Gene Delivery Using Physical Methods

Challenges in Delivery of Therapeutic Genomics and Proteomics

Volumn , Issue , 2011, Pages 83-126

  Jinturkar, Kaustubh A ^a   Rathi, Mohan N ^a   Misra, Ambikanandan ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84878845666     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-384964-9.00003-7     Document Type: Chapter

References (279)

1. Verma IM, Somia N Gene therapy-promises, problems and prospects. Nature 1997, 389:239-242.
2. Humbert SM, Guy RH Physical methods for gene transfer: improving the kinetics of gene delivery into cells. Adv Drug Delivery Rev 2005, 57:733-753.
3. Young LS, Searle PF, Onion D, Mautner V Viral gene therapy strategies: from basic science to clinical application. J Pathol 2006, 208:299-318.
4. Rettig GR, Rice KG Non-viral gene delivery: from the needle to the nucleus. Expert Opin Biol Ther 2007, 7:799-808.
5. Wolff JA, Malone R, Williams WP, Chong W, Acsadi G, Jani A, et al. Direct gene transfer into mouse muscle in vivo. Science 1990, 247:1465-1468.
6. Lechardeur D, Sohn KJ, Haardt M, Joshi PB, Monck M, Graham RW, et al. Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer. Gene Ther 1999, 6:482-497.
7. Houk BE, Hochhaus G, Hughes JA Kinetic modeling of plasmid DNA degradation in rat plasma. AAPS PharmSci 1999, 1:E9.
8. Wang S, Fuller D, Manson K, Wyand M, Lu S A new animal model to test the AIDS Vaccine efficacy in non-human primates: gene gun-mediated mucosal infection with proviral DNA plasmids. Antiviral Ther 2000, 5:29.
9. Te-hui W.Chou, Subhabrata B, Shan Lu Gene delivery using physical methods: an overview. Methods in molecular biology, vol. 245: gene delivery to mammalian cells: vol. 1: non-viral gene transfer techniques 2004, 147-165. Humana Press, Totowa, New Jersey. W.C. Heiser (Ed.).
10. Danko I, Wolff JA Direct gene transfer into muscle. Vaccine 1994, 12:1499-1502.
11. Levy MY, Barron LG, Meyer KB, Szoka Jr FC Characterization of plasmid DNA transfer into mouse skeletal muscle: evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Ther 1996, 3:201-211.
12. Takeshita S, Isner JM Peripheral angiogenesis: therapeutic angiogenesis for peripheral vascular occlusive disease. Curr Interv Cardiol Rep 1999, 1:147-156.
13. Vincent KA, Shyu KG, Luo Y, Magner M, Tio RA, Jiang C, et al. Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor. Circulation 2000, 102:2255-2261.
14. Kalka C, Masuda H, Takahashi T, Gordon R, Tepper O, Gravereaux E, et al. Vascular endothelial growth factor (165) gene transfer augments circulating endothelial progenitor cells in human subjects. Circ Res 2000, 86:1198-1202.
15. Isner JM Clinical trials in gene therapy. Curr Cardiol Rep 2000, 2:11-12.
16. Hickman MA, Malone RW, Lehmann-Bruinsma K, Sih TR, Knoell D, Szoka FC, et al. Gene expression following direct injection of DNA into liver. Hum Gene Ther 1994, 5:1477-1483.
17. Zhang G, Vargo D, Budker V, Armstrong N, Knechtle S, Wolff JA Expression of naked plasmid DNA injected into the afferent and efferent vessels of rodent and dog livers. Hum Gene Ther 1997, 8:1763-1772.
18. Yang JP, Huang L Direct gene transfer to mouse melanoma by intratumor injection of free DNA. Gene Ther 1996, 3:542-548.
19. Yu WH, Kashani-Sabet M, Liggitt D, Moore D, Heath TD, Debs RJ Topical gene delivery to murine skin. J Invest Dermatol 1999, 112:370-375.
20. Meyer KB, Thompson MM, Levy MY, Barron LG, Szoka FC Intratracheal gene delivery to the mouse airway: characterization of plasmid DNA expression and pharmacokinetics. Gene Ther 1995, 2:450-460.
21. He YK, Lui VW, Baar J, Wang L, Shurin M, Almonte C, et al. Potentiation of E7 antisense RNA-induced antitumor immunity by co-delivery of IL-12 gene in HPV16 DNA-positive mouse tumor. Gene Ther 1998, 5:1462-1471.
22. Zheng H, Brigham KL, Gao X Expression and pharmacokinetics of intratracheally administered naked DNA in mouse airways. Mol Ther 2000, 1:S22.
23. Glasspool MJ, Malone RW Marked enhancement of direct respiratory tissue transfection by aurintricarboxylic acid. Hum Gene Ther 1999, 10:1703-1713.
24. Hashida M, Mahato RI, Kawabata K, Miyao T, Nishikawa M, Takakura Y Pharmacokinetics and targeted delivery of proteins and genes. J Control Release 1996, 41:91-917.
25. Budker V, Zhang G, Knechtle S, Wolff JA Naked DNA delivered intraportally expresses efficiently in hepatocytes. Gene Ther 1996, 3:593-598.
26. Budker V, Zhang G, Danko I, Williams P, Wolff J The efficient expression of intravascularly delivered DNA in rat muscle. Gene Ther 1998, 5:272-276.
27. Kameda S, Maruyama H, Higuchi N, Iino N, Nakamura G, Miyazaki J, et al. Kidney-targeted naked DNA transfer by retrograde injection into the renal vein in mice. Biochem Biophys Res Commun 2004, 314:390-395.
28. Hao J, Li SK, Kao.WYW, Liu C-Y Gene delivery to cornea. Brain Res Bull 2010, 81:256-261.
29. Stechschulte SU, Joussen AM, von Recum HA, Poulaki V, Moromizato Y, Yuan J, et al. Rapid ocular angiogenic control via naked DNA delivery to cornea. Invest Ophthalmol Vis Sci 2001, 42:1975-1979.
30. Ambati BK, Nozaki M, Singh N, Takeda A, Jani PD, Suthar T, et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature 2006, 443:993-997.
31. Singh N, Higgins E, Amin S, Jani P, Richter E, Patel A, et al. Unique homologous siRNA blocks hypoxia-induced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularization. Cornea 2007, 26:65-72.
32. Budker V, Budker T, Zhang G, Subbotin V, Loomis A, Wolff JA Hypothesis: naked plasmid DNA is taken up by cells in vivo by a receptor-mediated process. J Gene Med 2000, 2:76-88.
33. Chang DC, Reese TS Changes in membrane structure induced by electroporation as revealed by rapid-freezing electron microscopy. Biophys J 1990, 58:1-12.
34. Melkonyan H, Sorg C, Klempt M Electroporation efficiency in mammalian cells is increased by dimethyl sulfoxide (DMSO). Nucleic Acids Res 1996, 24:4356-4357.
35. Yang TA, Heiser WC, Sedivy JM Efficient in situ electroporation of mammalian cells grown on microporous membranes. Nucleic Acids Res 1995, 23:2803-2810.
36. Zhang L, Nolan E, Kreitschitz S, Rabussay DP Enhanced delivery of naked DNA to the skin by non-invasive in vivo electroporation. Biochim Biophys Acta 2002, 1572:1-9.
37. Tjelle TE, Salte R, Mathiesen I, Kjeken R A novel electroporation device for gene delivery in large animals and humans. Vaccine 2006, 24:4667-4670.
38. Huang KS, Li M, Su CC, Huang HH, Fang CS, Lin YC. Enhancement of an electroporation system for gene delivery using electrophoresis with planar electrodes. Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Abstract Book; 2005, 1. p. 522-5.
39. Gothelf A, Mir LM, Gehl J Electrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporation. Cancer Treat Rev 2003, 29:371-387.
40. Bigey P, Bureau MF, Scherman D In vivo plasmid DNA electrotransfer. Curr Opin Biotechnol 2002, 13:443-447.
41. Gehl J Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research. Acta Physiol Scand 2003, 177:437-447.
42. McMahon JM, Wells DJ Electroporation for gene transfer to skeletal muscles: current status. BioDrugs 2004, 18:155-165.
43. Bloquel C, Fabre E, Bureau MF, Scherman D Plasmid DNA electrotransfer for intracellular and secreted proteins expression: new methodological developments and applications. J Gene Med 2004, 6:S11-S23.
44. Li S, Benninger M Applications of muscle electroporation gene therapy. Curr Gene Ther 2002, 2:101-105.
45. Schertzer JD, Lynch GS Plasmid-based gene transfer in mouse skeletal muscle by electroporation. Methods Mol Biol 2008, 433:115-125.
46. Pang WK, Zhao Y, Peng J, Peng B, Xu Y. Therapeutic protein production in vivo after electroporation-assisted intramuscular gene delivery. Engineering in Medicine and Biology Society, Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Abstract Book; 2005, 6. p. 6229-32.
47. Baowei P, Yonggang Z, Huili L, Wengka P, Yuhong Xu In vivo plasmid DNA electroporation resulted in transfection of satellite cells and lasting transgene expression in regenerated muscle fibers. Biochem Biophys Res Commun 2005, 338:1490-1498.
48. Hyung SJ, Hyun JK, Jeong MK, Young SL, Koung LK, Jeong AK, et al. A novel ex vivo angiogenesis assay based on electroporation-mediated delivery of naked plasmid DNA to skeletal muscle. Poster Abstr/Cardiovasc Path 2004, 13:S17-S79.
49. Chiarella P, Massi ED, Robertis M, Sibilio A, Parrella P, Fazio VM, et al. Electroporation of skeletal muscle induces danger signal release and antigen-presenting cell recruitment independently of DNA Vaccine administration. Expert Opin Biol Ther 2008, 8:1645-1657.
50. Scheerlinck PY, Karlis J, Tjelle TE, Presidente PJA, Mathiesen I, Newton SE In vivo electroporation improves immune responses to DNA vaccination in sheep. Vaccine 2004, 22:1820-1825.
51. Shawn B, Maria E, Baca E, Marianna F, Michael S, Deitmar R, et al. Electroporation improves the efficacy of DNA Vaccines in large animals. Vaccine 2002, 20:3399-3408.
52. Li S, Xia X, Zhang X, Suen J Regression of tumors by IFN-alpha electroporation gene therapy and analysis of the responsible genes by cDNA array. Gene Ther 2002, 9:390-397.
53. Li S, Zhang X, Xia X, Zhou L, Breau R, Suen J, et al. Intramuscular electroporation delivery of IFN-alpha gene therapy for inhibition of tumor growth located at a distant site. Gene Ther 2001, 8:400-407.
54. Yo-ichi Y, Mitsuo S, Hirofumi H, Ryosuke M, Tatsuya R, Takayuki H, et al. Electroporation-mediated interleukin-12 gene therapy for hepatocellular carcinoma in the mice model. Cancer Res 2001, 61:1005-1012.
55. Yo-ichi Y, Mitsuo S, Ryosuke M, Eiji T, Norifumi H, Shinji T, et al. Muscle-targeted interleukin-12 gene therapy of orthotopic hepatocellular carcinoma in mice using in vivo electrosonoporation. Mol Cancer Ther 2004, 3:1177.
56. Daud AI, DeConti RC, Andrews S, Urbas P, Riker AI, Sondak VK, et al. Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma. J Clin Oncol 2008, 26:5896-5903.
57. Heller R, Jaroszeski M, Atkin A, Moradpour D, Gilbert R, Wands J, et al. In vivo gene electroinjection and expression in rat liver. FEBS Lett 1996, 389:225-228.
58. Takeshi S, Shin BS, Keiko F, Toshiyuki M, Kuniaki T Direct gene transfer into rat liver cells by in vivo electroporation. FEBS Lett 1998, 425:436-440.
59. Matsuno Y, Iwata H, Umeda Y, Takagi H, Mori Y, Kosugi A, et al. Hepatocyte growth factor gene transfer into the liver via the portal vein using electroporation attenuates rat liver cirrhosis. Gene Ther 2003, 10:1559-1566.
60. Dean DA, Machado A, Blair P, Yeldandi AV, Young JL Electroporation as a method for high-level non-viral gene transfer to the lung. Gene Ther 2003, 10:1608-1615.
61. Yukio U, Tsutomu M, Yukihiro M, Koyo S, Hisashi I, Hisato T, et al. Skeletal muscle targeting in vivo electroporation-mediated HGF gene therapy of bleomycin-induced pulmonary fibrosis in mice. Lab Invest 2004, 84:836-844.
62. Terada Y, Tanaka H, Okado T, Inoshita S, Kuwahara M, Akiba T, et al. Efficient and ligand-dependent regulated erythropoietin production by naked DNA injection and in vivo electroporation Am J Kidney Dis International Congress on Uremia Research, Nara, Japan, 2001;38: S50-S53.
63. Glomeruli MT, Yoshitaka I, Hiroyuki N, Enyu I, Masatsugu H Electroporation-mediated gene transfer that targets glomeruli. J Am Soc Nephrol 2001, 12:949-954.
64. Harrison Rachel L, Barry JB, Leslie T Electroporation-mediated gene transfer in cardiac tissue. FEBS Lett 1998, 435:1-5.
65. Long YC, Jaichandran S, Ho LP, Tien SL, Tan SY, Kon OL FVIII gene delivery by muscle electroporation corrects murine hemophilia A. J Gene Med 2005, 7:494-505.
66. Viggo FI, Van T, Peter P, Filip L, Griet N, Marc L, et al. Highly efficient gene delivery by mRNA electroporation in human hematopoietic cells: superiority to lipofection and passive pulsing of mRNA and to electroporation of plasmid cDNA for tumor antigen loading of dendritic cells. Blood 2001, 98:49-56.
67. Gao X, Kim KS, Liu D Non-viral gene delivery: what we know and what is next. AAPS J 2007, 9:E92-E104.
68. Liu F, Song Y, Liu D Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999, 6:1258-1266.
69. Zhang G, Budker V, Wolff JA High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 1999, 10:1735-1737.
70. Takeshi S, Dexi L Hydrodynamic gene delivery: its principles and applications. Mol Ther 2007, 15:2063-2069.
71. Maruyama H, Higuchi N, Nishikawa Y, Hirahara H, Iino N, Kameda S, et al. Kidney targeted naked DNA transfer by retrograde renal vein injection in rats. Hum Gene Ther 2002, 13:455-468.
72. Zhang G, Budker V, Williams P, Subbotin V, Wolff J Efficient expression of naked DNA delivered intraarterialy to limb muscles of nonhuman primates. Hum Gene Ther 2001, 12:427-438.
73. Liu DX, Knapp JE Hydrodynamics-based gene delivery. Curr Opin Mol Ther 2001, 3:192-197.
74. Zhang G, Gao X, Song YK, Vollmer R, Stolz DB, Gasiorowski JZ, et al. Hydroporation as the mechanism of hydrodynamic delivery. Gene Ther 2004, 11:675-682.
75. Andrianaivo F, Lecocq M, Wattiaux-De Coninck S, Wattiaux R, Jadot M Hydrodynamics-based transfection of the liver: entrance into hepatocytes of DNA that causes expression takes place very early after injection. J Gene Med 2004, 6:877-883.
76. Kobayashi N, Nishikawa M, Hirata K, Takakura Y Hydrodynamics-based procedure involves transient hyper permeability in the hepatic cellular membrane: implication of a nonspecific process in efficient intracellular gene delivery. J Gene Med 2004, 6:584-592.
77. Chen CY, Liu HS, Lin XZ Hydrodynamics-based gene delivery to the liver by bile duct injection of plasmid DNA-the impact of lasting biliary obstruction and injection volume. Hepatogastroenterology 2005, 52:25-28.
78. Danialou G, Comtois AS, Matecki S, Nalbantoglu J, Karpati G, Gilbert R, et al. Optimization of regional intraarterial naked DNA-mediated transgene delivery to skeletal muscles in a large animal model. Mol Ther 2005, 11:257-266.
79. Yoshino H, Hashizume K, Kobayashi E Naked plasmid DNA transfer to the porcine liver using rapid injection with large volume. Gene Ther 2006, 13:1696-1702.
80. Dagnaes-Hansen F, Holst HU, Sondergaard M, Vorup-Jensen T, Flyvbjerg A, Jensen UB, et al. Physiological effects of human growth hormone produced after hydrodynamic gene transfer of a plasmid vector containing the human ubiquitin promotor. J Mol Med 2002, 80:665-670.
81. Hanawa H, Watanabe R, Hayashi M, Yoshida T, Abe S, Komura S, et al. A novel method to assay proteins in blood plasma after intravenous injection of plasmid DNA. Tohoku J Exp Med 2004, 202:155-161.
82. Holst HU, Dagnaes-Hansen F, Corydon TJ, Andreasen PH, Jorgensen MM, Kolvraa S, et al. LDL receptor-GFP fusion proteins: new tools for the characterisation of disease-causing mutations in the LDL receptor gene. Eur J Hum Genet 2001, 9:815-822.
83. Jiang JJ, Yamato E, Miyazaki J Intravenous delivery of naked plasmid DNA for in vivo cytokine expression. Biochem Biophys Res Commun 2001, 289:1088-1092.
84. Slattum PS, Loomis AG, Machnik KJ, Watt MA, Duzeski JL, Budker VG, et al. Efficient in vitro and in vivo expression of covalently modified plasmid DNA. Mol Ther 2003, 8:255-263.
85. Vorup-Jensen T, Jensen UB, Liu H, Kawasaki T, Uemura K, Thiel S, et al. Tail-vein injection of Mannan-binding lectin DNA leads to high expression levels of multimeric protein in liver. Mol Ther 2001, 3:867-874.
86. Giladi H, Ketzinel-Gilad M, Rivkin L, Felig Y, Nussbaum O, Galun E Small interfering RNA inhibits hepatitis B virus replication in mice. Mol Ther 2003, 8:769-776.
87. Maruyama H, Higuchi N, Nishikawa Y, Kameda S, Iino N, Kazama JJ, et al. High-level expression of naked DNA delivered to rat liver via tail vein injection. J Gene Med 2002, 4:333-341.
88. Chabicovsky M, Herkner K, Rossmanith W Overexpression of activin beta (C) or activin beta (E) in the mouse liver inhibits regenerative deoxyribonucleic acid synthesis of hepatic cells. Endocrinology 2003, 144:3497-3504.
89. Imagawa T, Watanabe S, Katakura S, Boivin GP, Hirsch R Gene transfer of a fibronectin peptide inhibits leukocyte recruitment and suppresses inflammation in mouse collagen-induced arthritis. Arthritis Rheuma 2002, 46:1102-1108.
90. Layzer JM, McCaffrey AP, Tanner AK, Huang Z, Kay MA, Sullenger BA In vivo activity of nuclease-resistant siRNAs. RNA 2004, 10:766-771.
91. McCaffrey AP, Hashi K, Meuse L, Shen SL, Lancaster AM, Lukavsky PJ, et al. Determinants of hepatitis C translational initiation in vitro, in cultured cells and mice. Mol Ther 2002, 5:676-684.
92. McCaffrey AP, Meuse L, Karimi M, Contag CH, Kay MA A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice. Hepatology 2003, 38:503-508.
93. Miao CH, Ye X, Thompson AR High-level factor VIII gene expression in vivo achieved by non-viral liver-specific gene therapy vectors. Hum Gene Ther 2003, 14:1297-1305.
94. Ye PQ, Thompson AR, Sarkar R, Shen ZP, Lillicrap DP, Kaufman RJ, et al. Naked DNA transfer of factor VIII induced transgene specific, species-independent immune response in hemophilia A mice. Mol Ther 2004, 10:117-126.
95. Eastman SJ, Baskin KM, Hodges BL, Chu QM, Gates A, Dreusicke R, et al. Development of catheter-based procedures for transducing the isolated rabbit liver with plasmid DNA. Hum Gene Ther 2002, 13:2065-2077.
96. Hagstrom JE, Hegge J, Zhang G, Noble M, Budker V, Lewis DL, et al. A facile non-viral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs. Mol Ther 2004, 10:386-398.
97. Chen ZY, He CY, Meuse L, Kay MA Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo. Gene Ther 2004, 11:856-864.
98. Liang KW, Nishikawa M, Liu F, Sun B, Ye Q, Huang L Restoration of dystrophin expression in mdx mice by intravascular injection of naked DNA containing full length dystrophin cDNA. Gene Ther 2004, 11:901-908.
99. Song YK, Liu F, Zhang G, Liu D Hydrodynamics-based transfection: simple and efficient method for introducing and expressing transgenes in animals by intravenous injection of DNA. Methods Enzymol 2002, 346:92-105.
100. Suda T, Gao X, Stolz DB, Liu D Structural impact of hydrodynamic injection on mouse liver. Gene Ther 2007, 14:129-137.
101. Sebestyen MG, Budker VG, Budker T, Subbotin VM, Zhang G, Monahan SD, et al. Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules. J Gene Med 2006, 8:852-873.
102. Kobayashi N, Kuramoto T, Yamaoka K, Hashida M, Takakura Y Hepatic uptake and gene expression mechanisms following intravenous administration of plasmid DNA by conventional and hydrodynamics-based procedures. J Pharmacol Exp Ther 2001, 297:853-860.
103. McCaffrey AP, Meuse L, Pham TT, Conklin DS, Hannon GJ, Kay MA RNA interference in adult mice. Nature 2002, 418:38-39.
104. Lewis DL, Hagstrom JE, Loomis AG, Wolff JA, Herweijer H Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat Genet 2002, 32:107-108.
105. Bates MK, Zhang G, Sebestyen MG, Neal ZC, Wolff JA, Herweijer H Genetic immunization for antibody generation in research animals by intravenous delivery of plasmid DNA. BioTechniques 2006, 40:199-208.
106. Neal ZC, Bates MK, Albertini MR, Herweijer H Hydrodynamic limb vein delivery of a xenogeneic DNA cancer vaccine effectively induces antitumor immunity. Mol Ther 2007, 15:422-430.
107. Cui FD, Asada H, Kishida T, Itokawa Y, Nakaya T, Ueda Y, et al. Intravascular naked DNA Vaccine encoding glycoprotein B induces protective humoral and cellular immunity against herpes simplex virus type-1 infection in mice. Gene Ther 2003, 10:2059-2066.
108. Magin-Lachmann C, Kotzamanis G, D'Aiuto L, Cooke H, Huxley C, Wagner E In vitro and in vivo delivery of intact BAC DNA: comparison of different methods. J Gene Med 2004, 6:195-209.
109. Chu Q, Joseph M, Przybylska M, Yew NS, Scheule RK Transient siRNA-mediated attenuation of liver expression from an alpha-galactosidase a plasmid reduces subsequent humoral immune responses to the transgene product in mice. Mol Ther 2005, 12:264-273.
110. Hodges BL, Taylor KM, Joseph MF, Bourgeois SA, Scheule RK Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides. Mol Ther 2004, 10:269-278.
111. Sondergaard M, Dagnaes-Hansen F, Flyvbjerg A, Jensen TG Normalization of growth in hypophysectomized mice using hydrodynamic transfer of the human growth hormone gene. Am J Physiol Endocrinol Metab 2003, 285:E427-E432.
112. Miao CH, Ye P, Thompson AR, Rawlings DJ, Ochs HD Immunomodulation of transgene responses following naked DNA transfer of human factor VIII into hemophilia mice. Blood 2006, 108:19-27.
113. Miao CH A novel gene expression system: non-viral gene transfer for hemophilia as model systems. Adv Genet 2005, 54:143-177.
114. Takakusaki Y, Hisayasu S, Hirai Y, Shimada T Co-expression of formylglycine-generating enzyme is essential for synthesis and secretion of functional arylsulfatase A in a mouse model of metachromatic leukodystrophy. Hum Gene Ther 2005, 16:929-936.
115. He CX, Shi D, Wu WJ, Ding YF, Feng DM, Lu B, et al. Insulin expression in livers of diabetic mice mediated by hydrodynamics-based administration. World J Gastroenterol 2004, 10:567-572.
116. Dai C, Yang J, Bastacky S, Xia J, Li Y, Liu Y Intravenous administration of hepatocyte growth factor gene ameliorates diabetic nephropathy in mice. J Am Soc Nephrol 2004, 15:2637-2647.
117. Gonzalez Muniesa P, Milagro FI, Campion J, Martinez JA Reduction in energy efficiency induced by expression of the uncoupling protein, UCP1, in mouse liver mitochondria. Int J Mol Med 2006, 17:591-597.
118. Jiang J, Yamato E, Miyazaki J Long-term control of food intake and body weight by hydrodynamics-based delivery of plasmid DNA encoding leptin or CNTF. J Gene Med 2003, 5:977-983.
119. Chang H, Hanawa H, Liu H, Yoshida T, Hayashi M, Watanabe R, et al. Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats. J Immunol 2006, 177:3635-3643.
120. Elnaggar R, Hanawa H, Liu H, Yoshida T, Hayashi M, Watanabe R, et al. The effect of hydrodynamics-based delivery of an IL-13-Ig fusion gene for experimental autoimmune myocarditis in rats and its possible mechanism. Eur J Immunol 2005, 35:1995-2005.
121. Liu H, Hanawa H, Yoshida T, Elnaggar R, Hayashi M, Watanabe R, et al. Effect of hydrodynamics-based gene delivery of plasmid DNA encoding interleukin-1 receptor antagonist-Ig for treatment of rat autoimmune myocarditis: possible mechanism for lymphocytes and noncardiac cells. Circulation 2005, 111:1593-1600.
122. Sato A, Ohtsuki M, Hata M, Kobayashi E, Murakami T Antitumor activity of IFN-lambda in murine tumor models. J Immunol 2006, 176:7686-7694.
123. Takehara T, Uemura A, Tatsumi T, Suzuki T, Kimura R, Shiotani A, et al. Natural killer cell-mediated ablation of metastatic liver tumors by hydrodynamic injection of IFN alpha gene to mice. Int J Cancer 2007, 120:1252-1260.
124. Ortaldo JR, Winkler-Pickett RT, Bere Jr.EW, Watanabe M, Murphy WJ, Wiltrout RH In vivo hydrodynamic delivery of cDNA encoding IL-2: rapid, sustained redistribution, activation of mouse NK cells, and therapeutic potential in the absence of NKT cells. J Immunol 2005, 175:693-699.
125. Kobayashi N, Kuramoto T, Chen S, Watanabe Y, Takakura Y Therapeutic effect of intravenous interferon gene delivery with naked plasmid DNA in murine metastasis models. Mol Ther 2002, 6:737-744.
126. Tada M, Hatano E, Taura K, Nitta T, Koizumi N, Ikai I, et al. High volume hydrodynamic injection of plasmid DNA via the hepatic artery results in a high level of gene expression in rat hepatocellular carcinoma induced by diethylnitrosamine. J Gene Med 2006, 8:1018-1026.
127. Mann MJ, Gibbons GH, Hutchinson H, Poston RS, Hoyt EG, Robbins RC, et al. Pressure-mediated oligonucleotide transfection of rat and human cardiovascular tissues. Proc Natl Acad Sci USA 1999, 96:6411-6416.
128. Yazawa H, Murakami T, Li HM, Back T, Kurosaka K, Suzuki Y, et al. Hydrodynamics-based gene delivery of naked DNA encoding fetal liver kinase-1gene effectively suppresses the growth of pre-existing tumors. Cancer Gene Ther 2006, 13:993-1001.
129. Kim KS, Park YS Antitumor effects of angiostatin K1-3 and endostatin genes coadministered by the hydrodynamics-based transfection method. Oncol Res 2005, 15:343-350.
130. Yonenaga Y, Mori A, Fujimoto A, Nagayama S, Tachibana T, Onodera H, et al. The administration of naked plasmid DNA into the liver induces antitumor innate immunity in a murine liver metastasis model. J Gene Med 2007, 9:299-307.
131. Kitajima M, Tsuyama Y, Miyano-Kurosaki N, Takaku H Anti-tumor effect of intravenous TNFalpha gene delivery naked plasmid DNA using a hydrodynamics based procedure. Nucleosides Nucleotides Nucleic Acids 2005, 24:647-650.
132. Chen HW, Lee YP, Chung YF, Shih YC, Tsai JP, Tao MH, et al. Inducing long-term survival with lasting anti-tumor immunity in treating B cell lymphoma by a combined dendritic cell-based and hydrodynamic plasmid-encoding IL-12 gene therapy. Int Immunol 2003, 15:427-435.
133. Wang G, Tschoi M, Spolski R, Lou Y, Ozaki K, Feng C, et al. In vivo antitumor activity of interleukin 21 mediated by natural killer cells. Cancer Res 2003, 63:9016-9022.
134. Wen J, Matsumoto K, Taniura N, Tomioka D, Nakamura T Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice. Cancer Gene Ther 2004, 11:419-430.
135. Yang PL, Althage A, Chung J, Chisari FV Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc Natl Acad Sci USA 2002, 99:13825-13830.
136. Al Dosari M, Zhang G, Knapp JE, Liu D Evaluation of viral and mammalian promoters for driving transgene expression in mouse liver. Biochem Biophys Res Commun 2006, 339:673-678.
137. Dosari M, Zhang G, Knapp JE, Liu D Direct assessment of promoter activity of human cytochrome p450 genes using optimized transfection in vitro and in vivo. Biosci Rep 2006, 26:217-229.
138. Xu ZL, Mizuguchi H, Ishii-Watabe A, Uchida E, Mayumi T, Hayakawa T Optimization of transcriptional regulatory elements for constructing plasmid vectors. Gene 2001, 272:149-156.
139. Notley C, Killoran A, Cameron C, Wynd K, Hough C, Lillicrap D The canine factor VIII 3′-untranslated region and a concatemeric hepatocyte nuclear factor 1 regulatory element enhance factor VIII transgene expression in vivo. Hum Gene Ther 2002, 13:1583-1593.
140. Cui FD, Kishida T, Ohashi S, Asada H, Yasutomi K, Satoh E, et al. Highly efficient gene transfer into murine liver achieved by intravenous administration of naked Epstein-Barr virus (EBV)-based plasmid vectors. Gene Ther 2001, 8:1508-1513.
141. Stoll SM, Sclimenti CR, Baba EJ, Meuse L, Kay MA, Calos MP Epstein-Barr virus/human vector provides high-level, long-term expression of alpha1-antitrypsin in mice. Mol Ther 2001, 4:122-129.
142. Yew NS, Zhao H, Przybylska M, Wu IH, Tousignant JD, Scheule RK, et al. CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo. Mol Ther 2002, 5:731-738.
143. Klein T, Wolf E, Wu R, Sanford J High-velocity microprojectiles for delivering nucleic acids into living cells. Nature 1987, 327:70-73.
144. McCabe DM, Swain E, Martinell B, Christou P Stable transformation of soybean ( Glycine max) by particle acceleration. Biotechnology 1988, 6:923-926.
145. Yang N, Burkholder J, Roberts B, Martinell B, McCabe D In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc Nat Acad Sci USA 1990, 87:9568-9572.
146. Cheng L, Ziegelhoffer PR, Yang NS In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment. Proc Natl Acad Sci USA 1993, 90:4455-4459.
147. Williams RS, Johnston SA, Riedy M, DeVit MJ, McElligott SG, Sanford JC Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. Proc Natl Acad Sci USA 1991, 88:2726-2730.
148. Heiser WC Gene transfer into mammalian cells by particle bombardment. Anal Biochem 1994, 217:185-196.
149. Sanford JC, Smith FD, Russell JA Optimizing the biolistic process for different biological applications. Methods Enzymol 1993, 217:483-509.
150. Fynan EF, Webster RG, Fuller DH, Haynes JR, Santoro JC, Robinson HR DNA Vaccines: protective immunizations by aperteral, mucosal, and gene-gun inoculations. Proc Natl Acad Sci USA 1993, 90:11478-11482.
151. Pertmer TM, Eisenbraum MD, McCabe DM, Prayaga SK, Fuller DH, Haynes JR Gene gun-based nucleic acid immunization: elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA. Vaccine 1995, 13:1427-1430.
152. Eisenbraum MD, Fuller DH, Haynes JR Examination of parameters affecting the elicitation of humoral immune responses by particle bombardment mediated genetic immunization. DNA Cell Biol 1993, 12:791-797.
153. Macklin MD, Drape RJ, Swain WF Preparations for particle-mediated gene transfer using the Accell gene gun. Methods Mol Med 1998, 29:297-303.
154. Yoshida A, Nagata T, Uchijima M, Koide Y Protective CTL response is induced in the absence of CD4 T cells and IFN-gamma by gene gun DNA vaccination with a minigene encoding a CTL epitope of Listeria monocytogenes. Vaccine 2001, 19:4297-4306.
155. Price BM, Galloway DR, Baker NR, Gilleland LB, Staczek J, Gilleland HE Protection against Pseudomonas aeruginosa chronic lung infection in mice by genetic immunization against outer membrane protein F (OprF) of P. aeruginosa. Infect Immun 2001, 69:3510-3515.
156. Tahtinen M, Strengell M, Collings A, Pitkanen J, Kjerrstrom A, Hakkarainen K, et al. DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating pBN-vector. Vaccine 2001, 19:2039-2047.
157. Han R, Cladel NM, Reed CA, Peng X, Budgeon LR, Pickel M, et al. DNA vaccination prevents and/or delays carcinoma development of papilloma virus-induced skin papillomas on rabbits. J Virol 2000, 74:9712-9716.
158. Han R, Cladel NM, Reed CA, Peng X, Christensen ND Protection of rabbits from viral challenge by gene gun-based intracutaneous vaccination with a combination of cottontail rabbit papillomavirus E1, E2, E6, and E7 genes. J Virol 1999, 73:7039-7043.
159. Richmond JF, Mustafa F, Lu S, Santoro JC, Weng J, O'Connell M, et al. Screening of HIV-1 Env glycoproteins for the ability to raise neutralizing antibody using DNA immunization and recombinant vaccinia virus boosting. Virology 1997, 230:265-274.
160. McCluskie MJ, Brazolot Millan CL, Gramzinski RA, Robinson HL, Santoro JC, Fuller JT, et al. Route and method of delivery of DNA Vaccine influence immune responses in mice and non-human primates. Mol Med 1999, 5:287-300.
161. Lodmell DL, Parnell MJ, Bailey JR, Ewalt LC, Hanson CA One-time gene gun or intramuscular rabies DNA vaccination of non-human primates: comparison of neutralizing antibody responses and protection against rabies virus 1 year after vaccination. Vaccine 2001, 20:838-844.
162. Fuller DH, Murphey-Corb M, Clements J, Barnett S, Haynes JR Induction of immunodeficiency virus-specific immune responses in rhesus monkeys following gene gun-mediated DNA vaccination. J Med Primatol 1996, 25:236-241.
163. Barnett SW, Rajasekar S, Legg H, Doe B, Fuller DH, Haynes JR, et al. Vaccination with HIV-1 gp120 DNA induces immune responses that are boosted by a recombinant gp120 protein subunit. Vaccine 1997, 15:869-873.
164. Tang DC, Devit M, Johnston SA Genetic immunization is a simple method for eliciting an immune response. Nature 1992, 356:152-154.
165. Lin MT, Pulkkinen L, Uitto J, Yoon K The gene gun: current applications in cutaneous gene therapy. Int J Dermatol 2000, 39:161-170.
166. Sun WH, Burkholder JK, Sun J, Culp J, Turner J, Lu XG, et al. In vivo cytokine gene transfer by gene gun suppresses tumor growth in mice. Proc Natl Acad Sci USA 1995, 92:2889-2893.
167. Mahvi DM, Sheehy MJ, Yang NS DNA cancer Vaccines: a gene gun approach. Immunol Cell Biol 1997, 75:456-460.
168. Seigne J, Turner J, Diaz J, Hackney J, Pow-Sang J, Helal M, et al. A feasibility study of gene gun mediated immunotherapy for renal cell carcinoma. J Urol 1999, 162:1259-1263.
169. Wang J, Murakami T, Hakamata Y, Ajiki T, Jinbu Y, Akasaka Y, et al. Gene gun-mediated oral mucosal transfer of interleukin 12 cDNA coupled with an irradiated melanoma vaccine in a hamster model: successful treatment of oral melanoma and distant skin lesion. Cancer Gene Ther 2001, 8:705-712.
170. Boyle CM, Robinson HL Basic mechanisms of DNA-raised antibody responses to intramuscular and gene gun immunizations. DNA Cell Biol 2000, 19:157-165.
171. Robinson HL DNA Vaccines: basic mechanism and immune responses (review). Int J Mol Med 1999, 4:549-555.
172. Wang S, Joshi S, Lu S Delivery of DNA to skin by particle bombardment. Methods in molecular biology, vol. 245: gene delivery to mammalian cells: vol. 1: non-viral gene transfer techniques 2004, 185-196. Humana Press, Totowa, New Jersey. W.C. Heiser (Ed.).
173. Shiraishi A, Converse RL, Liu CY, Zhou F, Kao CW, Kao WW Identification of the cornea-specific keratin 12 promoter by in vivo particle-mediated gene transfer. Invest Ophthalmol Vis Sci 1998, 39:2554-2561.
174. Wang IJ, Carlson EC, Liu CY, Kao CW, Hu FR, Kao WW Cis-regulatory elements of the mouse Krt1.12 gene. Mol Vis 2002, 8:94-101.
175. Zagon IS, Sassani JW, Verderame MF, McLaughlin PJ Particle-mediated gene transfer of opioid growth factor receptor cDNA regulates cell proliferation of the corneal epithelium. Cornea 2005, 24:614-619.
176. Zhang EP, Franke J, Schroff M, Junghans C, Wittig B, Hoffmann F Ballistic CTLA4 and IL-4 gene transfer into the lower lid prolongs orthotopic corneal graft survival in mice. Graefe's Arch Clin Exp Ophthalmol 2003, 241:921-926.
177. Muller A, Zhang EP, Schroff M, Wittig B, Hoffmann F Influence of ballistic gene transfer on antigen-presenting cells in murine corneas. Graefe's Arch Clin Exp Ophthalmol 2002, 240:851-859.
178. Tuting T, Storkus WJ, Falo LD DNA immunization targeting the skin: molecular control of adaptive immunity. J Invest Dermatol 1998, 111:183-188.
179. Pertmer TM, Roberts TR, Haynes JR Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery. J Virol 1996, 70:6119-6125.
180. Smooker PM, Steeper KR, Drew DR, Strugnell RA, Spithill TW Humoral responses in mice following vaccination with DNA encoding glutathione S-transferase of Fasciola hepatica: effects of mode of vaccination and the cellular compartment of antigen expression. Parasite Immunol 1999, 21:357-364.
181. Feltquate DM, Heaney S, Webster RG, Robinson HL Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunisation. J Immunol 1997, 158:2278-2284.
182. Macklin MD, McCabe D, McGregor MW, Neumann V, Meyer T, Callan R, et al. Immunization of pigs with a particle-mediated DNA Vaccine to influenza A virus protects against challenge with homologous virus. J Virol 1998, 72:1491-1496.
183. Lunn DP, Soboll G, Schram BR, Quass J, McGregor MW, Drape RJ, et al. Antibody responses to DNA vaccination of horses using the influenza virus hemagglutinin gene. Vaccine 1999, 17:2245-2258.
184. Qiu P, Ziegelhoffer P, Sun J, Yang NS Gene gun delivery of mRNA in situ results in efficient transgene expression and genetic immunization. Gene Ther 1996, 3:262-268.
185. Sato H, Hattori S, Kawamoto S, Kudoh I, Hayashi A, Yamamoto I, et al. In vivo gene gun-mediated DNA delivery into rodent brain tissue. Biochem Biophys Res Commun 2000, 270:163-170.
186. Klinman DM, Conover J, Leiden JM, Rosenberg AS, Sechler JM Safe and effective regulation of hematocrit by gene gun administration of an erythropoietin-encoding DNA plasmid. Hum Gene Ther 1999, 10:659-665.
187. O'Brien J, Lummis SC Biolistic and diolistic transfection: using the gene gun to deliver DNA and lipophilic dyes into mammalian cells. Methods 2004, 33:121-125.
188. Weiner DB, Kennedy RC Genetic vaccines. Sci Am 1999, 281:50-57.
189. Zelenin AV, Titomirov AV, Kolesnikov VA Genetic transformation of mouse cultured cells with the help of high-velocity mechanical DNA injection. FEBS Lett 1989, 244:65-67.
190. Johnston SA Biolistic transformation: microbes to mice. Nature 1990, 346:776-777.
191. Woffendin C, Yang ZY, Udaykumar XL, Yang NS, Sheehy MJ, Nabel GJ Non-viral and viral delivery of a human immunodeficiency virus protective gene into primary human T-cells. Proc Natl Acad Sci USA 1994, 91:11581-11585.
192. Chuang YC, Chou AK, Wu PC, Chiang PH, Yu TJ, Yang LC, et al. Gene therapy for bladder pain with gene gun particle encoding pro-opiomelanocortin cDNA. J Urol 2003, 170:2044-2048.
193. Matsuno Y, Iwata H, Umeda Y, Takagi H, Mori Y, Miyazaki J, et al. Non-viral gene gun mediated transfer into the beating heart. ASAIO J 2003, 49:641-644.
194. Kitagawa T, Iwazawa T, Robbins PD, Lotze MT, Tahara H Advantages and limitations of particle-mediated transfection (gene gun) in cancer immuno-gene therapy using IL-10, IL-12 or B7-1 in murine tumor models. J Gene Med 2003, 5:958-965.
195. Chen CH, Ji H, Suh KW, Choti MA, Pardoll DM, Wu TC Gene gun-mediated DNA vaccination induces antitumor immunity against human papillomavirus type 16 E7-expressing murine tumor metastases in the liver and lungs. Gene Ther 1999, 6:1972-1981.
196. White SA, LoBuglio AF, Arani RB, Pike MJ, Moore SE, Barlow DL, et al. Induction of anti-tumor immunity by intrasplenic administration of a carcinoembryonic antigen DNA Vaccine. J Gene Med 2000, 2:135-140.
197. Kouraklis G Progress in cancer gene therapy. Acta Oncol 1999, 38:675-683.
198. Barber MA A technique for the inoculation of bacteria and other substances into living cells. J Infect Dis 1911, 8:348-360.
199. Barber MA The pipette method in the isolation of single microorganisms and the inoculation of substances into living cells. Philipp J Sci 1914, 9:307-358.
200. Graessmann M, Graessmann A Microinjection of tissue culture cells. Methods Enzymol 1983, 101:482-492.
201. Ansorge W Improved system for capillary microinjection into living cells. Exp Cell Res 1982, 140:31-37.
202. Ansorge W, Pepperkok R Performance of an automated system for capillary microinjection into living cells. J Biochem Biophys Methods 1988, 16:283-292.
203. Pepperkok R, Zanetti M, King R, Delia D, Ansorge W, Philipson L, et al. Automatic microinjection system facilitates detection of growth inhibitory mRNA. Proc Natl Acad Sci USA 1988, 85:6748-6752.
204. Kagawa Y, Inoki Y, Endo H Gene therapy by mitochondrial transfer. Adv Drug Del Rev 2001, 49:107-119.
205. Capecchi MR High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell 1980, 22:479-488.
206. Zabner J, Fasbender AJ, Moninger T, Poellinger KA, Welsh MJ Cellular and molecular barriers to gene transfer by a cationic lipid. J Biol Chem 1995, 270:18997-19007.
207. Bohlen G, Raabe A, Dahm-Daphi J, Dikomey E, Schild SE, Dunst J, et al. Development of new microinjection system for adenoviral gene delivery (MAGD). ASCO Annual Meeting. J Clin Oncol 2009, 27:e22167. abstract no.
208. Chenuet S, Derouazi M, Hacker D, Wurm F DNA delivery by microinjection for the generation of recombinant mammalian cell lines. Methods Mol Biol 2009, 518:99-112.
209. Wells DJ Gene therapy progress and prospects: electroporation and other physical methods. Gene Ther 2004, 11:1363-1369.
210. Kim HJ, Greenleaf JF, Kinnick RR, Bronk JT, Bolander ME Ultrasound-mediated transfection of mammalian cells. Hum Gene Ther 1996, 7:1339-1346.
211. Mitragotri S, Blankschtein D, Langer R Transdermal drug delivery using low-frequency sonophoresis. Pharm Res 1996, 13:411-420.
212. Wyber JA, Andrews J, D'Emanuele A The use of sonication for the efficient delivery of plasmid DNA into cells. Pharm Res 1997, 14:750-756.
213. Huber PE, Jenne J, Debus J, Wannenmacher MF, Pfisterer P A comparison of shock wave and sinusoidal-focused ultrasound-induced localized transfection of HeLa cells. Ultrasound Med Biol 1999, 25:1451-1457.
214. Tata DB, Dunn F, Tindall DJ Selective clinical ultrasound signals mediate differential gene transfer and expression in two human prostate cancer cell lines: LnCap and PC-3. Biochem Biophys Res Commun 1997, 234:64-67.
215. Koch S, Pohl P, Cobet U, Rainov NG Ultrasound enhancement of liposome-mediated cell transfection is caused by cavitation effects. Ultrasound Med Biol 2000, 26:897-903.
216. Anwer K, Kao G, Proctor B, Anscombe I, Florack V, Earls R, et al. Ultrasound enhancement of cationic lipid-mediated gene transfer to primary tumors following systemic administration. Gene Ther 2000, 7:1833-1839.
217. Maresca G, Summaria V, Colagrande C, Manfredi R, Calliada F New prospects for ultrasound contrast agents. Eur J Radiol 1998, 27:S171-S178.
218. Lawrie A, Brisken AF, Francis SE, Cumberland DC, Crossman DC, Newman CM Microbubble-enhanced ultrasound for vascular gene delivery. Gene Ther 2000, 7:2023-2027.
219. Bao S, Thrall BD, Miller DL Transfection of a reporter plasmid into cultured cells by sonoporation in vitro. Ultrasound Med Biol 1997, 23:953-959.
220. Miller DL, Quddus J Lysis and sonoporation of epidermoid and phagocytic monolayer cells by diagnostic ultrasound activation of contrast agent gas bodies. Ultrasound Med Biol 2001, 27:1107-1113.
221. Greenleaf WJ, Bolander ME, Sarkar G, Goldring MB, Greenleaf JF Artificial cavitation nuclei significantly enhance acoustically induced cell transfection. Ultrasound Med Biol 1998, 24:587-595.
222. Miller MW Gene transfection and drug delivery. Ultrasound Med Biol 2000, 26:59-62.
223. Endoh M, Koibuchi N, Sato M, Morishita R, Kanzaki T, Murata Y, et al. Fetal gene transfer by intrauterine injection with microbubble-enhanced ultrasound. Mol Ther 2002, 5:501-508.
224. Unger EC, Hersh E, Vannan M, McCreery T Gene delivery using ultrasound contrast agents. Echocardiogr J 2001, 18:355-361.
225. Miller DL, Bao S, Gies R, Thrall BD Ultrasonic enhancement of gene transfection in murine melanoma tumors. Ultrasound Med Biol 1999, 25:1425-1430.
226. Huber PE, Pfisterer P In vitro and in vivo transfection of plasmid DNA in the dunning prostate tumor R3327-AT1 is enhanced by focused ultrasound. Gene Ther 2000, 7:1516-1525.
227. Miller DL, Song J Tumor growth reduction and DNA transfer by cavitation-enhanced high-intensity focused ultrasound in vivo. Ultrasound Med Biol 2003, 29:887-893.
228. Taniyama Y, Tachibana K, Hiraoka K, Aoki M, Yamamoto S, Matsumoto K, et al. Development of safe and efficient novel non-viral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle. Gene Ther 2002, 9:372-380.
229. Lu QL, Liang HD, Partridge T, Blomley MJ Microbubble ultrasound improves the efficiency of gene transduction in skeletal muscle in vivo with reduced tissue damage. Gene Ther 2003, 10:396-405.
230. Taniyama Y, Tachibana K, Hiraoka K, Namba T, Yamasaki K, Hashiya N, et al. Local delivery of plasmid DNA into rat carotid artery using ultrasound. Circulation 2002, 105:1233-1239.
231. Huber PE, Mann MJ, Melo LG, Ehsan A, Kong D, Zhang L, et al. Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery. Gene Ther 2003, 10:1600-1607.
232. Schratzberger P, Krainin JG, Schratzberger G, Silver M, Ma H, Kearney M, et al. Transcutaneous ultrasound augments naked DNA transfection of skeletal muscle. Mol Ther 2002, 6:576-583.
233. Danialou G, Comtois AS, Dudley RW, Nalbantoglu J, Gilbert R, Karpati G, et al. Ultrasound increases plasmid-mediated gene transfer to dystrophic muscles without collateral damage. Mol Ther 2002, 6:687-693.
234. Chen S, Shohet RV, Bekeredjian R, Frenkel P, Grayburn PA Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction. J Am Coll Cardiol 2003, 42:301-308.
235. Bekeredjian R, Chen S, Frenkel PA, Grayburn PA, Shohet RV Ultrasound-targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart. Circulation 2003, 108:1022-1026.
236. Pislaru SV, Pislaru C, Kinnick RR, Singh R, Gulati R, Greenleaf JF, et al. Optimization of ultrasound-mediated gene transfer: comparison of contrast agents and ultrasound modalities. Eur Heart J 2003, 24:1690-1698.
237. Thomas P, McCreery R, Sweitzer H, Unger EC DNA delivery to cells in culture using ultrasound. Methods in molecular biology, vol. 245: gene delivery to mammalian cells: vol. 1: non-viral gene transfer techniques 2004, 287-292. Humana Press, Totowa, New Jersey. W.C. Heiser (Ed.).
238. Yamashita Y, Shimada M, Tachibana K, Harimoto N, Tsujita E, Shirabe K, et al. In vivo gene transfer into muscle via electrosonoporation. Hum Gene Ther 2002, 13:2079-2084.
239. Kalia YN, Naik A, Garrison J, Guy RH Iontophoretic drug delivery. Adv Drug Deliv Rev 2004, 56:619-658.
240. Oh SY, Leung L, Bommannan D, Guy RH, Potts RO Effect of current, ionic strength and temperature on the electrical properties of skin. J Control Release 1993, 27:115-125.
241. Wirtz R Die ionentheraphie in der augenheilkunde. Klin Monatsbl Augenheilkd 1908, 46:543-579.
242. Bejjani RA, Andrieu C, Bloquel C, Berdugo M, BenEzra D, Behar-Cohen F Electrically assisted ocular gene therapy. Surv Ophthalmol 2007, 52:196-208.
243. Monteiro-Riviere NA, Inman AO, Riviere JE Identification of the pathway of iontophoretic drug delivery: light and ultra-structural studies using mercuric chloride in pigs. Pharm Res 1994, 11:251-256.
244. Cullander C What are the pathways of iontophoretic current flow through mammalian skin?. Adv Drug Deliv Rev 1992, 9:119-135.
245. Hirvonen J, Kalia YN, Guy RH Transdermal delivery of peptides by iontophoresis. Nat Biotechnol 1996, 14:1710-1713.
246. Yasukawa T, Ogura Y, Tabata Y, Kimura H, Wiedemann P, Honda Y Drug delivery systems for vitreoretinal diseases. Prog Retinal Eye Res 2004, 23:253-281.
247. Jinsong H, Kevin L, Winston WY, Kao S, Chia-Yang L Gene delivery to cornea. Brain Res Bull 2010, 81:256-261.
248. Bloquel C, Bourges JL, Touchard E, Berdugo M, BenEzra D, Behar-Cohen F Non-viral ocular gene therapy: potential ocular therapeutic avenues. Adv Drug Delivery Rev 2006, 58:1224-1242.
249. Asahara T, Shinomiya K, Naito T, Shiota H Induction of gene into the rabbit eye by iontophoresis: preliminary report. Jpn J Ophthalmol 2001, 45:31-39.
250. Berdugo M, Valamanesh F, Andrieu C, Klein C, Benezra D, Courtois Y, et al. Delivery of antisense oligonucleotide to the cornea by iontophoresis. Antisense Nucleic Acid Drug Dev 2003, 13:107-114.
251. Voigt M, de Kozak Y, Halhal M, Courtois Y, Behar-Cohen F Down-regulation of NOSII gene expression by iontophoresis of anti-sense oligonucleotide in endotoxin-induced uveitis. Biochem Biophys Res Commun 2002, 295:336-341.
252. Andrieu-Soler C, Casas M, Faussat AM, Gandolphe C, Doat M, Tempe D, et al. Stable transmission of targeted gene modification using single-stranded oligonucleotides with flanking LNAs. Nucleic Acids Res 2005, 33:3733-3742.
253. Hao J, Li SK, Liu CY, Kao WW Electrically assisted delivery of macromolecules into the corneal epithelium. Exp Eye Res 2009, 89:934-941.
254. Scherer F, Anton M, Schillinger U, Henke J, Bergemann C, Kruger A, et al. Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo. Gene Ther 2002, 9:102-109.
255. Huth S, Lausier J, Gersting S, Rudolph C, Welsch U, Rosenecker J Insights into the mechanisms of magnetofection using PEI-based magnetofections for gene transfer. J Gene Med 2004, 6:923-936.
256. Gupa PK, Hung CT Magnetically controlled targeted chemotherapy. Microspheres and regional cancer therapy 1993, 71-116. CRC Press, Boca Raton, FL. N. Willmott, J. Daly (Eds.).
257. Goodwin SC, Bittner CA, Peterson CL, Wong G Single-dose toxicity study of hepatic intra-arterial infusion of doxorubicin coupled to a novel magnetically targeted drug carrier. Toxicol Sci 2001, 60:177-183.
258. Krotz F, Sohn HY, Gloe T, Plank C, Pohl U Magnetofection potentiates gene delivery to cultured endothelial cells. J Vasc Res 2003, 40:425-434.
259. Krotz F, de Wit C, Sohn HY, Zahler S, Gloe T, Pohl U, Plank C Magnetofection-a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo. Mol Ther 2003, 7:700-710.
260. Plank C, Schillinger U, Scherer F, Bergemann C, Remy JS, Krotz F, et al. The magnetofection method: using magnetic force to enhance gene delivery. Biol Chem 2003, 384:737-747.
261. Gersting SW, Schillinger U, Lausier J, Nicklaus P, Rudolph C, Plank C, et al. Gene delivery to respiratory epithelial cells by magnetofection. J Gene Med 2004, 6:913-922.
262. Widder KJ, Morris RM, Poore G, Howard Jr., Senyei AE Tumor remission in Yoshida sarcoma-bearing rats by selective targeting of magnetic albumin microspheres containing doxorubicin. Proc Natl Acad Sci USA 1981, 78:579-581.
263. Widder KJ, Morris RM, Poore GA, Howard DP, Senyei AE Selective targeting of magnetic albumin microspheres containing low-dose doxorubicin: total remission in Yoshida sarcoma-bearing rats. Eur J Cancer Clin Oncol 1983, 19:135-139.
264. Johnson J, Kent T, Koda J, Peterson C, Rudge S, Tapolsky G The MTC technology: a platform technology for the site-specific delivery of pharmaceutical agents. Eur Cells Mater 2002, 3:12-15.
265. Plank C, Anton M, Rudolph C, Rosenecker J, Krotz F Enhancing and targeting nucleic acid delivery by magnetic force. Expert Opin Biol Ther 2003, 3:745-758.
266. Schillinger U, Brill T, Rudolph C, Huth S, Gersting S, Krotz F, et al. Advances in magnetofection-magnetically guided nucleic acid delivery. J Magn Magn Mater 2005, 293:501-508.
267. Tao W, Wilkinson J, Stanbridge EJ, Berns MW Direct gene transfer into human cultured cells facilitated by laser micropuncture of the cell membrane. Proc Natl Acad Sci USA 1987, 84:4180-4184.
268. Sagi S, Knoll T, Trojan L, Schaaf A, Alken P, Michel MS Gene delivery into prostate cancer cells by holmium laser application. Prostate Cancer Prostatic Dis 2003, 6:127-130.
269. Palumbo G, Caruso M, Crescenzi E, Tecce MF, Roberti G, Colasanti A Targeted gene transfer in eukaryotic cells by dye-assisted laser optoporation. J Photochem Photobiol B 1996, 36:41-46.
270. Zeira E, Manevitch A, Khatchatouriants A, Pappo O, Hyam E, Darash-Yahana M, et al. Femto-second infrared laser-an efficient and safe in vivo gene delivery system for prolonged expression. Mol Ther 2003, 8:342-350.
271. Kurata S, Tsukakoshi M, Kasuya T, Ikawa Y The laser method for efficient introduction of foreign DNA into cultured cells. Exp Cell Res 1986, 162:372-378.
272. Shirahata Y, Ohkohchi N, Itagak H, Satomi S New technique for gene transfection using laser irradiation. J Invest Med 2001, 49:184-190.
273. Tirlapur UK, Konig K Targeted transfection by femtosecond laser. Nature 2002, 418:290-291.
274. Terakawa M, Ogura M, Sato S, Wakisaka H, Ashida H, Uenoyama M, et al. Gene transfer into mammalian cells by use of a nanosecond pulsed laser induced stress wave. Opt Lett 2004, 29:1227-1229.
275. Bohlin L. An attempt of nanowire-aided impalefection of nerve cells. Project for FYS 241. Experimental Biophysics, Lund University, Sweden. Dated 20 May 2010; 2006.
276. Melechko AV, Desikan R, McKnight TE, Klein KL, Rack PD Synthesis of vertically aligned carbon nanofibres for interfacing with live systems. J Phys D: Appl Phys 2009, 42:1-28.
277. McKnight TE, Melechko AV, Hensley DK, Mann DGJ, Griffin GD, Simpson ML Tracking gene expression after DNA delivery using spatially indexed nanofiber arrays. Nano Lett 2004, 4:1213-1219.
278. Peckys DB, Melechko AV, Simpson ML, McKnight TE Immobilization and release strategies for DNA delivery using carbon nanofibers arrays and self-assembled monolayers. Nanotechnol 2009, 20:1-8.
279. Mann DGJ, McKnight TE, McPherson JT, Hoyt PR, Melechko AV, Simpson ML, et al. Inducible RNA interference-mediated gene silencing using nanostructured gene delivery arrays. ACS Nano 2008, 2:69-76.