Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells

Diabetes

Volumn 56, Issue 2, 2007, Pages 394-403

  JeBailey, Lellean ^a,b   Wanono, Oshrit ^a   Niu, Wenyan ^a,c   Roessler, Jessica ^a   Rudich, Assaf ^a,d   Klip, Amira ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c TIANJIN MEDICAL UNIVERSITY   (China)

^d BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; GLUCOSE OXIDASE; GLUCOSE TRANSPORTER 4; INSULIN; OXIDIZING AGENT; PROTEIN KINASE B; RAC PROTEIN; SERINE; SMALL INTERFERING RNA; THREONINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE TRANSLOCATION; GLUCOSE TRANSPORT; INSULIN RESISTANCE; MUSCLE CELL; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTINS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLUCOSE; GLUCOSE OXIDASE; GLUCOSE TRANSPORTER TYPE 4; INSULIN; INSULIN RESISTANCE; MUSCLE FIBERS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RAC GTP-BINDING PROTEINS; RECEPTOR, INSULIN; SPHINGOSINE;

EID: 33847026801     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-0823     Document Type: Article

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