PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET

Neurobiology of Aging

Volumn 30, Issue 8, 2009, Pages 1217-1226

  Venneti, Sriram ^a   Lopresti, Brian J ^a   Wang, Guoji ^a   Hamilton, Ronald L ^a   Mathis, Chester A ^a   Klunk, William E ^a   Apte, Udayan M ^a   Wiley, Clayton A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Astrocyte; Microglia; Peripheral benzodiazepine receptor; PET; PK11195

Indexed keywords

N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; TRITIUM;

AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CELL ACTIVATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FEMALE; FRONTAL CORTEX; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; ISOTOPE LABELING; LIGAND BINDING; MALE; MICROGLIA; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; TRANSGENIC MOUSE;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ASTROCYTES; BRAIN; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; FRONTAL LOBE; HUMANS; ISOQUINOLINES; MALE; MICE; MICE, TRANSGENIC; MICROGLIA; POSITRON-EMISSION TOMOGRAPHY; PRESENILIN-1; RECEPTORS, CELL SURFACE; TRITIUM;

EID: 67349181734     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2007.11.005     Document Type: Article

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