Activation of the small GTPase Rac1 by a specific guanine-nucleotide-exchange factor suffices to induce glucose uptake into skeletal-muscle cells

Biology of the Cell

Volumn 100, Issue 11, 2008, Pages 645-661

  Ueda, Shuji ^a   Kataoka, Tohru ^a   Satoh, Takaya ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Glucose transporter 4 (GLUT4); Glucose uptake; GTPase; Guanine nucleotide exchange factor (GEF); Rac1; Skeletal muscle

Indexed keywords

GLUCOSE TRANSPORTER 4; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INSULIN; PROTEIN KINASE B; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RNA; GLUCOSE; ONCOPROTEIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE TRANSPORT; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME SPECIFICITY; GLUCOSE TRANSPORT; IN SITU HYBRIDIZATION; MUSCLE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN INDUCTION; PROTEIN TRANSPORT; RAT; RNA INTERFERENCE; SKELETAL MUSCLE; ANIMAL; CELL CULTURE; CELL MEMBRANE; GENETICS; HUMAN; METABOLISM; MYOBLAST;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; ENZYME ACTIVATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INSULIN; MUSCLE, SKELETAL; MYOBLASTS; ONCOGENE PROTEIN V-AKT; PROTEIN TRANSPORT; RAC1 GTP-BINDING PROTEIN; RATS; RHO GTP-BINDING PROTEINS;

EID: 56149122236     PISSN: 02484900     EISSN: 1768322X     Source Type: Journal    
DOI: 10.1042/BC20070160     Document Type: Article

References (34)

1. Abdel-Latif, D., Steward, M., Macdonald, D.L., Francis, G.A., Dinauer, M.C. and Lacy, P. (2004) Rac2 is critical for neutrophil primary granule exocytosis. Blood 104, 832-839
2. Berwick, D.C., Dell, G.C., Welsh, G.I., Heesom, K.J., Hers, I., Fletcher, L.M., Cooke, F.T. and Tavare, J.M. (2004) Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles. J. Cell Sci. 117, 5985-5993
3. Bogan, J.S., McKee, A.E. and Lodish, H.F. (2001) Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrations. Mol. Cell. Biol. 21, 4785-4806
4. Burridge, K. and Wennerberg, K. (2004) Rho and Rac take center stage. Cell 116, 167-179
5. Chiang, S.H., Baumann, C.A., Kanzaki, M., Thurmond, D.C., Watson, R.T., Neudauer, C.L., Macara, I.G., Pessin, J.E. and Saltiel, A.R. (2001) Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature 410, 944-948
6. Cho, H., Mu, J., Kim, J.K., Thorvaldsen, J.L., Chu, Q., Crenshaw, III, E.B., Kaestner, K.H., Bartolomei, M.S., Shulman, G.I. and Birnbaum, M.J. (2001) Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292, 1728-1731
7. Cho, Y.J., Zhang, B., Kaartinen, V., Haataja, L., de Curtis, I., Groffen, J. and Heisterkamp, N. (2005) Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia. Mol. Cell. Biol. 25, 5777-5785
8. Corbetta, S., Gualdoni, S., Albertinazzi, C., Paris, S., Croci, L., Consalez, G.G. and de Curtis, I. (2005) Generation and characterization of Rac3 knockout mice. Mol. Cell. Biol. 25, 5763-5776
9. Emoto, M., Langille, S.E. and Czech, M.P. (2001) A role for kinesin in insulin-stimulated GLUT4 glucose transporter translocation in 3T3-L1 adipocytes. J. Biol. Chem. 276, 10677-10682
10. Hong-Geller, E. and Cerione, R.A. (2000) Cdc42 and Rac stimulate exocytosis of secretory granules by activating the IP(3)/calcium pathway in RBL-2H3 mast cells. J. Cell Biol. 148, 481-494
11. Huang, S. and Czech, M.P. (2007) The GLUT4 glucose transporter. Cell Metab. 5, 237-252
12. Humeau, Y., Popoff, M.R., Kojima, H., Doussau, F. and Poulain, B. (2002) Rac GTPase plays an essential role in exocytosis by controlling the fusion competence of release sites. J. Neurosci. 22, 7968-7981
13. Inoue, M., Chang, L., Hwang, J., Chiang, S.H. and Saltiel, A.R. (2003) The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. Nature 422, 629-633
14. JeBailey, L., Rudich, A., Huang, X., Di Ciano-Oliveira, C., Kapus, A. and Klip, A. (2004) Skeletal muscle cells and adipocytes differ in their reliance on TC10 and Rac for insulin-induced actin remodeling. Mol. Endocrinol. 18, 359-372
15. JeBailey, L., Wanono, O., Niu, W., Roessler, J., Rudich, A. and Klip, A. (2007) Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells. Diabetes 56, 394-403
16. Khayat, Z.A., Tong, P., Yaworsky, K., Bloch, R.J. and Klip, A. (2000) Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes. J. Cell Sci. 113, 279-290
17. Koumanov, F., Jin, B., Yang, J. and Holman, G.D. (2005) Insulin signaling meets vesicle traffic of GLUT4 at a plasma-membrane-activated fusion step. Cell Metab. 2, 179-189
18. Mizushima, S. and Nagata, S. (1990) pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18, 5322
19. Norman, J.C., Price, L.S., Ridley, A.J. and Koffer, A. (1996) The small GTP-binding proteins, Rac and Rho, regulate cytoskeletal organization and exocytosis in mast cells by parallel pathways. Mol. Biol. Cell 7, 1429-1442
20. Omata, W., Shibata, H., Li, L., Takata, K. and Kojima, I. (2000) Actin filaments play a critical role in insulin-induced exocytotic recruitment but not in endocytosis of GLUT4 in isolated rat adipocytes. Biochem. J. 346, 321-328
21. Patki, V., Buxton, J., Chawla, A., Lifshitz, L., Fogarty, K., Carrington, W., Tuft, R. and Corvera, S. (2001) Insulin action on GLUT4 traffic visualized in single 3T3-l1 adipocytes by using ultra-fast microscopy. Mol. Biol. Cell 12, 129-141
22. Roberts, A.W., Kim, C., Zhen, L., Lowe, J.B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J.D., Borneo, J.B., Bradford, G.B. et al. (1999) Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity 10, 183-196
23. Rossman, K.L., Der, C.J. and Sondek, J. (2005) GEF means go: turning on RHOGTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell Biol. 6, 167-180
24. Saltiel, A.R. and Kahn, C.R. (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806
25. Sano, H., Kane, S., Sano, E., Miinea, C.P., Asara, J.M., Lane, W.S., Garner, C.W. and Lienhard, G.E. (2003) Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J. Biol. Chem. 278, 14599-14602
26. Schmidt, A. and Hall, A. (2002) Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev. 16, 1587-1609
27. Shepherd, P.R., Withers, D.J. and Siddle, K. (1998) Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem. J. 333, 471-490
28. Sugihara, K., Nakatsuji, N., Nakamura, K., Nakao, K., Hashimoto, R., Otani, H., Sakagami, H., Kondo, H., Nozawa, S., Aiba, A. and Katsuki, M. (1998) Rac1 is required for the formation of three germ layers during gastrulation. Oncogene 17, 3427-3433
29. Tapon, N., Nagata, K., Lamarche, N. and Hall, A. (1998) A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. EMBO J. 17, 1395-1404
30. Tsakiridis, T., Vranic, M. and Klip, A. (1994) Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane. J. Biol. Chem. 269, 29934-29942
31. Ueda, S., Kataoka, T. and Satoh, T. (2004) Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites. Cell. Signalling 16, 899-906
32. Wang, Q., Somwar, R., Bilan, P.J., Liu, Z., Jin, J., Woodgett, J.R. and Klip, A. (1999) Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol. Cell. Biol. 19, 4008-4018
33. Wennerberg, K. and Der, C.J. (2004) Rho-family GTPases: it's not only Rac and Rho (and I like it). J. Cell Sci. 117, 1301-1312
34. Zeigerer, A., McBrayer, M.K. and McGraw, T.E. (2004) Insulin stimulation of GLUT4 exocytosis, but not its inhibition of endocytosis, is dependent on RabGAPAS160. Mol. Biol. Cell 15, 4406-4415