Autocrine glutamate signaling promotes glioma cell invasion

Cancer Research

Volumn 67, Issue 19, 2007, Pages 9463-9471

  Lyons, Susan A ^a   Chung, W Joon ^a   Weaver, Amy K ^a   Ogunrinu, Toyin ^a   Sontheimer, Harald ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMPA RECEPTOR; CALCIUM ION; CARRIER PROTEIN; CYSTINE; CYSTINE GLUTAMATE EXCHANGER; GLUTAMIC ACID; SALAZOSULFAPYRIDINE; SODIUM CHLORIDE; SPIDER VENOM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CANCER INVASION; CANCER MODEL; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; FEMALE; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; SCID MOUSE; TUMOR XENOGRAFT;

AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; BRAIN NEOPLASMS; CALCIUM; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; GLIOBLASTOMA; GLUTAMIC ACID; HUMANS; MICE; MICE, NUDE; NEOPLASM INVASIVENESS; RANDOM ALLOCATION; RECEPTORS, AMPA; SIGNAL TRANSDUCTION; SULFASALAZINE;

EID: 35148854098     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-2034     Document Type: Article

References (34)

1. Laerum OD, Bjerkvig R, Steinsvag S, de Ridder L. Invasiveness of primary brain tumors. [review] [91 refs]. Cancer Metastasis Rev 1984;3:223-36.
2. Takano T, Lin JH, Arcuino G, Gao Q, Yang J, Nedergaard M. Glutamate release promotes growth of malignant gliomas. Nat Med 2001;7:1010-5.
3. Kaba SE, Kyritsis AP. Recognition and management of gliomas. Drugs 1997;53:235-44.
4. Ye ZC, Sontheimer H. Glioma cells release excitotoxic concentrations of glutamate. Cancer Res 1999;59:4383-91.
5. Ishiuchi S, Tsuzuki K, Yoshida Y, et al. Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells. Nat Med 2002;8:971-8.
6. Behrens PF, Langemann H, Strohschein R, Draeger J, Hennig J. Extracellular glutamate and other metabolites in and around RG2 rat glioma: an intracerebral microdialysis study. J Neurooncol 2000;47:11-22.
7. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. [review]. Neuron 1988;1:623-34.
8. Olney JW. New mechanisms of excitatory transmitter neurotoxicity. [review] [12 refs]. J Neural Transm Suppl 1994;43:47-51.
9. Bar-Peled O, Ben-Hur H, Biegon A, et al. Distribution of glutamate transporter subtypes during human brain development. J Neurochem 1997;69:2571-80.
10. Danbolt NC. Glutamate uptake. Prog Neurobiol 2001;65:1-105.
11. Ye ZC, Rothstein JD, Sontheimer H. Compromised glutamate transport in human glioma cells: reduction mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange. J Neurosci 1999;19:10767-77.
12. Sontheimer H. Malignant gliomas: perverting glutamate and ion homeostasis for selective advantage. Trends Neurosci 2003;26:543-9.
13. Oberndorfer S, Schmal T, Lahrmann H, Urbanits S, Lindner K, Grisold W. [The frequency of seizures in patients with primary brain tumors or cerebral metastases. An evaluation from the Ludwig Boltzmann Institute of Neuro-Oncology and the Department of Neurology, Kaiser Franz Josef Hospital, Vienna]. Wien Klin Wochenschr 2002;114:911-6.
14. Sato H, Tamba M, Ishii T, Bannai S. Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. J Biol Chem 1999;274:11455-8.
15. McBean GJ. Cerebral cystine uptake: a tale of two transporters. Trends Pharmacol Sci 2002;23:299-302.
16. McBean GJ, Flynn J. Molecular mechanisms of cystine transport. Biochem Soc Trans 2001;29:6-22.
17. Chung WJ, Lyons SA, Nelson GM, et al. Inhibition of cystine uptake disrupts the growth of primary brain tumors. J Neurosci 2005;25:7101-10.
18. 2+ fluctuations modulate the rate of neuronal migration. Neuron 1996;17:275-85.
19. -: an obligate exchanger of L-glutamate and L-cystine. Neuropharmacology 2004;46:273-84.
20. Gout PW, Buckley AR, Simms CR, Bruchovsky N. Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug. Leukemia 2001;15:1633-40.
21. Fosse VM, Kolstad J, Fonnum F. A bioluminescence method for the measurement of l-glutamate: applications to the study of changes in the release of L-glutamate from lateral geniculate nucleus and superior colliculus after visual cortex ablation in rats. J Neurochem 1986;47:340-9.
22. Ransom CB, O'Neal JT, Sontheimer H. Volume-activated chloride currents contribute to the resting conductance and invasive migration of human glioma cells. J Neurosci 2001;21:7674-83.
23. Soroceanu L, Gillespie Y, Khazaeli MB, Sontheimer H. Use of chlorotoxin for targeting of primary brain tumors. Cancer Res 1998;58:4871-9.
24. Gegelashvili G, Dehnes Y, Danbolt C, Schousboe A. The high-affinity glutamate transporters GLT1, GLAST, EAAT4 are regulated via different signalling mechanisms. Neurochemistry International 2000;37:163-70.
25. Gegelashvili G, Civenni G, Racagni G, Danbolt NC, Schousboe I, Schousboe A. Glutamate receptor agonists up-regulate glutamate transporter GLAST in astrocytes. Neuroreport 1996;8:261-5.
26. Anderson CM, Swanson RA. Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 2000;32:1-14.
27. Rakic P, Komuro H. The role of receptor/channel activity in neuronal cell migration. J Neurobiol 1995;26:299-315.
28. 2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition. Science 1991;252:851-3.
29. Pellegrini-Giampietro DE, Bennett MV, Zukin RS. Are Ca(2+)-permeable kainate/AMPA receptors more abundant in immature brain? Neurosci Let 1992;144:65-9.
30. Deng W, Rosenberg PA, Volpe JJ, Jensen FE. Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors. Proc Natl Acad Sci U S A 2003;100:6801-6.
31. Rakic P, Cameron RS, Komuro H. Recognition, adhesion, transmembrane signaling and cell motility in guided neuronal migration. [Review]. Curr Opin Neurobiol 1994;4:63-9.
32. Berridge MJ, Lipp P, Bootman MD. The versatility and universality of calcium signalling. Nat Rev Mol Cell Bio 2000;1:11-21.
33. Uhm JH, Gladson CL, Rao JS. The role of integrins in the malignant phenotype of gliomas. Front Biosci 1999;4:59-61.
34. András IE, Deli MA, Veszelka S, et al. The NMDA and AMPA/KA receptors are involved in glutamate-induced alterations of occludin expression and phosphorylation in brain endothelial cells. J Cereb Blood Flow Metab 2007;8:1431-43.