The Na-K-Cl cotransporter in the brain edema of acute liver failure

Journal of Hepatology

Volumn 54, Issue 2, 2011, Pages 272-278

  Jayakumar, Arumugam R ^a,b   Valdes, Vanessa ^a   Norenberg, Michael D ^a,b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Brain edema; Liver failure; NKCC

Indexed keywords

AMMONIA; BUMETANIDE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; THIOACETAMIDE;

ACUTE LIVER FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN EDEMA; BRAIN SLICE; BRAIN WATER; CONTROLLED STUDY; INTRACRANIAL HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ANIMALS; BRAIN EDEMA; BUMETANIDE; LIVER FAILURE, ACUTE; MALE; PHOSPHORYLATION; RATS; RATS, WISTAR; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS; THIOACETAMIDE;

EID: 78751570908     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.06.041     Document Type: Article

References (71)

1. E.A. Jones, and K. Weissenborn Neurology and the liver J Neurol Neurosurg Psychiatry 63 1997 279 293
2. A.J. Ware, A.N. D'Agostino, and B. Combes Cerebral edema: a major complication of massive hepatic necrosis Gastroenterology 61 1971 877 884
3. A.T. Blei The pathophysiology of brain edema in acute liver failure Neurochem Int 47 2005 71 77
4. R. Jalan Acute liver failure: current management and future prospects J Hepatol 42 2005 S115 123
5. M.D. Norenberg A light and electron microscopic study of experimental portal-systemic (ammonia) encephalopathy. Progression and reversal of the disorder Lab Invest 36 1977 618 627
6. P.G. Traber, and M.C. Dal Canto Electron microscopic evaluation of brain edema in rabbits with galactosamine-induced fulminant hepatic failure: ultrastructure and integrity of the blood-brain barrier Hepatology 7 1987 1272 1277
7. M.S. Swain, A.T. Blei, R.F. Butterworth, and R.P. Kraig Intracellular pH rises and astrocytes swell after portacaval anastomosis in rats Am J Physiol Regul Integr Comp Physiol 261 1991 R1491 R1496
8. J. Albrecht, and E.A. Jones Hepatic encephalopathy: molecular mechanisms underlying the clinical syndrome J Neurol Sci 170 1999 138 146
9. A.S. Hazell, and R.F. Butterworth Hepatic encephalopathy: an update of pathophysiologic mechanisms Proc Soc Exp Biol Med 222 1999 99 112
10. M.D. Norenberg, L. Baker, and L.O. Norenberg Ammonia-induced astrocyte swelling in primary culture Neurochem Res 16 1991 833 836
11. C. Zwingmann, U. Flögel, J. Pfeuffer, and D. Leibfritz Effect of ammonia exposition on glioma cells: changes in cell volume and organic osmolytes studied by diffusion-weighted and high-resolution NMR spectroscopy Dev Neurosci 22 2000 463 471
12. R. Ganz, and M. Swain Ammonia-induced swelling of rat cerebral cortical slices: implications for the pathogenesis of brain edema in acute hepatic failure Metab Brain Dis 4 1989 213 223
13. T.M. Voorhies, M.E. Ehrlich, and T.E. Duffy Acute hyperammonemia in the young primate. Physiologic and neuropathological correlates Pediatr Res 17 1983 970 975
14. C.L. Willard-Mack Inhibition of glutamine synthetase reduces ammonia-induced astrocyte swelling in rat Neuroscience 71 1996 589 599
15. M. Haas The Na-K-Cl cotransporters Am J Physiol 267 1994 C869 C885
16. M. Haas, and B. Forbush The Na-K-Cl co-transporters J Bioenerg Biomembr 30 1998 161 172
17. T.N. Nagaraja, and N. Brookes Intracellular acidification induced by passive and active transport of ammonium ions in astrocytes Am J Physiol 274 1998 C883 C891
18. R.T. Worrell, L. Merk, and J.B. Matthews Ammonium transport in the colonic crypt cell line, T84: role for Rhesus glycoproteins and NKCC1 Am J Physiol Gastrointest Liver Physiol 294 2008 G429 G440
19. M.R. Kaplan, D.B. Mount, and E. Delpire Molecular mechanisms of NaCl cotransport Annu Rev Physiol 58 1996 649 668
20. H. Chen, and D. Sun The role of Na-K-Cl co-transporter in cerebral ischemia Neurol Res 27 2005 280 286
21. K.T. Kahle, and J.M. Simard Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport Physiology (Bethesda) 24 2009 257 265
22. F. Staub, and A. Winkler Swelling, acidosis, and irreversible damage of glial cells from exposure to arachidonic acid in vitro J Cereb Blood Flow Metab 14 1994 1030 1039
23. A.W. Unterberg, J. Stover, B. Kress, and K.L. Kiening Edema and brain trauma Neuroscience 129 2004 1021 1029
24. --cotransporter in choroid plexus attenuates traumatic brain injury-induced brain edema and neuronal damage Eur J Pharmacol 548 2006 99 105
25. A.R. Jayakumar, K.S. Panickar, and M. Moriyama Ion transporting systems in the mechanism of astrocyte swelling after trauma J Neurochem 104 2008 135
26. A.R. Jayakumar, and M. Liu Na-K-Cl Cotransporter-1 in the mechanism of ammonia-induced astrocyte swelling J Biol Chem 283 2008 33874 33882
27. Z. Zimmermann, and P. Ferenci Hepatic encephalopathy in thioacetamide induced acute liver failure in rats: characterization an improved model and study of amino acid-ergic neurotransmission Hepatology 9 1989 54 60
28. W. Hilgier, J.E. Olson, and J. Albrecht Relation of taurine transport and brain edema in rats with simple hyperammonemia or liver failure J Neurosci Res 45 1996 69 74
29. M.D. Norenberg, and A.R. Jayakumar Oxidative-nitrosative stress, the permeability transition and MAP kinases in the mechanism of brain edema in acute liver failure J Neurochem 104 2008 31
30. K.V. Rama Rao, and P.V. Reddy Brain edema in acute liver failure: inhibition by l-histidine Am J Pathol 176 2010 1400 1408
31. S.H. Gammal, A.S. Basile, and D. Geller Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands Hepatology 11 1990 371 378
32. T.I. Lam, S.E. Anderson, N. Glaser, and M.E. O'Donnell Bumetanide reduces cerebral edema formation in rats with diabetic ketoacidosis Diabetes 54 2005 510 516
33. P. Sandstrom Evidence for diabetogenic action of bumetanide in mice Eur J Pharmacol 150 1988 35 41
34. A. Marmarou, W. Poll, K. Shulman, and H. Bhagavan A simple gravimetric technique for measurement of cerebral edema J Neurosurg 49 1978 530 537
35. J.C. Bernstein, and Y. Israel Active transport of Rb86 in human red cells and rat brain slices Pharmacol Exp Ther 174 1970 323 329
36. J.A. Wong, A.R. Gosmanov, E.G. Schneider, and D.B. Thomason Insulin-independent, MAPK-dependent stimulation of NKCC activity in skeletal muscle Am J Physiol Regul Integr Comp Physiol 281 2001 R561 R571
37. B. Brahma, R.E. Forman, E.E. Stewart, C. Nicholson, and M.E. Rice Ascorbate inhibits edema in brain slices J Neurochem 74 2000 1263 1270
38. - regulation J Neurophysiol 81 1999 1939 1948
39. C. Lytle, and B. Forbush The Na-K-Cl cotransport protein of shark rectal gland. II. Regulation by direct phosphorylation J Biol Chem 267 1992 25438 25443
40. I. Gimenez, and B. Forbush Short-term stimulation of the renal Na-K-Cl cotransporter (NKCC2) by vasopressin involves phosphorylation and membrane translocation of the protein J Biol Chem 278 2003 26946 26951
41. M. Swain, R.F. Butterworth, and A.T. Blei Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats Hepatology 15 1992 449 453
42. --cotransporter in the nervous system: evidence for a scaffolding role of the kinase J Biol Chem 278 2003 52848 52856
43. T. Moriguchi, and S. Urushiyama WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1 J Biol Chem 280 2005 42685 42693
44. K.B. Gagnon, R. England, and E. Delpire Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter Mol Cell Biol 26 2006 689 698
45. A.C. Vitari, J. Thastrup, and F.H. Rafiqi Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1 Biochem J 397 2006 223 231
46. P.W. Flatman Cotransporters, WNKs and hypertension: an update Curr Opin Nephrol Hypertens 17 2008 186 192
47. G.Ø. Andersen, and T. Skomedal Alpha1-AR-mediated activation of NKCC in rat cardiomyocytes involves ERK-dependent phosphorylation of the cotransporter Am J Physiol Heart Circ Physiol 286 2004 H1354 360
48. --cotransport in ATP-treated C11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms J Biol Chem 281 2006 31317 31325
49. A.R. Jayakumar, K.S. Panickar, Ch.R. Murthy, and M.D. Norenberg Oxidative stress and mitogen-activated protein kinase phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes J Neurosci 26 2006 4774 4784
50. A.R. Jayakumar, and M.D. Norenberg The Na-K-Cl co-transporter in astrocyte swelling Metab Brain Dis 25 2010 31 38
51. R. Juncos, and J.L. Garvin Superoxide enhances Na-K-2Cl cotransporter activity in the thick ascending limb Am J Physiol Renal Physiol 288 2005 F982 F987
52. S. Chin, and N.A. Delamere Stimulation of active sodium-potassium transport by hydrogen peroxide in cultured rabbit nonpigmented ciliary epithelium Curr Eye Res 18 1999 254 260
53. L.A. MacMillan-Crow, J.S. Greendorfer, S.M. Vickers, and J.A. Thompson Tyrosine nitration of c-SRC tyrosine kinase in human pancreatic ductal adenocarcinoma Arch Biochem Biophys 377 2000 350 356
54. C. Mallozzi, A.M. Di Stasi, and M. Minetti Nitrotyrosine mimics phosphotyrosine binding to the SH2 domain of the src family tyrosine kinase lyn FEBS Lett 503 2001 189 195
55. E. Kosenko, and Y. Kaminsky Superoxide production and antioxidant enzymes in ammonia intoxication in rats Free Radic Res 27 1997 637 644
56. C.R. Murthy Ammonia-induced production of free radicals in primary cultures of rat astrocytes J Neurosci Res 66 2001 282 288
57. M.D. Norenberg Oxidative and nitrosative stress in ammonia neurotoxicity Hepatology 37 2003 245 248
58. F. Schliess, B. Görg, and R. Fischer Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes FASEB J 16 2002 739 741
59. C. Bemeur, P. Desjardins, and R.F. Butterworth Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy Metab Brain Dis 25 2010 3 9
60. W. Jiang, P. Desjardins, and R.F. Butterworth Hypothermia attenuates oxidative/nitrosative stress, encephalopathy and brain edema in acute (ischemic) liver failure Neurochem Int 55 2009 124 128
61. - secretory capacity by butyrate J Clin Invest 101 1998 2072 2079
62. --cotransporter in cultured pancreatic duct cells Am J Physiol 277 1999 C1100 1110
63. - induced swelling and EAA release in astrocytes Am J Physiol Cell Physiol 282 2002 C1136 C1146
64. - secretion by EGF Am J Physiol Cell Physiol 294 2008 C1362 C1370
65. S. Javaheri, C. Davis, and D.H. Rogers Ionic composition of cisternal CSF in acute respiratory acidosis: lack of effect of large dose bumetanide J Neurochem 61 1993 1525 1529
66. M.E. O'Donnell Bumetanide inhibition of the blood-brain barrier Na-K-Cl cotransporter reduces edema formation in the rat middle cerebral artery occlusion model of stroke J Cereb Blood Flow Metab 24 2004 1046 1056
67. E. Delpire, E. Days, L.M. Lewis, D. Mi, K. Kim, and C.W. Lindsley Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2 Proc Natl Acad Sci USA 106 2009 5383 5388
68. P. Hannaert, and M. Alvarez-Guerra Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs Naunyn Schmiedebergs Arch Pharmacol 365 2002 193 199
69. H.L. Rosomoff, and P.M. Kochanek Resuscitation from severe brain trauma Crit Care Med 24 1996 S48 S56
70. G. Linares, and S.A. Mayer Hypothermia for the treatment of ischemic and hemorrhagic stroke Crit Care Med 37 2009 S243 249
71. - cotransporter NKCC1 J Child Neurol 24 2009 572 576