Characterization of plasmid DNA transfer into mouse skeletal muscle: Evaluation of uptake mechanism, expression and secretion of gene products into blood

Gene Therapy

Volumn 3, Issue 3, 1996, Pages 201-211

  Levy, M Y ^a   Barron, L G ^a   Meyer, K B ^a   Szoka Jr , F C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

1 antitrypsin; Gene transfer; Injection technique; Skeletal muscle; Systemic delivery; Uptake mechanism

Indexed keywords

ALPHA 1 ANTITRYPSIN; ANTIBODY; COMPLEMENTARY DNA; DEXTRAN SULFATE; DNA; GENE PRODUCT; LUCIFERASE; MESSENGER RNA; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; GENE TRANSFER; IMMUNOHISTOCHEMISTRY; INTRAMUSCULAR DRUG ADMINISTRATION; ISOTOPE LABELING; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; SOUTHERN BLOTTING; TISSUE DISTRIBUTION;

ADENOSINE TRIPHOSPHATE; ALPHA 1-ANTITRYPSIN; ANIMALS; ANTIBODIES; AURINTRICARBOXYLIC ACID; BLOTTING, SOUTHERN; DEXTRAN SULFATE; DNA, RECOMBINANT; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNOHISTOCHEMISTRY; IODINE RADIOISOTOPES; LUCIFERASES; MICE; MICE, INBRED ICR; MUSCLE, SKELETAL; PLASMIDS; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; TISSUE DISTRIBUTION;

EID: 0029875289     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Quantin B et al. Adenovirus as an expression vector in muscle cells in vivo. Proc Natl Acad Sci USA 1992; 89: 2581-2584.
2. Stratford-Perricaudet LD et al. Widespread long-term gene transfer to mouse skeletal muscle and heart. J Clin Invest 1992; 90: 626-630.
3. Thomason DB, Booth FW. Stable incorporation of a bacterial gene into adult rat skeletal muscle in vivo. Am J Physiol 1990; 258: C578-C581.
4. Hughes SM, Blau HM. Muscle fiber pattern is independent of cell lineage in postnatal rodent development. Cell 1992; 68: 659-671.
5. Wolff JA et al. Direct gene transfer into mouse muscle in vivo. Science 1990; 247: 1465-1468.
6. Wolff JA et al. Conditions affecting direct gene transfer into rodent muscle in vivo. Biotechniques 1991; 11: 474-485.
7. Jiao S et al. Direct gene transfer into nonhuman primate myofibers in vivo. Hum Gene Ther 1992; 3: 21-33.
8. Wolff JA et al. Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum Mol Genet 1992; 1: 363-369.
9. Wells DJ, Goldspink G. Age and sex influence expression of plasmid DNA directly injected into mouse skeletal muscle. FEBS Lett 1992; 306: 203-205.
10. Davis HL, Whalen RG, Demenix BA. Direct gene transfer into skeletal muscle in vivo: factors affecting efficiency of transfer and stability of expression. Hum Gene Ther 1993; 4: 151-159.
11. Manthorpe M et al. Gene therapy by intramuscular injection of plasmid DNA: studies on firefly luciferase gene expression in mice. Hum Gene Ther 1993; 4: 411-418.
12. Davis HL et al. Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle. Hum Gene Ther 1993; 4: 733-740.
13. Davis HL, Michel M-L, Whalen RG. DNA-based immunization for hepatitis B induces continuous secretion of antigen and high levels of circulating antibody. Hum Mol Genet 1993; 2: 1847-1851.
14. Ulmer JB et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993; 259: 1745-1749.
15. Davis HL et al. Direct gene transfer in skeletal muscle: plasmid DNA-based immunization against the hepatitis B virus surface antigen. Vaccine 1994; 12: 1503-1509.
16. Katsumi A et al. Humoral and cellular immunity to an encoded protein induced by direct DNA injection. Hum Gene Ther 1994; 5: 1335-1339.
17. Barr E, Leiden JM. Systemic delivery of recombinant proteins by genetically modified myoblasts. Science 1991; 254: 1507-1509.
18. Dhawan J et al. Systemic delivery of human growth hormone by injection of genetically engineered myoblasts. Science 1991; 254: 1509-1512.
19. Yao S-N, Kurachi K. Expression of human factor IX in mice after injection of genetically modified myoblasts. Proc Natl Acad Sci USA 1992; 89: 3357-3361.
20. Yao S-N, Smith KJ, Kurachi K. Primary myoblast-mediated gene transfer: persistent expression of human factor IX in mice. Gene Therapy 1994; 1: 99-107.
21. Hamamori Y, Samal B, Tian J, Kedes L. Persistent erythropoiesis by myoblast transfer of erythropoietin cDNA. Hum Gene Ther 1994; 5: 1349-1356.
22. Wolff JA et al. Expression of naked plasmids by cultured myotubes and entry of plasmids into T tubules and caveolae of mammalian skeletal muscle. J Cell Sci 1992; 103: 1249-1259.
23. Dowty ME, Wolff JA. Possible mechanisms of DNA uptake in skeletal muscle. In: Wolff JA (ed). Gene Therapeutics: Methods and Applications of Direct Gene Transfer. Birkhauser: Boston, 1994, pp 82-98.
24. Karpati G, Acsadi G. The potential for gene therapy in Duchenne muscular dystrophy and other genetic muscular diseases. Muscle Nerve 1993; 16: 1141-1153.
25. Wang B et al. Gene inoculation generates immune responses against human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1993; 90: 4156-4160.
26. Danko I et al. Pharmacological enhancement of in vivo foreign gene expression in muscle. Gene Therapy 1994; 1: 114-121.
27. Hallick RB, Chelm BK, Gray PW, Orozco EM Jr. Use of aurintricarboxylic acid as an inhibitor of nucleases during nucleic acid isolation. Nucleic Acids Res 1977; 4: 3055-3064.
28. Regoeczi E. Iodine-Labeled Plasma Proteins, vol 2. CRC Press: Boca Raton, 1987, p 56.
29. Herweijer H, Fritz JD, Hagstrom JE, Wolff JA. Direct gene transfer in vivo. In: Chang PL (ed). Somatic Gene Therapy. CRC Press: Boca Raton, 1995, pp 183-202.
30. Sikes ML et al. In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection. Hum Gene Ther 1994; 5: 837-844.
31. Hickman MA et al. Gene expression following direct injection of DNA into liver. Hum Gene Ther 1994; 5: 1477-1483.
32. Meyer KB et al. Intratracheal gene delivery to the mouse airway: characterization of plasmid DNA expression and Pharmacokinetics. Gene Therapy 1995; 2: 450-160.
33. Peters R. Fluorescence microphotolysis to measure nucleocytoplasmic transport and intracellular mobility. Biochim Biophys Acta 1986; 864: 305-359.
34. Luby-Phelps K et al. Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells. Proc Natl Acad Sci USA 1987; 84: 4910-4913.
35. Casolaro MA et al. Augmentation of lung antineutrophil elastase capacity with recombinant human α-1-antitrypsin. J Appl Physiol 1987; 63: 2015-2023.
36. Tang D-C, DeVit M, Johnston SA. Genetic immunization is a simple method for eliciting an immune response. Nature 1992; 356: 152-154.
37. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: a Laboratory Manual (2nd edn). Colid Spring Harbor Laboratory Press, Cold Spring Harbor, 1989, p 9.16.
38. Ausubel FM et al. Current Protocols in Molecular Biology. Current Protocols, 1987, p 22.1.
39. Michalski JP et al. A modified double antibody sandwich enzyme-linked immunosorbent assay for measurment of alpha-1-antitrypsin in biologic fluid. J Immun Met 1985; 83: 101-112.