Thiol Modification of Cysteine 327 in the Eighth Transmembrane Domain of the Light Subunit xCT of the Heteromeric Cystine/Glutamate Antiporter Suggests Close Proximity to the Substrate Binding Site/Permeation Pathway

Journal of Biological Chemistry

Volumn 279, Issue 12, 2004, Pages 11214-11221

  Jiménez Vidal, Maite ^a,b   Gasol, Emma ^a   Zorzano, Antonio ^a   Nunes, Virginia ^b   Palacín, Manuel ^a,c   Chillarón, Josep ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Institut de Recerca Oncologica   (Spain)

^c Barcelona Science Park   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; CONFORMATIONS;

MUTANTS; TRANSMEMBRANE DOMAINS;

PROTEINS;

4 CHLOROMERCURIBENZOIC ACID; ALANINE; ANTIPORTER; ARGININE; CYSTEINE; CYSTINE; CYSTINE GLUTAMATE ANTIPORTER; GLUTAMIC ACID; PROTEIN SUBUNIT; SERINE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; IC 50; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; TEMPERATURE DEPENDENCE; XENOPUS;

AMINO ACID SEQUENCE; AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; BINDING SITES; CARRIER PROTEINS; CYSTEINE; DIMERIZATION; HUMANS; MEMBRANE PROTEINS; MERCURY COMPOUNDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SEQUENCE HOMOLOGY, AMINO ACID; SULFHYDRYL COMPOUNDS; XENOPUS;

ANIMALIA;

EID: 1642524280     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309866200     Document Type: Article

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