisolía V Felipo 1994 Brain ATP depletion induced by acute ammonia intoxication in rats is mediated by activation of the NMDA receptor and of Na/K ATPase J Neurochem 63 2172 2178
    • (1994) J Neurochem , vol.63 , pp. 2172-2178
    • Kosenko, E.1    Kaminsky, Y.2    Grau, E.3    Miñana, M.D.4    Marcaida, G.5    Grisolía, S.6    Felipo, V.7
  • 32
    • 0034644823 scopus 로고    scopus 로고
    • Alteration of mitochondrial calcium homeostasis by ammonia-induced activation of NMDA receptors in rat brain in vivo
    • E Kosenko Y Kaminsky IG Stavroskaya V Felipo 2000 Alteration of mitochondrial calcium homeostasis by ammonia-induced activation of NMDA receptors in rat brain in vivo Brain Res 880 139 146
    • (2000) Brain Res , vol.880 , pp. 139-146
    • Kosenko, E.1    Kaminsky, Y.2    Stavroskaya, I.G.3    Felipo, V.4
  • 34
    • 0024300134 scopus 로고
    • Protective effect of long term ammonium ingestion against acute ammonium intoxication
    • MD Minana V Felipo S Grisolía 1988 Protective effect of long term ammonium ingestion against acute ammonium intoxication Biochem Biophys Res Commun 153 979 983
    • (1988) Biochem Biophys Res Commun , vol.153 , pp. 979-983
    • Minana, M.D.1    Felipo, V.2    Grisolía, S.3
  • 35
    • 0034256942 scopus 로고    scopus 로고
    • Differential effects of acute and chronic hyperammonemia on signal transduction pathways associated to NMDA receptors
    • P Monfort C Montoliu C Hermenegildo MD Muñoz V Felipo 2000 Differential effects of acute and chronic hyperammonemia on signal transduction pathways associated to NMDA receptors Neurochem Int 37 249 253
    • (2000) Neurochem Int , vol.37 , pp. 249-253
    • Monfort, P.1    Montoliu, C.2    Hermenegildo, C.3    Muñoz, M.D.4    Felipo, V.5
  • 36
    • 0035799999 scopus 로고    scopus 로고
    • Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis
    • P Monfort R Corbalán L Martinez JC López-Talavera J Córdoba V Felipo 2001 Altered content and modulation of soluble guanylate cyclase in the cerebellum of rats with portacaval anastomosis Neuroscience 104 1119 1125
    • (2001) Neuroscience , vol.104 , pp. 1119-1125
    • Monfort, P.1    Corbalán, R.2    Martinez, L.3    López-Talavera, J.C.4    Córdoba, J.5    Felipo, V.6
  • 37
    • 0036981248 scopus 로고    scopus 로고
    • Effects of hyper-ammonemia and liver disease on glutamatergic neurotransmission
    • P Monfort MD Muñoz A ElAyadi E Kosenko V Felipo 2002 Effects of hyper-ammonemia and liver disease on glutamatergic neurotransmission Metab Brain Dis 17 237 250
    • (2002) Metab Brain Dis , vol.17 , pp. 237-250
    • Monfort, P.1    Muñoz, M.D.2    Elayadi, A.3    Kosenko, E.4    Felipo, V.5
  • 39
    • 0023268981 scopus 로고
    • Gamma-Aminobutyric acid (GABA) and HE: Testing the validity of electroencephalographic evidence of the GABA hypothesis
    • MS Myslobodsky 1987 gamma-Aminobutyric acid (GABA) and HE: testing the validity of electroencephalographic evidence of the GABA hypothesis Hepatogastroenterology 34 58 64
    • (1987) Hepatogastroenterology , vol.34 , pp. 58-64
    • Myslobodsky, M.S.1
  • 40
    • 0030833288 scopus 로고    scopus 로고
    • The peripheral benzodiazepine receptor and neurosteroids in HE
    • MD Norenberg Y Itzhak AS Bender 1997 The peripheral benzodiazepine receptor and neurosteroids in HE Adv Exp Med Biol 420 95 111
    • (1997) Adv Exp Med Biol , vol.420 , pp. 95-111
    • Norenberg, M.D.1    Itzhak, Y.2    Bender, A.S.3
  • 41
    • 34250192245 scopus 로고    scopus 로고
    • Glutamate-induced activation of nitric oxide synthase is impaired in cerebral cortex in vivo in rats with chronic liver failure
    • R Rodrigo S Erceg J Rodriguez-Diaz J Saez-Valero B Piedrafita I Suarez V Felipo 2007 Glutamate-induced activation of nitric oxide synthase is impaired in cerebral cortex in vivo in rats with chronic liver failure J Neurochem 102 51 64
    • (2007) J Neurochem , vol.102 , pp. 51-64
    • Rodrigo, R.1    Erceg, S.2    Rodriguez-Diaz, J.3    Saez-Valero, J.4    Piedrafita, B.5    Suarez, I.6    Felipo, V.7
  • 43
    • 0020063020 scopus 로고
    • Hepatic encephalopathy and the gamma-aminobutyric acid neurotransmitter system
    • DF Schafer EA Jones 1982 Hepatic encephalopathy and the gamma-aminobutyric acid neurotransmitter system Lancet 1 18 29
    • (1982) Lancet , vol.1 , pp. 18-29
    • Schafer, D.F.1    Jones, E.A.2
  • 44
    • 1642491776 scopus 로고    scopus 로고
    • Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis
    • DL Shawcross NA Davies R Williams R Jalan 2004 Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis J Hepatol 40 247 254
    • (2004) J Hepatol , vol.40 , pp. 247-254
    • Shawcross, D.L.1    Davies, N.A.2    Williams, R.3    Jalan, R.4
  • 47
    • 0041334000 scopus 로고    scopus 로고
    • Mini-asterixis in hepatic encephalopathy induced by pathologic thalamo-motor-cortical coupling
    • L Timmermann J Gross M Butz G Kircheis D Haussinger A Schnitzler 2003 Mini-asterixis in hepatic encephalopathy induced by pathologic thalamo-motor-cortical coupling Neurology 615 689 692
    • (2003) Neurology , vol.615 , pp. 689-692
    • Timmermann, L.1    Gross, J.2    Butz, M.3    Kircheis, G.4    Haussinger, D.5    Schnitzler, A.6
  • 48
    • 0030990406 scopus 로고    scopus 로고
    • Memantine, a noncompetitive NMDA receptor antagonist improves hyperammonemia-induced encephalopathy and acute hepatic encephalopathy in rats
    • BA Vogels MA Maas J Daalhuisen G Quack RA Chamuleau 1997 Memantine, a noncompetitive NMDA receptor antagonist improves hyperammonemia-induced encephalopathy and acute hepatic encephalopathy in rats Hepatology 25 820 827
    • (1997) Hepatology , vol.25 , pp. 820-827
    • Vogels, B.A.1    Maas, M.A.2    Daalhuisen, J.3    Quack, G.4    Chamuleau, R.A.5
  • 49
    • 0033975013 scopus 로고    scopus 로고
    • Sustained behavioral stimulation following selective activation of group i metabotropic glutamate receptors in rat striatum
    • JQ Wang L Mao 2000 Sustained behavioral stimulation following selective activation of group I metabotropic glutamate receptors in rat striatum Pharmacol Biochem Behav 653 439 447
    • (2000) Pharmacol Biochem Behav , vol.653 , pp. 439-447
    • Wang, J.Q.1    Mao, L.2
  • 50
    • 0032421058 scopus 로고    scopus 로고
    • The basal ganglia and portal-systemic encephalopathy
    • K Weissenborn H Kolbe 1998 The basal ganglia and portal-systemic encephalopathy Metab Brain Dis 134 261 272
    • (1998) Metab Brain Dis , vol.134 , pp. 261-272
    • Weissenborn, K.1    Kolbe, H.2
  • 51
    • 27944445780 scopus 로고    scopus 로고
    • Neurological and neuropsychiatric syndromes associated with liver disease
    • Suppl 3
    • K Weissenborn M Bokemeyer J Krause J Ennen B Ahl 2005 Neurological and neuropsychiatric syndromes associated with liver disease AIDS 19 Suppl 3 S93 S98
    • (2005) AIDS , vol.19
    • Weissenborn, K.1    Bokemeyer, M.2    Krause, J.3    Ennen, J.4    Ahl, B.5
  • 52
    • 0030593430 scopus 로고    scopus 로고
    • Role of nitric oxide and cyclic GMP in the dizocilpine-induced impairment of spontaneous alternation behaviour in mice
    • K Yamada M Hiramatsu Y Noda 1996 Role of nitric oxide and cyclic GMP in the dizocilpine-induced impairment of spontaneous alternation behaviour in mice Neuroscience 74 365 374
    • (1996) Neuroscience , vol.74 , pp. 365-374
    • Yamada, K.1    Hiramatsu, M.2    Noda, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.