Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

Neurochemistry International

Volumn 59, Issue 4, 2011, Pages 482-488

  Dadsetan, Sherry ^a   Bak, Lasse K ^a   Sørensen, Michael ^b   Keiding, Susanne ^b   Vilstrup, Hendrik ^b   Ott, Peter ^b   Leke, Renata ^c   Schousboe, Arne ^a   Waagepetersen, Helle S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Alanine; Glutamate dehydrogenase; Glutamine; Glutamine synthetase; Hyperammonemia; MSO

Indexed keywords

ALANINE; AMMONIA; AMMONIUM CHLORIDE; ASPARTIC ACID; GLUCOSE; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; GLUTAMINE; METHIONINE SULFOXIMINE;

AMINO ACID SYNTHESIS; AMMONIA FIXATION; ANIMAL CELL; ARTICLE; ASTROCYTE; CHEMICAL REACTION; COCULTURE; CONTROLLED STUDY; ISOTOPE LABELING; METABOLISM; MOUSE; NERVE CELL; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL;

ALANINE; ALANINE TRANSAMINASE; AMMONIA; ANIMALS; ASTROCYTES; CELLS, CULTURED; CEREBRAL CORTEX; COCULTURE TECHNIQUES; GLUTAMATE DEHYDROGENASE; GLUTAMATE-AMMONIA LIGASE; GLUTAMINE; HYPERAMMONEMIA; METHIONINE SULFOXIMINE; MICE; MICE, INBRED STRAINS; NEURONS;

EID: 79955646990     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2011.03.008     Document Type: Article

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