Optimization of regional intraarterial naked DNA-mediated transgene delivery to skeletal muscles in a large animal model

Molecular Therapy

Volumn 11, Issue 2, 2005, Pages 257-266

  Danialou, Gawiyou ^a   Comtois, Alain S ^b   Matecki, Stefan ^a   Nalbantoglu, Josephine ^c   Karpati, George ^c   Gilbert, Renald ^d   Geoffroy, Pascale ^e   Gilligan, Sandra ^e   Tanguay, Jean Francois ^e   Petrof, Basil J ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^e MONTREAL HEART INSTITUTE   (Canada)

Author keywords

Dystrophin; Intraarterial injection; Intravascular administration; Muscular dystrophy; Nonviral vector; Pig muscles; Plasmid DNA; Systemic delivery

Indexed keywords

BETA GALACTOSIDASE; DNA; NAKED DNA; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY SIZE; CLINICAL PROTOCOL; CONTROLLED STUDY; CORRELATION ANALYSIS; EDEMA; FEMORAL ARTERY; GASTROCNEMIUS MUSCLE; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; GENETIC TRANSFECTION; HINDLIMB; HYPOTHESIS; INJECTION; MONITORING; MUSCLE CELL; MUSCLE INJURY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRESSURE MEASUREMENT; PROCESS OPTIMIZATION; RAT; SKELETAL MUSCLE; STATISTICAL SIGNIFICANCE; SWINE; TISSUE PRESSURE; TISSUE TYPES; TRANSGENE;

ANIMALS; DNA; INJECTIONS, INTRAVENOUS; MALE; MODELS, ANIMAL; MUSCLE, SKELETAL; PRESSURE; RATS; SWINE; TRANSGENES;

ANIMALIA; SUS SCROFA;

EID: 19944431815     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.09.016     Document Type: Article

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