Role of a novel PH-kinase domain interface in PKB/Akt regulation: Structural mechanism for allosteric inhibition

PLoS Biology

Volumn 7, Issue 1, 2009, Pages

  Calleja, Véronique ^a   Laguerre, Michel ^b   Parker, Peter J ^a,c   Larijani, Banafshé ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b INSTITUT EUROPÉEN DE CHIMIE ET BIOLOGIE   (France)

^c GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOTRANSFERASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL ANALYSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; FLUORESCENCE LIFETIME IMAGING MICROSCOPY; FLUORESCENCE RESONANCE ENERGY TRANSFER; MICROSCOPY; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PH; PROTEIN DOMAIN; PROTEIN QUATERNARY STRUCTURE; ANIMAL; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; MUTAGENESIS; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; GENE EXPRESSION REGULATION; MICE; MUTAGENESIS; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 58849120491     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1000017     Document Type: Article

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