Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation

Molecular Pharmaceutics

Volumn 3, Issue 3, 2006, Pages 340-350

  Ahmed, Fariyal ^a   Pakunlu, Refika I ^c   Srinivas, Goundla ^b   Brannan, Aaron ^d   Bates, Frank ^d   Klein, Michael L ^b   Minko, Tamara ^c   Discher, Dennis E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Cancer chemotherapy; Drug delivery; PEG PLA; Polymer vesicles

Indexed keywords

COPOLYMER; CYTOTOXIC AGENT; DOXORUBICIN; MACROGOL; PACLITAXEL; POLYCAPROLACTONE; POLYLACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG POTENTIATION; DRUG RELEASE; DRUG RETENTION; DRUG STABILITY; DRUG UPTAKE; HUMAN; HUMAN CELL; IN VIVO STUDY; LIPID MEMBRANE; LYSOSOME; MAXIMUM TOLERATED DOSE; MEMBRANE VESICLE; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; TUMOR GROWTH;

ANIMALS; BREAST NEOPLASMS; COMPUTER SIMULATION; DOXORUBICIN; DRUG DELIVERY SYSTEMS; HUMANS; HYDROGEN-ION CONCENTRATION; IN SITU HYBRIDIZATION, FLUORESCENCE; LYSOSOMES; MEMBRANE FUSION; MICE; MICE, NUDE; MICELLES; PACLITAXEL; POLYETHYLENE GLYCOLS; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 33745770615     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp050103u     Document Type: Article

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