TNF and leptin tell essentially the same story in alzheimer's disease

Journal of Alzheimer's Disease

Volumn 26, Issue 2, 2011, Pages 201-205

  Clark, Ian A ^a   Alleva, Lisa M ^a   Vissel, Bryce ^b  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Alzheimer's disease; inflammation; leptin; tumor necrosis factor

Indexed keywords

ETANERCEPT; INFLIXIMAB; LEPTIN; PENTETRAZOLE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR INHIBITOR;

ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID; GENE MUTATION; IN VITRO STUDY; IN VIVO STUDY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

EID: 80052785449     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2011-110266     Document Type: Article

References (55)

1. Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, Jones RW, Bullock R, Love S, Neal JW, Zotova E, Nicoll JA (2008) Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372, 216-223. (Pubitemid 351978111)
2. Green RC, Schneider LS, Amato DA, Beelen AP, Wilcock G, Swabb EA, Zavitz KH (2009) Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial. JAMA 302, 2557-2564.
3. Cummings J (2010) What can be inferred from the interruption of the semagacestat trial for treatment of Alzheimer's disease? Biol Psychiatry 68, 876-878.
4. Clark IA, Alleva LM, Vissel B (2010) The roles of TNF in brain dysfunction and disease. Pharmacol Ther128, 519-548.
5. Tobinick E (2009) Tumour necrosis factor modulation for treatment of Alzheimer's disease: rationale and current evidence. CNS Drugs 23, 713-725.
6. Floyd RA, Krueger JM (1997) Diurnal variationofTNF-alpha in the rat brain. Neuro Report 8, 915-918.
7. Asakuma S, Hiraku O, Kurose Y, Kobayashi S, Terashima Y (2004) Diurnal rhythm of cerebrospinal fluid and plasma leptin levels related to feeding in non-lactating and lactating rats. J Endocrinol 180, 283-286. (Pubitemid 38312609)
8. Das UN (2001) Is obesity an inflammatory condition? Nutrition 17, 953-966. (Pubitemid 34020662)
9. Fewlass DC, Noboa K, Pi Sunyer FX, Johnston JM, Yan SD, Tezapsidis N (2004) Obesity-related leptin regulates Alzheimer's Abeta. FASEB J 18, 1870-1878. (Pubitemid 39602272)
10. Paz-Filho GJ, Babikian T, Asarnow R, Delibasi T, Esposito K, Erol HK, Wong ML, Licinio J (2008) Leptin replacement improves cognitive development. PLoS One 3, e3098.
11. Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK, Wolozin B, Perry G, Zhu X, Greco SJ, Sarkar S (2009) Leptin: a novel therapeutic strategy for Alzheimer's disease. J Alzheimers Dis 16, 731-740.
12. Paz-Filho G, Wong ML, Licinio J (2010) The procognitive effects of leptin in the brain and their clinical implications. Int J Clin Pract 64, 1808-1812.
13. Harvey J (2010) Leptin: the missing link in Alzheimer disease? Clin Chem 56, 696-697.
14. Zumbach MS, Boehme MW, Wahl P, Stremmel W, Ziegler R, Nawroth PP (1997) Tumor necrosis factor increases serum leptin levels in humans. J Clin Endocrinol Metab 82, 4080-4082. (Pubitemid 27525517)
15. Kirchgessner TG, Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS (1997) Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes. J Clin Invest 100, 2777-2782. (Pubitemid 28007546)
16. Fawcett RL, Waechter AS, Williams LB, Zhang P, Louie R, Jones R, Inman M, Huse J, Considine RV (2000) Tumor necrosis factor-alpha inhibits leptin production in subcutaneous and omental adipocytes from morbidly obese humans. J Clin Endocrinol Metab 85, 530-535. (Pubitemid 32273629)
17. Bruun JM, Pedersen SB, Kristensen K, Richelsen B (2002) Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro. Mol Cell Endocrinol 190, 91-99. (Pubitemid 34464102)
18. van Crevel R, Karyadi E, Netea MG, Verhoef H, Nelwan RH, West CE, van der Meer JW (2002) Decreased plasma leptin concentrations in tuberculosis patients are associated with wasting and inflammation. J Clin Endocrinol Metab 87, 758-763. (Pubitemid 34158249)
19. Aulitzky WE, Tilg H, Gastl G, Mull R, Flener R, Vogel W, Herold M, Berger M, Judmaier G, Huber C (1991) Recombinant tumour necrosis factor alpha administered sub-cutaneously or intramuscularly for treatment of advanced malignant disease: a phase I trial. Eur J Cancer 27, 462-467.
20. Popa C, Netea MG, Radstake TR, van Riel PL, Barrera P, van der Meer JW (2005) Markers of inflammation are negatively correlated with serum leptin in rheumatoid arthritis. Ann Rheum Dis 64, 1195-1198. (Pubitemid 41113356)
21. Laurin D, David Curb J, Masaki KH, White LR, Launer LJ (2009) Midlife C-reactive protein and risk of cognitive decline: a 31-year follow-up.Neurobiol Aging 30, 1724-1727.
22. Schuitemaker A, Dik MG, Veerhuis R, Scheltens P, Schoo-nenboom NS, Hack CE, Blankenstein MA, Jonker C (2009) Inflammatory markers in AD and MCI patients with different biomarker profiles. Neurobiol Aging 30, 1885-1889.
23. Lieb W, Beiser AS, Vasan RS, Tan ZS, Au R, Harris TB, Roubenoff R, Auerbach S, DeCarli C, Wolf PA, Seshadri S (2009) Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA 302, 2565-2572.
24. Tarkowski E, Andreasen N, Tarkowski A, Blennow K (2003) Intrathecal inflammation precedes development of Alzheimer's disease. J Neurol Neurosurg Psych 74, 1200-1205.
25. Xiao E, Xia Zhang L, Vulliemoz NR, Ferin M, Wardlaw SL (2003) Leptin modulates inflammatory cytokine and neuroen-docrine responses to endotoxin in the primate. Endocrinol 144, 4350-4353. (Pubitemid 37204834)
26. Franchimont D, Roland S, Gustot T, Quertinmont E, Toubouti Y, Gervy MC, Deviere J, Van Gossum A (2005) Impact of infliximab on serum leptin levels in patients with Crohn's disease. J Clin Endocrinol Metab 90, 3510-3516. (Pubitemid 41014321)
27. Faggioni R, Moser A, Feingold KR, Grunfeld C (2000) Reduced leptin levels in starvation increase susceptibility to endotoxic shock. Am J Pathol 156, 1781-1787. (Pubitemid 30646715)
28. Lafrance V, Inoue W, Kan B, Luheshi GN (2010) Leptin modulates cell morphology and cytokine release in microglia. Brain Behav Immun 24, 358-365.
29. Shi JQ, Shen W, Chen J, Wang BR, Zhong LL, Zhu YW, Zhu HQ, Zhang QQ, Zhang YD, Xu J (2011) Anti-TNF-alpha reduces amyloid plaques and tau phosphorylation and induces CD11 c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains. Brain Res 1368, 239-247.
30. Liu J, Garza JC, Bronner J, Kim CS, Zhang W, Lu XY (2010) Acute administrationofleptinproduces anxiolytic-like effects: a comparison with fluoxetine. Psychopharmacology 207, 535-545.
31. Bercik P, Verdu EF, Foster JA, Macri J, Potter M, Huang X, Malinowski P, Jackson W, Blennerhassett P, Neufeld KA, Lu J, Khan W, Corthesy Theulaz I, Cherbut C, Bergonzelli GE, Collins SM (2010) Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice. Gastroenterology 139, 2102-2112.
32. He P, Zhong Z, Lindholm K, Berning L, Lee W, Lemere C, Staufenbiel M, Li R, Shen Y (2007) Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice. J Cell Biol 178, 829-841. (Pubitemid 47347367)
33. Greco SJ, Bryan KJ, Sarkar S, Zhu X, Smith MA, Ash-ford JW, Johnston JM, Tezapsidis N, Casadesus G (2010) Chronic leptin supplementation ameliorates pathology and improves cognitive performance in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis 19, 1155-1167.
34. Ekdahl CT, Claasen JH, Bonde S, Kokaia Z, Lindvall O (2003) Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci USA 100, 13632-13637. (Pubitemid 37444791)
35. Abdipranoto-Cowley A, Park JS, Croucher D, Daniel J, Hen-shall S, Galbraith S, Mervin K, Vissel B (2009) Activin A is essential for neurogenesis following neurodegeneration. Stem Cells 27, 1330-1346.
36. Bernardino L, Agasse F, Silva B, Ferreira R, Grade S, Malva JO (2008) Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal sub-ventricular zone cell cultures. Stem Cells 26, 2361-2371.
37. Garza JC, Guo M, Zhang W, Lu XY (2008) Leptin increases adult hippocampal neurogenesis in vivo and in vitro. J Biol Chem 283, 18238-18247.
38. Iosif RE, Ekdahl CT, Ahlenius H, Pronk CJ, Bonde S, Kokaia Z, Jacobsen SE, Lindvall O (2006) Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J Neurosci 26, 9703-9712. (Pubitemid 44427709)
39. Kubota K, Inoue K, Hashimoto R, Kumamoto N, Kosuga A, Tatsumi M, Kamijima K, Kunugi H, Iwata N, Ozaki N, Takeda M, Tohyama M (2009) Tumor necrosis factor receptor-associated protein 1 regulates cell adhesion and synaptic morphology via modulation of N-cadherin expression. J Neurochem 110, 496-508.
40. O'Malley D, MacDonald N, Mizielinska S, Connolly CN, Irving AJ, Harvey J (2007) Leptin promotes rapid dynamic changesin hippocampal dendritic morphology.Mol Cell Neu-rosci 35, 559-572. (Pubitemid 47193112)
41. Riazi K, Galic MA, Kuzmiski JB, Ho W, Sharkey KA, Pittman QJ (2008) Microglial activation and TNFalpha production mediate altered CNS excitability following peripheral inflammation. Proc Natl Acad Sci USA 105, 17151-17156.
42. Xu L, Rensing N, Yang XF, Zhang HX, Thio LL, Rothman SM, Weisenfeld AE, Wong M, Yamada KA (2008) Lep-tin inhibits 4-aminopyridine-and pentylenetetrazole-induced seizures and AMPAR-mediated synaptic transmission in rodents. J Clin Invest 118, 272-280.
43. Stellwagen D, Beattie EC, Seo JY, Malenka RC (2005) Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha. J Neurosci 25, 3219-3228. (Pubitemid 40463557)
44. Moult PR, Cross A, Santos SD, Carvalho AL, Lindsay Y, Connolly CN, Irving AJ, Leslie NR, Harvey J (2010) Leptin regulates AMPA receptor trafficking via PTEN inhibition. J Neurosci 30, 4088-4101.
45. Giese KP (2009) GSK-3: a key player in neurodegeneration and memory. IUBMB Life 61, 516-521.
46. Takada Y, Fang X, Jamaluddin MS, Boyd DD, Aggarwal BB (2004) Genetic deletion of glycogen synthase kinase-3 beta abrogates activation of Ikappa Balpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J Biol Chem 279, 39541-39554. (Pubitemid 39258221)
47. Eto M, Kouroedov A, Cosentino F, Luscher TF (2005) Glyco-gen synthase kinase-3 mediates endothelial cell activation by tumor necrosis factor-alpha. Circulation 112, 1316-1322. (Pubitemid 41266727)
48. Greco SJ, Sarkar S, Casadesus G, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N (2009) Leptin inhibits glyco-gen synthase kinase-3 beta to prevent tau phosphorylation in neuronal cells. Neurosci Lett 455, 191-194.
49. Marwarha G, Dasari B, Prabhakara JP, Schommer J, Ghribi O (2010) beta-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway. J Neurochem 115, 373-384.
50. Greco SJ, Sarkar S, Johnston JM, Tezapsidis N (2009) Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells. Biochem Biophys Res Commun 380, 98-104.
51. Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Gorgun CZ, Car-ling D, Hotamisligil GS, Febbraio MA, Kay TW, Kemp BE (2006) Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab 4, 465-474. (Pubitemid 44834113)
52. Ren WJ, Liu Y, Zhou LJ, Li W, Zhong Y, Pang RP, Xin WJ, Wei XH, Wang J, Zhu HQ, Wu CY, Qin ZH, Liu G, Liu XG (2011) Peripheral nerve injury leads to working memory deficits and dysfunction of the hippocampus by upregula-tion of TNF-alpha in rodents. Neuropsychopharmacology 36, 979-992.
53. Greco SJ, Sarkar S, Johnston JM, Zhu X, Su B, Casadesus G, Ashford JW, Smith M A, Tezapsidis N (2008) Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. Biochem Biophys Res Commun 376, 536-541.
54. Tobinick EL, Gross H, Weinberger A, Cohen H (2006) TNF-alpha modulation for treatment of Alzheimer's disease: A 6-month pilot study. Med Gen Med Neurol Neurosurg 8, 25.
55. Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, Laferla FM, Callahan LM, Federoff HJ, Bowers WJ (2008) Chronic neuron-specific tumor necrosis factor expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am J Pathol 173, 1768-1782.