Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease

Neurobiology of Aging

Volumn 31, Issue 5, 2010, Pages 747-757

  Wirths, Oliver ^a   Breyhan, Henning ^a   Marcello, Andrea ^a   Cotel, Marie Caroline ^a   Brück, Wolfgang ^a   Bayer, Thomas A ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Alzheimer; Amyloid; Axonal degeneration; Inflammation; Microglia; Neurodegenerative diseases; Spinal cord; Transgenic mice

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA ACTIN; CATHEPSIN D; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; METALLOTHIONEIN; OSTEOPONTIN; TATA BINDING PROTEIN; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENETIC ASSOCIATION; HIPPOCAMPUS; HOMEOSTASIS; INFLAMMATION; MICROGLIA; MOUSE; NERVE DEGENERATION; NERVE FIBER DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENE; UPREGULATION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ASTROCYTES; BLOTTING, WESTERN; BRAIN; DISEASE MODELS, ANIMAL; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MICE; MICE, TRANSGENIC; MICROGLIA; NERVE DEGENERATION; NEURONS; PRESENILIN-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77950530068     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2008.06.011     Document Type: Article

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