Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo

Journal of Controlled Release

Volumn 142, Issue 3, 2010, Pages 392-403

  Cardoso, A L C ^a,b   Costa, P ^a,b   de Almeida, L P ^a,c   Simoes S ^a,c   Plesnila, N ^d   Culmsee, C ^e   Wagner, E ^e   Pedroso de Lima, M C ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

Author keywords

c Jun; Excitotoxicity; Kainate; Neuroprotection; siRNA; Tf lipoplexes

Indexed keywords

BRAIN INJURY; CATIONIC LIPOSOMES; CYTOKINE PRODUCTION; EXCITOTOXICITY; GLUCOSE DEPRIVATION; IN-VIVO; INDUCED DAMAGE; KAINIC ACID; LIPOPLEXES; NEURODEGENERATIVE DISORDERS; NEURONAL CELL; NEURONAL DEATH; NEURONAL SURVIVAL; NEUROPROTECTION; NONVIRAL VECTORS; NUCLEAR TRANSLOCATIONS; RNA INTERFERENCE; SEIZURE ACTIVITY; THERAPEUTIC TARGETS; UP-REGULATION;

AMINO ACIDS; ANIMALS; CELL DEATH; GLUCOSE; LIPOSOMES; OXYGEN; PHOSPHOLIPIDS; RNA; TRANSCRIPTION; TRANSCRIPTION FACTORS;

CELL CULTURE;

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; CHOLESTEROL; GLUCOSE; GLUTAMIC ACID; INTERLEUKIN 1BETA; INTERLEUKIN 6; KAINIC ACID; LIPOPLEX; LIPOSOME; MESSENGER RNA; OXYGEN; PROTEIN C JUN; SMALL INTERFERING RNA; TRANSFERRIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN INJURY; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG FORMULATION; DRUG TARGETING; EXCITOTOXICITY; GENE SILENCING; GENE TRANSLOCATION; HIPPOCAMPUS; IN VIVO STUDY; MOUSE; NERVE CELL; NERVE CELL CULTURE; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; RNA INTERFERENCE; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CELLS, CULTURED; CHOLESTEROL; DRUG CARRIERS; DRUG COMPOUNDING; FATTY ACIDS, MONOUNSATURATED; GENE SILENCING; GLUTAMIC ACID; HUMANS; IMMUNOHISTOCHEMISTRY; KAINIC ACID; LIPOSOMES; MICE; MICE, INBRED C57BL; NEURONS; NEUROPROTECTIVE AGENTS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-JUN; QUATERNARY AMMONIUM COMPOUNDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SEIZURES; TRANSFERRIN;

EID: 77349098528     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.11.004     Document Type: Article

References (34)

1. Liou A.K., Clark R.S., Henshall D.C., Yin X.M., and Chen J. To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways. Progress In Neurobiology 69 (2003) 103-142
2. Choi D.W., and Rothman S.M. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annual Review Of Neuroscience 13 (1990) 171-182
3. Nicotera P., Ankarcrona M., Bonfoco E., Orrenius S., and Lipton S.A. Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress. Advances In Neurology 72 (1997) 95-101
4. Mehta S.L., Manhas N., and Raghubir R. Molecular targets in cerebral ischemia for developing novel therapeutics. Brain Research Reviews 54 (2007) 34-66
5. Hossain M.A. Molecular mediators of hypoxic-ischemic injury and implications for epilepsy in the developing brain. Epilepsy & Behavior 7 (2005) 204-213
6. Sugino T., Nozaki K., and Hashimoto N. Activation of mitogen-activated protein kinases in gerbil hippocampus with ischemic tolerance induced by 3-nitropropionic acid. Neuroscience Letters 278 (2000) 101-104
7. Han B.H., and Holtzman D.M. BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. Journal of Neuroscience 20 (2000) 5775-5781
8. Harada J., and Sugimoto M. An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neurons. Japanese Journal of Pharmacology 79 (1999) 369-378
9. Xia Z., Dickens M., Raingeaud J., Davis R.J., and Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science (New York, N.Y.) 270 (1995) 1326-1331
10. Brecht S., Kirchhof R., Chromik A., Willesen M., Nicolaus T., Raivich G., Wessig J., Waetzig V., Goetz M., Claussen M., Pearse D., Kuan C.Y., Vaudano E., Behrens A., Wagner E., Flavell R.A., Davis R.J., and Herdegen T. Specific pathophysiological functions of JNK isoforms in the brain. The European Journal Of Neuroscience 21 (2005) 363-377
11. Yang D.D., Kuan C.Y., Whitmarsh A.J., Rincon M., Zheng T.S., Davis R.J., Rakic P., and Flavell R.A. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389 (1997) 865-870
12. Borsello T., Clarke P.G., Hirt L., Vercelli A., Repici M., Schorderet D.F., Bogousslavsky J., and Bonny C. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nature Medicine 9 (2003) 1180-1186
13. Ameyar M., Wisniewska M., and Weitzman J.B. A role for AP-1 in apoptosis: the case for and against. Biochimie 85 (2003) 747-752
14. Whitfield J., Neame S.J., Paquet L., Bernard O., and Ham J. Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 29 (2001) 629-643
15. Cardoso A.L., Simoes S., de Almeida L.P., Pelisek J., Culmsee C., Wagner E., and Pedroso de Lima M.C. siRNA delivery by a transferrin-associated lipid-based vector: a non-viral strategy to mediate gene silencing. The Journal Of Gene Medicine 9 (2007) 170-183
16. Cardoso A.L., Simoes S., de Almeida L.P., Plesnila N., Pedroso de Lima M.C., Wagner E., and Culmsee C. Tf-lipoplexes for neuronal siRNA delivery: a promising system to mediate gene silencing in the CNS. Journal Of Controlled Release 132 (2008) 113-123
17. Campbell M.J. Lipofection reagents prepared by a simple ethanol injection technique. BioTechniques 18 (1995) 1027-1032
18. Culmsee C., Zhu C., Landshamer S., Becattini B., Wagner E., Pellecchia M., Blomgren K., and Plesnila N. Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. Journal Of Neuroscience 25 (2005) 10262-10272
19. Paxinos G.F., and K.B.J. The Mouse Brain in Stereotaxic Coordinates. second edition ed (2004), Elsevier Academic Press, San Diego
20. Racine R., Okujava V., and Chipashvili S. Modification of seizure activity by electrical stimulation. 3. Mechanisms. Electroencephalography and Clinical Neurophysiology 32 (1972) 295-299
21. Lee H.K., Choi S.S., Han E.J., Lee J.Y., Kwon M.S., Shim E.J., Seo Y.J., and Suh H.W. Role of nicotinic acetylcholine receptors in the regulation of kainic acid-induced hippocampal cell death in mice. Brain Research Bulletin 64 (2004) 309-317
22. Shim E.J., Seo Y.J., Kwon M.S., Ham Y.O., Choi O.S., Lee J.Y., Choi S.M., and Suh H.W. The intracerebroventricular kainic acid-induced damage affects animal nociceptive behavior. Brain Research Bulletin 73 (2007) 203-209
23. Miller V.M., Xia H., Marrs G.L., Gouvion C.M., Lee G., Davidson B.L., and Paulson H.L. Allele-specific silencing of dominant disease genes. Proceedings of the National Academy of Sciences of the United States of America 100 (2003) 7195-7200
24. Fountaine T.M., and Wade-Martins R. RNA interference-mediated knockdown of alpha-synuclein protects human dopaminergic neuroblastoma cells from MPP(+) toxicity and reduces dopamine transport. Journal of Neuroscience Research 85 (2007) 351-363
25. Gonzalez-Alegre P., Bode N., Davidson B.L., and Paulson H.L. Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia. Journal of Neuroscience 25 (2005) 10502-10509
26. Harper S.Q., Staber P.D., He X., Eliason S.L., Martins I.H., Mao Q., Yang L., Kotin R.M., Paulson H.L., and Davidson B.L. RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proceedings of the National Academy of Sciences of the United States of America 102 (2005) 5820-5825
27. Miller V.M., Gouvion C.M., Davidson B.L., and Paulson H.L. Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles. Nucleic Acids Research 32 (2004) 661-668
28. Gao Y., Signore A.P., Yin W., Cao G., Yin X.M., Sun F., Luo Y., Graham S.H., and Chen J. Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway. Journal of Cerebral Blood Flow and Metabolism 25 (2005) 694-712
29. Sng J.C., Taniura H., and Yoneda Y. A tale of early response genes. Biological & Pharmaceutical Bulletin 27 (2004) 606-612
30. Waetzig V., Czeloth K., Hidding U., Mielke K., Kanzow M., Brecht S., Goetz M., Lucius R., Herdegen T., and Hanisch U.K. c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia. Glia 50 (2005) 235-246
31. Bozyczko-Coyne D., O'Kane T.M., Wu Z.L., Dobrzanski P., Murthy S., Vaught J.L., and Scott R.W. CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis. Journal of Neurochemistry 77 (2001) 849-863
32. Maroney A.C., Glicksman M.A., Basma A.N., Walton K.M., Knight Jr. E., Murphy C.A., Bartlett B.A., Finn J.P., Angeles T., Matsuda Y., Neff N.T., and Dionne C.A. Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway. Journal of Neuroscience 18 (1998) 104-111
33. Hasegawa S., Yamaguchi M., Nagao H., Mishina M., and Mori K. Enhanced cell-to-cell contacts between activated microglia and pyramidal cell dendrites following kainic acid-induced neurotoxicity in the hippocampus. Journal of Neuroimmunology 186 (2007) 75-85
34. Owens T., Wekerle H., and Antel J. Genetic models for CNS inflammation. Nature Medicine 7 (2001) 161-166