Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance

Journal of Biological Chemistry

Volumn 288, Issue 24, 2013, Pages 17520-17531

  Chiu, Tim Ting ^a,b   Sun, Yi ^a   Koshkina, Alexandra ^a   Klip, Amira ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

C-JUN N-TERMINAL KINASE; CONSTITUTIVELY ACTIVES; GLUCOSE TRANSPORTER 4; HETERODIMERIZATION; MOLECULAR MECHANISM; PARTIAL RESTORATION; PHOSPHATIDYLINOSITOL; SIGNALING MOLECULES;

ACTIVATION ANALYSIS; CELL MEMBRANES; CERAMIDES; CHEMICAL ACTIVATION; SIGNALING;

INSULIN;

CERAMIDE; GLUCOSE TRANSPORTER 4; INSULIN RECEPTOR SUBSTRATE 1; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN AS160; PROTEIN KINASE B; RAC1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; INSULIN LIKE ACTIVITY; INSULIN RESISTANCE; INTRACELLULAR SIGNALING; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RAT;

AKT; AS160; CERAMIDE; GLUT4; INSULIN RESISTANCE; JUN N-TERMINAL KINASE (JNK); RAC1;

ANIMALS; CELL LINE; CELL MEMBRANE; CELL POLARITY; ENZYME ACTIVATION; GLUCOSE TRANSPORTER TYPE 4; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INSULIN; INSULIN RESISTANCE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM PROTEINS; PHOSPHATIDYLINOSITOLS; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RAC1 GTP-BINDING PROTEIN; RATS; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 84879049413     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.467647     Document Type: Article

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