Activation of NF-ΚB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: Therapeutic implications

Oncogene

Volumn 21, Issue 37, 2002, Pages 5673-5683

  Mitsiades, Constantine S ^a   Mitsiades, Nicholas ^a   Poulaki, Vassiliki ^a   Schlossman, Robert ^a   Akiyama, Masaharu ^a   Chauhan, Dharminder ^a   Hideshima, Teru ^a   Treon, Steven P ^a   Munshi, Nikhil C ^a   Richardson, Paul G ^a   Anderson, Kenneth C ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Apo2L; IAPs; IGF 1; Multiple myeloma; NF B; TRAIL

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; APOPTOSIS INHIBITOR; BFL1 PROTEIN; CIAP PROTEIN; CYTOTOXIC AGENT; DEXAMETHASONE; DOXORUBICIN; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 HYDROXYMETHYLINOSITOL 2 O METHYL 3 O OCTADECYLCARBONATE; PROTEIN; PROTEIN KINASE B; SOMATOMEDIN C; SURVIVIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; AKT1 PROTEIN, HUMAN; APOPTOSIS REGULATORY PROTEIN; DNA BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXO1A PROTEIN, HUMAN; MEMBRANE PROTEIN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE; TNFSF10 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SENSITIVITY; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; UPREGULATION;

INTRACISTERNAL A-PARTICLES;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-6; MEMBRANE GLYCOPROTEINS; MULTIPLE MYELOMA; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0037158513     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1205664     Document Type: Article

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