메뉴 건너뛰기




Volumn 20, Issue 4-5, 1998, Pages 434-443

15N-NMR spectroscopy studies of ammonia transport and glutamine synthesis in the hyperammonemic rat brain

Author keywords

Ammonia fixation; Glutamate glutamine cycle; Glutamine synthesis; Hyperammonemia; In vivo 15N NMR spectroscopy

Indexed keywords

AMMONIA; AMMONIUM ACETATE; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; GLUTAMINE; NITROGEN 15; ACETIC ACID DERIVATIVE; NITROGEN;

EID: 0031595306     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000017341     Document Type: Conference Paper
Times cited : (63)

References (41)
  • 1
    • 0025196959 scopus 로고
    • Metabolism and role of glutamate in mammalian brain
    • Erecińska M, Silver IA: Metabolism and role of glutamate in mammalian brain. Prog Neurobiol 1990;35:245-296.
    • (1990) Prog Neurobiol , vol.35 , pp. 245-296
    • Erecińska, M.1    Silver, I.A.2
  • 2
    • 0025691629 scopus 로고
    • Counterflow of L-glutamate in plasma membrane vesicles and reconstituted preparations from rat brain
    • Pines G, Kanner B: Counterflow of L-glutamate in plasma membrane vesicles and reconstituted preparations from rat brain. Biochem 1990;29:11209-11214.
    • (1990) Biochem , vol.29 , pp. 11209-11214
    • Pines, G.1    Kanner, B.2
  • 3
    • 0003144101 scopus 로고
    • The role of astrocytes in the inactivation of neurotransmitters
    • Kettenmann H, Ransom BR (eds): New York, Oxford UniversityPress
    • Martin DL: The role of astrocytes in the inactivation of neurotransmitters; in Kettenmann H, Ransom BR (eds): Neuroastrocytes. New York, Oxford UniversityPress, 1995, pp 732-745.
    • (1995) Neuroastrocytes , pp. 732-745
    • Martin, D.L.1
  • 4
    • 85052772258 scopus 로고
    • Glutamate as a neurotransmitter
    • Kvamme E (ed): Boca Raton, CRC Press
    • Shank RP, Aprison MHV: Glutamate as a neurotransmitter; in Kvamme E (ed): Glutamate in Mammals. Boca Raton, CRC Press, 1988, vol 2, pp 3-20.
    • (1988) Glutamate in Mammals , vol.2 , pp. 3-20
    • Shank, R.P.1    Aprison, M.H.V.2
  • 5
    • 0023277382 scopus 로고
    • Biochemistry and physiology of brain ammonia
    • Cooper AJL, Plum F: Biochemistry and physiology of brain ammonia. Physiol Rev 1987;67: 440-519.
    • (1987) Physiol Rev , vol.67 , pp. 440-519
    • Cooper, A.J.L.1    Plum, F.2
  • 6
    • 0025777874 scopus 로고
    • Utilization of alpha-ketoglutarate as a precursor for transmitter glutamate in cultured cerebellar granule cells
    • Peng L, Schousboe A, Hertz L: Utilization of alpha-ketoglutarate as a precursor for transmitter glutamate in cultured cerebellar granule cells. Neurochem Res 1991;16:29-34.
    • (1991) Neurochem Res , vol.16 , pp. 29-34
    • Peng, L.1    Schousboe, A.2    Hertz, L.3
  • 11
    • 0027351016 scopus 로고
    • 15N NMR study of in vivo cerebral glutamine synthesis in hyperammonemic rats
    • 15N NMR study of in vivo cerebral glutamine synthesis in hyperammonemic rats. NMR Biomed 1993;6: 21-26.
    • (1993) NMR Biomed , vol.6 , pp. 21-26
    • Kanamori, K.1    Parivar, F.2    Ross, B.D.3
  • 12
    • 0027209260 scopus 로고
    • 15N n.m.r. measurement of the in vivo rate of glutamine synthesis and utilization at steady state in the brain of the hyperammonaemic rat
    • 15N n.m.r. measurement of the in vivo rate of glutamine synthesis and utilization at steady state in the brain of the hyperammonaemic rat. Biochem J 1993;293: 461-468.
    • (1993) Biochem J , vol.293 , pp. 461-468
    • Kanamori, K.1    Ross, B.D.2
  • 13
    • 0028815804 scopus 로고
    • 15N nuclear magnetic resonance
    • 15N nuclear magnetic resonance. Biochem J 1995;305:329-336.
    • (1995) Biochem J , vol.305 , pp. 329-336
    • Kanamori, K.1    Ross, B.D.2
  • 15
    • 0028880956 scopus 로고
    • 15N heteronuclear multiple-quantum coherence transfer NMR
    • 15N heteronuclear multiple-quantum coherence transfer NMR. Biochem J 1995;311: 681-688.
    • (1995) Biochem J , vol.311 , pp. 681-688
    • Kanamori, K.1    Ross, B.D.2    Kuo, E.L.3
  • 16
    • 0029788778 scopus 로고    scopus 로고
    • Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo
    • Kanamori K, Ross BD, Chung JC, Kuo EL: Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo. J Neurochem 1996;67:1584-1594.
    • (1996) J Neurochem , vol.67 , pp. 1584-1594
    • Kanamori, K.1    Ross, B.D.2    Chung, J.C.3    Kuo, E.L.4
  • 18
    • 0025194934 scopus 로고
    • 15N-n.m.r. study of cerebral, hepatic and renal nitrogen metabolism in hyperammonaemic rats
    • 15N-n.m.r. study of cerebral, hepatic and renal nitrogen metabolism in hyperammonaemic rats. Biochem J 1990;270:473-481.
    • (1990) Biochem J , vol.270 , pp. 473-481
    • Farrow, N.A.1    Kanamori, K.2    Ross, B.D.3    Parivar, F.4
  • 20
    • 0030726451 scopus 로고    scopus 로고
    • Improvements on an in vivo automatic shimming method (FASTERMAP)
    • Shen J, Rycyna RE, Rothman DL: Improvements on an in vivo automatic shimming method (FASTERMAP). Magn Reson Med 1997; 38:834-839.
    • (1997) Magn Reson Med , vol.38 , pp. 834-839
    • Shen, J.1    Rycyna, R.E.2    Rothman, D.L.3
  • 21
    • 0026608455 scopus 로고
    • NMR determination of intracerebral glucose concentration and transport kinetics in rat brain in vivo
    • Mason GF, Rothman DL, Behar KL, Shulman RG: NMR determination of intracerebral glucose concentration and transport kinetics in rat brain in vivo. 3 Cereb Blood Flow Metab 1992; 12:448-455.
    • (1992) 3 Cereb Blood Flow Metab , vol.12 , pp. 448-455
    • Mason, G.F.1    Rothman, D.L.2    Behar, K.L.3    Shulman, R.G.4
  • 22
    • 0000521134 scopus 로고
    • Spin-echo water suppression for the generation of pure-phase two-dimensional NMR spectra
    • Sklenar V, Bax A: Spin-echo water suppression for the generation of pure-phase two-dimensional NMR spectra. J Magn Reson B 1987;74: 469-479.
    • (1987) J Magn Reson B , vol.74 , pp. 469-479
    • Sklenar, V.1    Bax, A.2
  • 24
    • 0017780771 scopus 로고
    • Complete mass spectra of N-trifluoroacetyl-n-butyl esters of amino acids
    • Leimer KR, Rice RH, Gehrke CW: Complete mass spectra of N-trifluoroacetyl-n-butyl esters of amino acids. J Chromatogr 1977;141:121-144.
    • (1977) J Chromatogr , vol.141 , pp. 121-144
    • Leimer, K.R.1    Rice, R.H.2    Gehrke, C.W.3
  • 25
    • 0026699650 scopus 로고
    • Stable isotope tracer analysis by GC-MS, including quantification of isotopomer effects
    • Rosenblatt J, Chinkes D, Wolfe M, Wolfe RR: Stable isotope tracer analysis by GC-MS, including quantification of isotopomer effects. Am J Physiol 1992;263:E584-596.
    • (1992) Am J Physiol , vol.263
    • Rosenblatt, J.1    Chinkes, D.2    Wolfe, M.3    Wolfe, R.R.4
  • 26
    • 0015787774 scopus 로고
    • The acute action of ammonia on rat brain metabolism in vivo
    • Hawkins RA, Miller AL, Nielsen RC, Veech RL: The acute action of ammonia on rat brain metabolism in vivo. Biochem J 1973;134: 1001-1008.
    • (1973) Biochem J , vol.134 , pp. 1001-1008
    • Hawkins, R.A.1    Miller, A.L.2    Nielsen, R.C.3    Veech, R.L.4
  • 27
    • 0017954946 scopus 로고
    • Cerebral blood flow and metabolism in chronically hyperammonemic rats: Effects of an acute ammonia challenge
    • Gjedde A, Lockwood AH, Duffy TE, Plum F: Cerebral blood flow and metabolism in chronically hyperammonemic rats: Effects of an acute ammonia challenge. Ann Neurol 1978;3:325-330.
    • (1978) Ann Neurol , vol.3 , pp. 325-330
    • Gjedde, A.1    Lockwood, A.H.2    Duffy, T.E.3    Plum, F.4
  • 28
    • 0027400553 scopus 로고
    • Cerebral cortex ammonia and glutamine metabolism in two rat models of chronic liver insufficiency induced hyperammonemia: Influence of pair-feeding
    • Dejong CHC, Deutz NEP, Soeters PB: Cerebral cortex ammonia and glutamine metabolism in two rat models of chronic liver insufficiency induced hyperammonemia: influence of pair-feeding. J Neurochem 1993;60:1047-1057.
    • (1993) J Neurochem , vol.60 , pp. 1047-1057
    • Dejong, C.H.C.1    Deutz, N.E.P.2    Soeters, P.B.3
  • 33
    • 0018843027 scopus 로고
    • Factors that affect the uptake of ammonia by the brain: The blood-brain pH gradient
    • Lockwood A, Roldald DF, Campbell JA, Richman TB: Factors that affect the uptake of ammonia by the brain: the blood-brain pH gradient. Brain Res 1980;181:259-266.
    • (1980) Brain Res , vol.181 , pp. 259-266
    • Lockwood, A.1    Roldald, D.F.2    Campbell, J.A.3    Richman, T.B.4
  • 34
    • 0024382442 scopus 로고
    • Regional cerebral blood flow and histopathologic changes after middle cerebral artery occlusion in rats
    • Bolander HG, Persson L, Hillered L, d'Argy R, Ponten U, Olsson Y: Regional cerebral blood flow and histopathologic changes after middle cerebral artery occlusion in rats. Stroke 1989; 20:930-937.
    • (1989) Stroke , vol.20 , pp. 930-937
    • Bolander, H.G.1    Persson, L.2    Hillered, L.3    D'Argy, R.4    Ponten, U.5    Olsson, Y.6
  • 35
    • 0025950408 scopus 로고
    • Ischemic thresholds of cerebral protein synthesis and energy state following middle cerebral artery occlusion
    • Mies G, Ishimaru S, Xie Y, Seo K, Hossman KA: Ischemic thresholds of cerebral protein synthesis and energy state following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1991;11:753-761.
    • (1991) J Cereb Blood Flow Metab , vol.11 , pp. 753-761
    • Mies, G.1    Ishimaru, S.2    Xie, Y.3    Seo, K.4    Hossman, K.A.5
  • 36
    • 0031018960 scopus 로고    scopus 로고
    • 15N coupling patterns and isotopic shifts
    • 15N coupling patterns and isotopic shifts. Eur Biochem J 1997;243:597-604.
    • (1997) Eur Biochem J , vol.243 , pp. 597-604
    • Lapidot, A.1    Gopher, A.2
  • 37
    • 0021332488 scopus 로고
    • α-Ketoglutarate and malate uptake and metabolism by synaptosomes: Further evidence for an astrocyte to neuron metabolic shuttle
    • Shank RP, Campbell GL: α-Ketoglutarate and malate uptake and metabolism by synaptosomes: further evidence for an astrocyte to neuron metabolic shuttle. J Neurochem 1984;42: 1153-1161.
    • (1984) J Neurochem , vol.42 , pp. 1153-1161
    • Shank, R.P.1    Campbell, G.L.2
  • 38
    • 0021988603 scopus 로고
    • Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools
    • Shank RP, Bennett GS, Freytag SO, Campbell GL: Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools. Brain Res 1985;329:364-367.
    • (1985) Brain Res , vol.329 , pp. 364-367
    • Shank, R.P.1    Bennett, G.S.2    Freytag, S.O.3    Campbell, G.L.4
  • 39
    • 0023372146 scopus 로고
    • Regional distribution of astrocytes with intense immunoreactivity for glutamate dehydrogenase in rat brain: Implications for neuroglia interactions in glutamate transmission
    • Aoki C, Milner TA, Sheu K-FR, Blass JP, Pickel VM: Regional distribution of astrocytes with intense immunoreactivity for glutamate dehydrogenase in rat brain: Implications for neuroglia interactions in glutamate transmission. J Neurosci 1987;7:2214-2231.
    • (1987) J Neurosci , vol.7 , pp. 2214-2231
    • Aoki, C.1    Milner, T.A.2    Sheu, K.-F.R.3    Blass, J.P.4    Pickel, V.M.5
  • 40
    • 0023145046 scopus 로고
    • Immunocytochemical characterization of glutamate dehydrogenase in the cerebellum of the rat
    • Wenthold RJ, Altschuler RA, Skaqqs KK, Reeks KA: Immunocytochemical characterization of glutamate dehydrogenase in the cerebellum of the rat. J Neurochem 1987;48:636-643.
    • (1987) J Neurochem , vol.48 , pp. 636-643
    • Wenthold, R.J.1    Altschuler, R.A.2    Skaqqs, K.K.3    Reeks, K.A.4
  • 41
    • 0028036505 scopus 로고
    • Quantitative ultrastructural localization of glutamate dehydrogenase in the rat cerebellar cortex
    • Rothe F, Brosz M, Storm-Mathisen J: Quantitative ultrastructural localization of glutamate dehydrogenase in the rat cerebellar cortex. Neuroscience 1995;62:1133-1146.
    • (1995) Neuroscience , vol.62 , pp. 1133-1146
    • Rothe, F.1    Brosz, M.2    Storm-Mathisen, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.