Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles

Journal of Clinical Investigation

Volumn 108, Issue 3, 2001, Pages 371-381

  Tong, Peter ^a,c   Khayat, Zayna A ^a,b   Huang, Carol ^a   Patel, Nish ^a   Ueyama, Atsunori ^a,d   Klip, Amira ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CELLUBREVIN; GLUCOSE TRANSPORTER; INSULIN; SNARE PROTEIN; SYNAPTOBREVIN; SYNAPTOBREVIN 2; SYNAPTOSOMAL ASSOCIATED PROTEIN 23; SYNTAXIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; IMMUNOGOLD STAINING; INSULIN RESISTANCE; MOUSE; MUSCLE FIBER MEMBRANE; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCANNING ELECTRON MICROSCOPY; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CELL LINE; CELL MEMBRANE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; INSULIN; INSULIN RESISTANCE; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, FLUORESCENCE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; MUSCLE, SKELETAL; QA-SNARE PROTEINS; QB-SNARE PROTEINS; QC-SNARE PROTEINS; R-SNARE PROTEINS; RATS; VESICLE-ASSOCIATED MEMBRANE PROTEIN 3;

EID: 0034907579     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200112348     Document Type: Article

References (50)

1. Exercise induces recruitment of the "insulin-responsive glucose transporter". Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle
2. Identification of an intracellular pool of glucose transporters from basal and insulin-stimulated rat skeletal muscle
3. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus
4. Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM
5. Insulin action and insulin resistance in human skeletal muscle
6. Disassembly of the actin network inhibits insulin-dependent stimulation of glucose transport and prevents recruitment of glucose transporters to the plasma membrane
7. The small guanosine triphosphate-binding protein Rab4 is involved in insulin-induced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells
8. Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3-L1adipocytes
9. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
10. Divergent insulin and platelet-derived growth factor regulation of focal adhesion kinase (pp125FAK) tyrosine phosphorylation, and rearrangement of actin stress fibers
11. Effects of general receptor for phosphoinositides 1 on insulin and insulin-like growth factor I-induced cytoskeletal rearrangement, glucose transporter-4 translocation, and deoxyribonucleic acid synthesis
12. Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes
13. Actin Filaments play a critical role in insulin-induced exocytotic recruitment but not in endocytosis of GLUT4 in isolated rat adipocytes
14. A role for kinesin in insulin-stimulated GLUT4 glucose transporter translocation in adipocytes 3T3-L1
15. Insulin action on GLUT4 traffic visualized in single 3T3-11 adipocytes by using ultra-fast microscopy
16. SNAP receptors implicated in vesicle targeting and fusion
17. Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins
18. Vesicle-associated membrane protein 2 plays a specific role in the insulin-dependent trafficking of the facilitative glucose transporter GLUT4 in 3T3-L1 adipocytes
19. VAMP2, but not VAMP3/cellubrevin, mediates insulin-dependent incorporation of GLUT4 into the plasma membrane of L6 myoblasts
20. Syntaxin 4 in 3T3-L1 adipocytes: Regulation by insulin and participation in insulin-dependent glucose transport
21. Syntaxin 4, VAMP2, and/or VAMP3/cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytes
22. SNAP23 promotes insulin-dependent glucose uptake in 3 T3-L1 adipocytes: Possible interaction with cytoskeleton
23. Syndet, an adipocyte target SNARE involved in the insulin-induced translocation of GLUT4 to the cell surface
24. Cellubrevin is a resident protein of insulin-sensitive GLUT4 glucose transporter vesicles in 3T3-L1 adipocytes
25. Direct demonstration of insulin-induced GLUT4 translocation to the surface of intact cells by insertion of a c-myc epitope into an exofacial GLUT4 domain
26. GLUT4 translocation by insulin in intact muscle cells: Detection by a fast and quantitative assay
27. 3H]cytochalasin B binding sites
28. Hyperosmolarity reduces GLUT4 endocytosis and inreases its exocytosis from a VAMP2-independent pool in L6 muscle cells
29. A novel approach for scanning electron microscopy of colloidal gold-labeled cell surfaces
30. Mechanism and regulation of GLUT-4 vesicle fusion in muscle and fat cells
31. Effects of cytochalasins and phalloidin on actin
32. Latrunculins: Novel marine toxins that disrupt microfilament organization in cultured cells
33. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin
34. Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments
35. Development of insulin resistance in 3T3-L1 adipocytes
36. Detection of the GLUT3 facilitative glucose transporter in rat L6 muscle cells: Regulation by cellular differentiation, insulin and insulin-like growth factor-I
37. GLUT-4myc ectopic expression in L6 myoblasts generates a GLUT-4-specific pool conferring insulin sensitivity
38. Immunoelectron microscopic evidence that GLUT4 translocation explains the stimulation of glucose transport in isolated rat white adipose cells
39. Members of the VAMP family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocytes
40. Expression of vesicle-associated membrane protein 2 (VAMP-2)/synaptobrevin II and cellubrevin in rat skeletal muscle and in a muscle cell line
41. Insulin recruits GLUT4 from specialized VAMP2-carrying vesicles as well as from the dynamic endosomal/trans-Golgi network in rat adipocytes
42. Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein
43. Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance
44. A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B
45. Hyperglycemia impairs the insulin signaling step between PI 3-kinase and Akt/PKB activations in ZDF rat liver
46. Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation
47. Role for the microtubule cytoskeleton in GLUT4 vesicle trafficking and in the regulation of insulin-stimulated glucose uptake
48. Perinuclear localization and insulin responsiveness of GLUT4 requires cytoskeletal integrity in 3T3-L1 adipocytes
49. Insulin-mediated GLUT4 translocation is dependent on the microtubule network
50. Crossroads on cytoskeletal highways