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Volumn 38, Issue 3, 1999, Pages 383-394

Reduction in the MK-801 binding sites of the NMDA sub-type of glutamate receptor in a mouse model of congenital hyperammonemia: Prevention by acetyl-L-carnitine

Author keywords

Acetyl L carnitine; Excitotoxicity; Glutamate; NMDA receptors; Ornithine transcarbamylase; spf mouse

Indexed keywords

4 AMINOPYRIDINE; DIZOCILPINE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; LEVACECARNINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; ORNITHINE CARBAMOYLTRANSFERASE; VERATRIDINE;

EID: 0032978522     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00160-9     Document Type: Article
Times cited : (20)

References (58)
  • 1
    • 0026065504 scopus 로고
    • MK-801 inhibition of acetylcholine receptor channels
    • Amador, M., Dani, J.A., 1991. MK-801 inhibition of acetylcholine receptor channels. Synapase 7, 207-215.
    • (1991) Synapase , vol.7 , pp. 207-215
    • Amador, M.1    Dani, J.A.2
  • 3
    • 0026584524 scopus 로고
    • Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
    • Beal, M.F., 1992. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 31, 119-130.
    • (1992) Ann. Neurol. , vol.31 , pp. 119-130
    • Beal, M.F.1
  • 4
    • 0001034416 scopus 로고
    • Urea cycle enzymes
    • Scriver, C.R., Beaudet, A.L., Sly, W.S., Valle, D. (Eds.), McGraw Hill, New York
    • Brusilow, S.W., Horwich, A.L., 1995. Urea cycle enzymes. In: Scriver, C.R., Beaudet, A.L., Sly, W.S., Valle, D. (Eds.), The Metabolic and Molecular Bases of Inherited Disease. McGraw Hill, New York, pp. 1187-1232.
    • (1995) The Metabolic and Molecular Bases of Inherited Disease , pp. 1187-1232
    • Brusilow, S.W.1    Horwich, A.L.2
  • 5
    • 0029690198 scopus 로고    scopus 로고
    • Urea cycle disorders: Diagnosis, pathophysiology, and therapy
    • Brusilow, S.W., Maestri, N.B., 1996. Urea cycle disorders: diagnosis, pathophysiology, and therapy. Adv. Pediatr. 43, 127-170.
    • (1996) Adv. Pediatr. , vol.43 , pp. 127-170
    • Brusilow, S.W.1    Maestri, N.B.2
  • 7
    • 0028221641 scopus 로고
    • Acetyl-L-carnitine affects aged brain receptorial system in rodents
    • Castorina, M., Ferraris, L., 1994. Acetyl-L-carnitine affects aged brain receptorial system in rodents. Life Sci. 54, 1205-1214.
    • (1994) Life Sci. , vol.54 , pp. 1205-1214
    • Castorina, M.1    Ferraris, L.2
  • 8
    • 0023695008 scopus 로고
    • Carnitine acetyltransferase: A review of its biology, enzymology, and bioorganic chemistry
    • Colucci, W.J., Gandour, R.D., 1988. Carnitine acetyltransferase: a review of its biology, enzymology, and bioorganic chemistry. Bioorg. Chem. 16, 307-334.
    • (1988) Bioorg. Chem. , vol.16 , pp. 307-334
    • Colucci, W.J.1    Gandour, R.D.2
  • 9
    • 0023265045 scopus 로고
    • +-gradients and neurotransmitter amino acid levels in isolated rat brain synaptosomes
    • +-gradients and neurotransmitter amino acid levels in isolated rat brain synaptosomes. J. Neurochem. 49, 1229-1241.
    • (1987) J. Neurochem. , vol.49 , pp. 1229-1241
    • Dagani, F.1    Erecinska, M.2
  • 10
    • 0027500472 scopus 로고
    • Acetyl-L-carnitine: Behavioral, electrophysiological, and neurochemical effects
    • Davis, S., Markoswka, D.S., Wenk, G.L., Barnes, C.A., 1993. Acetyl-L-carnitine: behavioral, electrophysiological, and neurochemical effects. Neurobiol. Aging 14, 107-115.
    • (1993) Neurobiol. Aging , vol.14 , pp. 107-115
    • Davis, S.1    Markoswka, D.S.2    Wenk, G.L.3    Barnes, C.A.4
  • 11
    • 0028139971 scopus 로고
    • Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: An experimental study based on in vivo brain dialysis
    • De Knegt, R., Schalm, S.W., van der Rijt, C.C.D., Fekkes, D., Dalm, E., Hekking-Weyma, I., 1994. Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: an experimental study based on in vivo brain dialysis. J. Hepatol. 20, 19-26.
    • (1994) J. Hepatol. , vol.20 , pp. 19-26
    • De Knegt, R.1    Schalm, S.W.2    Van Der Rijt, C.C.D.3    Fekkes, D.4    Dalm, E.5    Hekking-Weyma, I.6
  • 12
    • 0042461295 scopus 로고
    • Abnormal ornithine carbamoyltransferase in mice having the sparse-fur mutation
    • DeMars, R., LeVan, S.L., Trend, B.L., Russell, L.B., 1976. Abnormal ornithine carbamoyltransferase in mice having the sparse-fur mutation. Proc. Natl. Acad. Sci. USA 73, 1693-1697.
    • (1976) Proc. Natl. Acad. Sci. USA , vol.73 , pp. 1693-1697
    • DeMars, R.1    Levan, S.L.2    Trend, B.L.3    Russell, L.B.4
  • 13
    • 0019796481 scopus 로고
    • Utilization of acetylcarnitine, citrate, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain
    • Dolezal, V., Tucek, S., 1981. Utilization of acetylcarnitine, citrate, acetate, pyruvate and glucose for the synthesis of acetylcholine in rat brain. J. Neurochem. 36, 1323-1330.
    • (1981) J. Neurochem. , vol.36 , pp. 1323-1330
    • Dolezal, V.1    Tucek, S.2
  • 14
  • 15
    • 0023543626 scopus 로고
    • The neurotransmitter amino acid transport systems: A fresh outlook on an old problem
    • Erecinska, M., 1987. The neurotransmitter amino acid transport systems: a fresh outlook on an old problem. Biochem. Pharmacol. 36, 3547-3555.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 3547-3555
    • Erecinska, M.1
  • 16
    • 0024741155 scopus 로고
    • L-Acetylcarnitine attenuates the age-dependent decrease of NMDA-sensitive glutamate receptors in rat hippocampus
    • Fiori, L., Rampello, L., 1989. L-Acetylcarnitine attenuates the age-dependent decrease of NMDA-sensitive glutamate receptors in rat hippocampus. Acta Neurol. (Napoli) 5, 346-350.
    • (1989) Acta Neurol. (Napoli) , vol.5 , pp. 346-350
    • Fiori, L.1    Rampello, L.2
  • 17
    • 0028107682 scopus 로고
    • Neuroprotective activity of acetyl-L-carnitine: Studies in vitro
    • Forloni, G., Angeretti, N., Smiroldo, S., 1994. Neuroprotective activity of acetyl-L-carnitine: studies in vitro. J. Neurosci. Res. 37, 92-96.
    • (1994) J. Neurosci. Res. , vol.37 , pp. 92-96
    • Forloni, G.1    Angeretti, N.2    Smiroldo, S.3
  • 18
    • 0022377835 scopus 로고
    • Transient hyperammonemia during aging in ornithine transcarbamylase-deficient, sparse-fur mice
    • Gushiken, T., Yoshimura, N., Saheki, T., 1985. Transient hyperammonemia during aging in ornithine transcarbamylase-deficient, sparse-fur mice. Biochem. Intl. 5, 637-643.
    • (1985) Biochem. Intl. , vol.5 , pp. 637-643
    • Gushiken, T.1    Yoshimura, N.2    Saheki, T.3
  • 19
    • 0023478104 scopus 로고
    • Accumulation of large neutral amino acids in the brain of sparse-fur mice at hyperammonemic state
    • Inoue, I., Gushiken, T., Kobayashi, K., Saheki, T., 1987. Accumulation of large neutral amino acids in the brain of sparse-fur mice at hyperammonemic state. Biochem. Med. Metab. Biol. 38, 378-386.
    • (1987) Biochem. Med. Metab. Biol. , vol.38 , pp. 378-386
    • Inoue, I.1    Gushiken, T.2    Kobayashi, K.3    Saheki, T.4
  • 20
    • 0030789808 scopus 로고    scopus 로고
    • Decreased glutamate transporter (GLt 1) expression in frontal cortex of rats with acute liver failure
    • Knecht, K., Michalak, A., Rose, C., Rothstein, J.D., Butterworth, R.F., 1997. Decreased glutamate transporter (GLt 1) expression in frontal cortex of rats with acute liver failure. Neurosci. Lett. 229, 201-203.
    • (1997) Neurosci. Lett. , vol.229 , pp. 201-203
    • Knecht, K.1    Michalak, A.2    Rose, C.3    Rothstein, J.D.4    Butterworth, R.F.5
  • 22
    • 0027205354 scopus 로고
    • +-dependent binding of glutamate in rat cortical and hippocampal synaptic membranes
    • +-dependent binding of glutamate in rat cortical and hippocampal synaptic membranes. Neurosci. Lett. 158, 113-116.
    • (1993) Neurosci. Lett. , vol.158 , pp. 113-116
    • Lisy, V.1    Stastny, F.2
  • 24
    • 0027171494 scopus 로고
    • Excitotoxicity, energy metabolism and neurodegeneration
    • Ludolph, A.C., Riepe, M., Ullrich, K., 1993. Excitotoxicity, energy metabolism and neurodegeneration. J. Inher. Metab. Dis. 16, 716-723.
    • (1993) J. Inher. Metab. Dis. , vol.16 , pp. 716-723
    • Ludolph, A.C.1    Riepe, M.2    Ullrich, K.3
  • 25
    • 0031882897 scopus 로고    scopus 로고
    • Nitric oxide causes glutamate release from brain synaptosomes
    • McNaught, K.S.P., Brown, G.C., 1998. Nitric oxide causes glutamate release from brain synaptosomes. J. Neurochem. 70, 1541-1546.
    • (1998) J. Neurochem. , vol.70 , pp. 1541-1546
    • McNaught, K.S.P.1    Brown, G.C.2
  • 26
    • 0030434484 scopus 로고    scopus 로고
    • Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxixity in mice and glutamate toxicity in primary cultures of neurons
    • Minana, M.-D., Hermenegildo, C., Llansola, M., Montoliu, C., Grisolia, S., Felipo, V., 1996. Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxixity in mice and glutamate toxicity in primary cultures of neurons. J. Pharmacol. Expt. Ther. 279, 194-199.
    • (1996) J. Pharmacol. Expt. Ther. , vol.279 , pp. 194-199
    • Minana, M.-D.1    Hermenegildo, C.2    Llansola, M.3    Montoliu, C.4    Grisolia, S.5    Felipo, V.6
  • 27
    • 0020681435 scopus 로고
    • The release and neosynthesis of glutamic acid increased in Experimental models of hepatic encephalopahty
    • Moroni, F., Lombardi, G., Moneti, G., Cortesini, C., 1983. The release and neosynthesis of glutamic acid increased in Experimental models of hepatic encephalopahty. J. Neurochem. 40, 850-854.
    • (1983) J. Neurochem. , vol.40 , pp. 850-854
    • Moroni, F.1    Lombardi, G.2    Moneti, G.3    Cortesini, C.4
  • 28
    • 0028567119 scopus 로고
    • Ornithine transcarbamylase deficiency: A model for gene therapy
    • Felipo, V., Felipo, S. (Eds.), Grisolia, Plenum Press, New York
    • Morsy, M.A., Caskey, C.T., 1994. Ornithine transcarbamylase deficiency: a model for gene therapy. In: Felipo, V., Felipo, S. (Eds.), Hepatic Encephalopathies, Hyperammonemia and Ammonia Toxicity. Grisolia, Plenum Press, New York, pp. 145-154.
    • (1994) Hepatic Encephalopathies, Hyperammonemia and Ammonia Toxicity , pp. 145-154
    • Morsy, M.A.1    Caskey, C.T.2
  • 29
    • 0023370658 scopus 로고
    • Calcium dependent and independent release of glutamate from synaptosomes monitored by continuous fluorometry
    • Nicholls, D.G., Sihra, T.S., Sanchez-Prieto, J., 1987. Calcium dependent and independent release of glutamate from synaptosomes monitored by continuous fluorometry. J. Neurochem. 49, 50-57.
    • (1987) J. Neurochem. , vol.49 , pp. 50-57
    • Nicholls, D.G.1    Sihra, T.S.2    Sanchez-Prieto, J.3
  • 30
    • 0031238547 scopus 로고    scopus 로고
    • The glial glutamate transporter in hyperammonemia and hepatic encephalopathy. Relation to energy metabolism and glutamatergic neurotransmission
    • Norenberg, M.D., Huo, Z., Neary, J.T., Roig-Cantesano, A., 1997. The glial glutamate transporter in hyperammonemia and hepatic encephalopathy. Relation to energy metabolism and glutamatergic neurotransmission. Glia 21, 124-133.
    • (1997) Glia , vol.21 , pp. 124-133
    • Norenberg, M.D.1    Huo, Z.2    Neary, J.T.3    Roig-Cantesano, A.4
  • 33
    • 0018384552 scopus 로고
    • Ornithine transcarbamylase deficiency in mutant mice I. Studies on the characterization of enzyme defect and suitability as animal model of human disease
    • Qureshi, I.A., Letarte, J., Ouellet, R., 1979. Ornithine transcarbamylase deficiency in mutant mice I. Studies on the characterization of enzyme defect and suitability as animal model of human disease. Pediatr. Res. 13, 807-811.
    • (1979) Pediatr. Res. , vol.13 , pp. 807-811
    • Qureshi, I.A.1    Letarte, J.2    Ouellet, R.3
  • 34
    • 0345401833 scopus 로고    scopus 로고
    • Decreased activities of electron transport chain complexes in synaptosomes and non-synaptic mitochondria in congenitally hyperammonemic spf mice: Restoration by acetyl-L-carnitine
    • held at Vienna, Austria
    • Qureshi, I.A., Rao, K.V.R., 1997. Decreased activities of electron transport chain complexes in synaptosomes and non-synaptic mitochondria in congenitally hyperammonemic spf mice: restoration by acetyl-L-carnitine. Proceedings of Advances in Inherited Urea Cycle Disorders, held at Vienna, Austria, pp.44.
    • (1997) Proceedings of Advances in Inherited Urea Cycle Disorders , pp. 44
    • Qureshi, I.A.1    Rao, K.V.R.2
  • 36
    • 0027522102 scopus 로고
    • 3H]PK11195 in congenital ornithine transcarbamylase-deficient sparse fur mouse
    • 3H]PK11195 in congenital ornithine transcarbamylase-deficient sparse fur mouse. Pediatr. Res. 34, 777-780.
    • (1993) Pediatr. Res. , vol.34 , pp. 777-780
    • Rao, V.L.R.1    Qureshi, I.A.2    Butterworth, R.F.3
  • 37
    • 0037997376 scopus 로고    scopus 로고
    • Progressive decrease of cerebral cytochrome C oxidase activity in sparse-fur mice: Role of acetyl-L-carnitine in restoring the ammonia-induced cerebral energy depletion
    • Rao, K.V.R., Mawal, Y.R., Qureshi, I.A., 1997. Progressive decrease of cerebral cytochrome C oxidase activity in sparse-fur mice: role of acetyl-L-carnitine in restoring the ammonia-induced cerebral energy depletion. Neurosci. Lett. 224, 83-86.
    • (1997) Neurosci. Lett. , vol.224 , pp. 83-86
    • Rao, K.V.R.1    Mawal, Y.R.2    Qureshi, I.A.3
  • 38
    • 0028284186 scopus 로고
    • Synaptosomal high affinity transport systems for essential amino acids in rat brain cortex
    • Rao, K.V.R., Murthy, Ch.R.K., 1994. Synaptosomal high affinity transport systems for essential amino acids in rat brain cortex. Neurosci. Lett. 175, 103-106.
    • (1994) Neurosci. Lett. , vol.175 , pp. 103-106
    • Rao, K.V.R.1    Murthy, Ch.R.K.2
  • 39
    • 0025900872 scopus 로고
    • Ammonia-induced alterations in glutamate and muscimol binding to cerebellar synaptic membranes
    • Rao, V.L.R., Agrawal, A.K., Murthy, Ch.R.K., 1991. Ammonia-induced alterations in glutamate and muscimol binding to cerebellar synaptic membranes. Neurosci. Lett. 130, 251-254.
    • (1991) Neurosci. Lett. , vol.130 , pp. 251-254
    • Rao, V.L.R.1    Agrawal, A.K.2    Murthy, Ch.R.K.3
  • 40
    • 0029042318 scopus 로고
    • Developmental deficiency of the cholinergic system in congenitally hyperammonemic spf mice: Effect of acetyl-L-carnitine
    • Ratnakumari, L., Qureshi, I.A., Maysinger, D., Butterworth, R.F., 1995. Developmental deficiency of the cholinergic system in congenitally hyperammonemic spf mice: effect of acetyl-L-carnitine. J. Pharmacol. Exp. Ther. 274, 437-443.
    • (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 437-443
    • Ratnakumari, L.1    Qureshi, I.A.2    Maysinger, D.3    Butterworth, R.F.4
  • 44
    • 0027203913 scopus 로고
    • Effect of L-carnitine on cerebral and hepatic energy metabolites in congenitally hyperammonemic sparse-fur mice and its role during benzoate therapy
    • Ratnakumari, L., Qureshi, I.A., Butterworth, R.F., 1993. Effect of L-carnitine on cerebral and hepatic energy metabolites in congenitally hyperammonemic sparse-fur mice and its role during benzoate therapy. Metabolism 42, 1039-1046.
    • (1993) Metabolism , vol.42 , pp. 1039-1046
    • Ratnakumari, L.1    Qureshi, I.A.2    Butterworth, R.F.3
  • 45
    • 0026752613 scopus 로고
    • Effects of congenital hyperammonemia on the cerebral and hepatic levels of the intermediates of energy metabolism in spf mice
    • Ratnakumari, L., Qureshi, I.A., Butterworth, R.F., 1992. Effects of congenital hyperammonemia on the cerebral and hepatic levels of the intermediates of energy metabolism in spf mice. Biochem. Biophys. Res. Commun. 184, 746-751.
    • (1992) Biochem. Biophys. Res. Commun. , vol.184 , pp. 746-751
    • Ratnakumari, L.1    Qureshi, I.A.2    Butterworth, R.F.3
  • 46
    • 0027999155 scopus 로고
    • Evidence for cholinergic neuronal loss in brain in congenital ornithine transcarbamylase deficiency
    • Ratnakumari, L., Qureshi, I.A., Butterworth, R.F., 1994. Evidence for cholinergic neuronal loss in brain in congenital ornithine transcarbamylase deficiency. Neurosci. Lett. 178, 63-65.
    • (1994) Neurosci. Lett. , vol.178 , pp. 63-65
    • Ratnakumari, L.1    Qureshi, I.A.2    Butterworth, R.F.3
  • 47
    • 0028240536 scopus 로고
    • Regional amino acid neurotransmitter changes in brains of spf/Y mice with congenital ornithine transcarbamylase deficiency
    • Ratnakumari, L., Qureshi, I.A., Butterworth, R.F., 1994a. Regional amino acid neurotransmitter changes in brains of spf/Y mice with congenital ornithine transcarbamylase deficiency. Metab. Brain Dis. 9, 43-51.
    • (1994) Metab. Brain Dis. , vol.9 , pp. 43-51
    • Ratnakumari, L.1    Qureshi, I.A.2    Butterworth, R.F.3
  • 49
    • 0026667916 scopus 로고
    • Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine
    • Rosenthal, R.E., Williams, R., Bogaert, Y.E., Getson, P.R., Fiskum, G., 1992. Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine. Stroke 23, 1312-1318.
    • (1992) Stroke , vol.23 , pp. 1312-1318
    • Rosenthal, R.E.1    Williams, R.2    Bogaert, Y.E.3    Getson, P.R.4    Fiskum, G.5
  • 50
    • 0017820108 scopus 로고
    • Evaluation of glutamate as a hippocanpal neurotransmitter: Glutamate uptake and release from synaptosomes
    • Sandoval, M.E., Horch, P., Cotman, C.W., 1978. Evaluation of glutamate as a hippocanpal neurotransmitter: glutamate uptake and release from synaptosomes. Brain Res. 142, 285-299.
    • (1978) Brain Res. , vol.142 , pp. 285-299
    • Sandoval, M.E.1    Horch, P.2    Cotman, C.W.3
  • 51
    • 0025079063 scopus 로고
    • Hepatic encephalopathy influences high-affinity uptake of transmitter glutamate and aspartate into the hippocampal formation
    • Schmidt, W., Wolf, G., Grungreiff, K., Meier, M., Reum, T., 1990. Hepatic encephalopathy influences high-affinity uptake of transmitter glutamate and aspartate into the hippocampal formation. Metab. Brain Dis. 5, 19-31.
    • (1990) Metab. Brain Dis. , vol.5 , pp. 19-31
    • Schmidt, W.1    Wolf, G.2    Grungreiff, K.3    Meier, M.4    Reum, T.5
  • 52
    • 0031055293 scopus 로고    scopus 로고
    • Acetyl-L- Carnitine arginine amide prevents β25-35-induced neurotoxicity in cerebellar granule cells
    • Scorziello, A., Meucci, O., Calvani, M., Schettini, G., 1997. Acetyl-L- carnitine arginine amide prevents β25-35-induced neurotoxicity in cerebellar granule cells. Neurochem. Res. 22, 257-265.
    • (1997) Neurochem. Res. , vol.22 , pp. 257-265
    • Scorziello, A.1    Meucci, O.2    Calvani, M.3    Schettini, G.4
  • 53
    • 0029986949 scopus 로고    scopus 로고
    • Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat
    • Sima, A.A., Ristic, H., Merry, A., Kamijo, M., Lattimer, S.A., Stevens, M.J., Greene, D.A., 1996. Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat. J. Clin. Invest. 97, 1900-1907.
    • (1996) J. Clin. Invest. , vol.97 , pp. 1900-1907
    • Sima, A.A.1    Ristic, H.2    Merry, A.3    Kamijo, M.4    Lattimer, S.A.5    Stevens, M.J.6    Greene, D.A.7
  • 54
    • 0026002366 scopus 로고
    • Long-term acetyl-L-carnitine treatment in Alzheimer's disease
    • Spagnoli, A., Lucca, U., Menasce, G., et al., 1991. Long-term acetyl-L-carnitine treatment in Alzheimer's disease. Neurology 41, 1726-1732.
    • (1991) Neurology , vol.41 , pp. 1726-1732
    • Spagnoli, A.1    Lucca, U.2    Menasce, G.3
  • 56
    • 0030015166 scopus 로고    scopus 로고
    • Normal and abnormal calcium homeostasis in neurons: A basis for the pathophysiology of traumatic and ischemic central nervous system injury
    • Tymianski, M., Tator, C.H., 1996. Normal and abnormal calcium homeostasis in neurons: a basis for the pathophysiology of traumatic and ischemic central nervous system injury. Neurosurgery 38, 1176-1195.
    • (1996) Neurosurgery , vol.38 , pp. 1176-1195
    • Tymianski, M.1    Tator, C.H.2
  • 57
    • 0030042794 scopus 로고    scopus 로고
    • Prolonged metabolic correction in adult ornithine transcarbamylase-deficient mice with adenoviral vectors
    • Ye, X., Robinson, M.B., Batshaw, M.L., Furth, E.E., Smith, I., Wilson, J.M., 1996. Prolonged metabolic correction in adult ornithine transcarbamylase-deficient mice with adenoviral vectors. J. Biol. Chem. 271, 3639-3646.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3639-3646
    • Ye, X.1    Robinson, M.B.2    Batshaw, M.L.3    Furth, E.E.4    Smith, I.5    Wilson, J.M.6
  • 58
    • 0030961455 scopus 로고    scopus 로고
    • Adenovirus-mediated in vivo gene transfer rapidly protects ornithine transcarbamylase-deficient mice from an ammonium challenge
    • Ye, X., Robinson, M.B., Pabin, C., Quinn, T., Jawad, A., Wilson, J.M., Batshaw, M.L., 1997. Adenovirus-mediated in vivo gene transfer rapidly protects ornithine transcarbamylase-deficient mice from an ammonium challenge. Pediatr. Res. 41, 527-534.
    • (1997) Pediatr. Res. , vol.41 , pp. 527-534
    • Ye, X.1    Robinson, M.B.2    Pabin, C.3    Quinn, T.4    Jawad, A.5    Wilson, J.M.6    Batshaw, M.L.7


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