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Volumn 35, Issue 1, 2011, Pages 52-60

NF-κB localization in multiple myeloma plasma cells and mesenchymal cells

Author keywords

Bortezomib; Mesenchymal cells; Multiple myeloma; NF B

Indexed keywords

ANTINEOPLASTIC AGENT; BORTEZOMIB; CISPLATIN; CYTARABINE; DAUNORUBICIN; DEXAMETHASONE; DOXORUBICIN; EPIRUBICIN; ETOPOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MELPHALAN; METHOTREXATE; MITOXANTRONE; PACLITAXEL; THALIDOMIDE; VINCRISTINE;

EID: 78650176111     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.06.023     Document Type: Article
Times cited : (15)

References (46)
  • 2
    • 0033121314 scopus 로고    scopus 로고
    • Role of NF-kappaB in the rescue of multiple myeloma cells from glucocorticoid-induced apoptosis by bcl-2
    • Feinman R., Koury J., Thames M., et al. Role of NF-kappaB in the rescue of multiple myeloma cells from glucocorticoid-induced apoptosis by bcl-2. Blood 1999, 93:3044-3052.
    • (1999) Blood , vol.93 , pp. 3044-3052
    • Feinman, R.1    Koury, J.2    Thames, M.3
  • 3
    • 33645312379 scopus 로고    scopus 로고
    • Circuitry of nuclear factor κB signaling
    • Hoffmann A., Baltimore D. Circuitry of nuclear factor κB signaling. Imm Rev 2006, 210:171-186.
    • (2006) Imm Rev , vol.210 , pp. 171-186
    • Hoffmann, A.1    Baltimore, D.2
  • 4
    • 73849095427 scopus 로고    scopus 로고
    • The nuclear signaling of NF-kappaB: current knowledge, new insights, and future perspectives
    • January
    • Wan F., Lenardo M.J. The nuclear signaling of NF-kappaB: current knowledge, new insights, and future perspectives. Cell Res 2010, 20(January (1)):24-33.
    • (2010) Cell Res , vol.20 , Issue.1 , pp. 24-33
    • Wan, F.1    Lenardo, M.J.2
  • 5
    • 1842425016 scopus 로고    scopus 로고
    • Nuclear factor-kappaB modulation as a therapeutic approach in hematologic malignancies
    • Panwalkar A., Verstovsek S., Giles F. Nuclear factor-kappaB modulation as a therapeutic approach in hematologic malignancies. Cancer 2004, 100:1578-1589.
    • (2004) Cancer , vol.100 , pp. 1578-1589
    • Panwalkar, A.1    Verstovsek, S.2    Giles, F.3
  • 6
    • 0036624741 scopus 로고    scopus 로고
    • Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications
    • Mitsiades N., Mitsiades C.S., Poulaki V., et al. Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications. Blood 2002, 99:4079-4086.
    • (2002) Blood , vol.99 , pp. 4079-4086
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 7
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
    • Senftleben U., Cao Y., Xiao G., et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 2001, 293(5534):1495-1499.
    • (2001) Science , vol.293 , Issue.5534 , pp. 1495-1499
    • Senftleben, U.1    Cao, Y.2    Xiao, G.3
  • 8
    • 0034745420 scopus 로고    scopus 로고
    • NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100
    • Xiao G., Harhaj E.W., Sun S.C. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 2001, 7(2):401-409.
    • (2001) Mol Cell , vol.7 , Issue.2 , pp. 401-409
    • Xiao, G.1    Harhaj, E.W.2    Sun, S.C.3
  • 9
    • 0033920566 scopus 로고    scopus 로고
    • Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition
    • An W.G., Hwang S.G., Trepel J.B., Blagosklonny M.V. Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition. Leukemia 2000, 14:1276-1283.
    • (2000) Leukemia , vol.14 , pp. 1276-1283
    • An, W.G.1    Hwang, S.G.2    Trepel, J.B.3    Blagosklonny, M.V.4
  • 10
    • 0034062989 scopus 로고    scopus 로고
    • Proteasome inhibition: a new strategy in cancer treatment
    • Adams J., Palombella V.J., Elliott P.J. Proteasome inhibition: a new strategy in cancer treatment. Invest New Drugs 2000, 18:109-121.
    • (2000) Invest New Drugs , vol.18 , pp. 109-121
    • Adams, J.1    Palombella, V.J.2    Elliott, P.J.3
  • 11
    • 0027302498 scopus 로고
    • Interleukin-6 gene expression in multiple myeloma: a characteristic of immature tumor cells
    • Hata H., Xiao H., Petrucci M.T., et al. Interleukin-6 gene expression in multiple myeloma: a characteristic of immature tumor cells. Blood 1993, 81:3357-3364.
    • (1993) Blood , vol.81 , pp. 3357-3364
    • Hata, H.1    Xiao, H.2    Petrucci, M.T.3
  • 12
    • 0030041147 scopus 로고    scopus 로고
    • Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B
    • Chauhan D., Uchiyama H., Akbarali Y., et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B. Blood 1996, 87:1104-1112.
    • (1996) Blood , vol.87 , pp. 1104-1112
    • Chauhan, D.1    Uchiyama, H.2    Akbarali, Y.3
  • 13
    • 0346336804 scopus 로고    scopus 로고
    • Treatment of multiple myeloma
    • Barlogie B., Shaughnessy J., Tricot G., et al. Treatment of multiple myeloma. Blood 2004, 103:20-32.
    • (2004) Blood , vol.103 , pp. 20-32
    • Barlogie, B.1    Shaughnessy, J.2    Tricot, G.3
  • 14
    • 34447292863 scopus 로고    scopus 로고
    • Multiple myeloma: a prototypic disease model for the characterization and therapeutic targeting of interactions between tumor cells and their local microenvironment
    • July
    • Mitsiades C.S., Mitsiades N.S., Richardson P.G., et al. Multiple myeloma: a prototypic disease model for the characterization and therapeutic targeting of interactions between tumor cells and their local microenvironment. J Cell Biochem 2007, 101(July (4)):950-968.
    • (2007) J Cell Biochem , vol.101 , Issue.4 , pp. 950-968
    • Mitsiades, C.S.1    Mitsiades, N.S.2    Richardson, P.G.3
  • 15
    • 33845518467 scopus 로고    scopus 로고
    • Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials
    • Jagannath S., Richardson P.G., Sonneveld P., et al. Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials. Leukemia 2007, 21:151-157.
    • (2007) Leukemia , vol.21 , pp. 151-157
    • Jagannath, S.1    Richardson, P.G.2    Sonneveld, P.3
  • 16
    • 41949099660 scopus 로고    scopus 로고
    • Alkylating agents induce activation of NFkappaB in multiple myeloma cells
    • Baumann P., Mandl-Weber S., Oduncu F., Schmidmaier R. Alkylating agents induce activation of NFkappaB in multiple myeloma cells. Leuk Res 2008, 32:1144-1147.
    • (2008) Leuk Res , vol.32 , pp. 1144-1147
    • Baumann, P.1    Mandl-Weber, S.2    Oduncu, F.3    Schmidmaier, R.4
  • 17
    • 0027980321 scopus 로고
    • The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B
    • Palombella V.J., Rando O.J., Goldberg A.L., Maniatis T. The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell 1994, 78:773-785.
    • (1994) Cell , vol.78 , pp. 773-785
    • Palombella, V.J.1    Rando, O.J.2    Goldberg, A.L.3    Maniatis, T.4
  • 18
    • 0034541196 scopus 로고    scopus 로고
    • Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB
    • Andela V.B., Schwarz E.M., Puzas J.E., et al. Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB. Cancer Res 2000, 60:6557-6562.
    • (2000) Cancer Res , vol.60 , pp. 6557-6562
    • Andela, V.B.1    Schwarz, E.M.2    Puzas, J.E.3
  • 19
    • 33846258010 scopus 로고    scopus 로고
    • BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway
    • Endo T., Nishio M., Enzler T., et al. BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood 2007, 109:703-710.
    • (2007) Blood , vol.109 , pp. 703-710
    • Endo, T.1    Nishio, M.2    Enzler, T.3
  • 20
    • 19944428834 scopus 로고    scopus 로고
    • Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling
    • Lam L.T., Davis R.E., Pierce J., et al. Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling. Clin Cancer Res 2005, 11:28-40.
    • (2005) Clin Cancer Res , vol.11 , pp. 28-40
    • Lam, L.T.1    Davis, R.E.2    Pierce, J.3
  • 21
    • 0030052683 scopus 로고    scopus 로고
    • REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma
    • Houldsworth J., Mathew S., Rao P.H., et al. REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma. Blood 1996, 87:25-29.
    • (1996) Blood , vol.87 , pp. 25-29
    • Houldsworth, J.1    Mathew, S.2    Rao, P.H.3
  • 22
    • 19944427042 scopus 로고    scopus 로고
    • Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells
    • Frelin C., Imbert V., Griessinger E., et al. Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells. Blood 2005, 105:804-811.
    • (2005) Blood , vol.105 , pp. 804-811
    • Frelin, C.1    Imbert, V.2    Griessinger, E.3
  • 23
    • 49849096091 scopus 로고    scopus 로고
    • Antitumor activity of bortezomib alone and in combination with TRAIL in human acute myeloid leukemia
    • Conticello C., Adamo L., Vicari L., et al. Antitumor activity of bortezomib alone and in combination with TRAIL in human acute myeloid leukemia. Acta Haematol 2008, 120:19-30.
    • (2008) Acta Haematol , vol.120 , pp. 19-30
    • Conticello, C.1    Adamo, L.2    Vicari, L.3
  • 24
    • 31544448567 scopus 로고    scopus 로고
    • NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome
    • Braun T., Carvalho G., Coquelle A., et al. NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome. Blood 2006, 107:1156-1165.
    • (2006) Blood , vol.107 , pp. 1156-1165
    • Braun, T.1    Carvalho, G.2    Coquelle, A.3
  • 25
    • 2342526586 scopus 로고    scopus 로고
    • Bortezomib: a novel therapy approved for multiple myeloma
    • Richardson P.G., Anderson K.C. Bortezomib: a novel therapy approved for multiple myeloma. Clin Adv Hematol Oncol 2003, 1:596-600.
    • (2003) Clin Adv Hematol Oncol , vol.1 , pp. 596-600
    • Richardson, P.G.1    Anderson, K.C.2
  • 27
    • 34547598337 scopus 로고    scopus 로고
    • Multiple myeloma: lusting for NF-kappaB
    • Gilmore T.D. Multiple myeloma: lusting for NF-kappaB. Cancer Cell 2007, 12:95-97.
    • (2007) Cancer Cell , vol.12 , pp. 95-97
    • Gilmore, T.D.1
  • 28
    • 34547660308 scopus 로고    scopus 로고
    • Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
    • Keats J.J., Fonseca R., Chesi M., et al. Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell 2007, 12:131-144.
    • (2007) Cancer Cell , vol.12 , pp. 131-144
    • Keats, J.J.1    Fonseca, R.2    Chesi, M.3
  • 29
    • 34547562418 scopus 로고    scopus 로고
    • Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
    • Annunziata C.M., Davis R.E., Demchenko Y., et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 2007, 12:115-130.
    • (2007) Cancer Cell , vol.12 , pp. 115-130
    • Annunziata, C.M.1    Davis, R.E.2    Demchenko, Y.3
  • 30
    • 0037342894 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents
    • Ma M.H., Yang H.H., Parker K., et al. The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res 2003, 9:1136-1144.
    • (2003) Clin Cancer Res , vol.9 , pp. 1136-1144
    • Ma, M.H.1    Yang, H.H.2    Parker, K.3
  • 31
    • 0027305464 scopus 로고
    • Structural alterations of the NF-kappa B transcription factor lyt-10 in lymphoid malignancies
    • Fracchiolla N.S., Lombardi L., Salina M., et al. Structural alterations of the NF-kappa B transcription factor lyt-10 in lymphoid malignancies. Oncogene 1993, 8:2839-2845.
    • (1993) Oncogene , vol.8 , pp. 2839-2845
    • Fracchiolla, N.S.1    Lombardi, L.2    Salina, M.3
  • 32
    • 0031039111 scopus 로고    scopus 로고
    • Identification of a tumor-associated mutant form of the NF-kappaB RelA gene with reduced DNA-binding and transactivating activities
    • Trecca D., Guerrini L., Fracchiolla N.S., et al. Identification of a tumor-associated mutant form of the NF-kappaB RelA gene with reduced DNA-binding and transactivating activities. Oncogene 1997, 14:791-799.
    • (1997) Oncogene , vol.14 , pp. 791-799
    • Trecca, D.1    Guerrini, L.2    Fracchiolla, N.S.3
  • 33
    • 18544367201 scopus 로고    scopus 로고
    • NF-kappa B as a therapeutic target in multiple myeloma
    • Hideshima T., Chauhan D., Richardson P., et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem 2002, 277:16639-16647.
    • (2002) J Biol Chem , vol.277 , pp. 16639-16647
    • Hideshima, T.1    Chauhan, D.2    Richardson, P.3
  • 34
    • 33750283069 scopus 로고    scopus 로고
    • MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo
    • Hideshima T., Neri P., Tassone P., et al. MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. Clin Cancer Res 2006, 12:5887-5894.
    • (2006) Clin Cancer Res , vol.12 , pp. 5887-5894
    • Hideshima, T.1    Neri, P.2    Tassone, P.3
  • 35
    • 0035725855 scopus 로고    scopus 로고
    • Analysis of expression of nuclear factor kappa B (NF-kappa B) in multiple myeloma: downregulation of NF-kappa B induces apoptosis
    • Ni H., Ergin M., Huang Q., et al. Analysis of expression of nuclear factor kappa B (NF-kappa B) in multiple myeloma: downregulation of NF-kappa B induces apoptosis. Br J Haematol 2001, 115:279-286.
    • (2001) Br J Haematol , vol.115 , pp. 279-286
    • Ni, H.1    Ergin, M.2    Huang, Q.3
  • 36
    • 0141955061 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells
    • Bharti A.C., Donato N., Aggarwal B.B. Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J Immunol 2003, 171:3863-3871.
    • (2003) J Immunol , vol.171 , pp. 3863-3871
    • Bharti, A.C.1    Donato, N.2    Aggarwal, B.B.3
  • 37
    • 52449135431 scopus 로고    scopus 로고
    • Bortezomib-resistant nuclear factor-kappaB activity in multiple myeloma cells
    • Markovina S., Callander N.S., O'Connor S.L., et al. Bortezomib-resistant nuclear factor-kappaB activity in multiple myeloma cells. Mol Cancer Res 2008, 6:1356-1364.
    • (2008) Mol Cancer Res , vol.6 , pp. 1356-1364
    • Markovina, S.1    Callander, N.S.2    O'Connor, S.L.3
  • 38
    • 70349243697 scopus 로고    scopus 로고
    • Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells
    • Hideshima T., Ikeda H., Chauhan D., et al. Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cells. Blood 2009, 114:1046-1052.
    • (2009) Blood , vol.114 , pp. 1046-1052
    • Hideshima, T.1    Ikeda, H.2    Chauhan, D.3
  • 39
    • 76949085955 scopus 로고    scopus 로고
    • Captivating Bortezomib: an active but still mysterious drug
    • Epub 2009 Oct 12. PubMed PMID: 19819547
    • Di Raimondo F., Conticello C. Captivating Bortezomib: an active but still mysterious drug. Leuk Res 2010, 34(4):411-412. Epub 2009 Oct 12. PubMed PMID: 19819547.
    • (2010) Leuk Res , vol.34 , Issue.4 , pp. 411-412
    • Di Raimondo, F.1    Conticello, C.2
  • 40
    • 70449480557 scopus 로고    scopus 로고
    • Bortezomib paradigm shift in myeloma
    • McConkey D.J. Bortezomib paradigm shift in myeloma. Blood 2009, 114:931-932.
    • (2009) Blood , vol.114 , pp. 931-932
    • McConkey, D.J.1
  • 41
    • 18144431710 scopus 로고    scopus 로고
    • 2+ is a critical determinant of Velcade (PS-341/bortezomib) cytotoxicity in myeloma cell lines
    • 2+ is a critical determinant of Velcade (PS-341/bortezomib) cytotoxicity in myeloma cell lines. Cancer Res 2005, 65(9):3828-3836.
    • (2005) Cancer Res , vol.65 , Issue.9 , pp. 3828-3836
    • Landowsky, T.H.1    Megli, C.J.2    Nullmeyer, K.D.3
  • 42
    • 2542523228 scopus 로고    scopus 로고
    • Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors
    • Pei X.Y., Dai Y., Grant S. Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors. Clin Cancer Res 2004, 10(11):3839-3852.
    • (2004) Clin Cancer Res , vol.10 , Issue.11 , pp. 3839-3852
    • Pei, X.Y.1    Dai, Y.2    Grant, S.3
  • 43
    • 77955871803 scopus 로고    scopus 로고
    • Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma. Blood (March). [Epub ahead of print].
    • Kikuchi J, Wada T, Shimizu R, et al. Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma. Blood 2010 (March). [Epub ahead of print].
    • (2010)
    • Kikuchi, J.1    Wada, T.2    Shimizu, R.3
  • 44
    • 22244452016 scopus 로고    scopus 로고
    • Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells
    • Qin J.Z., Ziffra J., Stennett L., et al. Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells. Cancer Res 2005, 65(14):6282-6293.
    • (2005) Cancer Res , vol.65 , Issue.14 , pp. 6282-6293
    • Qin, J.Z.1    Ziffra, J.2    Stennett, L.3
  • 45
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima T., Richardson P., Chauhan D., et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001, 61(7):3071-3076.
    • (2001) Cancer Res , vol.61 , Issue.7 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3
  • 46
    • 5644225628 scopus 로고    scopus 로고
    • Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib
    • Podar K., Shringarpure R., Tai Y.T., et al. Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib. Cancer Res 2004, 64(20):7500-7506.
    • (2004) Cancer Res , vol.64 , Issue.20 , pp. 7500-7506
    • Podar, K.1    Shringarpure, R.2    Tai, Y.T.3


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