Relationships between regional and neuronal loss and neurofibrillary changes in the hippocampal formation and duration and severity of Alzheimer disease

Journal of Neuropathology and Experimental Neurology

Volumn 56, Issue 4, 1997, Pages 414-420

  Bobinski, Maciej ^a   Wegiel, Jerzy ^a   Tarnawski, Michal ^a   Bobinski, Margaret ^a   Reisberg, Barry ^b   De Leon, Mony J ^b   Miller, Douglas C ^b   Wisniewski, Henryk M ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alzheimer disease; Clinicopathological correlations; Hippocampus; Neurofibrillary pathology; Neuronal loss; Stereology

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; CELL LOSS; DISEASE SEVERITY; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; NERVE FUNCTION; NEUROFILAMENT; PRIORITY JOURNAL; STATISTICAL ANALYSIS; STEREOLOGY; SUBICULUM;

EID: 0030669037     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199704000-00010     Document Type: Article

References (21)

1. Ball MJ. Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. Acta Neuropathol (Berl) 1977;37:111-18
2. Ball MJ. Topographic distribution of neurofibrillary tangles and granulovacuolar degeneration in hippocampal cortex of ageing and demented patients. Interdiscipl Topics Geront 1988;25:16-37
3. Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239-59
4. Bobinski M, Wegiel J, Wisniewski HM, et al. Atrophy of hippocampal formation subdivisions correlates with stage and duration of Alzheimer disease. Dementia 1995;6:205-10
5. De Leon MJ, George AE, Stylopoulos LA, Smith G, Miller DC. Early marker for Alzheimer's disease: The atrophic hippocampus [letter]. Lancet 1989;2:672-73
6. De Leon MJ, Golomb J, George AE, et al. The radiologic prediction of Alzheimer disease: The atrophic hippocampal formation. AJNR 1993;14:897-906
7. Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL. Alzheimer's disease: Cell-specific pathology isolates the hippoeampal formation. Science 1984;225:1168-70
8. Hyman BT, Van Hoesen GW, Damasio AR. Memory-related neural systems in Alzheimer's disease: An anatomic study. Neurology 1990;40:1721-30
9. West MJ, Coleman PD, Flood DG, Troncoso JC. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 1994;344:769-72
10. Reisberg B. Functional assessment staging (FAST). Psychopharmacol Bull 1988;24:653-59
11. Mirra SS, Hart M, Terry RD. Making the diagnosis of Alzheimer's disease. A primer for practicing pathologists. Arch Pathol Lab Med 1993;117:132-44
12. Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA. Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 1989;3:519-26
13. Perry G, Mulvihill P, Manetto V, et al. Ubiquitin epitopes in Alzheimer paired helical filaments: A study with monoclonal antibodies to ubiquitin and paired helical filaments. J Cell Biol 1987;105:203a
14. Wang GP, Grundke-Iqbal I, Kascsak RJ, Iqbal K, Wisniewski HM. Alzheimer neurofibrillary tangles: Monoclonal antibodies to inherent antigen(s). Acta Neuropathol 1984;62:268-75
15. Grundke-Iqbal I, Iqbal K, Tung Y-C, Quinlan M, Wisniewski HM, Binder LI. Abnormal phosphorylation of the microtubule-associated protein (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 1986;83:4913-17
16. West MJ, Gundersen HJG. Unbiased stereological estimation of the number of neurons in the human hippocampus. J Comp Neurol 1990;296:1-22
17. Bobinski MJ, Wegiel J, Wisniewski HM, et al. Neurofibrillary pathology - Correlation with hippocampal formation atrophy in Alzheimer disease. Neurobiol Aging 1996;17:909-19
18. Gomez-Isla T, Price JL, McKeel Jr. DW, Morris JC, Growdon JH, Hyman BT. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci 1996;16:4491-500
19. Coleman PD, Flood DG. Neuron numbers and dendritic extent in normal aging and Alzheimer's disease. Neurobiol Aging 1987;8: 521-45
20. Davies DC, Horwood N, Isaacs SL, Mann DMA. The effect of age and Alzheimer's disease on pyramidal neuron density in the individual fields of the hippocampal formation. Acta Neuropathol 1992;83:510-17
21. West MJ. Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging 1993;14:287-93