Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain

Journal of Controlled Release

Volumn 142, Issue 3, 2010, Pages 422-430

  Kim, Il Doo ^a   Lim, Chae Moon ^a   Kim, Jung Bin ^a   Nam, Hye Yeong ^b   Nam, Kihoon ^b   Kim, Seung Woo ^a   Park, Jong Sang ^b   Lee, Ja Kyeong ^a  

^a Inha University School of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Brain ischemia; e PAM R; MCAO; PAMAM dendrimer; Primary cortical culture; siRNA transfection

Indexed keywords

BRAIN ISCHEMIA; CYTOKINES; GENE CARRIER; GENE FUNCTION; GENE KNOCK DOWN; GENE SILENCING; HIGH-MOBILITY GROUPS; MIDDLE CEREBRAL ARTERY; NEURONAL CELL; NEUROPROTECTION; NONVIRAL; PAMAM DENDRIMER; PHYSIOLOGICAL CONDITION; RAT BRAIN; RNA INTERFERENCE; SIRNA DELIVERY; TARGET GENES; THERAPEUTIC APPLICATION; TRANSFECTION EFFICIENCY;

AMINO ACIDS; ASSOCIATIVE STORAGE; BRAIN; CELL CULTURE; CELL DEATH; DENDRIMERS; ESTERIFICATION; ESTERS; GENE EXPRESSION; GENE TRANSFER; NEURONS; NUCLEIC ACIDS; PNEUMATIC DRIVES; PULSE AMPLITUDE MODULATION; STRATEGIC PLANNING; SULFUR COMPOUNDS;

RNA;

DENDRIMER; HIGH MOBILITY GROUP B1 PROTEIN; HYDROGEN PEROXIDE; N METHYL DEXTRO ASPARTIC ACID; POLYAMIDOAMINE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BIODEGRADABILITY; BRAIN CORTEX; BRAIN INFARCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG MECHANISM; FETUS; FLUORESCENCE ANALYSIS; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC TRANSFECTION; KNOCKOUT GENE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT; RNA INTERFERENCE; TISSUE CULTURE; TISSUE DISTRIBUTION; TISSUE LEVEL;

ANIMALS; ASTROCYTES; BIOCOMPATIBLE MATERIALS; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DENDRIMERS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENE SILENCING; HMGB1 PROTEIN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; NEURONS; NEUROPROTECTIVE AGENTS; NYLONS; POLYESTERS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 77349107167     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.11.011     Document Type: Article

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