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Volumn , Issue , 2012, Pages

Targeting beta amyloid: A clinical review of immunotherapeutic approaches in Alzheimer's disease

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; BAN 2401; BAPINEUZUMAB; CAD 106; GANTENERUMAB; PONEZUMAB; SOLANEZUMAB; UNCLASSIFIED DRUG; V 950; VANUTIDE CRIDIFICAR;

EID: 84856479445     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.1155/2012/628070     Document Type: Review
Times cited : (80)

References (78)
  • 2
    • 77949335521 scopus 로고    scopus 로고
    • The worldwide societal costs of dementia: Estimates for 2009
    • Wimo A., Winblad B., Jnsson L., The worldwide societal costs of dementia: estimates for 2009 Alzheimer's and Dementia 2010 6 2 98 103
    • (2010) Alzheimer's and Dementia , vol.6 , Issue.2 , pp. 98-103
    • Wimo, A.1    Winblad, B.2    Jnsson, L.3
  • 4
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J., Selkoe D. J., The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 2002 297 5580 353 356 (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 5
    • 13644266898 scopus 로고    scopus 로고
    • Age- and region-dependent alterations in Aβ-degrading enzymes: Implications for Aβ-induced disorders
    • DOI 10.1016/j.neurobiolaging.2004.06.013
    • Caccamo A., Oddo S., Sugarman M. C., Akbari Y., LaFerla F. M., Age- and region-dependent alterations in A -degrading enzymes: implications for A -induced disorders Neurobiology of Aging 2005 26 5 645 654 (Pubitemid 40228756)
    • (2005) Neurobiology of Aging , vol.26 , Issue.5 , pp. 645-654
    • Caccamo, A.1    Oddo, S.2    Sugarman, M.C.3    Akbari, Y.4    LaFerla, F.M.5
  • 8
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group
    • Biomarkers Definitions Working Group, Biomarkers and surrogate endpoints: preferred definitions and conceptual framework Clinical Pharmacology and Therapeutics 2001 69 3 89 95
    • (2001) Clinical Pharmacology and Therapeutics , vol.69 , Issue.3 , pp. 89-95
  • 11
    • 17044430985 scopus 로고    scopus 로고
    • CSF biomarkers for mild cognitive impairment and early Alzheimer's disease
    • Andreasen N., Blennow K., CSF biomarkers for mild cognitive impairment and early Alzheimer's disease Clinical Neurology and Neurosurgery 2005 107 3 165 173
    • (2005) Clinical Neurology and Neurosurgery , vol.107 , Issue.3 , pp. 165-173
    • Andreasen, N.1    Blennow, K.2
  • 14
    • 77956057086 scopus 로고    scopus 로고
    • Murine models of Alzheimer's disease and their use in developing immunotherapies
    • Wisniewski T., Sigurdsson E. M., Murine models of Alzheimer's disease and their use in developing immunotherapies Biochimica et Biophysica Acta 2010 1802 10 847 859
    • (2010) Biochimica et Biophysica Acta , vol.1802 , Issue.10 , pp. 847-859
    • Wisniewski, T.1    Sigurdsson, E.M.2
  • 27
    • 77949962484 scopus 로고    scopus 로고
    • Intravenous immunoglobulins as a treatment for Alzheimer's disease: Rationale and current evidence
    • Dodel R., Neff F., Noelker C., Pul R., Du Y., Bacher M., Oertel W., Intravenous immunoglobulins as a treatment for Alzheimer's disease: rationale and current evidence Drugs 2010 70 5 513 528
    • (2010) Drugs , vol.70 , Issue.5 , pp. 513-528
    • Dodel, R.1    Neff, F.2    Noelker, C.3    Pul, R.4    Du, Y.5    Bacher, M.6    Oertel, W.7
  • 29
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: A case report
    • DOI 10.1038/nm840
    • Nicoll J. A. R., Wilkinson D., Holmes C., Steart P., Markham H., Weller R. O., Neuropathology of human Alzheimer disease after immunization with amyloid- peptide: a case report Nature Medicine 2003 9 4 448 452 (Pubitemid 36460079)
    • (2003) Nature Medicine , vol.9 , Issue.4 , pp. 448-452
    • Nicolll, J.A.R.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 33
    • 40449086748 scopus 로고    scopus 로고
    • Progress in the active immunotherapeutic approach to Alzheimer's disease: Clinical investigations into AN1792-associated meningoencephalitis
    • DOI 10.1159/000113700
    • Pride M., Seubert P., Grundman M., Hagen M., Eldridge J., Black R. S., Progress in the active immunotherapeutic approach to Alzheimer's disease: clinical investigations into AN1792-associated meningoencephalitis Neurodegenerative Diseases 2008 5 3-4 194 196 (Pubitemid 351347848)
    • (2008) Neurodegenerative Diseases , vol.5 , Issue.3-4 , pp. 194-196
    • Pride, M.1    Seubert, P.2    Grundman, M.3    Hagen, M.4    Eldridge, J.5    Black, R.S.6
  • 34
    • 1042265187 scopus 로고    scopus 로고
    • Neuropathology and Pathogenesis of Encephalitis Following Amyloid-β Immunization in Alzheimer's Disease
    • Ferrer I., Rovira M. B., Guerra M. L. S., Rey M. J., Costa-Juss F., Neuropathology and pathogenesis of encephalitis following amyloid- immunization in Alzheimer's disease Brain Pathology 2004 14 1 11 20 (Pubitemid 38200585)
    • (2004) Brain Pathology , vol.14 , Issue.1 , pp. 11-20
    • Ferrer, I.1    Boada Rovira, M.2    Sanchez Guerra, M.L.3    Rey, M.J.4    Costa-Jussa, F.5
  • 35
    • 18144415471 scopus 로고    scopus 로고
    • Effects of Aβ immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease
    • DOI 10.1212/01.WNL.0000159743.08996.99
    • Fox N. C., Black R. S., Gilman S., Rossor M. N., Griffith S. G., Jenkins L., Koller M., Effects of A immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease Neurology 2005 64 9 1563 1572 (Pubitemid 40617692)
    • (2005) Neurology , vol.64 , Issue.9 , pp. 1563-1572
    • Fox, N.C.1    Black, R.S.2    Gilman, S.3    Rossor, M.N.4    Griffith, S.G.5    Jenkins, L.6    Koller, M.7
  • 43
    • 67650409845 scopus 로고    scopus 로고
    • Safety, tolerability and immunogenicity of the A immunotherapeutic vaccine CAD106 in a first-in-man study in Alzheimer patients
    • Winblad B., Safety, tolerability and immunogenicity of the A immunotherapeutic vaccine CAD106 in a first-in-man study in Alzheimer patients Alzheimer's and Dementia 2008 4 4 T128
    • (2008) Alzheimer's and Dementia , vol.4 , Issue.4 , pp. 128
    • Winblad, B.1
  • 44
    • 76849109048 scopus 로고    scopus 로고
    • Results of the first-in-man study with the active A Immunotherapy CAD106 in Alzheimer patients
    • Winblad B. G., Minthon L., Floesser A., Results of the first-in-man study with the active A Immunotherapy CAD106 in Alzheimer patients Alzheimer's and Dementia 2009 5 4 P113 P114
    • (2009) Alzheimer's and Dementia , vol.5 , Issue.4
    • Winblad, B.G.1    Minthon, L.2    Floesser, A.3
  • 45
    • 84856478479 scopus 로고    scopus 로고
    • Optimization of the treatment regimen with active A immunotherapy CAD106 in alzheimer patients
    • Graf A., Andreasen N., Riviere M. E., Optimization of the treatment regimen with active A immunotherapy CAD106 in alzheimer patients Alzheimer's and Dementia 2010 6 4 S532
    • (2010) Alzheimer's and Dementia , vol.6 , Issue.4 , pp. 532
    • Graf, A.1    Andreasen, N.2    Riviere, M.E.3
  • 46
    • 84856454638 scopus 로고    scopus 로고
    • A novel multivalent Abeta peptide vaccine with preclinical evidence of a central immune response that generates antisera recognizing a wide range of abeta peptide species
    • Savage M. J., Wu G., McCampbell A., A novel multivalent Abeta peptide vaccine with preclinical evidence of a central immune response that generates antisera recognizing a wide range of abeta peptide species Alzheimer's and Dementia 2010 6 4 S142
    • (2010) Alzheimer's and Dementia , vol.6 , Issue.4 , pp. 142
    • Savage, M.J.1    Wu, G.2    McCampbell, A.3
  • 52
    • 78649500577 scopus 로고    scopus 로고
    • Immunotherapy with bapineuzumab lowers CSF tau protein levels in patients with Alzheimer's disease
    • Blennow K., Zetterberg H., Wei J., Liu E., Black R., Grundman M., Immunotherapy with bapineuzumab lowers CSF tau protein levels in patients with Alzheimer's disease Alzheimer's and Dementia 2010 6 4 S134 S135
    • (2010) Alzheimer's and Dementia , vol.6 , Issue.4
    • Blennow, K.1    Zetterberg, H.2    Wei, J.3    Liu, E.4    Black, R.5    Grundman, M.6
  • 53
    • 0038509216 scopus 로고    scopus 로고
    • APOE ε4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of Aβ protein
    • DOI 10.1046/j.1365-2990.2003.00457.x
    • Chalmers K., Wilcock G. K., Love S., APOE 4 influences the pathological phenotype of Alzheimer's disease by favouring cerebrovascular over parenchymal accumulation of A protein Neuropathology and Applied Neurobiology 2003 29 3 231 238 (Pubitemid 36718171)
    • (2003) Neuropathology and Applied Neurobiology , vol.29 , Issue.3 , pp. 231-238
    • Chalmers, K.1    Wilcock, G.K.2    Love, S.3
  • 54
    • 78649498680 scopus 로고    scopus 로고
    • Apolipoprotein e 4 prevalence in Alzheimer's disease patients varies across global populations: A systematic literature review and meta-analysis
    • Crean S., Ward A., Mercaldi C. J., Collins J. M., Cook M. N., Baker N. L., Arrighi H. M., Apolipoprotein E 4 prevalence in Alzheimer's disease patients varies across global populations: a systematic literature review and meta-analysis Dementia and Geriatric Cognitive Disorders 2011 31 1 20 30
    • (2011) Dementia and Geriatric Cognitive Disorders , vol.31 , Issue.1 , pp. 20-30
    • Crean, S.1    Ward, A.2    Mercaldi, C.J.3    Collins, J.M.4    Cook, M.N.5    Baker, N.L.6    Arrighi, H.M.7
  • 55
    • 34247519766 scopus 로고    scopus 로고
    • Course of cerebral amyloid angiopathy-related inflammation
    • DOI 10.1212/01.wnl.0000260066.98681.2e, PII 0000611420070424000014
    • Kinnecom C., Lev M. H., Wendell L., Smith E. E., Rosand J., Frosch M. P., Greenberg S. M., Course of cerebral amyloid angiopathy-related inflammation Neurology 2007 68 17 1411 1416 (Pubitemid 46661556)
    • (2007) Neurology , vol.68 , Issue.17 , pp. 1411-1416
    • Kinnecom, C.1    Lev, M.H.2    Wendell, L.3    Smith, E.E.4    Rosand, J.5    Frosch, M.P.6    Greenberg, S.M.7
  • 56
    • 10744225948 scopus 로고    scopus 로고
    • Clinical Manifestations of Cerebral Amyloid Angiopathy-Related Inflammation
    • DOI 10.1002/ana.10810
    • Eng J. A., Frosch M. P., Choi K., Rebeck G. W., Greenberg S. M., Clinical manifestations of cerebral amyloid angiopathy-related inflammation Annals of Neurology 2004 55 2 250 256 (Pubitemid 38167002)
    • (2004) Annals of Neurology , vol.55 , Issue.2 , pp. 250-256
    • Eng, J.A.1    Frosch, M.P.2    Choi, K.3    Rebeck, G.W.4    Greenberg, S.M.5
  • 60
    • 77951086901 scopus 로고    scopus 로고
    • Safety and changes in plasma and cerebrospinal fluid amyloid after a single administration of an amyloid monoclonal antibody in subjects with Alzheimer disease
    • Siemers E. R., Friedrich S., Dean R. A., Gonzales C. R., Farlow M. R., Paul S. M., Demattos R. B., Safety and changes in plasma and cerebrospinal fluid amyloid after a single administration of an amyloid monoclonal antibody in subjects with Alzheimer disease Clinical Neuropharmacology 2010 33 2 67 73
    • (2010) Clinical Neuropharmacology , vol.33 , Issue.2 , pp. 67-73
    • Siemers, E.R.1    Friedrich, S.2    Dean, R.A.3    Gonzales, C.R.4    Farlow, M.R.5    Paul, S.M.6    Demattos, R.B.7
  • 61
    • 79955827710 scopus 로고    scopus 로고
    • Solanezumab was safe and well-tolerated for Asian patients with mild-to-moderate Alzheimer's disease in a multicenter, randomized, open-label, multi-dose study
    • Goto T., Fujikoshi S., Uenaka K., Solanezumab was safe and well-tolerated for Asian patients with mild-to-moderate Alzheimer's disease in a multicenter, randomized, open-label, multi-dose study Alzheimer's and Dementia 2010 6 4 S308
    • (2010) Alzheimer's and Dementia , vol.6 , Issue.4 , pp. 308
    • Goto, T.1    Fujikoshi, S.2    Uenaka, K.3
  • 62
    • 76849103927 scopus 로고    scopus 로고
    • Identification, characterization, and comparison of amino-terminally truncated A 42 peptides in Alzheimer's disease brain tissue and in plasma from Alzheimer's patients receiving solanezumab immunotherapy treatment
    • DeMattos R. B., Racke M. M., Gelfanova V., Identification, characterization, and comparison of amino-terminally truncated A 42 peptides in Alzheimer's disease brain tissue and in plasma from Alzheimer's patients receiving solanezumab immunotherapy treatment Alzheimer's and Dementia 2009 5 4 P156 P157
    • (2009) Alzheimer's and Dementia , vol.5 , Issue.4
    • Demattos, R.B.1    Racke, M.M.2    Gelfanova, V.3
  • 63
    • 84856414617 scopus 로고    scopus 로고
    • Characterization of amino-terminally truncated Abeta-42 peptides in plasma from Alzheimer's patients receiving solanezumab immunotherapy treatment
    • DeMattos R. B., Racke M., Gelfanova V., Characterization of amino-terminally truncated Abeta-42 peptides in plasma from Alzheimer's patients receiving solanezumab immunotherapy treatment Alzheimer's and Dementia 2010 6 4 S542
    • (2010) Alzheimer's and Dementia , vol.6 , Issue.4 , pp. 542
    • Demattos, R.B.1    Racke, M.2    Gelfanova, V.3
  • 65
    • 76849108861 scopus 로고    scopus 로고
    • Measurement of cerebrospinal fluid total tau and phospho-tau in phase 2 trials of therapies targeting A β
    • Siemers E. R., Dean R. A., Lachno D. R., Measurement of cerebrospinal fluid total tau and phospho-tau in phase 2 trials of therapies targeting A Alzheimer's and Dementia 2009 5 4 P258
    • (2009) Alzheimer's and Dementia , vol.5 , Issue.4 , pp. 258
    • Siemers, E.R.1    Dean, R.A.2    Lachno, D.R.3
  • 66
    • 77956482565 scopus 로고    scopus 로고
    • Biochemical biomarkers as endpoints in clinical trials: Applications in phase 1, 2 and 3 studies
    • Siemers E., Biochemical biomarkers as endpoints in clinical trials: applications in phase 1, 2 and 3 studies Alzheimer's and Dementia 2009 5 4 P95
    • (2009) Alzheimer's and Dementia , vol.5 , Issue.4 , pp. 95
    • Siemers, E.1
  • 67
    • 84856497962 scopus 로고    scopus 로고
    • Safety and pharmacokinetics following a single 10-minute intravenous infusion of the anti-amyloid mAb ponezumab (PF-04360365) in patients with mild to moderate Alzheimer's disease
    • Burstein A. H., Zhao Q., Ross J., Safety and pharmacokinetics following a single 10-minute intravenous infusion of the anti-amyloid mAb ponezumab (PF-04360365) in patients with mild to moderate Alzheimer's disease Alzheimer's and Dementia 2010 6 4 S585
    • (2010) Alzheimer's and Dementia , vol.6 , Issue.4 , pp. 585
    • Burstein, A.H.1    Zhao, Q.2    Ross, J.3
  • 68
    • 84856415644 scopus 로고    scopus 로고
    • Safety and pharmacokinetics following a single infusion of the anti-amyloid monoclonal antibody ponezumab (PF-04360365) in patients with mild-to-moderate Alzheimer's disease: Final results
    • Landen J. W., Zhao Q., Cohen S., Safety and pharmacokinetics following a single infusion of the anti-amyloid monoclonal antibody ponezumab (PF-04360365) in patients with mild-to-moderate Alzheimer's disease: final results Alzheimer's and Dementia 2010 6 4 e57
    • (2010) Alzheimer's and Dementia , vol.6 , Issue.4 , pp. 57
    • Landen, J.W.1    Zhao, Q.2    Cohen, S.3
  • 69
    • 78651382429 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of ponezumab (PF-04360365) following a single-dose intravenous infusion in patients with mild to moderate Alzheimer's disease
    • Zhao Q., Landen J., Burstein A. H., Pharmacokinetics and pharmacodynamics of ponezumab (PF-04360365) following a single-dose intravenous infusion in patients with mild to moderate Alzheimer's disease Alzheimer's and Dementia 2010 6 4 S143
    • (2010) Alzheimer's and Dementia , vol.6 , Issue.4 , pp. 143
    • Zhao, Q.1    Landen, J.2    Burstein, A.H.3
  • 70
    • 77953352375 scopus 로고    scopus 로고
    • Preliminary population pharmacokinetic modeling of PF-04360365, a humanized anti-amyloid monoclonal antibody, in patients with mild-to-moderate Alzheimer's disease
    • Nicholas T., Knebel W., Gastonguay M. R., Preliminary population pharmacokinetic modeling of PF-04360365, a humanized anti-amyloid monoclonal antibody, in patients with mild-to-moderate Alzheimer's disease Alzheimer's and Dementia 2009 5 4 P253
    • (2009) Alzheimer's and Dementia , vol.5 , Issue.4 , pp. 253
    • Nicholas, T.1    Knebel, W.2    Gastonguay, M.R.3
  • 71
    • 78651409424 scopus 로고    scopus 로고
    • IP/MS analysis of human CSF A following a single dose of the C-terminal anti-A antibody ponezumab (PF-04360365) to Alzheimer patients
    • Wood K. M., McCush F., Conboy J. J., IP/MS analysis of human CSF A following a single dose of the C-terminal anti-A antibody ponezumab (PF-04360365) to Alzheimer patients Alzheimer's and Dementia 2010 6 4 S311
    • (2010) Alzheimer's and Dementia , vol.6 , Issue.4 , pp. 311
    • Wood, K.M.1    McCush, F.2    Conboy, J.J.3
  • 72
    • 84856440430 scopus 로고    scopus 로고
    • Safety of the anti-amyloid monoclonal antibody ponezumab (PF-04360365) following a single-dose intravenous infusion in Japanese patients with mild-to-moderate Alzheimer's disease: Preliminary results
    • Fujimoto Y., Miyoshi I., Ishibashi T., Safety of the anti-amyloid monoclonal antibody ponezumab (PF-04360365) following a single-dose intravenous infusion in Japanese patients with mild-to-moderate Alzheimer's disease: preliminary results Alzheimer's and Dementia 2010 6 4 S310
    • (2010) Alzheimer's and Dementia , vol.6 , Issue.4 , pp. 310
    • Fujimoto, Y.1    Miyoshi, I.2    Ishibashi, T.3
  • 73
    • 84856498620 scopus 로고    scopus 로고
    • Pharmacokinetics of ponezumab (PF-04360365) following a single-dose intravenous infusion in Japanese patients with mild-to-moderate Alzheimer's disease: Preliminary results
    • Zhao Q., Abe S., Miyoshi I., Pharmacokinetics of ponezumab (PF-04360365) following a single-dose intravenous infusion in Japanese patients with mild-to-moderate Alzheimer's disease: preliminary results Alzheimer's and Dementia 2010 6 4 S305
    • (2010) Alzheimer's and Dementia , vol.6 , Issue.4 , pp. 305
    • Zhao, Q.1    Abe, S.2    Miyoshi, I.3
  • 77
    • 68949169046 scopus 로고    scopus 로고
    • IV immunoglobulin is associated with a reduced risk of Alzheimer disease and related disorders
    • Fillit H., Hess G., Hill J., Bonnet P., Toso C., IV immunoglobulin is associated with a reduced risk of Alzheimer disease and related disorders Neurology 2009 73 3 180 185
    • (2009) Neurology , vol.73 , Issue.3 , pp. 180-185
    • Fillit, H.1    Hess, G.2    Hill, J.3    Bonnet, P.4    Toso, C.5


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