Unique homologous siRNA blocks hypoxia-induced VEGF upregulation in human corneal cells and inhibits and regresses murine corneal neovascularization

Cornea

Volumn 26, Issue 1, 2007, Pages 65-72

  Singh, Nirbhai ^a   Higgins, Eric ^a   Amin, Shivan ^a   Jani, Pooja ^a   Richter, Elizabeth ^a   Patel, Anup ^a   Kaur, Rajwinder ^a   Wang, Jin ^a   Ambati, Jayakrishna ^b   Dong, Zheng ^a   Ambati, Balamurali K ^a,c,d  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d BA 2723 ^*  (United States)

Author keywords

Angiogenesis; Inhibition; Neovascularization; RNA interference; siRNA; Vascular endothelial growth factor

Indexed keywords

MESSENGER RNA; PLASMID VECTOR; SMALL INTERFERING RNA; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAUSTIC BURN; CELL HYPOXIA; CONTROLLED STUDY; CORNEA BURN; CORNEA CELL; CORNEA EPITHELIUM; CORNEA NEOVASCULARIZATION; DRUG INHIBITION; LEUKOCYTE COUNT; LYMPHOCYTIC INFILTRATION; MESSENGER RNA SYNTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; REMISSION; RNA INTERFERENCE; SEQUENCE HOMOLOGY; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE; UPREGULATION;

ANIMALS; ANOXIA; CELL CULTURE TECHNIQUES; CORNEAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIUM, CORNEAL; GENE SILENCING; GENE TARGETING; HUMANS; LEUKOCYTE COUNT; LUMINESCENT PROTEINS; MICE; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33845968846     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/ICO.0b013e31802b4201     Document Type: Article

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