Nitroarginine, an inhibitor of nitric oxide synthase, prevents changes in superoxide radical and antioxidant enzymes induced by ammonia intoxication

Metabolic Brain Disease

Volumn 13, Issue 1, 1998, Pages 29-41

  Kosenko, Elena ^a   Kaminsky, Yuri ^a   Lopata, Oksana ^a   Muravyov, Nikolay ^a   Kaminsky, Alexander ^a   Hermenegildo, Carlos ^b   Felipo, Vicente ^b  

^a INSTITUTE OF THEORETICAL AND EXPERIMENTAL BIOPHYSICS   (Russian Federation)

^b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

Author keywords

Ammonia toxicity; Antioxidant enzymes; Hyperammonemia; Nitric oxide; Nitroarginine; Superoxide radical

Indexed keywords

AMMONIA; ANTIOXIDANT; CATALASE; ENZYME; GLUTATHIONE PEROXIDASE; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HYPERAMMONEMIA; INTOXICATION; LIVER TOXICITY; MALE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT;

AMMONIA; ANIMALS; ANTIOXIDANTS; BRAIN; CATALASE; FREE RADICALS; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LIVER; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROARGININE; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; SUPEROXIDES;

ANIMALIA;

EID: 0031949404     PISSN: 08857490     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020626928259     Document Type: Article

References (42)

1. Aebi, H.E. (1984). Catalase. In Methods of Enzymatic Analysis vol. 3 (ed. H. U. Bergmeyer), Wiley, New York, pp. 273-286.
2. Asahi, M., Fujii, J., Suzuki, K., Seo, H.G., Kuzuya, T., Hori, M., et al. (1995). Inactivation of glutathione peroxidase by nitric oxide. Implication for cytotoxicity. J. Biol. Chem. 270:21035-21039.
3. Beauchamp, C. and Fridovich, I. (1971). Improved assays and an assay applicable to acrylamide gels. Anal. Biochem. 44:276-287.
4. Bolaños, J.P., Peuchen, S., Heales, S.J., Land, J.M. and Clark, J.B. (1994). Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J. Neurochem. 63:910-916.
5. Boveris, A. (1984). Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria. Methods in Enzymology, 105:429-435.
6. Brown, G.C. (1995). Reversible binding and inhibition of catalase by nitric oxide. Eur. J. Biochem. 232:188-191.
7. Butterworth, R.F. (1992). Pathogenesis and treatment of portal-systemic encephalopathy: an update. Dig. Dis. Sci. 37:321-327.
8. Butterworth, R.F. (1994). Hepatic Encephalopathy. In: (Arias et al., eds) The Liver: Biology and Pathobiology, Third edition, Raven Press Ltd. New York, 1193-1208.
9. Cohen, G., Dembiec, D. and Marcus, J. (1970). Measurement of catalase activity in tissue extracts. Anal. Biochem. 34:30-38.
10. Corrocher, R., Casaril, M., Guidi, C., Gabrielli, G.B., Miatto, O. and DeSandre, G. (1980). Glutathione-peroxidase and glutathione-reductase activities of normal and pathologic human liver: relationship with age. Scand. J. Gastroenterol. 15:781-786.
11. Farias-Eisner, R., Chaudhuri, G., Aeberhard, E., and Fukuto, J.M. (1996). The chemistry and tumoricidal activity of nitric oxide/hydrogen peroxide and the implications to cell resistence/susceptibility. J. Biol. Chem. 271:6144-6151.
12. Felipo, V., Grau, E., Miñana, M.D. and Grisolía, S. (1993). Ammonium injection induces an N-methyl-D-aspartate receptor-mediated proteolysis of the microtubule-associated protein MAP-2. J. Neurochem. 60:1626-1630.
13. Ferenci, P., Püspök, A. and Steindl, P. (1992). Current concepts in the pathophysiology of hepatic encephalopathy. Eur. J. Clin. Invest. 22:573-581.
14. Forman, H.J. and Kennedy, J. (1976). Dihidroorotate-dependent superoxide production in rat brain and liver. A function of the primary dehydrogenase. Arch. Biochem. Biophys. 173:219-224.
15. Golderg, D.M. and Spooner, R.J. (1984). Glutathione reductase. In Methods of Enzymatic Analysis vol. 3 (ed. H. U. Bergmeyer), Wiley, New York, pp. 259-265.
16. Hahn, M., Massen, O., Nencki, M. and Pavlov, I. (1893). Die Eck'sche Fistel zwischen der unteren Hohlvene und der Pfortader und ihre Folgen f,r den Organisms. Archiv fur Experimentelle Pathologie und Pharmakologie, 32:161-210.
17. Hawkins, R.A., Miller, A.L., Nielsen, R.C. and Veech, R.L. (1973). The acute action of ammonia on rat brain metabolism in vivo. Biochem. J. 134:1001-1008.
18. Hermenegildo, C., Marcaida, G., Montoliu, C., Grisolía, S., Miñana; M.D. and Felipo, V., (1996). NMDA receptor antagonists prevent acute ammonia toxicity in mice. Neurochem. Res. 21:1237-1244.
19. Hindfelt, B. and Siesjö, B.K. (1971). Cerebral effects of acute ammonia intoxication. Scand J. Clin. & Lab. Invest. 28:365-374.
20. Hindfelt, B., Plum, F. and Duffy, T.E. (1977). Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts. J. Clin. Invest. 59:386-396.
21. Kosenko, E., Kaminsky, Y., Felipo, V., Miñana, M.D. and Grisolía, S. (1993). Chronic hyperammonemia prevents changes in brain energy and ammonia metabolites induced by acute ammonia intoxication. Biochim. Biophys. Acta, 1180:321-326.
22. +-ATPase. J. Neurochem. 63:2172-2178.
23. Kosenko, E., Kaminsky, Y., Grau, E., Miñana, M.D., Grisolía, S. and Felipo, V. (1995). Nilroarginine, an inhibitor of nitric oxide synthetase, attenuates ammonia toxicity and ammonia-induced alterations in brain metabolism. Neurochem. Res. 20:451-456.
24. Kosenko, E., Felipo, V., Miñana, M.D., Grisolía, S. and Kaminsky, Y. (1997a). Effects of acute hyperammonemia in vivo on oxidative metabolism in nonsynaptic rat brain mitochondria. Metab. Brain Dis. 12:69-82.
25. Kosenko, E., Kaminsky, Y., Kaminsky, A., Valencia, M., Lee, L., Hermenegildo, C. and Felipo, V. (1997b). Superoxide production and antioxidant enzymes in ammonia intoxication in rats. Free Rad. Res. 27:637-644.
26. Lawrence, R.A. and Burk, R.F. (1976). Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun. 71:952-958.
27. Loschen, G, Azzi, A., Richter, C. and Flohé, L. (1974). Superoxide radicals as precursors of mitochondrial hydrogen peroxide. FEBS Lett. 42:68-72.
28. Lowry, O.H., Rosebrough, N.J., Fair, A.L., and Randall, R.J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
29. Marcaida, G., Miñana, M.D., Grisolía, S. and Felipo, V. (1995). Lack of correlation between glutamate-induced depletion of ATP and neuronal death in primary cultures of cerebellum. Brain Res. 695:146-150.
30. +-ATPase that results in its activation in cerebellar neurons in culture. J. Neurochem. 66:99-104.
31. McCord, J.M. and Fridovich, I. (1969). Superoxide dismutase: An enzymic function for erythrocuprein (hemocuprein). J. Biol. Chem. 244:6049-6055.
32. Miñana, M.D., Felipo, V. and Grisolía, S. (1988). Protective effect of long term ammonium ingestion against acute ammonium intoxication. Biochem. Biophys. Res. Commun. 153:979-983.
33. 2-associated relaxation. Am. J. Physiol. 271:H1900-H1906.
34. Nadkarni, G.D. and D'Souza, N.B. (1988). Hepatic antioxidant enzymes and lipid peroxidation in carbon tetrachloride-induced liver cirrhosis in rats. Biochem. Med. Metab. Biol. 40:42-45.
35. O'Connor, J.E. and Costell, M. (1990). New roles of carnitine metabolism in ammonia cytotoxicity. In Cirrhosis, Hepatic Encephalopathy, and Ammonium Toxicity (eds. S. Grisolía, V. Felipo and M. D. Miñana), Adv. Exp. Med. Biol. Plenum Press, New York, 272, pp. 183-195.
36. Ozenirler, S., Tuncer, C., Ongun, O., Altan, N. and Kandilci, U. (1994). Activities of superoxide dismutase in erythrocyte of nonalcoholic chronic liver diseases. Gen. Pharmacol. 25:1349-1351.
37. Plum, F. and Hindfelt, B. (1976). The neurological complications of liver disease. In Metabolic and Deficiency Diseases of the Nervous System, Part 1, 27 (eds. P.J. Vinken, G.W. Bruyn and H.L. Klawans), American Elsevier Publ. Co. Inc., New York, pp. 349-377.
38. Sanz, N., Diez-Fernández, C., Fernández-Simon, L., Alvarez, A. and Cascales, M. (1995). Relationship between antioxidant systems, intracellular thiols and DNA ploidy in liver of rats during experimental cirrhogenesis. Carcinogenesis, 16:1585-1593.
39. Schenker, S., McCandless, D.W., Brophy, E., and Lewis, M.S. (1967). Studies on intracerebral toxicity of ammonia. J. Clin. Invest. 46:838-848.
40. Sorgato, M.C., Sartorelli, L., Loschen, G. and Azzi, A. (1974). Oxygen radicals and hydrogen peroxide in rat brain mitochondria. FEBS Lett. 45:92-95.
41. Thomas, G. and Ramwell, P.W. (1988). Vasodilatory properties of mono-L-arginine containing compounds. Biochem. Biophys. Res. Commun. 154:332-338.
42. Wettstein, M., Gerok, W. and Häussinger, D. (1994). Endotoxin-induced nitric oxide synthesis in the perfused rat liver: effects of L-arginine and ammonium chloride. Hepatology, 19:641-647.