Vaccination with HIV-1 gp120 DNA induces immune responses that are boosted by a recombinant gp120 protein subunit

Vaccine

Volumn 15, Issue 8, 1997, Pages 869-873

  Barnett, Susan W ^b   Rajasekar, Sabita ^b   Legg, Harold ^b   Doe, Barbara ^b   Fuller, Deborah H ^a   Haynes, Joel R ^a   Walker, Christopher M ^b   Steimer, Kathelyn S ^b  

^a 8520 University Green   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

DNA vaccine; Env gp120; HIV

Indexed keywords

DNA VACCINE; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; PLASMID DNA; PROTEIN SUBUNIT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY TITER; CHO CELL; CONFERENCE PAPER; CYTOTOXIC T LYMPHOCYTE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOMODULATION; INTRAMUSCULAR DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; VIRUS ENVELOPE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADJUVANTS, IMMUNOLOGIC; AIDS VACCINES; ANIMALS; BIOLISTICS; DNA, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GUINEA PIGS; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; INJECTIONS, INTRAMUSCULAR; MICE; MICE, INBRED BALB C; PLASMIDS; POLYSORBATES; SQUALENE; SURFACE-ACTIVE AGENTS; T-LYMPHOCYTES, CYTOTOXIC; VACCINATION; VACCINES, DNA; VACCINES, SYNTHETIC;

EID: 0030872511     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(96)00264-2     Document Type: Conference Paper

References (10)

1. Koup, R.A., Safrit, J.T., Cao, Y., Andrews, C.A., McLeod, G., Borkowski, W., Farthing, C. and Ho, D.D. Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 1994, 68, 4650-4655
2. SF2. AIDS 1995, 9, 1313-1322
3. Chapman, B.S., Thayer, R.M., Vincent, K.A. and Haigwood, N.L. Effect of intron A from human cytomegalovirus (Towne) immediate-early gene on heterologous expression in mammalian cells. Nucleic Acids Res. 1991, 19, 3979-3986
4. Haigwood, N.L., Nara, P.L., Brooks, E., Van Nest, G.A., Ott, G., Higgins, K.W., Dunlop, N., Scandella, C.J., Eichberg, J.W. and Steimer, K.S. Native but not denatured recombinant HIV-1 gp120 generates broad spectrum neutralizing antibodies in baboons. J. Virol. 1992, 66, 172-182
5. Davis, H.L., Whalen, R.G. and Demeneix, B.A. Direct gene transfer into skeletal muscle in vivo: Factors affecting efficiency of transfer and stability of expression. Human Gene Therapy 1993, 4, 151-159
6. Fuller, D.H. and Haynes, J.R. A qualitative progression in HIV type 1 glycoprotein 120-specific cytotoxic cellular and humoral immune responses in mice receiving a DNA-based glycoprotein 120 vaccine. AIDS Res. Hum. Retroviruses 1994, 11, 1433-1441
7. Van Nest, G.A., Steimer, K.S., Haigwood, N.L., Burke, R.L. and Ott, G. Advanced adjuvant formulations for use with recombinant subunit vaccines. In Vaccines 92, Modem Approaches to New Vaccines. Ed. by Brown, F., Chanock, R., Ginsberg, H.S., Lerner, R. Cold Spring Harbor Laboratory Press, 1992, pp. 57-62.
8. Steimer, K.S., Scandella, C.J., Skiles, P.V. and Haigwood, N.L. Neutralization of divergent HIV-1 isolates by conformation-dependent human antibodies to gp120. Science 1991, 254, 105-108
9. Doe, B., Steimer, K.S. and Walker, C.M. Induction of HIV-1 envelope (gp120)-specific cytoxic T lymphocyte responses in mice by recombinant CHO cell-derived gp120 is enhanced by enzymatic removal of N-linked glycans. Eur. J. Immunol. 1994, 24, 2369-2376
10. Cohen, J. Vaccine drought spurs NIAID Plan to improve industry ties. News and Comments. Science 1996, 271, 1227-1228