Hydrodynamics-based procedure involves transient hyperpermeability in the hepatic cellular membrane: Implication of a nonspecific process in efficient intracellular gene delivery

Journal of Gene Medicine

Volumn 6, Issue 5, 2004, Pages 584-592

  Kobayashi, Naoki ^a   Nishikawa, Makiya ^a   Hirata, Kazuhiro ^a   Takakura, Yoshinobu ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Gene delivery; Hydrodynamics based procedure; Membrane permeability; Plasmid DNA

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GREEN FLUORESCENT PROTEIN; LUCIFERASE; NAKED DNA; PLASMID DNA; PLASMID VECTOR; PROPIDIUM IODIDE; SODIUM CHLORIDE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL ISOLATION; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE TRANSPORT; CELL VIABILITY; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; FEMALE; GENE EXPRESSION; GENE TRANSFER; HYDRODYNAMICS; LIVER CELL CULTURE; LIVER CELL MEMBRANE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; TRANSGENE;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; COLORING AGENTS; DNA; FEMALE; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HEPATOCYTES; LIVER; LUCIFERASES; MICE; MICROSCOPY, CONFOCAL; PERMEABILITY; PLASMIDS; PROPIDIUM; RNA; TRANSAMINASES;

EID: 1642555021     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.541     Document Type: Article

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