Role of transmembrane domain 8 in substrate selectivity and translocation of SteT, a member of the L-Amino acid Transporter (LAT) family

Journal of Biological Chemistry

Volumn 285, Issue 37, 2010, Pages 28764-28776

  Bartoccioni, Paola ^a,b   Del Rio, César ^a   Ratera, Merce ^a   Kowalczyk, Lukasz ^a   Baldwin, Jocelyn M ^c   Zorzano, Antonio ^a,d   Quick, Matthias ^e,f   Baldwin, Stephen A ^c   Vázquez Ibar, José Luis ^a,g   Palacín, Manuel ^a,b,d  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d UNIVERSITY OF BARCELONA   (Spain)

^e Center for Molecular Recognition Department of Psychiatry Columbia University College of Physicians and Surgeons ^*  (United States)

^f NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^g INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AMINO ACIDS; BINDING ENERGY; CARBOXYLIC ACIDS; ESCHERICHIA COLI; MODEL STRUCTURES; ORGANIC ACIDS; PHOSPHATASES;

AMINO ACID TRANSPORTER; BELONG TO; CONFORMATIONAL CHANGE; CYSTEINE-SCANNING MUTAGENESIS; ESCHERICHIA COLI CELLS; L-AMINO ACIDS; L-SERINE; ORGANIC CATIONS; POLYAMINES; SIDE CHAINS; STRUCTURAL MODELS; SUBSTRATE BINDING; SUBSTRATE SELECTIVITY; SUBSTRATE-BINDING SITES; THIOL REAGENTS; THIOLATION; TRANS-MEMBRANE DOMAINS; TRANSPORT CYCLE;

SUBSTRATES;

AMINO ACID TRANSPORTER; ARGININE AGMATINE ANTIPORTER; CYSTEINE; GLYCINE; LYSINE; SERINE; SERINE THREONINE ANTIPORTER; UNCLASSIFIED DRUG; BACTERIAL PROTEIN;

ALPHA HELIX; ARTICLE; BACILLUS SUBTILIS; BACTERIAL CELL; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ESCHERICHIA COLI; GENE MUTATION; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN TRANSPORT; AMINO ACID SUBSTITUTION; CHEMICAL STRUCTURE; GENETICS; METABOLISM; MISSENSE MUTATION; MUTAGENESIS; PHYSIOLOGY; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; TRANSPORT AT THE CELLULAR LEVEL;

ESCHERICHIA COLI; PROKARYOTA;

AMINO ACID SUBSTITUTION; AMINO ACID TRANSPORT SYSTEMS; BACILLUS SUBTILIS; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; ESCHERICHIA COLI; MODELS, MOLECULAR; MUTAGENESIS; MUTATION, MISSENSE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956534655     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.116632     Document Type: Article

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