Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery

Journal of Virology

Volumn 70, Issue 9, 1996, Pages 6119-6125

  Pertmer, Tamera M ^a,c   Roberts, Timothy R ^a   Haynes, Joel R ^a,b  

^a Auragen Inc   (United States)

^b 8520 University Green   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; INFLUENZA VACCINE; INTERLEUKIN 4; NUCLEOPROTEIN; VIRUS DNA; VIRUS PROTEIN;

ARTICLE; CYTOTOXIC T LYMPHOCYTE; EXPRESSION VECTOR; GENE TARGETING; IMMUNIZATION; IMMUNOGLOBULIN PRODUCTION; INFLUENZA; INFLUENZA VIRUS; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0029813303     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.9.6119-6125.1996     Document Type: Article

References (40)

1. Bos, J. D., and M. L. Kapsenberg. 1993. The skin immune system: progress in cutaneous biology. Immunol. Today 14:75-78.
2. Conry, R., and G. Widera. Submitted for publication.
3. Conry, R. M., A. F. LoBuglio, M. Wright, L. Sumerel, M. J. Pike, F. Johanning, R. Benjamin, D. Lu, and D. T. Curiel. 1995. Characterization of a messenger RNA polynucleotide vaccine vector. Cancer Res. 55:1397-1400.
4. Cox, G. J. M., T. J. Zamb, and L. A. Babiuk. 1993. Bovine herpesvirus I: immune responses in mice and cattle injected with plasmid DNA. J. Virol. 67:5664-5667.
5. Davis, H. L., M.-L. Michel, M. Mancini, M. Schleef, and R. G. Whalen. 1994. Direct gene transfer in skeletal muscle: plasmid DNA-based immunization against the hepatitis B virus surface antigen. Vaccine 12:1503-1509.
6. Davis, H. L., M.-L. Michel, and R. G. Whalen. 1993. DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody. Hum. Mol. Genet. 2:1847-1851.
7. Donnelly, J. J., A. Friedman, D. Martinez, D. L. Montgomery, J. W. Shiver, S. L. Motzel, J. B. Ulmer, and M. A. Liu. 1995. Preclinical efficacy of a prototype DNA vaccine: enhanced protection against antigenic drift in influenza virus. Nat. Med. 1:583-587.
8. Eisenbraun, M. D., D. H. Fuller, and J. R. Haynes. 1993. Examination of parameters affecting the elicitation of humoral immune responses by particle bombardment-mediated genetic immunization. DNA Cell Biol. 12:791-797.
9. Finkelman, F. D., I. M. Katona, T. R. Mosmann, and R. L. Coffman. 1988. IFN-γ regulates the isotypes of Ig secreted during in vivo humoral immune responses. J. Immunol. 140:1022-1027.
10. Fuller, D. H., and J. R. Haynes. 1994. A qualitative progression in HIV-1 gp120-specific cytotoxic cellular and humoral immune responses in mice receiving a DNA-based gp120 vaccine. AIDS Res. Hum. Retroviruses 10: 1433-1441.
11. Fynan, E. F., R. G. Webster, D. H. Fuller, J. R. Haynes, J. C. Santoro, and H. L. Robinson. 1993. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc. Natl. Acad. Sci. USA 90: 11478-11482.
12. Lyon, J., M. Sheehy, and J. Haynes. Unpublished data.
13. Mamula, M. J., and C. J. Janeway. 1993. Do B cells drive the diversification of immune responses? Immunol. Today 14:151-152.
14. Martins, L. P., L. L. Lau, M. S. Asano, and R. Ahmed. 1995. DNA vaccination against persistent viral infection. J. Virol. 69:2574-2582.
15. McCabe, D. 1995. PCT patent application. WO 95/19799, 27 July.
16. Michel, M.-L., H. L. Davis, M. Schleef, M. Mancini, P. Tiollais, and R. G. Whalen. 1995. DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infections in human. Proc. Natl. Acad. Sci. USA 92:5307-5311.
17. Mor, G., D. M. Klinman, S. Shapiro, E. Hagiwara, M. Sedegah, J. A. Norman, S. L. Hoffman, and A. D. Steinberg. 1995. Complexity of the cytokine and antibody response elicited by immunizing mice with Plasmodium yoelii circumsporozoite protein plasmid DNA. J. Immunol. 155:2039-2046.
18. Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145-173.
19. Pertmer, T. M., M. D. Eisenbraun, D. McCabe, S. K. Prayaga, D. H. Fuller, and J. R. Haynes. 1995. Gene gun-based nucleic acid immunization: elicitation of humoral and cytotoxic T-lymphocyte responses following epidermal delivery of nanogram quantities of DNA. Vaccine 13:1427-1430.
20. Pertmer, T. M., M. J. Ford, and J. R. Haynes. Unpublished data.
21. Prayaga, S., and J. Haynes. Unpublished data.
22. Raz, E., D. A. Carson, S. E. Parker, T. B. Parr, A. M. Abai, G. Aichinger, S. H. Gromkowski, M. Singh, D. Lew, M. A. Yankauckas, S. M. Baird, and G. H. Rhodes. 1994. Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. Natl. Acad. Sci. USA 91:9519-9523.
23. Roberts, T., and J. Haynes. Unpublished data.
24. Robinson, H. L., L. A. Hunt, and R. G. Webster. 1993. Protection against a lethal influenza virus challenge by immunization with a haemagglutininexpressing plasmid DNA. Vaccine 11:957-960.
25. Ron, Y., and J. Sprent. 1987. T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes. J. Immunol. 138:2848-2856.
26. Rotzschke, O., K. Falk, K. Deres, H. Schild, M. Norda, J. Metzger, G. Jung, and H.-G. Rammensee. 1990. Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells. Nature (London) 348:252-254.
27. Sedegah, M., R. Hedstrom, P. Hobart, and S. L. Hoffman. 1994. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc. Natl. Acad. Sci. USA 91:9866-9870.
28. Snapper, C. M., and W. E. Paul. 1987. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236:944-947.
29. Stingl, G. 1990. Dendritic cells of the skin. Dermatol. Clin. 8:673-679.
30. Stingl, G., E. Tschachler, V. Groh, K. Wolff, and C. Hauser. 1989. Theimmune functions of epidermal cells. Immunol. Ser. 4:3-72.
31. Tang, D. C., M. J. Devit, and S. A. Johnston. 1992. Genetic immunization is a simple method for eliciting an immune response. Nature (London) 356: 152-154.
32. Ulmer, J. B., J. J. Donnelly, S. E. Parker, G. H. Rhodes, P. L. Felgner, V. J. Dwarki, S. H. Gromkowski, R. R. Deck, C. M. Dewitt, A. Friedman, L. A. Hawe, K. R. Leander, D. Martinez, H. C. Perry, J. W. Shiver, D. L. Montgomery, and M. A. Lui. 1993. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259:1745-1749.
33. Wang, B., K. E. Ugen, V. Srikantan, M. G. Agadjanyan, K. Dang, Y. Refaeli, A. Sato, J. Boyer, W. V. Williams, and D. B. Weiner. 1993. Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 90:4156-4160.
34. Watanabe, A., E. Raz, H. Kohsaka, H. Tighe, S. M. Baird, T. J. Kipps, and D. A. Carson. 1993. Induction of antibodies to a k V region by gene immunization. J. Immunol. 151:2871-2876.
35. Wells, D. J. 1993. Improved gene transfer by direct plasmid injection associated with regeneration in mouse skeletal muscle. FEBS Lett. 332:179-182.
36. Wolff, J. A., R. W. Malone, P. Williams, W. Chong, G. Acsadi, A. Jani, and P. L. Felgner. 1990. Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468.
37. Xiang, Z., and H. C. J. Ertl. 1995. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 2:129-135.
38. Xu, D., and F. Y. Liew. 1995. Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63, of L. major. Immunology 84:173-176.
39. Yokoyama, M., J. Zhang, and J. L. Whitton. 1995. DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection. J. Virol. 69:2684-2688.
40. Zarozinski, C. C., E. F. Fynan, L. K. Selin, H. L. Robinson, and R. M. Welsh. 1995. Protective CTL-dependent immunity and enhanced immunopathology in mice immunized by particle bombardment with DNA encoding an internal virion protein. J. Immunol. 154:4010-4017.