Functional characterization of tyrosine transport in fibroblast cells from healthy controls

Neuroscience Letters

Volumn 434, Issue 1, 2008, Pages 56-60

  Vumma, Ravi ^a   Wiesel, Frits Axel ^b   Flyckt, Lena ^c   Bjerkenstedt, Lars ^d   Venizelos, Nikolaos ^a  

^a ÖREBRO UNIVERSITY   (Sweden)

^b Department of Neuroscience   (Sweden)

^c DANDERYD HOSPITAL   (Sweden)

^d LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Human fibroblasts; Tyrosine and alanine transport, LAT1, LAT2, LAT3, LAT4

Indexed keywords

ALANINE; AMINO ACID TRANSPORTER; PROTEIN LAT1; PROTEIN LAT2; PROTEIN LAT3; PROTEIN LAT4; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SODIUM TRANSPORT;

EID: 40649117365     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.01.028     Document Type: Article

References (39)

1. M. Ackenheil Neurotransmitters and signal transduction processes in bipolar affective disorders: a synopsis J. Affect. Disord. 62 2001 101 111
2. S. Asano M. Kameyama A. Oura A. Morisato H. Sakai Y. Tabuchi A. Chairoungdua H. Endou Y. Kanai L-type amino acid transporter-1 expressed in human astrocytomas, U343MGa Biol. Pharm. Bull. 30 2007 415 422
3. E. Babu Y. Kanai A. Chairoungdua K. Kim do Y. Iribe S. Tangtrongsup P. Jutabha Y. Li N. Ahmed S. Sakamoto N. Anzai S. Nagamori H. Endou Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters J. Biol. Chem. 278 2003 43838 43845
4. L. Bjerkenstedt G. Edman L. Hagenfeldt G. Sedvall F.A. Wiesel Plasma amino acids in relation to cerebrospinal fluid monoamine metabolites in schizophrenic patients and healthy controls Br. J. Psychiatry 147 1985 276 282
5. S. Bodoy L. Martin A. Zorzano M. Palacin R. Estevez J. Bertran Identification of LAT4, a novel amino acid transporter with system L activity J. Biol. Chem. 280 2005 12002 12011
6. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
7. S. Broer A. Broer J.T. Hansen W.A. Bubb V.J. Balcar F.A. Nasrallah B. Garner C. Rae Alanine metabolism, transport, and cycling in the brain J. Neurochem. 102 2007 1758 1770
8. W.A. Campbell N.L. Thompson Overexpression of LAT1/CD98 light chain is sufficient to increase system L-amino acid transport activity in mouse hepatocytes but not fibroblasts J. Biol. Chem. 276 2001 16877 16884
9. A. Carlsson L.O. Hansson N. Waters M.L. Carlsson Neurotransmitter aberrations in schizophrenia: new perspectives and therapeutic implications Life Sci. 61 1997 75 94
10. T.B. Choi W.M. Pardridge Phenylalanine transport at the human blood–brain barrier. Studies with isolated human brain capillaries J. Biol. Chem. 261 1986 6536 6541
11. E. Fernell A. Karagiannakis G. Edman L. Bjerkenstedt F.A. Wiesel N. Venizelos Aberrant amino acid transport in fibroblasts from children with autism Neurosci. Lett. 418 2007 82 86
12. L. Flyckt N. Venizelos G. Edman L. Bjerkenstedt L. Hagenfeldt F.A. Wiesel Aberrant tyrosine transport across the cell membrane in patients with schizophrenia Arch. Gen. Psychiatry 58 2001 953 958
13. L. Hagenfeldt N. Venizelos L. Bjerkenstedt F.A. Wiesel Decreased tyrosine transport in fibroblasts from schizophrenic patients Life Sci. 41 1987 2749 2757
14. C.J. Harmer S.F. McTavish L. Clark G.M. Goodwin P.J. Cowen Tyrosine depletion attenuates dopamine function in healthy volunteers Psychopharmacology (Berl) 154 2001 105 111
15. T. Hatanaka W. Huang R. Ling P.D. Prasad M. Sugawara F.H. Leibach V. Ganapathy Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A Biochim. Biophys. Acta 1510 2001 10 17
16. T. Hatanaka W. Huang R.G. Martindale V. Ganapathy Differential influence of cAMP on the expression of the three subtypes (ATA1, ATA2, and ATA3) of the amino acid transport system A FEBS Lett. 505 2001 317 320
17. T. Hatanaka W. Huang H. Wang M. Sugawara P.D. Prasad F.H. Leibach V. Ganapathy Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A Biochim. Biophys. Acta 1467 2000 1 6
18. R.A. Hawkins R.L. O’Kane I.A. Simpson J.R. Vina Structure of the blood–brain barrier and its role in the transport of amino acids J. Nutr. 136 2006 218S 226S
19. R. Hyde P.M. Taylor H.S. Hundal Amino acid transporters: roles in amino acid sensing and signalling in animal cells Biochem. J. 373 2003 1 18
20. D.M. Jackson A. Westlind-Danielsson Dopamine receptors: molecular biology, biochemistry and behavioural aspects Pharmacol. Ther. 64 1994 291 370
21. Y. Kanai H. Endou Functional properties of multispecific amino acid transporters and their implications to transporter-mediated toxicity J. Toxicol. Sci. 28 2003 1 17
22. D.M. Killian P.J. Chikhale Predominant functional activity of the large, neutral amino acid transporter (LAT1) isoform at the cerebrovasculature Neurosci. Lett. 306 2001 1 4
23. A.J. Montgomery S.F. McTavish P.J. Cowen P.M. Grasby Reduction of brain dopamine concentration with dietary tyrosine plus phenylalanine depletion: an [11C]raclopride PET study Am. J. Psychiatry 160 2003 1887 1889
24. E. Olsson F.A. Wiesel L. Bjerkenstedt N. Venizelos Tyrosine transport in fibroblasts from healthy volunteers and patients with schizophrenia Neurosci. Lett. 393 2006 211 215
25. P.D. Prasad H. Wang W. Huang R. Kekuda D.P. Rajan F.H. Leibach V. Ganapathy Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function Biochem. Biophys. Res. Commun. 255 1999 283 288
26. C.N. Ramchand M. Peet A.E. Clark A.E. Gliddon G.P. Hemmings Decreased tyrosine transport in fibroblasts from schizophrenics: implications for membrane pathology Prostaglandins Leukot. Essent. Fatty Acids 55 1996 59 64
27. M.A. Reveley J. De Belleroche A. Recordati S.R. Hirsch Increased CSF amino acids and ventricular enlargement in schizophrenia: a preliminary study Biol. Psychiatry 22 1987 413 420
28. +-independent neutral amino acid transporter with broad substrate selectivity J. Biol. Chem. 274 1999 19745 19751
29. M. Sugawara T. Nakanishi Y.J. Fei W. Huang M.E. Ganapathy F.H. Leibach V. Ganapathy Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A J. Biol. Chem. 275 2000 16473 16477
30. M. Sugawara T. Nakanishi Y.J. Fei R.G. Martindale M.E. Ganapathy F.H. Leibach V. Ganapathy Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle Biochim. Biophys. Acta 1509 2000 7 13
31. H. Takanaga N. Tokuda S. Ohtsuki K. Hosoya T. Terasaki ATA2 is predominantly expressed as system A at the blood–brain barrier and acts as brain-to-blood efflux transport for L-proline Mol. Pharmacol. 61 2002 1289 1296
32. M. Tomi M. Mori M. Tachikawa K. Katayama T. Terasaki K. Hosoya L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier Invest. Ophthalmol. Vis. Sci. 46 2005 2522 2530
33. N. Umeki Y. Fukasawa S. Ohtsuki S. Hori Y. Watanabe Y. Kohno T. Terasaki mRNA expression and amino acid transport characteristics of cultured human brain microvascular endothelial cells (hBME) Drug Metab. Pharmacokinet. 17 2002 367 373
34. H. Varoqui H. Zhu D. Yao H. Ming J.D. Erickson Cloning and functional identification of a neuronal glutamine transporter J. Biol. Chem. 275 2000 4049 4054
35. F.A. Wiesel J.L. Andersson G. Westerberg I.M. Wieselgren L. Bjerkenstedt L. Hagenfeldt B. Langstrom Tyrosine transport is regulated differently in patients with schizophrenia Schizophr. Res. 40 1999 37 42
36. F.A. Wiesel G. Blomqvist C. Halldin I. Sjogren L. Bjerkenstedt N. Venizelos L. Hagenfeldt The transport of tyrosine into the human brain as determined with L-[1-11C]tyrosine and PET J. Nucl. Med. 32 1991 2043 2049
37. F.A. Wiesel G. Edman L. Flyckt A. Eriksson H. Nyman N. Venizelos L. Bjerkenstedt Kinetics of tyrosine transport and cognitive functioning in schizophrenia Schizophr. Res. 74 2005 81 89
38. F.A. Wiesel N. Venizelos L. Bjerkenstedt L. Hagenfeldt Tyrosine transport in schizophrenia Schizophr. Res. 13 1994 255 258
39. R.A. Wise M.A. Bozarth A psychomotor stimulant theory of addiction Psychol. Rev. 94 1987 469 492