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Volumn 115, Issue 2, 2010, Pages 297-313

Synthesis and transport of creatine in the CNS: Importance for cerebral functions

Author keywords

Brain; Creatine; Creatine deficiency; Guanidinoacetate; Mitochondria; Neuroprotection

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMINO ACID TRANSPORTER; AMMONIA; AMYLOID BETA PROTEIN; CREATINE KINASE; CREATINE PHOSPHATE; CREATININE; CREATININE TRANSPORTER; GLYCINE AMIDINOTRANSFERASE; GUANIDINOACETATE METHYLTRANSFERASE; HUNTINGTIN; NEUROTRANSMITTER; UNCLASSIFIED DRUG;

EID: 78651274358     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06935.x     Document Type: Review
Times cited : (146)

References (189)
  • 1
    • 25444526661 scopus 로고    scopus 로고
    • Creatine transporter localization in developing and adult retina: Importance of creatine to retinal function
    • Acosta M. L., Kalloniatis M. and Christie D. L. (2005) Creatine transporter localization in developing and adult retina: Importance of creatine to retinal function. Am. J. Physiol. Cell Physiol. 289, C1015-C1023.
    • (2005) Am. J. Physiol. Cell Physiol. , vol.289
    • Acosta, M.L.1    Kalloniatis, M.2    Christie, D.L.3
  • 2
    • 65249129156 scopus 로고    scopus 로고
    • Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases
    • Adhihetty P. J. and Beal M. F. (2008) Creatine and its potential therapeutic value for targeting cellular energy impairment in neurodegenerative diseases. Neuromolecular. Med. 10, 275-290.
    • (2008) Neuromolecular. Med. , vol.10 , pp. 275-290
    • Adhihetty, P.J.1    Beal, M.F.2
  • 3
    • 0034024347 scopus 로고    scopus 로고
    • Oxidative modification of creatine kinase BB in Alzheimer's disease brain
    • Aksenov M., Aksenova M., Butterfield D. A. and Markesbery W. R. (2000) Oxidative modification of creatine kinase BB in Alzheimer's disease brain. J. Neurochem. 74, 2520-2527.
    • (2000) J. Neurochem. , vol.74 , pp. 2520-2527
    • Aksenov, M.1    Aksenova, M.2    Butterfield, D.A.3    Markesbery, W.R.4
  • 4
    • 33749328177 scopus 로고    scopus 로고
    • Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress
    • Alfieri R. R., Bonelli M. A., Cavazzoni A. et al. (2006) Creatine as a compatible osmolyte in muscle cells exposed to hypertonic stress. J. Physiol. 576, 391-401.
    • (2006) J. Physiol. , vol.576 , pp. 391-401
    • Alfieri, R.R.1    Bonelli, M.A.2    Cavazzoni, A.3
  • 7
    • 0034743672 scopus 로고    scopus 로고
    • Creatine increases survival and delays motor symptoms in a transgenic animal model of Huntington's disease
    • Andreassen O. A., Dedeoglu A., Ferrante R. J. et al. (2001) Creatine increases survival and delays motor symptoms in a transgenic animal model of Huntington's disease. Neurobiol. Dis. 8, 479-491.
    • (2001) Neurobiol. Dis. , vol.8 , pp. 479-491
    • Andreassen, O.A.1    Dedeoglu, A.2    Ferrante, R.J.3
  • 9
    • 35248884675 scopus 로고    scopus 로고
    • Creatine transporter deficiency: Prevalence among patients with mental retardation and pitfalls in metabolite screening
    • Arias A., Corbella M., Fons C. et al. (2007) Creatine transporter deficiency: Prevalence among patients with mental retardation and pitfalls in metabolite screening. Clin. Biochem. 40, 1328-1331.
    • (2007) Clin. Biochem. , vol.40 , pp. 1328-1331
    • Arias, A.1    Corbella, M.2    Fons, C.3
  • 10
    • 0033573708 scopus 로고    scopus 로고
    • Exogenous creatine delays anoxic depolarization and protects from hypoxic damage: Dose-effect relationship
    • Balestrino M., Rebaudo R. and Lunardi G. (1999) Exogenous creatine delays anoxic depolarization and protects from hypoxic damage: Dose-effect relationship. Brain Res. 816, 124-130.
    • (1999) Brain Res. , vol.816 , pp. 124-130
    • Balestrino, M.1    Rebaudo, R.2    Lunardi, G.3
  • 13
    • 33745016252 scopus 로고    scopus 로고
    • Arginine: Glycine amidinotransferase (AGAT) deficiency in a newborn: Early treatment can prevent phenotypic expression of the disease
    • Battini R., Alessandri M. G., Leuzzi V., Moro F., Tosetti M., Bianchi M. C. and Cioni G. (2006) Arginine: Glycine amidinotransferase (AGAT) deficiency in a newborn: Early treatment can prevent phenotypic expression of the disease. J. Pediatr. 148, 828-830.
    • (2006) J. Pediatr. , vol.148 , pp. 828-830
    • Battini, R.1    Alessandri, M.G.2    Leuzzi, V.3    Moro, F.4    Tosetti, M.5    Bianchi, M.C.6    Cioni, G.7
  • 14
    • 0029125857 scopus 로고
    • Aging, energy, and oxidative stress in neurodegenerative diseases
    • Beal M. F. (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38, 357-366.
    • (1995) Ann. Neurol. , vol.38 , pp. 357-366
    • Beal, M.F.1
  • 15
    • 0034237719 scopus 로고    scopus 로고
    • Energetics in the pathogenesis of neurodegenerative diseases
    • Beal M. F. (2000) Energetics in the pathogenesis of neurodegenerative diseases. Trends Neurosci. 23, 298-304.
    • (2000) Trends Neurosci. , vol.23 , pp. 298-304
    • Beal, M.F.1
  • 16
    • 0038051345 scopus 로고    scopus 로고
    • Mitochondria, oxidative damage, and inflammation in Parkinson's disease
    • Beal M. F. (2003) Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann. N Y Acad. Sci. 991, 120-131.
    • (2003) Ann. N Y Acad. Sci. , vol.991 , pp. 120-131
    • Beal, M.F.1
  • 17
    • 2342598416 scopus 로고    scopus 로고
    • Experimental therapeutics in transgenic mouse models of Huntington's disease
    • Beal M. F. and Ferrante R. J. (2004) Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat. Rev. Neurosci. 5, 373-384.
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 373-384
    • Beal, M.F.1    Ferrante, R.J.2
  • 18
    • 0011443093 scopus 로고    scopus 로고
    • Major complications of cirrhosis
    • (Fauci A. S., Braunwald E., Isselbacher K. J., Wilson J. D., Martin J. B., Kasper D. L., Hauser S. L. and Longo D. L., eds). McGraw-Hill, New-York
    • Beal M. F. and Martin J. B. (1998) Major complications of cirrhosis, in Harrison's Principles of Internal Medicine (Fauci A. S., Braunwald E., Isselbacher K. J., Wilson J. D., Martin J. B., Kasper D. L., Hauser S. L. and Longo D. L., eds), pp. 2451-2457. McGraw-Hill, New-York.
    • (1998) Harrison's Principles of Internal Medicine , pp. 2451-2457
    • Beal, M.F.1    Martin, J.B.2
  • 19
    • 33845302602 scopus 로고    scopus 로고
    • Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro
    • Bélanger M., Asashima T., Ohtsuki S., Yamaguchi H., Ito S. and Terasaki T. (2007) Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro. Neurochem. Int. 50, 95-101.
    • (2007) Neurochem. Int. , vol.50 , pp. 95-101
    • Bélanger, M.1    Asashima, T.2    Ohtsuki, S.3    Yamaguchi, H.4    Ito, S.5    Terasaki, T.6
  • 20
    • 19944431628 scopus 로고    scopus 로고
    • Creatine supplementation lowers brain glutamate levels in Huntington's disease
    • Bender A., Auer D. P., Merl T. et al. (2005) Creatine supplementation lowers brain glutamate levels in Huntington's disease. J. Neurol. 252, 36-41.
    • (2005) J. Neurol. , vol.252 , pp. 36-41
    • Bender, A.1    Auer, D.P.2    Merl, T.3
  • 21
    • 33749835508 scopus 로고    scopus 로고
    • Creatine supplementation in Parkinson disease: A placebo-controlled randomized pilot trial
    • Bender A., Koch W., Elstner M. et al. (2006) Creatine supplementation in Parkinson disease: A placebo-controlled randomized pilot trial. Neurology 67, 1262-1264.
    • (2006) Neurology , vol.67 , pp. 1262-1264
    • Bender, A.1    Koch, W.2    Elstner, M.3
  • 22
    • 0032440436 scopus 로고    scopus 로고
    • The mitochondrial permeability transition
    • Bernardi P., Colonna R., Costantini P. et al. (1998) The mitochondrial permeability transition. Biofactors 8, 273-281.
    • (1998) Biofactors , vol.8 , pp. 273-281
    • Bernardi, P.1    Colonna, R.2    Costantini, P.3
  • 25
    • 0032745071 scopus 로고    scopus 로고
    • Mitochondrial enzyme activity in amyotrophic lateral sclerosis: Implications for the role of mitochondria in neuronal cell death
    • Borthwick G. M., Johnson M. A., Ince P. G., Shaw P. J. and Turnbull D. M. (1999) Mitochondrial enzyme activity in amyotrophic lateral sclerosis: Implications for the role of mitochondria in neuronal cell death. Ann. Neurol. 46, 787-790.
    • (1999) Ann. Neurol. , vol.46 , pp. 787-790
    • Borthwick, G.M.1    Johnson, M.A.2    Ince, P.G.3    Shaw, P.J.4    Turnbull, D.M.5
  • 26
    • 0034977189 scopus 로고    scopus 로고
    • Hypo-osmotic swelling-activated release of organic osmolytes in brain slices: Implications for brain oedema in vivo
    • Bothwell J. H., Rae C., Dixon R. M., Styles P. and Bhakoo K. K. (2001) Hypo-osmotic swelling-activated release of organic osmolytes in brain slices: Implications for brain oedema in vivo. J. Neurochem. 77, 1632-1640.
    • (2001) J. Neurochem. , vol.77 , pp. 1632-1640
    • Bothwell, J.H.1    Rae, C.2    Dixon, R.M.3    Styles, P.4    Bhakoo, K.K.5
  • 27
    • 0028213511 scopus 로고
    • Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: A quantitative evaluation of a one-year autopsy population from a geriatric hospital
    • Bouras C., Hof P. R., Giannakopoulos P., Michel J. P. and Morrison J. H. (1994) Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: A quantitative evaluation of a one-year autopsy population from a geriatric hospital. Cereb. Cortex 4, 138-150.
    • (1994) Cereb. Cortex , vol.4 , pp. 138-150
    • Bouras, C.1    Hof, P.R.2    Giannakopoulos, P.3    Michel, J.P.4    Morrison, J.H.5
  • 28
    • 77950338275 scopus 로고    scopus 로고
    • Current concepts in the pathogenesis of urea cycle disorders
    • Braissant O. (2010a) Current concepts in the pathogenesis of urea cycle disorders. Mol. Gen. Metab. 100, S3-S12.
    • (2010) Mol. Gen. Metab. , vol.100
    • Braissant, O.1
  • 29
    • 77950339065 scopus 로고    scopus 로고
    • Ammonia toxicity to the brain: Effects on creatine metabolism and transport and protective roles of creatine
    • Braissant O. (2010b) Ammonia toxicity to the brain: Effects on creatine metabolism and transport and protective roles of creatine. Mol. Gen. Metab. 100, S53-S58.
    • (2010) Mol. Gen. Metab. , vol.100
    • Braissant, O.1
  • 30
    • 43149113670 scopus 로고    scopus 로고
    • AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: A review
    • Braissant O. and Henry H. (2008) AGAT, GAMT and SLC6A8 distribution in the central nervous system, in relation to creatine deficiency syndromes: A review. J. Inherit. Metab. Dis. 31, 230-239.
    • (2008) J. Inherit. Metab. Dis. , vol.31 , pp. 230-239
    • Braissant, O.1    Henry, H.2
  • 31
    • 0035977693 scopus 로고    scopus 로고
    • Endogenous synthesis and transport of creatine in the rat brain: An in situ hybridization study
    • Braissant O., Henry H., Loup M., Eilers B. and Bachmann C. (2001) Endogenous synthesis and transport of creatine in the rat brain: An in situ hybridization study. Mol. Brain Res. 86, 193-201.
    • (2001) Mol. Brain Res. , vol.86 , pp. 193-201
    • Braissant, O.1    Henry, H.2    Loup, M.3    Eilers, B.4    Bachmann, C.5
  • 32
    • 0037112067 scopus 로고    scopus 로고
    • Ammonium-induced impairment of axonal growth is prevented through glial creatine
    • Braissant O., Henry H., Villard A. M. et al. (2002) Ammonium-induced impairment of axonal growth is prevented through glial creatine. J. Neurosci. 22, 9810-9820.
    • (2002) J. Neurosci. , vol.22 , pp. 9810-9820
    • Braissant, O.1    Henry, H.2    Villard, A.M.3
  • 34
    • 36049036264 scopus 로고    scopus 로고
    • Expression and function of AGAT, GAMT and CT1 in the mammalian brain
    • Braissant O., Bachmann C. and Henry H. (2007) Expression and function of AGAT, GAMT and CT1 in the mammalian brain. Subcell. Biochem. 46, 67-81.
    • (2007) Subcell. Biochem. , vol.46 , pp. 67-81
    • Braissant, O.1    Bachmann, C.2    Henry, H.3
  • 35
    • 41549151211 scopus 로고    scopus 로고
    • Ammonium alters creatine transport and synthesis in a 3D culture of developing brain cells, resulting in secondary cerebral creatine deficiency
    • Braissant O., Cagnon L., Monnet-Tschudi F., Speer O., Wallimann T., Honegger P. and Henry H. (2008) Ammonium alters creatine transport and synthesis in a 3D culture of developing brain cells, resulting in secondary cerebral creatine deficiency. Eur. J. Neurosci. 27, 1673-1685.
    • (2008) Eur. J. Neurosci. , vol.27 , pp. 1673-1685
    • Braissant, O.1    Cagnon, L.2    Monnet-Tschudi, F.3    Speer, O.4    Wallimann, T.5    Honegger, P.6    Henry, H.7
  • 36
    • 72749117347 scopus 로고    scopus 로고
    • Dissociation of AGAT, GAMT and SLC6A8 in CNS: Relevance to creatine deficiency syndromes
    • Braissant O., Béard E., Torrent C. and Henry H. (2010) Dissociation of AGAT, GAMT and SLC6A8 in CNS: Relevance to creatine deficiency syndromes. Neurobiol. Dis. 37, 423-433.
    • (2010) Neurobiol. Dis. , vol.37 , pp. 423-433
    • Braissant, O.1    Béard, E.2    Torrent, C.3    Henry, H.4
  • 37
    • 0034006323 scopus 로고    scopus 로고
    • Protective effect of the energy precursor creatine against toxicity of glutamate and beta-amyloid in rat hippocampal neurons
    • Brewer G. J. and Wallimann T. W. (2000) Protective effect of the energy precursor creatine against toxicity of glutamate and beta-amyloid in rat hippocampal neurons. J. Neurochem. 74, 1968-1978.
    • (2000) J. Neurochem. , vol.74 , pp. 1968-1978
    • Brewer, G.J.1    Wallimann, T.W.2
  • 38
    • 35548995604 scopus 로고    scopus 로고
    • Creatine: Endogenous metabolite, dietary, and therapeutic supplement
    • Brosnan J. T. and Brosnan M. E. (2007) Creatine: Endogenous metabolite, dietary, and therapeutic supplement. Annu. Rev. Nutr. 27, 241-261.
    • (2007) Annu. Rev. Nutr. , vol.27 , pp. 241-261
    • Brosnan, J.T.1    Brosnan, M.E.2
  • 39
    • 67649995770 scopus 로고    scopus 로고
    • Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance
    • Brosnan J. T., Wijekoon E. P., Warford-Woolgar L., Trottier N. L., Brosnan M. E., Brunton J. A. and Bertolo R. F. (2009) Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance. J. Nutr. 139, 1292-1297.
    • (2009) J. Nutr. , vol.139 , pp. 1292-1297
    • Brosnan, J.T.1    Wijekoon, E.P.2    Warford-Woolgar, L.3    Trottier, N.L.4    Brosnan, M.E.5    Brunton, J.A.6    Bertolo, R.F.7
  • 40
    • 0027515957 scopus 로고
    • NMDA antagonists partially protect against MPTP induced neurotoxicity in mice
    • Brouillet E. and Beal M. F. (1993) NMDA antagonists partially protect against MPTP induced neurotoxicity in mice. Neuroreport 4, 387-390.
    • (1993) Neuroreport , vol.4 , pp. 387-390
    • Brouillet, E.1    Beal, M.F.2
  • 41
    • 33646340668 scopus 로고    scopus 로고
    • The creatine kinase/creatine connection to Alzheimer's disease: CK-inactivation, APP-CK complexes and focal creatine deposits
    • Bürklen T. S., Schlattner U., Homayouni R., Gough K., Rak M., Szeghalmi A. and Wallimann T. (2006) The creatine kinase/creatine connection to Alzheimer's disease: CK-inactivation, APP-CK complexes and focal creatine deposits. J. Biomed. Biotechnol. 2006, 35936.
    • (2006) J. Biomed. Biotechnol. , vol.2006 , pp. 35936
    • Bürklen, T.S.1    Schlattner, U.2    Homayouni, R.3    Gough, K.4    Rak, M.5    Szeghalmi, A.6    Wallimann, T.7
  • 42
    • 36048953322 scopus 로고    scopus 로고
    • Hyperammonemia-induced toxicity for the developing central nervous system
    • Cagnon L. and Braissant O. (2007) Hyperammonemia-induced toxicity for the developing central nervous system. Brain Res. Rev. 56, 183-197.
    • (2007) Brain Res. Rev. , vol.56 , pp. 183-197
    • Cagnon, L.1    Braissant, O.2
  • 43
    • 53749090841 scopus 로고    scopus 로고
    • Role of caspases, calpain and cdk5 in ammonia-induced cell death in developing brain cells
    • Cagnon L. and Braissant O. (2008) Role of caspases, calpain and cdk5 in ammonia-induced cell death in developing brain cells. Neurobiol. Dis. 32, 281-292.
    • (2008) Neurobiol. Dis. , vol.32 , pp. 281-292
    • Cagnon, L.1    Braissant, O.2
  • 44
    • 57449084135 scopus 로고    scopus 로고
    • CNTF protects oligodendrocytes from ammonia toxicity: Intracellular signaling pathways involved
    • Cagnon L. and Braissant O. (2009) CNTF protects oligodendrocytes from ammonia toxicity: Intracellular signaling pathways involved. Neurobiol. Dis. 33, 133-142.
    • (2009) Neurobiol. Dis. , vol.33 , pp. 133-142
    • Cagnon, L.1    Braissant, O.2
  • 45
    • 0015821535 scopus 로고
    • S-adenosylmethionine: Guanidinoacetate N-methyltransferase activities in livers from rats with hormonal deficiencies or excesses
    • Carlson M. and Van Pilsum J. F. (1973) S-adenosylmethionine: Guanidinoacetate N-methyltransferase activities in livers from rats with hormonal deficiencies or excesses. Proc. Soc. Exp. Biol. Med. 143, 1256-1259.
    • (1973) Proc. Soc. Exp. Biol. Med. , vol.143 , pp. 1256-1259
    • Carlson, M.1    Van Pilsum, J.F.2
  • 46
    • 0033846236 scopus 로고    scopus 로고
    • Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance?
    • Casey A. and Greenhaff P. L. (2000) Does dietary creatine supplementation play a role in skeletal muscle metabolism and performance? Am. J. Clin. Nutr. 72, 607S-617S.
    • (2000) Am. J. Clin. Nutr. , vol.72
    • Casey, A.1    Greenhaff, P.L.2
  • 47
  • 48
    • 57649171115 scopus 로고    scopus 로고
    • Mitochondrial approaches for neuroprotection
    • Chaturvedi R. K. and Beal M. F. (2008) Mitochondrial approaches for neuroprotection. Ann. N Y Acad. Sci. 1147, 395-412.
    • (2008) Ann. N Y Acad. Sci. , vol.1147 , pp. 395-412
    • Chaturvedi, R.K.1    Beal, M.F.2
  • 49
    • 1242295211 scopus 로고    scopus 로고
    • Synaptic uptake and beyond: The sodium- and chloride-dependent neurotransmitter transporter family SLC6
    • Chen N. H., Reith M. E. and Quick M. W. (2004) Synaptic uptake and beyond: The sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflugers Arch. 447, 519-531.
    • (2004) Pflugers Arch. , vol.447 , pp. 519-531
    • Chen, N.H.1    Reith, M.E.2    Quick, M.W.3
  • 50
    • 47149101533 scopus 로고    scopus 로고
    • Treatment with L-Arginine improves neuropsychological disorders in a child with creatine transporter defect
    • Chilosi A., Leuzzi V., Battini R. et al. (2008) Treatment with L-Arginine improves neuropsychological disorders in a child with creatine transporter defect. Neurocase 14, 151-161.
    • (2008) Neurocase , vol.14 , pp. 151-161
    • Chilosi, A.1    Leuzzi, V.2    Battini, R.3
  • 51
    • 0342960821 scopus 로고    scopus 로고
    • Localized proton MR spectroscopy in infants with urea cycle defect
    • Choi C. G. and Yoo H. W. (2001) Localized proton MR spectroscopy in infants with urea cycle defect. AJNR Am. J. Neuroradiol. 22, 834-837.
    • (2001) AJNR Am. J. Neuroradiol. , vol.22 , pp. 834-837
    • Choi, C.G.1    Yoo, H.W.2
  • 54
    • 0032854736 scopus 로고    scopus 로고
    • Molecular characterization of the human CRT-1 creatine transporter expressed in Xenopus oocytes
    • Dai W., Vinnakota S., Qian X., Kunze D. L. and Sarkar H. K. (1999) Molecular characterization of the human CRT-1 creatine transporter expressed in Xenopus oocytes. Arch. Biochem. Biophys. 361, 75-84.
    • (1999) Arch. Biochem. Biophys. , vol.361 , pp. 75-84
    • Dai, W.1    Vinnakota, S.2    Qian, X.3    Kunze, D.L.4    Sarkar, H.K.5
  • 55
    • 0021978358 scopus 로고
    • Guanidinoacetate methyltransferase activity in tissues and cultured cells
    • Daly M. M. (1985) Guanidinoacetate methyltransferase activity in tissues and cultured cells. Arch. Biochem. Biophys. 236, 576-584.
    • (1985) Arch. Biochem. Biophys. , vol.236 , pp. 576-584
    • Daly, M.M.1
  • 58
    • 0026036424 scopus 로고
    • Guanidino compounds that are increased in hyperargininemia inhibit GABA and glycine responses on mouse neurons in cell culture
    • De Deyn P. P., Marescau B. and Macdonald R. L. (1991) Guanidino compounds that are increased in hyperargininemia inhibit GABA and glycine responses on mouse neurons in cell culture. Epilepsy Res. 8, 134-141.
    • (1991) Epilepsy Res. , vol.8 , pp. 134-141
    • De Deyn, P.P.1    Marescau, B.2    Macdonald, R.L.3
  • 59
    • 0038115294 scopus 로고    scopus 로고
    • Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice
    • Dedeoglu A., Kubilus J. K., Yang L., Ferrante K. L., Hersch S. M., Beal M. F. and Ferrante R. J. (2003) Creatine therapy provides neuroprotection after onset of clinical symptoms in Huntington's disease transgenic mice. J. Neurochem. 85, 1359-1367.
    • (2003) J. Neurochem. , vol.85 , pp. 1359-1367
    • Dedeoglu, A.1    Kubilus, J.K.2    Yang, L.3    Ferrante, K.L.4    Hersch, S.M.5    Beal, M.F.6    Ferrante, R.J.7
  • 60
    • 16344374718 scopus 로고    scopus 로고
    • Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition
    • Di Lisa F. and Bernardi P. (2005) Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition. Cardiovasc. Res. 66, 222-232.
    • (2005) Cardiovasc. Res. , vol.66 , pp. 222-232
    • Di Lisa, F.1    Bernardi, P.2
  • 62
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • Dirnagl U., Iadecola C. and Moskowitz M. A. (1999) Pathobiology of ischaemic stroke: An integrated view. Trends Neurosci. 22, 391-397.
    • (1999) Trends Neurosci. , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 64
    • 0031913691 scopus 로고    scopus 로고
    • Metabolism of glycine in primary astroglial cells: Synthesis of creatine, serine, and glutathione
    • Dringen R., Verleysdonk S., Hamprecht B., Willker W., Leibfritz D. and Brand A. (1998) Metabolism of glycine in primary astroglial cells: Synthesis of creatine, serine, and glutathione. J. Neurochem. 70, 835-840.
    • (1998) J. Neurochem. , vol.70 , pp. 835-840
    • Dringen, R.1    Verleysdonk, S.2    Hamprecht, B.3    Willker, W.4    Leibfritz, D.5    Brand, A.6
  • 65
    • 0035052706 scopus 로고    scopus 로고
    • Evolution and physiological roles of phosphagen systems
    • Ellington W. R. (2001) Evolution and physiological roles of phosphagen systems. Annu. Rev. Physiol. 63, 289-325.
    • (2001) Annu. Rev. Physiol. , vol.63 , pp. 289-325
    • Ellington, W.R.1
  • 66
    • 0242573129 scopus 로고    scopus 로고
    • Development of the blood-brain barrier
    • Engelhardt B. (2003) Development of the blood-brain barrier. Cell Tissue Res. 314, 119-129.
    • (2003) Cell Tissue Res. , vol.314 , pp. 119-129
    • Engelhardt, B.1
  • 69
    • 57649159177 scopus 로고    scopus 로고
    • Arginine supplementation in four patients with X-linked creatine transporter defect
    • Fons C., Sempere A., Arias A. et al. (2008) Arginine supplementation in four patients with X-linked creatine transporter defect. J. Inherit. Metab. Dis. 31, 724-728.
    • (2008) J. Inherit. Metab. Dis. , vol.31 , pp. 724-728
    • Fons, C.1    Sempere, A.2    Arias, A.3
  • 70
    • 76349099124 scopus 로고    scopus 로고
    • Response to creatine analogs in fibroblasts and patients with creatine transporter deficiency
    • Fons C., Arias A., Sempere A. et al. (2010) Response to creatine analogs in fibroblasts and patients with creatine transporter deficiency. Mol. Genet. Metab. 99, 296-299.
    • (2010) Mol. Genet. Metab. , vol.99 , pp. 296-299
    • Fons, C.1    Arias, A.2    Sempere, A.3
  • 71
    • 33745898264 scopus 로고    scopus 로고
    • Possible role of creatine concentrations in the brain in regulating appetite and weight
    • Galbraith R. A., Furukawa M. and Li M. (2006) Possible role of creatine concentrations in the brain in regulating appetite and weight. Brain Res. 1101, 85-91.
    • (2006) Brain Res. , vol.1101 , pp. 85-91
    • Galbraith, R.A.1    Furukawa, M.2    Li, M.3
  • 72
    • 3142636768 scopus 로고    scopus 로고
    • Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
    • Gauthier L. R., Charrin B. C., Borrell-Pages M. et al. (2004) Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 118, 127-138.
    • (2004) Cell , vol.118 , pp. 127-138
    • Gauthier, L.R.1    Charrin, B.C.2    Borrell-Pages, M.3
  • 73
    • 0026446242 scopus 로고
    • Early time course of N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline in the brain after acute stroke. A proton magnetic resonance spectroscopy study
    • Gideon P., Henriksen O., Sperling B., Christiansen P., Olsen T. S., Jorgensen H. S. and Arlien-Soborg P. (1992) Early time course of N-acetylaspartate, creatine and phosphocreatine, and compounds containing choline in the brain after acute stroke. A proton magnetic resonance spectroscopy study. Stroke 23, 1566-1572.
    • (1992) Stroke , vol.23 , pp. 1566-1572
    • Gideon, P.1    Henriksen, O.2    Sperling, B.3    Christiansen, P.4    Olsen, T.S.5    Jorgensen, H.S.6    Arlien-Soborg, P.7
  • 75
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green D. R. and Reed J. C. (1998) Mitochondria and apoptosis. Science 281, 1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 77
    • 1642547106 scopus 로고    scopus 로고
    • Cognitive outcome in urea cycle disorders
    • Gropman A. L. and Batshaw M. L. (2004) Cognitive outcome in urea cycle disorders. Mol. Genet. Metab. 81, S58-S62.
    • (2004) Mol. Genet. Metab. , vol.81
    • Gropman, A.L.1    Batshaw, M.L.2
  • 78
    • 76449109380 scopus 로고    scopus 로고
    • Exploring the therapeutic role of creatine supplementation
    • Gualano B., Artioli G. G., Poortmans J. R. and Lancha A. H. (2010) Exploring the therapeutic role of creatine supplementation. Amino Acids 38, 31-44.
    • (2010) Amino Acids , vol.38 , pp. 31-44
    • Gualano, B.1    Artioli, G.G.2    Poortmans, J.R.3    Lancha, A.H.4
  • 79
    • 0027537622 scopus 로고
    • (+)-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. cDNA cloning and functional expression
    • (+)-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. cDNA cloning and functional expression. J. Biol. Chem. 268, 8418-8421.
    • (1993) J. Biol. Chem. , vol.268 , pp. 8418-8421
    • Guimbal, C.1    Kilimann, M.W.2
  • 80
    • 0028360971 scopus 로고
    • Cloning and sequencing of rat kidney L-arginine: Glycine amidinotransferase. Studies on the mechanism of regulation by growth hormone and creatine
    • Guthmiller P., Van Pilsum J. F., Boen J. R. and McGuire D. M. (1994) Cloning and sequencing of rat kidney L-arginine: Glycine amidinotransferase. Studies on the mechanism of regulation by growth hormone and creatine. J. Biol. Chem. 269, 17556-17560.
    • (1994) J. Biol. Chem. , vol.269 , pp. 17556-17560
    • Guthmiller, P.1    Van Pilsum, J.F.2    Boen, J.R.3    McGuire, D.M.4
  • 81
    • 0028813282 scopus 로고
    • In situ hybridization analysis of CHOT1, a creatine transporter, in the rat central nervous system
    • Happe H. K. and Murrin L. C. (1995) In situ hybridization analysis of CHOT1, a creatine transporter, in the rat central nervous system. J. Comp. Neurol. 351, 94-103.
    • (1995) J. Comp. Neurol. , vol.351 , pp. 94-103
    • Happe, H.K.1    Murrin, L.C.2
  • 82
    • 0027724925 scopus 로고
    • Functional aspects of creatine kinase in brain
    • Hemmer W. and Wallimann T. (1993) Functional aspects of creatine kinase in brain. Dev. Neurosci. 15, 249-260. (Pubitemid 24258157)
    • (1993) Developmental Neuroscience , vol.15 , Issue.3-5 , pp. 249-260
    • Hemmer, W.1    Wallimann, T.2
  • 83
    • 0028198057 scopus 로고
    • Creatine kinase isoenzymes in chicken cerebellum: Specific localization of brain-type creatine kinase in Bergmann glial cells and muscle-type creatine kinase in Purkinje neurons
    • Hemmer W., Zanolla E., Furter-Graves E. M., Eppenberger H. M. and Wallimann T. (1994) Creatine kinase isoenzymes in chicken cerebellum: Specific localization of brain-type creatine kinase in Bergmann glial cells and muscle-type creatine kinase in Purkinje neurons. Eur. J. Neurosci. 6, 538-549.
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 538-549
    • Hemmer, W.1    Zanolla, E.2    Furter-Graves, E.M.3    Eppenberger, H.M.4    Wallimann, T.5
  • 84
    • 33644927838 scopus 로고    scopus 로고
    • Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG
    • Hersch S. M., Gevorkian S., Marder K. et al. (2006) Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG. Neurology 66, 250-252.
    • (2006) Neurology , vol.66 , pp. 250-252
    • Hersch, S.M.1    Gevorkian, S.2    Marder, K.3
  • 85
    • 33646241740 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and amyotrophic lateral sclerosis
    • Hervias I., Beal M. F. and Manfredi G. (2006) Mitochondrial dysfunction and amyotrophic lateral sclerosis. Muscle Nerve 33, 598-608.
    • (2006) Muscle Nerve , vol.33 , pp. 598-608
    • Hervias, I.1    Beal, M.F.2    Manfredi, G.3
  • 86
    • 67651159214 scopus 로고    scopus 로고
    • Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse
    • Ireland Z., Russell A. P., Wallimann T., Walker D. W. and Snow R. (2009) Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse. BMC Dev. Biol. 9, 39.
    • (2009) BMC Dev. Biol. , vol.9 , pp. 39
    • Ireland, Z.1    Russell, A.P.2    Wallimann, T.3    Walker, D.W.4    Snow, R.5
  • 88
    • 0036460110 scopus 로고    scopus 로고
    • Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility
    • Jost C. R., Van der Zee C. E., In't Zandt H. J. A., Oerlemans F., Verheij M., Streijger F., Fransen J., Heerschap A., Cools A. R. and Wieringa B. (2002) Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility. Eur. J. Neurosci. 15, 1692-1706.
    • (2002) Eur. J. Neurosci. , vol.15 , pp. 1692-1706
    • Jost, C.R.1    Van Der Zee, C.E.2    In't Zandt, H.J.A.3    Oerlemans, F.4    Verheij, M.5    Streijger, F.6    Fransen, J.7    Heerschap, A.8    Cools, A.R.9    Wieringa, B.10
  • 89
    • 41549130338 scopus 로고    scopus 로고
    • The neuroprotective role of creatine
    • Klein A. M. and Ferrante R. J. (2007) The neuroprotective role of creatine. Subcell. Biochem. 46, 205-243.
    • (2007) Subcell. Biochem. , vol.46 , pp. 205-243
    • Klein, A.M.1    Ferrante, R.J.2
  • 90
    • 0033051815 scopus 로고    scopus 로고
    • Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis
    • Klivenyi P., Ferrante R. J., Matthews R. T. et al. (1999) Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Nat. Med. 5, 347-350.
    • (1999) Nat. Med. , vol.5 , pp. 347-350
    • Klivenyi, P.1    Ferrante, R.J.2    Matthews, R.T.3
  • 91
    • 0032079517 scopus 로고    scopus 로고
    • Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1
    • Kong J. and Xu Z. (1998) Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J. Neurosci. 18, 3241-3250.
    • (1998) J. Neurosci. , vol.18 , pp. 3241-3250
    • Kong, J.1    Xu, Z.2
  • 92
    • 0036892242 scopus 로고    scopus 로고
    • Brain metabolite composition during early human brain development as measured by quantitative in vivo 1H magnetic resonance spectroscopy
    • Kreis R., Hofmann L., Kuhlmann B., Boesch C., Bossi E. and Hüppi P. S. (2002) Brain metabolite composition during early human brain development as measured by quantitative in vivo 1H magnetic resonance spectroscopy. Magn. Reson. Med. 48, 949-958.
    • (2002) Magn. Reson. Med. , vol.48 , pp. 949-958
    • Kreis, R.1    Hofmann, L.2    Kuhlmann, B.3    Boesch, C.4    Bossi, E.5    Hüppi, P.S.6
  • 93
    • 0028082199 scopus 로고
    • Guanidinoacetate methyltransferase in the mouse: Extensive expression in Sertoli cells of testis and in microvilli of caput epididymis
    • Lee H., Ogawa H., Fujioka M. and Gerton G. L. (1994) Guanidinoacetate methyltransferase in the mouse: Extensive expression in Sertoli cells of testis and in microvilli of caput epididymis. Biol. Reprod. 50, 152-162.
    • (1994) Biol. Reprod. , vol.50 , pp. 152-162
    • Lee, H.1    Ogawa, H.2    Fujioka, M.3    Gerton, G.L.4
  • 94
    • 0031810763 scopus 로고    scopus 로고
    • Creatine synthesis and transport systems in the male rat reproductive tract
    • Lee H., Kim J. H., Chae Y. J., Ogawa H., Lee M. H. and Gerton G. L. (1998) Creatine synthesis and transport systems in the male rat reproductive tract. Biol. Reprod. 58, 1437-1444.
    • (1998) Biol. Reprod. , vol.58 , pp. 1437-1444
    • Lee, H.1    Kim, J.H.2    Chae, Y.J.3    Ogawa, H.4    Lee, M.H.5    Gerton, G.L.6
  • 95
    • 63949087557 scopus 로고    scopus 로고
    • Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain
    • Lei H., Berthet C., Hirt L. and Gruetter R. (2009) Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain. J. Cereb. Blood Flow Metab. 29, 811-819.
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , pp. 811-819
    • Lei, H.1    Berthet, C.2    Hirt, L.3    Gruetter, R.4
  • 96
    • 33748771741 scopus 로고    scopus 로고
    • Intracerebroventricular administration of creatine protects against damage by global cerebral ischemia in rat
    • Lensman M., Korzhevskii D. E., Mourovets V. O. et al. (2006) Intracerebroventricular administration of creatine protects against damage by global cerebral ischemia in rat. Brain Res. 1114, 187-194.
    • (2006) Brain Res. , vol.1114 , pp. 187-194
    • Lensman, M.1    Korzhevskii, D.E.2    Mourovets, V.O.3
  • 99
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin M. T. and Beal M. F. (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787-795.
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 100
    • 33750972301 scopus 로고    scopus 로고
    • High frequency of creatine deficiency syndromes in patients with unexplained mental retardation
    • Lion-François L., Cheillan D., Pitelet G. et al. (2006) High frequency of creatine deficiency syndromes in patients with unexplained mental retardation. Neurology 67, 1713-1714.
    • (2006) Neurology , vol.67 , pp. 1713-1714
    • Lion-François, L.1    Cheillan, D.2    Pitelet, G.3
  • 101
    • 0020004311 scopus 로고
    • Reduced ATP concentration as a basis for synaptic transmission failure during hypoxia in the in vitro guinea-pig hippocampus
    • Lipton P. and Whittingham T. S. (1982) Reduced ATP concentration as a basis for synaptic transmission failure during hypoxia in the in vitro guinea-pig hippocampus. J. Physiol. 325, 51-65.
    • (1982) J. Physiol. , vol.325 , pp. 51-65
    • Lipton, P.1    Whittingham, T.S.2
  • 102
    • 33750297109 scopus 로고    scopus 로고
    • The creatine transporter mediates the uptake of creatine by brain tissue, but not the uptake of two creatine-derived compounds
    • Lunardi G., Parodi A., Perasso L. et al. (2006) The creatine transporter mediates the uptake of creatine by brain tissue, but not the uptake of two creatine-derived compounds. Neuroscience 142, 991-997.
    • (2006) Neuroscience , vol.142 , pp. 991-997
    • Lunardi, G.1    Parodi, A.2    Perasso, L.3
  • 103
    • 0026052173 scopus 로고
    • Developmental regulation of creatine kinase gene expression by myogenic factors in embryonic mouse and chick skeletal muscle
    • Lyons G. E., Mühlebach S., Moser A., Masood R., Paterson B. M., Buckingham M. E. and Perriard J. C. (1991) Developmental regulation of creatine kinase gene expression by myogenic factors in embryonic mouse and chick skeletal muscle. Development 113, 1017-1029.
    • (1991) Development , vol.113 , pp. 1017-1029
    • Lyons, G.E.1    Mühlebach, S.2    Moser, A.3    Masood, R.4    Paterson, B.M.5    Buckingham, M.E.6    Perriard, J.C.7
  • 105
    • 34249783450 scopus 로고    scopus 로고
    • Severe epilepsy in X-linked creatine transporter defect (CRTR-D)
    • Mancardi M. M., Caruso U., Schiaffino M. C. et al. (2007) Severe epilepsy in X-linked creatine transporter defect (CRTR-D). Epilepsia 48, 1211-1213.
    • (2007) Epilepsia , vol.48 , pp. 1211-1213
    • Mancardi, M.M.1    Caruso, U.2    Schiaffino, M.C.3
  • 106
    • 0029093834 scopus 로고
    • Cerebral metabolites in patients with acute and subacute strokes: Concentrations determined by quantitative proton MR spectroscopy
    • Mathews V. P., Barker P. B., Blackband S. J., Chatham J. C. and Bryan R. N. (1995) Cerebral metabolites in patients with acute and subacute strokes: Concentrations determined by quantitative proton MR spectroscopy. AJR Am. J. Roentgenol. 165, 633-638.
    • (1995) AJR Am. J. Roentgenol. , vol.165 , pp. 633-638
    • Mathews, V.P.1    Barker, P.B.2    Blackband, S.J.3    Chatham, J.C.4    Bryan, R.N.5
  • 108
  • 109
    • 33746016268 scopus 로고    scopus 로고
    • Mitochondria: More than just a powerhouse
    • McBride H. M., Neuspiel M. and Wasiak S. (2006) Mitochondria: More than just a powerhouse. Curr. Biol. 16, R551-R560.
    • (2006) Curr. Biol. , vol.16
    • McBride, H.M.1    Neuspiel, M.2    Wasiak, S.3
  • 110
    • 0021225314 scopus 로고
    • Repression of rat kidney L-arginine: Glycine amidinotransferase synthesis by creatine at a pretranslational level
    • McGuire D. M., Gross M. D., Van Pilsum J. F. and Towle H. C. (1984) Repression of rat kidney L-arginine: Glycine amidinotransferase synthesis by creatine at a pretranslational level. J. Biol. Chem. 259, 12034-12038.
    • (1984) J. Biol. Chem. , vol.259 , pp. 12034-12038
    • McGuire, D.M.1    Gross, M.D.2    Van Pilsum, J.F.3    Towle, H.C.4
  • 111
    • 33747075772 scopus 로고    scopus 로고
    • GAMT deficiency: Features, treatment, and outcome in an inborn error of creatine synthesis
    • Mercimek-Mahmutoglu S., Stoeckler-Ipsiroglu S., Adami A. et al. (2006) GAMT deficiency: Features, treatment, and outcome in an inborn error of creatine synthesis. Neurology 67, 480-484.
    • (2006) Neurology , vol.67 , pp. 480-484
    • Mercimek-Mahmutoglu, S.1    Stoeckler-Ipsiroglu, S.2    Adami, A.3
  • 113
    • 0024579332 scopus 로고
    • Creatine transport in cultured cells of rat and mouse brain
    • Möller A. and Hamprecht B. (1989) Creatine transport in cultured cells of rat and mouse brain. J. Neurochem. 52, 544-550.
    • (1989) J. Neurochem. , vol.52 , pp. 544-550
    • Möller, A.1    Hamprecht, B.2
  • 114
    • 3042511855 scopus 로고    scopus 로고
    • Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-retinal barrier
    • Nakashima T., Tomi M., Katayama K., Tachikawa M., Watanabe M., Terasaki T. and Hosoya K. (2004) Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-retinal barrier. J. Neurochem. 89, 1454-1461.
    • (2004) J. Neurochem. , vol.89 , pp. 1454-1461
    • Nakashima, T.1    Tomi, M.2    Katayama, K.3    Tachikawa, M.4    Watanabe, M.5    Terasaki, T.6    Hosoya, K.7
  • 117
    • 0036966277 scopus 로고    scopus 로고
    • Activation of GABA(A) receptors by guanidinoacetate: A novel pathophysiological mechanism
    • Neu A., Neuhoff H., Trube G., Fehr S., Ullrich K., Roeper J. and Isbrandt D. (2002) Activation of GABA(A) receptors by guanidinoacetate: A novel pathophysiological mechanism. Neurobiol. Dis. 11, 298-307.
    • (2002) Neurobiol. Dis. , vol.11 , pp. 298-307
    • Neu, A.1    Neuhoff, H.2    Trube, G.3    Fehr, S.4    Ullrich, K.5    Roeper, J.6    Isbrandt, D.7
  • 118
    • 0025052336 scopus 로고
    • The release and uptake of excitatory amino acids
    • Nicholls D. and Attwell D. (1990) The release and uptake of excitatory amino acids. Trends Pharmacol. Sci. 11, 462-468.
    • (1990) Trends Pharmacol. Sci. , vol.11 , pp. 462-468
    • Nicholls, D.1    Attwell, D.2
  • 119
    • 0024207765 scopus 로고
    • Brain tissue concentrations of ATP, phosphocreatine, lactate, and tissue pH in relation to reduced cerebral blood flow following experimental acute middle cerebral artery occlusion
    • Obrenovitch T. P., Garofalo O., Harris R. J., Bordi L., Ono M., Momma F., Bachelard H. S. and Symon L. (1988) Brain tissue concentrations of ATP, phosphocreatine, lactate, and tissue pH in relation to reduced cerebral blood flow following experimental acute middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 8, 866-874.
    • (1988) J. Cereb. Blood Flow Metab. , vol.8 , pp. 866-874
    • Obrenovitch, T.P.1    Garofalo, O.2    Harris, R.J.3    Bordi, L.4    Ono, M.5    Momma, F.6    Bachelard, H.S.7    Symon, L.8
  • 120
  • 121
    • 21244497743 scopus 로고    scopus 로고
    • New aspects of the blood-brain barrier transporters; its physiological roles in the central nervous system
    • Ohtsuki S. (2004) New aspects of the blood-brain barrier transporters; its physiological roles in the central nervous system. Biol. Pharm. Bull. 27, 1489-1496.
    • (2004) Biol. Pharm. Bull. , vol.27 , pp. 1489-1496
    • Ohtsuki, S.1
  • 123
    • 0035805092 scopus 로고    scopus 로고
    • Control of glutamate clearance and synaptic efficacy by glial coverage of neurons
    • Oliet S. H., Piet R. and Poulain D. A. (2001) Control of glutamate clearance and synaptic efficacy by glial coverage of neurons. Science 292, 923-926.
    • (2001) Science , vol.292 , pp. 923-926
    • Oliet, S.H.1    Piet, R.2    Poulain, D.A.3
  • 124
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • Parker W. D., Boyson S. J. and Parks J. K. (1989) Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann. Neurol. 26, 719-723.
    • (1989) Ann. Neurol. , vol.26 , pp. 719-723
    • Parker, W.D.1    Boyson, S.J.2    Parks, J.K.3
  • 128
    • 41049102922 scopus 로고    scopus 로고
    • Protective effects of some creatine derivatives in brain tissue anoxia
    • Perasso L., Lunardi G. L., Risso F. et al. (2008) Protective effects of some creatine derivatives in brain tissue anoxia. Neurochem. Res. 33, 765-775.
    • (2008) Neurochem. Res. , vol.33 , pp. 765-775
    • Perasso, L.1    Lunardi, G.L.2    Risso, F.3
  • 129
    • 0026466336 scopus 로고
    • Two-dimensional 1H spectroscopic imaging for evaluating the local metabolic response to focal ischemia in the conscious rat
    • Peres M., Bourgeois D., Roussel S. et al. (1992) Two-dimensional 1H spectroscopic imaging for evaluating the local metabolic response to focal ischemia in the conscious rat. NMR Biomed. 5, 11-19.
    • (1992) NMR Biomed. , vol.5 , pp. 11-19
    • Peres, M.1    Bourgeois, D.2    Roussel, S.3
  • 132
    • 0030582438 scopus 로고    scopus 로고
    • Arginine-related guanidino compounds and nitric oxide synthase in the brain of ornithine transcarbamylase deficient spf mutant mouse: Effect of metabolic arginine deficiency
    • Ratnakumari L., Qureshi I. A., Butterworth R. F., Marescau B. and De Deyn P. P. (1996) Arginine-related guanidino compounds and nitric oxide synthase in the brain of ornithine transcarbamylase deficient spf mutant mouse: Effect of metabolic arginine deficiency. Neurosci. Lett. 215, 153-156.
    • (1996) Neurosci. Lett. , vol.215 , pp. 153-156
    • Ratnakumari, L.1    Qureshi, I.A.2    Butterworth, R.F.3    Marescau, B.4    De Deyn, P.P.5
  • 133
    • 0242290992 scopus 로고    scopus 로고
    • MR spectroscopy of muscle and brain in guanidinoacetate methyltransferase (GAMT)-deficient mice: Validation of an animal model to study creatine deficiency
    • Renema W. K., Schmidt A., van Asten J. J., Oerlemans F., Ullrich K., Wieringa B., Isbrandt D. and Heerschap A. (2003) MR spectroscopy of muscle and brain in guanidinoacetate methyltransferase (GAMT)-deficient mice: Validation of an animal model to study creatine deficiency. Magn. Reson. Med. 50, 936-943.
    • (2003) Magn. Reson. Med. , vol.50 , pp. 936-943
    • Renema, W.K.1    Schmidt, A.2    Van Asten, J.J.3    Oerlemans, F.4    Ullrich, K.5    Wieringa, B.6    Isbrandt, D.7    Heerschap, A.8
  • 134
    • 3042544793 scopus 로고    scopus 로고
    • High prevalence of SLC6A8 deficiency in X-linked mental retardation
    • Rosenberg E. H., Almeida L. S., Kleefstra T. et al. (2004) High prevalence of SLC6A8 deficiency in X-linked mental retardation. Am. J. Hum. Genet. 75, 97-105.
    • (2004) Am. J Hum. Genet. , vol.75 , pp. 97-105
    • Rosenberg, E.H.1    Almeida, L.S.2    Kleefstra, T.3
  • 135
    • 52649160814 scopus 로고    scopus 로고
    • Creatine monohydrate in ALS: Effects on strength, fatigue, respiratory status and ALSFRS
    • Rosenfeld J., King R. M., Jackson C. E. et al. (2008) Creatine monohydrate in ALS: Effects on strength, fatigue, respiratory status and ALSFRS. Amyotroph. Lateral Scler. 9, 266-272.
    • (2008) Amyotroph. Lateral Scler. , vol.9 , pp. 266-272
    • Rosenfeld, J.1    King, R.M.2    Jackson, C.E.3
  • 136
    • 3142640821 scopus 로고    scopus 로고
    • Huntington's disease: New paths to pathogenesis
    • Ross C. A. (2004) Huntington's disease: New paths to pathogenesis. Cell 118, 4-7.
    • (2004) Cell , vol.118 , pp. 4-7
    • Ross, C.A.1
  • 137
    • 18844441689 scopus 로고    scopus 로고
    • Emerging chemotherapeutic strategies for Huntington's disease
    • Ryu H. and Ferrante R. J. (2005) Emerging chemotherapeutic strategies for Huntington's disease. Expert Opin. Emerg. Drugs. 10, 345-363.
    • (2005) Expert Opin. Emerg. Drugs. , vol.10 , pp. 345-363
    • Ryu, H.1    Ferrante, R.J.2
  • 139
    • 0029805748 scopus 로고    scopus 로고
    • Expression of the rat brain creatine transporter in situ and in transfected HeLa cells
    • Saltarelli M. D., Bauman A. L., Moore K. R., Bradley C. C. and Blakely R. D. (1996) Expression of the rat brain creatine transporter in situ and in transfected HeLa cells. Dev. Neurosci. 18, 524-534.
    • (1996) Dev. Neurosci. , vol.18 , pp. 524-534
    • Saltarelli, M.D.1    Bauman, A.L.2    Moore, K.R.3    Bradley, C.C.4    Blakely, R.D.5
  • 142
    • 0028264171 scopus 로고
    • The putative rat choline transporter CHOT1 transports creatine and is highly expressed in neural and muscle-rich tissues
    • Schloss P., Mayser W. and Betz H. (1994) The putative rat choline transporter CHOT1 transports creatine and is highly expressed in neural and muscle-rich tissues. Biochem. Biophys. Res. Commun. 198, 637-645.
    • (1994) Biochem. Biophys. Res. Commun. , vol.198 , pp. 637-645
    • Schloss, P.1    Mayser, W.2    Betz, H.3
  • 143
    • 2442475483 scopus 로고    scopus 로고
    • Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency
    • Schmidt A., Marescau B., Boehm E. A. et al. (2004) Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency. Hum. Mol. Genet. 13, 905-921.
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 905-921
    • Schmidt, A.1    Marescau, B.2    Boehm, E.A.3
  • 144
    • 0037306564 scopus 로고    scopus 로고
    • Creatine deficiency syndromes
    • Schulze A. (2003) Creatine deficiency syndromes. Mol. Cell. Biochem. 244, 143-150.
    • (2003) Mol. Cell. Biochem. , vol.244 , pp. 143-150
    • Schulze, A.1
  • 145
    • 43149090114 scopus 로고    scopus 로고
    • Pre-symptomatic treatment of creatine biosynthesis defects
    • Schulze A. and Battini R. (2007) Pre-symptomatic treatment of creatine biosynthesis defects. Subcell. Biochem. 46, 167-181.
    • (2007) Subcell. Biochem. , vol.46 , pp. 167-181
    • Schulze, A.1    Battini, R.2
  • 146
    • 0031457381 scopus 로고    scopus 로고
    • Creatine deficiency syndrome caused by guanidinoacetate methyltransferase deficiency: Diagnostic tools for a new inborn error of metabolism
    • Schulze A., Hess T., Wevers R. et al. (1997) Creatine deficiency syndrome caused by guanidinoacetate methyltransferase deficiency: Diagnostic tools for a new inborn error of metabolism. J. Pediatr. 131, 626-631.
    • (1997) J. Pediatr. , vol.131 , pp. 626-631
    • Schulze, A.1    Hess, T.2    Wevers, R.3
  • 148
    • 0035694594 scopus 로고    scopus 로고
    • Improving treatment of guanidinoacetate methyltransferase deficiency: Reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation
    • Schulze A., Ebinger F., Rating D. and Mayatepek E. (2001) Improving treatment of guanidinoacetate methyltransferase deficiency: Reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation. Mol. Genet. Metab. 74, 413-419.
    • (2001) Mol. Genet. Metab. , vol.74 , pp. 413-419
    • Schulze, A.1    Ebinger, F.2    Rating, D.3    Mayatepek, E.4
  • 149
    • 0037309446 scopus 로고    scopus 로고
    • Lack of creatine in muscle and brain in an adult with GAMT deficiency
    • Schulze A., Bachert P., Schlemmer H. et al. (2003) Lack of creatine in muscle and brain in an adult with GAMT deficiency. Ann. Neurol. 53, 248-251.
    • (2003) Ann. Neurol. , vol.53 , pp. 248-251
    • Schulze, A.1    Bachert, P.2    Schlemmer, H.3
  • 151
  • 153
    • 60849116967 scopus 로고    scopus 로고
    • Creatine synthesis: Hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo
    • Da Silva R. P., Nissim I., Brosnan M. E. and Brosnan J. T. (2009) Creatine synthesis: Hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo. Am. J. Physiol. Endocrinol. Metab. 296, E256-E261.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296
    • Da Silva, R.P.1    Nissim, I.2    Brosnan, M.E.3    Brosnan, J.T.4
  • 154
    • 0019303863 scopus 로고
    • Inhibition of arginine-glycine amidinotransferase by ornithine. A possible mechanism for the muscular and chorioretinal atrophies in gyrate atrophy of the choroid and retina with hyperornithinemia
    • Sipilä I. (1980) Inhibition of arginine-glycine amidinotransferase by ornithine. A possible mechanism for the muscular and chorioretinal atrophies in gyrate atrophy of the choroid and retina with hyperornithinemia. Biochim. Biophys. Acta 613, 79-84.
    • (1980) Biochim. Biophys. Acta , vol.613 , pp. 79-84
    • Sipilä, I.1
  • 155
    • 0034787869 scopus 로고    scopus 로고
    • Creatine and the creatine transporter: A review
    • Snow R. J. and Murphy R. M. (2001) Creatine and the creatine transporter: A review. Mol. Cell. Biochem. 224, 169-181.
    • (2001) Mol. Cell. Biochem. , vol.224 , pp. 169-181
    • Snow, R.J.1    Murphy, R.M.2
  • 156
    • 0030611177 scopus 로고    scopus 로고
    • 2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies
    • 2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies. Cell 89, 93-103.
    • (1997) Cell , vol.89 , pp. 93-103
    • Steeghs, K.1    Benders, A.2    Oerlemans, F.3
  • 158
    • 0030596907 scopus 로고    scopus 로고
    • Creatine replacement therapy in guanidinoacetate methyltransferase deficiency, a novel inborn error of metabolism
    • DOI 10.1016/S0140-6736(96)04116-5
    • Stöckler S., Hanefeld F. and Frahm J. (1996a) Creatine replacement therapy in guanidinoacetate methyltransferase deficiency, a novel inborn error of metabolism. Lancet 348, 789-790. (Pubitemid 26308483)
    • (1996) Lancet , vol.348 , Issue.9030 , pp. 789-790
    • Stockler, S.1    Hanefeld, F.2    Frahm, J.3
  • 159
    • 0029959969 scopus 로고    scopus 로고
    • Guanidinoacetate methyltransferase deficiency: The first inborn error of creatine metabolism in man
    • Stöckler S., Isbrandt D., Hanefeld F., Schmidt B. and von Figura K. (1996b) Guanidinoacetate methyltransferase deficiency: The first inborn error of creatine metabolism in man. Am. J. Hum. Genet. 58, 914-922. (Pubitemid 26115162)
    • (1996) American Journal of Human Genetics , vol.58 , Issue.5 , pp. 914-922
    • Stockler, S.1    Isbrandt, D.2    Hanefeld, F.3    Schmidt, B.4    Von Figura, K.5
  • 160
    • 43849095420 scopus 로고    scopus 로고
    • Cerebral creatine deficiency syndromes: Clinical aspects, treatment and pathophysiology
    • Stöckler S., Schutz P. W. and Salomons G. S. (2007) Cerebral creatine deficiency syndromes: Clinical aspects, treatment and pathophysiology. Subcell. Biochem. 46, 149-166.
    • (2007) Subcell. Biochem. , vol.46 , pp. 149-166
    • Stöckler, S.1    Schutz, P.W.2    Salomons, G.S.3
  • 162
    • 0038497516 scopus 로고    scopus 로고
    • Clinical characteristics and diagnostic clues in inborn errors of creatine metabolism
    • Stromberger C., Bodamer O. A. and Stöckler-Ipsiroglu S. (2003) Clinical characteristics and diagnostic clues in inborn errors of creatine metabolism. J. Inherit. Metab. Dis. 26, 299-308.
    • (2003) J. Inherit. Metab. Dis. , vol.26 , pp. 299-308
    • Stromberger, C.1    Bodamer, O.A.2    Stöckler-Ipsiroglu, S.3
  • 163
    • 0031716355 scopus 로고    scopus 로고
    • Mitochondria in sporadic amyotrophic lateral sclerosis
    • Swerdlow R. H., Parks J. K., Cassarino D. S. et al. (1998) Mitochondria in sporadic amyotrophic lateral sclerosis. Exp. Neurol. 153, 135-142.
    • (1998) Exp. Neurol. , vol.153 , pp. 135-142
    • Swerdlow, R.H.1    Parks, J.K.2    Cassarino, D.S.3
  • 164
    • 3142683647 scopus 로고    scopus 로고
    • Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis
    • Tachikawa M., Fukaya M., Terasaki T., Ohtsuki S. and Watanabe M. (2004) Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis. Eur. J. Neurosci. 20, 144-160.
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 144-160
    • Tachikawa, M.1    Fukaya, M.2    Terasaki, T.3    Ohtsuki, S.4    Watanabe, M.5
  • 165
    • 53149101457 scopus 로고    scopus 로고
    • Expression and possible role of creatine transporter in the brain and at the bloodcerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant
    • Tachikawa M., Fujinawa J., Takahashi M. et al. (2008) Expression and possible role of creatine transporter in the brain and at the bloodcerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant. J. Neurochem. 107, 768-778.
    • (2008) J. Neurochem. , vol.107 , pp. 768-778
    • Tachikawa, M.1    Fujinawa, J.2    Takahashi, M.3
  • 166
    • 70349329705 scopus 로고    scopus 로고
    • The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats: Involvement of creatine and taurine transporters
    • Tachikawa M., Kasai Y., Yokoyama R., Fujinawa J., Ganapathy V., Terasaki T. and Hosoya K. (2009) The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats: Involvement of creatine and taurine transporters. J. Neurochem. 111, 499-509.
    • (2009) J. Neurochem. , vol.111 , pp. 499-509
    • Tachikawa, M.1    Kasai, Y.2    Yokoyama, R.3    Fujinawa, J.4    Ganapathy, V.5    Terasaki, T.6    Hosoya, K.7
  • 167
    • 0035002174 scopus 로고    scopus 로고
    • Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders
    • Tarnopolsky M. A. and Beal M. F. (2001) Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders. Ann. Neurol. 49, 561-574.
    • (2001) Ann. Neurol. , vol.49 , pp. 561-574
    • Tarnopolsky, M.A.1    Beal, M.F.2
  • 168
    • 37349004102 scopus 로고    scopus 로고
    • Parkinson's disease
    • Thomas B. and Beal M. F. (2007) Parkinson's disease. Hum. Mol. Genet. 16(R2), R183-R194.
    • (2007) Hum. Mol. Genet. , vol.16 , Issue.R2
    • Thomas, B.1    Beal, M.F.2
  • 169
    • 2942561028 scopus 로고    scopus 로고
    • The importance of neuritic plaques and tangles to the development and evolution of AD
    • Tiraboschi P., Hansen L. A., Thal L. J. and Corey-Bloom J. (2004) The importance of neuritic plaques and tangles to the development and evolution of AD. Neurology 62, 1984-1989.
    • (2004) Neurology , vol.62 , pp. 1984-1989
    • Tiraboschi, P.1    Hansen, L.A.2    Thal, L.J.3    Corey-Bloom, J.4
  • 171
    • 67349099925 scopus 로고    scopus 로고
    • Secondary creatine deficiency in ornithine delta-aminotransferase deficiency
    • Valayannopoulos V., Boddaert N., Mention K. et al. (2009) Secondary creatine deficiency in ornithine delta-aminotransferase deficiency. Mol. Genet. Metab. 97, 109-113.
    • (2009) Mol. Genet. Metab. , vol.97 , pp. 109-113
    • Valayannopoulos, V.1    Boddaert, N.2    Mention, K.3
  • 172
    • 0019445775 scopus 로고
    • Gyrate atrophy of the choroid and retina. Biochemical considerations and experience with an arginine-restricted diet
    • Valle D., Walser M., Brusilow S., Kaiser-Kupfer M. I. and Takki K. (1981) Gyrate atrophy of the choroid and retina. Biochemical considerations and experience with an arginine-restricted diet. Ophthalmology 88, 325-330. (Pubitemid 11098634)
    • (1981) Ophthalmology , vol.88 , Issue.4 , pp. 325-330
    • Valle, D.1    Walser, M.2    Brusilow, S.3
  • 174
    • 0015250466 scopus 로고
    • Distribution of creatine, guanidinoacetate and enzymes for their biosynthesis in the animal kingdom. Implications for phylogeny
    • Van Pilsum J. F., Stephens G. C. and Taylor D. (1972) Distribution of creatine, guanidinoacetate and enzymes for their biosynthesis in the animal kingdom. Implications for phylogeny. Biochem. J. 126, 325-345.
    • (1972) Biochem. J. , vol.126 , pp. 325-345
    • Van Pilsum, J.F.1    Stephens, G.C.2    Taylor, D.3
  • 175
    • 0030696102 scopus 로고    scopus 로고
    • An immunohistochemical and morphometric study on astrocytes and microvasculature in the human cerebral cortex
    • Virgintino D., Monaghan P., Robertson D., Errede M., Bertossi M., Ambrosi G. and Roncali L. (1997) An immunohistochemical and morphometric study on astrocytes and microvasculature in the human cerebral cortex. Histochem. J. 29, 655-660.
    • (1997) Histochem. J. , vol.29 , pp. 655-660
    • Virgintino, D.1    Monaghan, P.2    Robertson, D.3    Errede, M.4    Bertossi, M.5    Ambrosi, G.6    Roncali, L.7
  • 176
    • 0026585611 scopus 로고
    • Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The'phosphocreatine circuit' for cellular energy homeostasis
    • Wallimann T., Wyss M., Brdiczka D., Nicolay K. and Eppenberger H. M. (1992) Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: The'phosphocreatine circuit' for cellular energy homeostasis. Biochem. J. 281, 21-40.
    • (1992) Biochem. J. , vol.281 , pp. 21-40
    • Wallimann, T.1    Wyss, M.2    Brdiczka, D.3    Nicolay, K.4    Eppenberger, H.M.5
  • 177
    • 0032406769 scopus 로고    scopus 로고
    • Some new aspects of creatine kinase (CK): Compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiology
    • Wallimann T., Dolder M., Schlattner U., Eder M., Hornemann T., O'Gorman E., Ruck A. and Brdiczka D. (1998) Some new aspects of creatine kinase (CK): Compartmentation, structure, function and regulation for cellular and mitochondrial bioenergetics and physiology. Biofactors 8, 229-234.
    • (1998) Biofactors , vol.8 , pp. 229-234
    • Wallimann, T.1    Dolder, M.2    Schlattner, U.3    Eder, M.4    Hornemann, T.5    O'Gorman, E.6    Ruck, A.7    Brdiczka, D.8
  • 179
    • 0031964205 scopus 로고    scopus 로고
    • Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo 1H magnetic resonance spectroscopy
    • Wang Y. and Li S. J. (1998) Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo 1H magnetic resonance spectroscopy. Magn. Reson. Med. 39, 28-33.
    • (1998) Magn. Reson. Med. , vol.39 , pp. 28-33
    • Wang, Y.1    Li, S.J.2
  • 180
    • 0029970085 scopus 로고    scopus 로고
    • A mouse model of gyrate atrophy of the choroid and retina. Early retinal pigment epithelium damage and progressive retinal degeneration
    • Wang T., Milam A. H., Steel G. and Valle D. (1996) A mouse model of gyrate atrophy of the choroid and retina. Early retinal pigment epithelium damage and progressive retinal degeneration. J. Clin. Invest. 97, 2753-2762.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2753-2762
    • Wang, T.1    Milam, A.H.2    Steel, G.3    Valle, D.4
  • 181
    • 34250348448 scopus 로고    scopus 로고
    • Spatiotemporal expression of the creatine metabolism related genes agat, gamt and ct1 during zebrafish embryogenesis
    • Wang L., Zhang Y., Shao M. and Zhang H. (2007) Spatiotemporal expression of the creatine metabolism related genes agat, gamt and ct1 during zebrafish embryogenesis. Int. J. Dev. Biol. 51, 247-253.
    • (2007) Int. J. Dev. Biol. , vol.51 , pp. 247-253
    • Wang, L.1    Zhang, Y.2    Shao, M.3    Zhang, H.4
  • 182
    • 0042508791 scopus 로고    scopus 로고
    • Neuropathologic changes in Alzheimer's disease
    • Wenk G. L. (2003) Neuropathologic changes in Alzheimer's disease. J. Clin. Psychiatry 64(Suppl 9), 7-10.
    • (2003) J. Clin. Psychiatry , vol.64 , Issue.SUPPL. 9 , pp. 7-10
    • Wenk, G.L.1
  • 183
    • 0019856538 scopus 로고
    • Cerebral synaptic transmission during anoxia is protected by creatine
    • Whittingham T. S. and Lipton P. (1981) Cerebral synaptic transmission during anoxia is protected by creatine. J. Neurochem. 37, 1618-1621.
    • (1981) J. Neurochem. , vol.37 , pp. 1618-1621
    • Whittingham, T.S.1    Lipton, P.2
  • 184
    • 0032836188 scopus 로고    scopus 로고
    • Brain water diffusion in normal and creatine-supplemented rats during transient global ischemia
    • Wick M., Fujimori H., Michaelis T. and Frahm J. (1999) Brain water diffusion in normal and creatine-supplemented rats during transient global ischemia. Magn. Reson. Med. 42, 798-802.
    • (1999) Magn. Reson. Med. , vol.42 , pp. 798-802
    • Wick, M.1    Fujimori, H.2    Michaelis, T.3    Frahm, J.4
  • 186
    • 0029053881 scopus 로고
    • An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
    • Wong P. C., Pardo C. A., Borchelt D. R., Lee M. K., Copeland N. G., Jenkins N. A., Sisodia S. S., Cleveland D. W. and Price D. L. (1995) An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14, 1105-1116.
    • (1995) Neuron , vol.14 , pp. 1105-1116
    • Wong, P.C.1    Pardo, C.A.2    Borchelt, D.R.3    Lee, M.K.4    Copeland, N.G.5    Jenkins, N.A.6    Sisodia, S.S.7    Cleveland, D.W.8    Price, D.L.9
  • 187
    • 0033935979 scopus 로고    scopus 로고
    • Creatine and creatinine metabolism
    • Wyss M. and Kaddurah-Daouk R. (2000) Creatine and creatinine metabolism. Physiol. Rev. 80, 1107-1213.
    • (2000) Physiol. Rev. , vol.80 , pp. 1107-1213
    • Wyss, M.1    Kaddurah-Daouk, R.2
  • 188
    • 3042796442 scopus 로고    scopus 로고
    • Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice
    • Zhu S., Li M., Figueroa B. E., Liu A. et al. (2004) Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice. J. Neurosci. 24, 5909-5912.
    • (2004) J. Neurosci. , vol.24 , pp. 5909-5912
    • Zhu, S.1    Li, M.2    Figueroa, B.E.3    Liu, A.4


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