-
1
-
-
84855471990
-
HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications
-
Khan, O. and La Thangue, N. B. (2012) HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications. Immunol. Cell Biol. 90, 85-94
-
(2012)
Immunol. Cell Biol.
, vol.90
, pp. 85-94
-
-
Khan, O.1
La Thangue, N.B.2
-
2
-
-
33644872992
-
Chromatin control and cancer-drug discovery: realizing the promise
-
Inche, A. G. and La Thangue, N. B. (2006) Chromatin control and cancer-drug discovery: realizing the promise. Drug Discovery Today 11, 97-109
-
(2006)
Drug Discovery Today
, vol.11
, pp. 97-109
-
-
Inche, A.G.1
La Thangue, N.B.2
-
3
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
Bolden, J. E., Peart, M. J. and Johnstone, R. W. (2006) Anticancer activities of histone deacetylase inhibitors. Nat. Rev. Drug Discovery 5, 769-784
-
(2006)
Nat. Rev. Drug Discovery
, vol.5
, pp. 769-784
-
-
Bolden, J.E.1
Peart, M.J.2
Johnstone, R.W.3
-
4
-
-
33644853802
-
Histone modifications: signalling receptors and potential elements of a heritable epigenetic code
-
Nightingale, K. P., O'Neill, L. P. and Turner, B. M. (2006) Histone modifications: signalling receptors and potential elements of a heritable epigenetic code. Curr. Opin. Genet. Dev. 16, 125-136
-
(2006)
Curr. Opin. Genet. Dev.
, vol.16
, pp. 125-136
-
-
Nightingale, K.P.1
O'Neill, L.P.2
Turner, B.M.3
-
5
-
-
0034912742
-
Histone acetyltransferases
-
Roth, S. Y., Denu, J. M. and Allis, C. D. (2001) Histone acetyltransferases. Annu. Rev. Biochem. 70, 81-120
-
(2001)
Annu. Rev. Biochem.
, vol.70
, pp. 81-120
-
-
Roth, S.Y.1
Denu, J.M.2
Allis, C.D.3
-
6
-
-
0344407016
-
Histone deacetylases: unique players in shaping the epigenetic histone code
-
Thiagalingam, S., Cheng, K. H., Lee, H. J., Mineva, N., Thiagalingam, A. and Ponte, J. F. (2003) Histone deacetylases: unique players in shaping the epigenetic histone code. Ann. N.Y. Acad. Sci. 983, 84-100
-
(2003)
Ann. N. Y. Acad. Sci.
, vol.983
, pp. 84-100
-
-
Thiagalingam, S.1
Cheng, K.H.2
Lee, H.J.3
Mineva, N.4
Thiagalingam, A.5
Ponte, J.F.6
-
7
-
-
34047136095
-
Sequence and expression analysis of histone deacetylases in rice
-
Fu, W., Wu, K. and Duan, J. (2007) Sequence and expression analysis of histone deacetylases in rice. Biochem. Biophys. Res. Commun. 356, 843-850
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.356
, pp. 843-850
-
-
Fu, W.1
Wu, K.2
Duan, J.3
-
8
-
-
0037406061
-
Class II histone deacetylases: versatile regulators
-
Verdin, E., Dequiedt, F. and Kasler, H. G. (2003) Class II histone deacetylases: versatile regulators. Trends. Genet. 19, 286-293
-
(2003)
Trends. Genet.
, vol.19
, pp. 286-293
-
-
Verdin, E.1
Dequiedt, F.2
Kasler, H.G.3
-
9
-
-
3943054839
-
The Sir2 family of protein deacetylases
-
Blander, G. and Guarente, L. (2004) The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 73, 417-435
-
(2004)
Annu. Rev. Biochem.
, vol.73
, pp. 417-435
-
-
Blander, G.1
Guarente, L.2
-
10
-
-
33750887809
-
The role of NAD+ dependent histone deacetylases (sirtuins) in ageing
-
Trapp, J. and Jung, M. (2006) The role of NAD+ dependent histone deacetylases (sirtuins) in ageing. Curr. Drug Targets 7, 1553-1560
-
(2006)
Curr. Drug Targets
, vol.7
, pp. 1553-1560
-
-
Trapp, J.1
Jung, M.2
-
11
-
-
0037067696
-
Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family
-
Gao, L., Cueto, M. A., Asselbergs, F. and Atadja, P. (2002) Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J. Biol. Chem. 277, 25748-25755
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 25748-25755
-
-
Gao, L.1
Cueto, M.A.2
Asselbergs, F.3
Atadja, P.4
-
12
-
-
38549157208
-
Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis
-
Weichert, W., Roske, A., Gekeler, V., Beckers, T., Ebert, M. P., Pross, M., Dietel, M., Denkert, C. and Rocken, C. (2008) Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis. Lancet Oncol. 9, 139-148
-
(2008)
Lancet Oncol
, vol.9
, pp. 139-148
-
-
Weichert, W.1
Roske, A.2
Gekeler, V.3
Beckers, T.4
Ebert, M.P.5
Pross, M.6
Dietel, M.7
Denkert, C.8
Rocken, C.9
-
13
-
-
79954535049
-
Histone deacetylases 1 6 and 8 are critical for invasion in breast cancer
-
Park, S. Y., Jun, J. A., Jeong, K. J., Heo, H. J., Sohn, J. S., Lee, H. Y., Park, C. G. and Kang, J. (2011) Histone deacetylases 1, 6 and 8 are critical for invasion in breast cancer. Oncol. Rep. 25, 1677-1681
-
(2011)
Oncol. Rep.
, vol.25
, pp. 1677-1681
-
-
Park, S.Y.1
Jun, J.A.2
Jeong, K.J.3
Heo, H.J.4
Sohn, J.S.5
Lee, H.Y.6
Park, C.G.7
Kang, J.8
-
14
-
-
4544322261
-
Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients
-
Osada, H., Tatematsu, Y., Saito, H., Yatabe, Y., Mitsudomi, T. and Takahashi, T. (2004) Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients. Int. J. Cancer 112, 26-32
-
(2004)
Int. J. Cancer
, vol.112
, pp. 26-32
-
-
Osada, H.1
Tatematsu, Y.2
Saito, H.3
Yatabe, Y.4
Mitsudomi, T.5
Takahashi, T.6
-
15
-
-
79960435624
-
Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells
-
Aldana-Masangkay, G. I., Rodriguez-Gonzalez, A., Lin, T., Ikeda, A. K., Hsieh, Y. T., Kim, Y. M., Lomenick, B., Okemoto, K., Landaw, E. M., Wang, D. et al. (2011) Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells. Leuk. Lymphoma 52, 1544-1555
-
(2011)
Leuk. Lymphoma
, vol.52
, pp. 1544-1555
-
-
Aldana-Masangkay, G.I.1
Rodriguez-Gonzalez, A.2
Lin, T.3
Ikeda, A.K.4
Hsieh, Y.T.5
Kim, Y.M.6
Lomenick, B.7
Okemoto, K.8
Landaw, E.M.9
Wang, D.10
-
16
-
-
0034662614
-
Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer
-
Mariadason, J. M., Corner, G. A. and Augenlicht, L. H. (2000) Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer. Cancer. Res. 60, 4561-4572
-
(2000)
Cancer. Res.
, vol.60
, pp. 4561-4572
-
-
Mariadason, J.M.1
Corner, G.A.2
Augenlicht, L.H.3
-
17
-
-
0042905956
-
Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines
-
Glaser, K. B., Staver, M. J., Waring, J. F., Stender, J., Ulrich, R. G. and Davidsen, S. K. (2003) Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. Mol. Cancer Ther. 2, 151-163
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 151-163
-
-
Glaser, K.B.1
Staver, M.J.2
Waring, J.F.3
Stender, J.4
Ulrich, R.G.5
Davidsen, S.K.6
-
18
-
-
58149307916
-
Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism
-
Chittur, S. V., Sangster-Guity, N. and Mccormick, P. J. (2008) Histone deacetylase inhibitors: a new mode for inhibition of cholesterol metabolism. BMC Genomics 9, 507
-
(2008)
BMC Genomics
, vol.9
, pp. 507
-
-
Chittur, S.V.1
Sangster-Guity, N.2
Mccormick, P.J.3
-
19
-
-
84871769796
-
Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1alpha 25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression
-
Seuter, S., Heikkinen, S. and Carlberg, C. (2012) Chromatin acetylation at transcription start sites and vitamin D receptor binding regions relates to effects of 1alpha,25-dihydroxyvitamin D3 and histone deacetylase inhibitors on gene expression. Nucleic Acids Res. 41, 110-124
-
(2012)
Nucleic Acids Res
, vol.41
, pp. 110-124
-
-
Seuter, S.1
Heikkinen, S.2
Carlberg, C.3
-
20
-
-
34447096461
-
HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway
-
Tsapis, M., Lieb, M., Manzo, F., Shankaranarayanan, P., Herbrecht, R., Lutz, P. and Gronemeyer, H. (2007) HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway. Int. J. Biochem. Cell Biol. 39, 1500-1509
-
(2007)
Int. J. Biochem. Cell Biol.
, vol.39
, pp. 1500-1509
-
-
Tsapis, M.1
Lieb, M.2
Manzo, F.3
Shankaranarayanan, P.4
Herbrecht, R.5
Lutz, P.6
Gronemeyer, H.7
-
21
-
-
84857034491
-
The pan-histone deacetylase inhibitor CR2408 disrupts cell cycle progression, diminishes proliferation and causes apoptosis in multiple myeloma cells
-
Baumann, P., Junghanns, C., Mandl-Weber, S., Strobl, S., Oduncu, F. and Schmidmaier, R. (2012) The pan-histone deacetylase inhibitor CR2408 disrupts cell cycle progression, diminishes proliferation and causes apoptosis in multiple myeloma cells. Br. J. Haematol. 156, 633-642
-
(2012)
Br. J. Haematol.
, vol.156
, pp. 633-642
-
-
Baumann, P.1
Junghanns, C.2
Mandl-Weber, S.3
Strobl, S.4
Oduncu, F.5
Schmidmaier, R.6
-
22
-
-
77957023872
-
Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide
-
Mizutani, H., Hiraku, Y., Tada-Oikawa, S., Murata, M., Ikemura, K., Iwamoto, T., Kagawa, Y., Okuda, M. and Kawanishi, S. (2010) Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide. Cancer Sci. 101, 2214-2219
-
(2010)
Cancer Sci
, vol.101
, pp. 2214-2219
-
-
Mizutani, H.1
Hiraku, Y.2
Tada-Oikawa, S.3
Murata, M.4
Ikemura, K.5
Iwamoto, T.6
Kagawa, Y.7
Okuda, M.8
Kawanishi, S.9
-
23
-
-
84856390338
-
Second-generation histone deacetylase inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells
-
Kalin, J. H., Butler, K. V., Akimova, T., Hancock, W. W. and Kozikowski, A. P. (2012) Second-generation histone deacetylase inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells. J. Med. Chem. 55, 639-651
-
(2012)
J. Med. Chem.
, vol.55
, pp. 639-651
-
-
Kalin, J.H.1
Butler, K.V.2
Akimova, T.3
Hancock, W.W.4
Kozikowski, A.P.5
-
24
-
-
84860501655
-
Molecular pathways: old drugs define new pathways: non-histone acetylation at the crossroads of the DNA damage response and autophagy
-
Botrugno, O. A., Robert, T., Vanoli, F., Foiani, M. and Minucci, S. (2012) Molecular pathways: old drugs define new pathways: non-histone acetylation at the crossroads of the DNA damage response and autophagy. Clin. Cancer Res. 18, 2436-2442
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 2436-2442
-
-
Botrugno, O.A.1
Robert, T.2
Vanoli, F.3
Foiani, M.4
Minucci, S.5
-
25
-
-
84865740818
-
HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy
-
Lin, K. T., Wang, Y. W., Chen, C. T., Ho, C. M., Su, W. H. and Jou, Y. S. (2012) HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. Clin. Cancer Res. 18, 4691-4701
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 4691-4701
-
-
Lin, K.T.1
Wang, Y.W.2
Chen, C.T.3
Ho, C.M.4
Su, W.H.5
Jou, Y.S.6
-
26
-
-
84873682553
-
Effects of valproic acid on proliferation, apoptosis, angiogenesis and metastasis of ovarian cancer in vitro and in vivo
-
Shan, Z., Feng-Nian, R., Jie, G. and Ting, Z. (2012) Effects of valproic acid on proliferation, apoptosis, angiogenesis and metastasis of ovarian cancer in vitro and in vivo. Asian Pac. J. Cancer Prev. 13, 3977-3982
-
(2012)
Asian Pac. J. Cancer Prev.
, vol.13
, pp. 3977-3982
-
-
Shan, Z.1
Feng-Nian, R.2
Jie, G.3
Ting, Z.4
-
27
-
-
79954842538
-
Histone deacetylase inhibitors block nuclear factor-κB-dependent transcription by interfering with RNA polymerase II recruitment
-
Furumai, R., Ito, A., Ogawa, K., Maeda, S., Saito, A., Nishino, N., Horinouchi, S. and Yoshida, M. (2011) Histone deacetylase inhibitors block nuclear factor-κB-dependent transcription by interfering with RNA polymerase II recruitment. Cancer Sci. 102, 1081-1087
-
(2011)
Cancer Sci
, vol.102
, pp. 1081-1087
-
-
Furumai, R.1
Ito, A.2
Ogawa, K.3
Maeda, S.4
Saito, A.5
Nishino, N.6
Horinouchi, S.7
Yoshida, M.8
-
28
-
-
45849144803
-
Histone deacetylase inhibitors exert time-dependent effects on nuclear factor-κB but consistently suppress the expression of proinflammatory genes in human myometrial cells
-
Lindstrom, T. M., Mohan, A. R., Johnson, M. R. and Bennett, P. R. (2008) Histone deacetylase inhibitors exert time-dependent effects on nuclear factor-κB but consistently suppress the expression of proinflammatory genes in human myometrial cells. Mol. Pharmacol. 74, 109-121
-
(2008)
Mol. Pharmacol.
, vol.74
, pp. 109-121
-
-
Lindstrom, T.M.1
Mohan, A.R.2
Johnson, M.R.3
Bennett, P.R.4
-
29
-
-
84864354431
-
p53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells
-
Bajbouj, K., Mawrin, C., Hartig, R., Schulze-Luehrmann, J., Wilisch-Neumann, A., Roessner, A. and Schneider-Stock, R. (2012) p53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells. J. Neuro-oncol. 107, 503-516
-
(2012)
J. Neuro-oncol.
, vol.107
, pp. 503-516
-
-
Bajbouj, K.1
Mawrin, C.2
Hartig, R.3
Schulze-Luehrmann, J.4
Wilisch-Neumann, A.5
Roessner, A.6
Schneider-Stock, R.7
-
30
-
-
70349636576
-
Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy
-
Pang, M., Kothapally, J., Mao, H., Tolbert, E., Ponnusamy, M., Chin, Y. E. and Zhuang, S. (2009) Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. Am. J. Physiol. Renal Physiol. 297, F996-F1005
-
(2009)
Am. J. Physiol. Renal Physiol.
, vol.297
-
-
Pang, M.1
Kothapally, J.2
Mao, H.3
Tolbert, E.4
Ponnusamy, M.5
Chin, Y.E.6
Zhuang, S.7
-
31
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D. and Weinberg, R. A. (2000) The hallmarks of cancer. Cell 100, 57-70
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
33
-
-
84872531927
-
Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross talk between MECP2 and NFI transcription factor family
-
Ray, B. K., Dhar, S., Henry, C. J., Rich, A. and Ray, A. (2012) Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross talk between MECP2 and NFI transcription factor family. Cancer. Res. 73, 736-744
-
(2012)
Cancer. Res.
, vol.73
, pp. 736-744
-
-
Ray, B.K.1
Dhar, S.2
Henry, C.J.3
Rich, A.4
Ray, A.5
-
34
-
-
84871795363
-
Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization
-
Tommasi, S., Zheng, A., Weninger, A., Bates, S. E., Li, X. A., Wu, X., Hollstein, M. and Besaratinia, A. (2012) Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization. Nucleic. Acids. Res. 41, 182-195
-
(2012)
Nucleic. Acids. Res.
, vol.41
, pp. 182-195
-
-
Tommasi, S.1
Zheng, A.2
Weninger, A.3
Bates, S.E.4
Li, X.A.5
Wu, X.6
Hollstein, M.7
Besaratinia, A.8
-
35
-
-
20144388146
-
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
-
Fraga, M. F., Ballestar, E., Villar-Garea, A., Boix-Chornet, M., Espada, J., Schotta, G., Bonaldi, T., Haydon, C., Ropero, S., Petrie, K. et al. (2005) Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat. Genet. 37, 391-400
-
(2005)
Nat. Genet.
, vol.37
, pp. 391-400
-
-
Fraga, M.F.1
Ballestar, E.2
Villar-Garea, A.3
Boix-Chornet, M.4
Espada, J.5
Schotta, G.6
Bonaldi, T.7
Haydon, C.8
Ropero, S.9
Petrie, K.10
-
36
-
-
0033997967
-
The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein
-
Melnick, A. M., Westendorf, J. J., Polinger, A., Carlile, G. W., Arai, S., Ball, H. J., Lutterbach, B., Hiebert, S. W. and Licht, J. D. (2000) The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein. Mol. Cell. Biol. 20, 2075-2086
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 2075-2086
-
-
Melnick, A.M.1
Westendorf, J.J.2
Polinger, A.3
Carlile, G.W.4
Arai, S.5
Ball, H.J.6
Lutterbach, B.7
Hiebert, S.W.8
Licht, J.D.9
-
37
-
-
84859487538
-
Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically
-
Zapotocky, M., Mejstrikova, E., Smetana, K., Stary, J., Trka, J. and Starkova, J. (2012) Valproic acid triggers differentiation and apoptosis in AML1/ETO-positive leukemic cells specifically. Cancer Lett. 319, 144-153
-
(2012)
Cancer Lett
, vol.319
, pp. 144-153
-
-
Zapotocky, M.1
Mejstrikova, E.2
Smetana, K.3
Stary, J.4
Trka, J.5
Starkova, J.6
-
38
-
-
84888581624
-
Acetylation increases EWS-FLI1 DNA binding and transcriptional activity
-
Schlottmann, S., Erkizan, H. V., Barber-Rotenberg, J. S., Knights, C., Cheema, A., Uren, A., Avantaggiati, M. L. and Toretsky, J. A. (2012) Acetylation increases EWS-FLI1 DNA binding and transcriptional activity. Front. Oncol. 2, 107
-
(2012)
Front. Oncol.
, vol.2
, pp. 107
-
-
Schlottmann, S.1
Erkizan, H.V.2
Barber-Rotenberg, J.S.3
Knights, C.4
Cheema, A.5
Uren, A.6
Avantaggiati, M.L.7
Toretsky, J.A.8
-
39
-
-
84859311379
-
HDAC1 inactivation induces mitotic defect and caspase-independent autophagic cell death in liver cancer
-
Xie, H. J., Noh, J. H., Kim, J. K., Jung, K. H., Eun, J. W., Bae, H. J., Kim, M. G., Chang, Y. G., Lee, J. Y., Park, H. and Nam, S. W. (2012) HDAC1 inactivation induces mitotic defect and caspase-independent autophagic cell death in liver cancer. PLoS ONE 7, e34265
-
(2012)
PLoS ONE
, vol.7
-
-
Xie, H.J.1
Noh, J.H.2
Kim, J.K.3
Jung, K.H.4
Eun, J.W.5
Bae, H.J.6
Kim, M.G.7
Chang, Y.G.8
Lee, J.Y.9
Park, H.10
Nam, S.W.11
-
40
-
-
84859565614
-
HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins
-
Jung, K. H., Noh, J. H., Kim, J. K., Eun, J. W., Bae, H. J., Xie, H. J., Chang, Y. G., Kim, M. G., Park, H., Lee, J. Y. and Nam, S. W. (2012) HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins. J. Cell. Biochem. 113, 2167-2177
-
(2012)
J. Cell. Biochem.
, vol.113
, pp. 2167-2177
-
-
Jung, K.H.1
Noh, J.H.2
Kim, J.K.3
Eun, J.W.4
Bae, H.J.5
Xie, H.J.6
Chang, Y.G.7
Kim, M.G.8
Park, H.9
Lee, J.Y.10
Nam, S.W.11
-
41
-
-
84862019471
-
Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy
-
Gupta, M., Han, J. J., Stenson, M., Wellik, L. and Witzig, T. E. (2012) Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy. Leukemia 26, 1356-1364
-
(2012)
Leukemia
, vol.26
, pp. 1356-1364
-
-
Gupta, M.1
Han, J.J.2
Stenson, M.3
Wellik, L.4
Witzig, T.E.5
-
42
-
-
84865325063
-
Overexpression of histone deacetylase 6 contributes to accelerated migration and invasion activity of hepatocellular carcinoma cells
-
Kanno, K., Kanno, S., Nitta, H., Uesugi, N., Sugai, T., Masuda, T., Wakabayashi, G. and Maesawa, C. (2012) Overexpression of histone deacetylase 6 contributes to accelerated migration and invasion activity of hepatocellular carcinoma cells. Oncol. Rep. 28, 867-873
-
(2012)
Oncol. Rep.
, vol.28
, pp. 867-873
-
-
Kanno, K.1
Kanno, S.2
Nitta, H.3
Uesugi, N.4
Sugai, T.5
Masuda, T.6
Wakabayashi, G.7
Maesawa, C.8
-
43
-
-
77955616882
-
Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin
-
Hayashi, A., Horiuchi, A., Kikuchi, N., Hayashi, T., Fuseya, C., Suzuki, A., Konishi, I. and Shiozawa, T. (2010) Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin. Int.J. Cancer. 127, 1332-1346
-
(2010)
Int. J. Cancer.
, vol.127
, pp. 1332-1346
-
-
Hayashi, A.1
Horiuchi, A.2
Kikuchi, N.3
Hayashi, T.4
Fuseya, C.5
Suzuki, A.6
Konishi, I.7
Shiozawa, T.8
-
44
-
-
84855432518
-
Histone deacetylase inhibitors in the generation of the anti-tumour immune response
-
Leggatt, G. R. and Gabrielli, B. (2012) Histone deacetylase inhibitors in the generation of the anti-tumour immune response. Immunol. Cell Biol. 90, 33-38
-
(2012)
Immunol. Cell Biol.
, vol.90
, pp. 33-38
-
-
Leggatt, G.R.1
Gabrielli, B.2
-
45
-
-
77956519074
-
Histone deacetylase inhibitors: highlight on epigenetic regulation
-
Pecuchet, N., Cluzeau, T., Thibault, C., Mounier, N. and Vignot, S. (2010) Histone deacetylase inhibitors: highlight on epigenetic regulation. Bull. Cancer 97, 917-935
-
(2010)
Bull. Cancer
, vol.97
, pp. 917-935
-
-
Pecuchet, N.1
Cluzeau, T.2
Thibault, C.3
Mounier, N.4
Vignot, S.5
-
46
-
-
79955530689
-
Down-regulation of the tumor suppressor C-terminal Src kinase (Csk)-binding protein (Cbp)/PAG1 is mediated by epigenetic histone modifications via the mitogen-activated protein kinase (MAPK)/phosphatidylinositol 3-kinase (PI3K) pathway
-
Suzuki, K., Oneyama, C., Kimura, H., Tajima, S. and Okada, M. (2011) Down-regulation of the tumor suppressor C-terminal Src kinase (Csk)-binding protein (Cbp)/PAG1 is mediated by epigenetic histone modifications via the mitogen-activated protein kinase (MAPK)/phosphatidylinositol 3-kinase (PI3K) pathway. J. Biol. Chem. 286, 15698-15706
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 15698-15706
-
-
Suzuki, K.1
Oneyama, C.2
Kimura, H.3
Tajima, S.4
Okada, M.5
-
47
-
-
84866527136
-
Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity
-
Banik, D., Khan, A. N., Walseng, E., Segal, B. H. and Abrams, S. I. (2012) Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity. PLoS ONE 7, e45422
-
(2012)
PLoS ONE
, vol.7
-
-
Banik, D.1
Khan, A.N.2
Walseng, E.3
Segal, B.H.4
Abrams, S.I.5
-
48
-
-
84871822817
-
Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model
-
Kurundkar, D., Srivastava, R. K., Chaudhary, S. C., Ballestas, M. E., Kopelovich, L., Elmets, C. A. and Athar, M. (2012) Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model. Toxicol. Appl. Pharmacol. 266, 233-244
-
(2012)
Toxicol. Appl. Pharmacol.
, vol.266
, pp. 233-244
-
-
Kurundkar, D.1
Srivastava, R.K.2
Chaudhary, S.C.3
Ballestas, M.E.4
Kopelovich, L.5
Elmets, C.A.6
Athar, M.7
-
49
-
-
0034730127
-
Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation
-
Richon, V. M., Sandhoff, T. W., Rifkind, R. A. and Marks, P. A. (2000) Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc. Natl. Acad. Sci. U.S. A. 97, 10014-10019
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 10014-10019
-
-
Richon, V.M.1
Sandhoff, T.W.2
Rifkind, R.A.3
Marks, P.A.4
-
50
-
-
0033604457
-
Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53
-
Vrana, J. A., Decker, R. H., Johnson, C. R., Wang, Z., Jarvis, W. D., Richon, V. M., Ehinger, M., Fisher, P. B. and Grant, S. (1999) Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53. Oncogene 18, 7016-7025
-
(1999)
Oncogene
, vol.18
, pp. 7016-7025
-
-
Vrana, J.A.1
Decker, R.H.2
Johnson, C.R.3
Wang, Z.4
Jarvis, W.D.5
Richon, V.M.6
Ehinger, M.7
Fisher, P.B.8
Grant, S.9
-
51
-
-
84865309290
-
Apoptosis induction by SAHA in cutaneous T-cell lymphoma cells is related to downregulation of c-FLIP and enhanced TRAIL signaling
-
Al-Yacoub, N., Fecker, L. F., Mobs, M., Plotz, M., Braun, F. K., Sterry, W. and Eberle, J. (2012) Apoptosis induction by SAHA in cutaneous T-cell lymphoma cells is related to downregulation of c-FLIP and enhanced TRAIL signaling. J. Invest. Dermatol. 132, 2263-2274
-
(2012)
J. Invest. Dermatol.
, vol.132
, pp. 2263-2274
-
-
Al-Yacoub, N.1
Fecker, L.F.2
Mobs, M.3
Plotz, M.4
Braun, F.K.5
Sterry, W.6
Eberle, J.7
-
52
-
-
84867844169
-
A new synthetic HDAC inhibitor, MHY218, induces apoptosis or autophagy-related cell death in tamoxifen-resistant MCF-7 breast cancer cells
-
Park, J. H., Ahn, M. Y., Kim, T. H., Yoon, S., Kang, K. W., Lee, J., Moon, H. R., Jung, J. H., Chung, H. Y. and Kim, H. S. (2012) A new synthetic HDAC inhibitor, MHY218, induces apoptosis or autophagy-related cell death in tamoxifen-resistant MCF-7 breast cancer cells. Invest. New Drugs 30, 1887-1898
-
(2012)
Invest. New Drugs
, vol.30
, pp. 1887-1898
-
-
Park, J.H.1
Ahn, M.Y.2
Kim, T.H.3
Yoon, S.4
Kang, K.W.5
Lee, J.6
Moon, H.R.7
Jung, J.H.8
Chung, H.Y.9
Kim, H.S.10
-
53
-
-
84861549063
-
Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro
-
Kang, F. W., Que, L., Wu, M., Wang, Z. L. and Sun, J. (2012) Effects of trichostatin A on HIF-1α and VEGF expression in human tongue squamous cell carcinoma cells in vitro. Oncol. Rep. 28, 193-199
-
(2012)
Oncol. Rep.
, vol.28
, pp. 193-199
-
-
Kang, F.W.1
Que, L.2
Wu, M.3
Wang, Z.L.4
Sun, J.5
-
54
-
-
0042261694
-
Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors
-
Sasakawa, Y., Naoe, Y., Noto, T., Inoue, T., Sasakawa, T., Matsuo, M., Manda, T. and Mutoh, S. (2003) Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors. Biochem. Pharmacol. 66, 897-906
-
(2003)
Biochem. Pharmacol.
, vol.66
, pp. 897-906
-
-
Sasakawa, Y.1
Naoe, Y.2
Noto, T.3
Inoue, T.4
Sasakawa, T.5
Matsuo, M.6
Manda, T.7
Mutoh, S.8
-
55
-
-
4644364508
-
The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584
-
Qian, D. Z., Wang, X., Kachhap, S. K., Kato, Y., Wei, Y., Zhang, L., Atadja, P. and Pili, R. (2004) The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584. Cancer Res. 64, 6626-6634
-
(2004)
Cancer Res
, vol.64
, pp. 6626-6634
-
-
Qian, D.Z.1
Wang, X.2
Kachhap, S.K.3
Kato, Y.4
Wei, Y.5
Zhang, L.6
Atadja, P.7
Pili, R.8
-
56
-
-
79959209876
-
Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism
-
Advani, A., Huang, Q., Thai, K., Advani, S. L., White, K. E., Kelly, D. J., Yuen, D. A., Connelly, K. A., Marsden, P. A. and Gilbert, R. E. (2011) Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism. Am. J. Pathol. 178, 2205-2214
-
(2011)
Am. J. Pathol.
, vol.178
, pp. 2205-2214
-
-
Advani, A.1
Huang, Q.2
Thai, K.3
Advani, S.L.4
White, K.E.5
Kelly, D.J.6
Yuen, D.A.7
Connelly, K.A.8
Marsden, P.A.9
Gilbert, R.E.10
-
57
-
-
84871824758
-
Mechanism of growth inhibition of prostate cancer xenografts by valproic acid
-
Sidana, A., Wang, M., Shabbeer, S., Chowdhury, W. H., Netto, G., Lupold, S. E., Carducci, M. and Rodriguez, R. (2012) Mechanism of growth inhibition of prostate cancer xenografts by valproic acid. J. Biomed. Biotechnol. 2012, 180363
-
(2012)
J. Biomed. Biotechnol.
, vol.2012
, pp. 180363
-
-
Sidana, A.1
Wang, M.2
Shabbeer, S.3
Chowdhury, W.H.4
Netto, G.5
Lupold, S.E.6
Carducci, M.7
Rodriguez, R.8
-
58
-
-
77954146994
-
Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21waf1/cip1 expression
-
Noro, R., Miyanaga, A., Minegishi, Y., Okano, T., Seike, M., Soeno, C., Kataoka, K., Matsuda, K., Yoshimura, A. and Gemma, A. (2010) Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21waf1/cip1 expression. Cancer Sci. 101, 1424-1430
-
(2010)
Cancer Sci
, vol.101
, pp. 1424-1430
-
-
Noro, R.1
Miyanaga, A.2
Minegishi, Y.3
Okano, T.4
Seike, M.5
Soeno, C.6
Kataoka, K.7
Matsuda, K.8
Yoshimura, A.9
Gemma, A.10
-
59
-
-
77954692325
-
A phase I, pharmacokinetic, and pharmacodynamic study of two schedules of vorinostat in combination with 5-fluorouracil and leucovorin in patients with refractory solid tumors
-
Fakih, M. G., Fetterly, G., Egorin, M. J., Muindi, J. R., Espinoza-Delgado, I., Zwiebel, J. A., Litwin, A., Holleran, J. L., Wang, K. and Diasio, R. B. (2010) A phase I, pharmacokinetic, and pharmacodynamic study of two schedules of vorinostat in combination with 5-fluorouracil and leucovorin in patients with refractory solid tumors. Clin. Cancer Res. 16, 3786-3794
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 3786-3794
-
-
Fakih, M.G.1
Fetterly, G.2
Egorin, M.J.3
Muindi, J.R.4
Espinoza-Delgado, I.5
Zwiebel, J.A.6
Litwin, A.7
Holleran, J.L.8
Wang, K.9
Diasio, R.B.10
-
60
-
-
79951894022
-
Effect of histone deacetylase inhibitor in combination with 5-fluorouracil on pancreas cancer and cholangiocarcinoma cell lines
-
Iwahashi, S., Ishibashi, H., Utsunomiya, T., Morine, Y., Ochir, T. L., Hanaoka, J., Mori, H., Ikemoto, T., Imura, S. and Shimada, M. (2011) Effect of histone deacetylase inhibitor in combination with 5-fluorouracil on pancreas cancer and cholangiocarcinoma cell lines. J. Med. Invest. 58, 106-109
-
(2011)
J. Med. Invest.
, vol.58
, pp. 106-109
-
-
Iwahashi, S.1
Ishibashi, H.2
Utsunomiya, T.3
Morine, Y.4
Ochir, T.L.5
Hanaoka, J.6
Mori, H.7
Ikemoto, T.8
Imura, S.9
Shimada, M.10
-
61
-
-
79952695963
-
Adamantanyl-histone deacetylase inhibitor H6CAHA exhibits favorable pharmacokinetics and augments prostate cancer radiation sensitivity
-
Konsoula, Z., Cao, H., Velena, A. and Jung, M. (2011) Adamantanyl-histone deacetylase inhibitor H6CAHA exhibits favorable pharmacokinetics and augments prostate cancer radiation sensitivity. Int. J. Radiat. Oncol. Biol. Phys. 79, 1541-1548
-
(2011)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.79
, pp. 1541-1548
-
-
Konsoula, Z.1
Cao, H.2
Velena, A.3
Jung, M.4
-
62
-
-
84866697070
-
Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma
-
Saelen, M. G., Ree, A. H., Kristian, A., Fleten, K. G., Furre, T., Hektoen, H. H. and Flatmark, K. (2012) Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma. Radiat. Oncol. 7, 165
-
(2012)
Radiat. Oncol.
, vol.7
, pp. 165
-
-
Saelen, M.G.1
Ree, A.H.2
Kristian, A.3
Fleten, K.G.4
Furre, T.5
Hektoen, H.H.6
Flatmark, K.7
-
63
-
-
84861775963
-
Valproic acid, a histone deacetylase inhibitor, enhances radiosensitivity in esophageal squamous cell carcinoma
-
Shoji, M., Ninomiya, I., Makino, I., Kinoshita, J., Nakamura, K., Oyama, K., Nakagawara, H., Fujita, H., Tajima, H., Takamura, H. et al. (2012) Valproic acid, a histone deacetylase inhibitor, enhances radiosensitivity in esophageal squamous cell carcinoma. Int. J. Oncol. 40, 2140-2146
-
(2012)
Int. J. Oncol.
, vol.40
, pp. 2140-2146
-
-
Shoji, M.1
Ninomiya, I.2
Makino, I.3
Kinoshita, J.4
Nakamura, K.5
Oyama, K.6
Nakagawara, H.7
Fujita, H.8
Tajima, H.9
Takamura, H.10
-
64
-
-
34848863333
-
Histone deacetylase 4 is required for TGF(1-induced myofibroblastic differentiation
-
Glenisson, W., Castronovo, V. and Waltregny, D. (2007) Histone deacetylase 4 is required for TGFβ1-induced myofibroblastic differentiation. Biochim. Biophys. Acta 1773, 1572-1582
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, pp. 1572-1582
-
-
Glenisson, W.1
Castronovo, V.2
Waltregny, D.3
-
65
-
-
74049116297
-
Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury
-
Marumo, T., Hishikawa, K., Yoshikawa, M., Hirahashi, J., Kawachi, S. and Fujita, T. (2010) Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury. Am. J. Physiol. Renal Physiol. 298, F133-F141
-
(2010)
Am. J. Physiol. Renal Physiol.
, vol.298
-
-
Marumo, T.1
Hishikawa, K.2
Yoshikawa, M.3
Hirahashi, J.4
Kawachi, S.5
Fujita, T.6
-
66
-
-
79960383466
-
Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins
-
Pang, M., Ma, L., Liu, N., Ponnusamy, M., Zhao, T. C., Yan, H. and Zhuang, S. (2011) Histone deacetylase 1/2 mediates proliferation of renal interstitial fibroblasts and expression of cell cycle proteins. J. Cell. Biochem. 112, 2138-2148
-
(2011)
J. Cell. Biochem.
, vol.112
, pp. 2138-2148
-
-
Pang, M.1
Ma, L.2
Liu, N.3
Ponnusamy, M.4
Zhao, T.C.5
Yan, H.6
Zhuang, S.7
-
67
-
-
80053485017
-
Sodium valproate blocks the transforming growth factor (TGF)-β1 autocrine loop and attenuates the TGF-β1-induced collagen synthesis in a human hepatic stellate cell line
-
Watanabe, T., Tajima, H., Hironori, H., Nakagawara, H., Ohnishi, I., Takamura, H., Ninomiya, I., Kitagawa, H., Fushida, S., Tani, T. et al. (2011) Sodium valproate blocks the transforming growth factor (TGF)-β1 autocrine loop and attenuates the TGF-β1-induced collagen synthesis in a human hepatic stellate cell line. Int. J. Mol. Med. 28, 919-925
-
(2011)
Int. J. Mol. Med.
, vol.28
, pp. 919-925
-
-
Watanabe, T.1
Tajima, H.2
Hironori, H.3
Nakagawara, H.4
Ohnishi, I.5
Takamura, H.6
Ninomiya, I.7
Kitagawa, H.8
Fushida, S.9
Tani, T.10
-
68
-
-
0033055983
-
A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture
-
Niki, T., Rombouts, K., De Bleser, P., De Smet, K., Rogiers, V., Schuppan, D., Yoshida, M., Gabbiani, G. and Geerts, A. (1999) A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. Hepatology 29, 858-867
-
(1999)
Hepatology
, vol.29
, pp. 858-867
-
-
Niki, T.1
Rombouts, K.2
De Bleser, P.3
De Smet, K.4
Rogiers, V.5
Schuppan, D.6
Yoshida, M.7
Gabbiani, G.8
Geerts, A.9
-
69
-
-
0036892348
-
Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor
-
Rombouts, K., Knittel, T., Machesky, L., Braet, F., Wielant, A., Hellemans, K., De Bleser, P., Gelman, I., Ramadori, G. and Geerts, A. (2002) Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor. J. Hepatol. 37, 788-796
-
(2002)
J. Hepatol.
, vol.37
, pp. 788-796
-
-
Rombouts, K.1
Knittel, T.2
Machesky, L.3
Braet, F.4
Wielant, A.5
Hellemans, K.6
De Bleser, P.7
Gelman, I.8
Ramadori, G.9
Geerts, A.10
-
70
-
-
84860529331
-
Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis
-
Davies, E. R., Haitchi, H. M., Thatcher, T. H., Sime, P. J., Kottmann, R. M., Ganesan, A., Packham, G., O'Reilly, K. M. and Davies, D. E. (2012) Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 46, 687-694
-
(2012)
Am. J. Respir. Cell Mol. Biol.
, vol.46
, pp. 687-694
-
-
Davies, E.R.1
Haitchi, H.M.2
Thatcher, T.H.3
Sime, P.J.4
Kottmann, R.M.5
Ganesan, A.6
Packham, G.7
O'Reilly, K.M.8
Davies, D.E.9
-
71
-
-
55649123444
-
Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin
-
Liu, F., Levin, M. D., Petrenko, N. B., Lu, M. M., Wang, T., Yuan, L. J., Stout, A. L., Epstein, J. A. and Patel, V. V. (2008) Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin. J. Mol. Cell. Cardiol. 45, 715-723
-
(2008)
J. Mol. Cell. Cardiol.
, vol.45
, pp. 715-723
-
-
Liu, F.1
Levin, M.D.2
Petrenko, N.B.3
Lu, M.M.4
Wang, T.5
Yuan, L.J.6
Stout, A.L.7
Epstein, J.A.8
Patel, V.V.9
-
72
-
-
33644861578
-
Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding
-
Kee, H. J., Sohn, I. S., Nam, K. I., Park, J. E., Qian, Y. R., Yin, Z., Ahn, Y., Jeong, M. H., Bang, Y. J., Kim, N. et al. (2006) Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding. Circulation 113, 51-59
-
(2006)
Circulation
, vol.113
, pp. 51-59
-
-
Kee, H.J.1
Sohn, I.S.2
Nam, K.I.3
Park, J.E.4
Qian, Y.R.5
Yin, Z.6
Ahn, Y.7
Jeong, M.H.8
Bang, Y.J.9
Kim, N.10
-
73
-
-
36049029411
-
Antifibrogenic effects of histone deacetylase inhibitors on pancreatic stellate cells
-
Bulow, R., Fitzner, B., Sparmann, G., Emmrich, J., Liebe, S. and Jaster, R. (2007) Antifibrogenic effects of histone deacetylase inhibitors on pancreatic stellate cells. Biochem. Pharmacol. 74, 1747-1757
-
(2007)
Biochem. Pharmacol.
, vol.74
, pp. 1747-1757
-
-
Bulow, R.1
Fitzner, B.2
Sparmann, G.3
Emmrich, J.4
Liebe, S.5
Jaster, R.6
-
74
-
-
77954730368
-
A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy
-
Pang, M., Ma, L., Gong, R., Tolbert, E., Mao, H., Ponnusamy, M., Chin, Y. E., Yan, H., Dworkin, L. D. and Zhuang, S. (2010) A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney Int. 78, 257-268
-
(2010)
Kidney Int
, vol.78
, pp. 257-268
-
-
Pang, M.1
Ma, L.2
Gong, R.3
Tolbert, E.4
Mao, H.5
Ponnusamy, M.6
Chin, Y.E.7
Yan, H.8
Dworkin, L.D.9
Zhuang, S.10
-
75
-
-
33645121520
-
Selective transcription and cellular proliferation induced by PDGF require histone deacetylase activity
-
Catania, A., Iavarone, C., Carlomagno, S. M. and Chiariello, M. (2006) Selective transcription and cellular proliferation induced by PDGF require histone deacetylase activity. Biochem. Biophys. Res. Commun. 343, 544-554
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.343
, pp. 544-554
-
-
Catania, A.1
Iavarone, C.2
Carlomagno, S.M.3
Chiariello, M.4
-
76
-
-
3142721913
-
Requirement of histone deacetylase activity for signaling by STAT1
-
Klampfer, L., Huang, J., Swaby, L. A. and Augenlicht, L. (2004) Requirement of histone deacetylase activity for signaling by STAT1. J. Biol. Chem. 279, 30358-30368
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 30358-30368
-
-
Klampfer, L.1
Huang, J.2
Swaby, L.A.3
Augenlicht, L.4
-
77
-
-
34547431097
-
Histone deacetylase inhibitors: a novel class of therapeutic agents in diabetic nephropathy
-
Lee, H. B., Noh, H., Seo, J. Y., Yu, M. R. and Ha, H. (2007) Histone deacetylase inhibitors: a novel class of therapeutic agents in diabetic nephropathy. Kidney. Int. Suppl. S61-S66
-
(2007)
Kidney. Int. Suppl.
-
-
Lee, H.B.1
Noh, H.2
Seo, J.Y.3
Yu, M.R.4
Ha, H.5
-
78
-
-
33845976704
-
Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-β1 in human renal epithelial cells
-
Yoshikawa, M., Hishikawa, K., Marumo, T. and Fujita, T. (2007) Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-β1 in human renal epithelial cells. J. Am. Soc. Nephrol. 18, 58-65
-
(2007)
J. Am. Soc. Nephrol.
, vol.18
, pp. 58-65
-
-
Yoshikawa, M.1
Hishikawa, K.2
Marumo, T.3
Fujita, T.4
-
79
-
-
79959804516
-
Histone deacetylases as regulators of inflammation and immunity
-
Shakespear, M. R., Halili, M. A., Irvine, K. M., Fairlie, D. P. and Sweet, M. J. (2011) Histone deacetylases as regulators of inflammation and immunity. Trends. Immunol. 32, 335-343
-
(2011)
Trends. Immunol.
, vol.32
, pp. 335-343
-
-
Shakespear, M.R.1
Halili, M.A.2
Irvine, K.M.3
Fairlie, D.P.4
Sweet, M.J.5
-
80
-
-
79251554670
-
Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection
-
Roger, T., Lugrin, J., Le Roy, D., Goy, G., Mombelli, M., Koessler, T., Ding, X. C., Chanson, A. L., Reymond, M. K., Miconnet, I. et al. (2011) Histone deacetylase inhibitors impair innate immune responses to Toll-like receptor agonists and to infection. Blood 117, 1205-1217
-
(2011)
Blood
, vol.117
, pp. 1205-1217
-
-
Roger, T.1
Lugrin, J.2
Le Roy, D.3
Goy, G.4
Mombelli, M.5
Koessler, T.6
Ding, X.C.7
Chanson, A.L.8
Reymond, M.K.9
Miconnet, I.10
-
81
-
-
34447119505
-
Histone deacetylase inhibitors affect dendritic cell differentiation and immunogenicity
-
Nencioni, A., Beck, J., Werth, D., Grunebach, F., Patrone, F., Ballestrero, A. and Brossart, P. (2007) Histone deacetylase inhibitors affect dendritic cell differentiation and immunogenicity. Clin. Cancer. Res. 13, 3933-3941
-
(2007)
Clin. Cancer. Res.
, vol.13
, pp. 3933-3941
-
-
Nencioni, A.1
Beck, J.2
Werth, D.3
Grunebach, F.4
Patrone, F.5
Ballestrero, A.6
Brossart, P.7
-
82
-
-
0034041033
-
Immunobiology of dendritic cells
-
Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, Y. J., Pulendran, B. and Palucka, K. (2000) Immunobiology of dendritic cells. Annu. Rev. Immunol. 18, 767-811
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 767-811
-
-
Banchereau, J.1
Briere, F.2
Caux, C.3
Davoust, J.4
Lebecque, S.5
Liu, Y.J.6
Pulendran, B.7
Palucka, K.8
-
83
-
-
1042290501
-
Activation of dendritic cells: translating innate into adaptive immunity
-
Reis e Sousa, C. (2004) Activation of dendritic cells: translating innate into adaptive immunity. Curr. Opin. Immunol. 16, 21-25
-
(2004)
Curr. Opin. Immunol.
, vol.16
, pp. 21-25
-
-
Reise Sousa, C.1
-
84
-
-
33748428027
-
Histone deacetylase inhibitors induce antigen specific anergy in lymphocytes: a comparative study
-
Edens, R. E., Dagtas, S. and Gilbert, K. M. (2006) Histone deacetylase inhibitors induce antigen specific anergy in lymphocytes: a comparative study. Int. Immunopharmacol. 6, 1673-1681
-
(2006)
Int. Immunopharmacol.
, vol.6
, pp. 1673-1681
-
-
Edens, R.E.1
Dagtas, S.2
Gilbert, K.M.3
-
85
-
-
34548079870
-
Regulating regulatory T cells to achieve transplant tolerance
-
Tao, R. and Hancock, W. W. (2007) Regulating regulatory T cells to achieve transplant tolerance. Hepatobiliary Pancreat. Dis. Int. 6, 348-357
-
(2007)
Hepatobiliary Pancreat. Dis. Int.
, vol.6
, pp. 348-357
-
-
Tao, R.1
Hancock, W.W.2
-
86
-
-
51449120215
-
Effect of a new immunosuppressant histon deacetylase (HDAC) inhibitor FR276457 in a rat cardiac transplant model
-
Kinugasa, F., Yamada, T., Noto, T., Matsuoka, H., Mori, H., Sudo, Y. and Mutoh, S. (2008) Effect of a new immunosuppressant histon deacetylase (HDAC) inhibitor FR276457 in a rat cardiac transplant model. Biol. Pharm. Bull. 31, 1723-1726
-
(2008)
Biol. Pharm. Bull.
, vol.31
, pp. 1723-1726
-
-
Kinugasa, F.1
Yamada, T.2
Noto, T.3
Matsuoka, H.4
Mori, H.5
Sudo, Y.6
Mutoh, S.7
-
87
-
-
68749092634
-
Effect of the immunosuppressant histone deacetylase inhibitor FR276457 in a canine renal transplant model
-
Kinugasa, F., Nagatomi, I., Nakanishi, T., Noto, T., Mori, H., Matsuoka, H., Sudo, Y. and Mutoh, S. (2009) Effect of the immunosuppressant histone deacetylase inhibitor FR276457 in a canine renal transplant model. Transpl. Immunol. 21, 198-202
-
(2009)
Transpl. Immunol.
, vol.21
, pp. 198-202
-
-
Kinugasa, F.1
Nagatomi, I.2
Nakanishi, T.3
Noto, T.4
Mori, H.5
Matsuoka, H.6
Sudo, Y.7
Mutoh, S.8
-
88
-
-
0035162560
-
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
-
Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B., Clark, L. B., Yasayko, S. A., Wilkinson, J. E., Galas, D., Ziegler, S. F. and Ramsdell, F. (2001) Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27, 68-73
-
(2001)
Nat. Genet.
, vol.27
, pp. 68-73
-
-
Brunkow, M.E.1
Jeffery, E.W.2
Hjerrild, K.A.3
Paeper, B.4
Clark, L.B.5
Yasayko, S.A.6
Wilkinson, J.E.7
Galas, D.8
Ziegler, S.F.9
Ramsdell, F.10
-
89
-
-
0035167967
-
The immune dysregulation, polyendocrinopathy, enteropathy X-linked syndrome (IPEX) is caused by mutations of FOXP3
-
Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M. E., Ferguson, P. J., Whitesell, L., Kelly, T. E., Saulsbury, F. T., Chance, P. F. and Ochs, H. D. (2001) The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27, 20-21
-
(2001)
Nat. Genet.
, vol.27
, pp. 20-21
-
-
Bennett, C.L.1
Christie, J.2
Ramsdell, F.3
Brunkow, M.E.4
Ferguson, P.J.5
Whitesell, L.6
Kelly, T.E.7
Saulsbury, F.T.8
Chance, P.F.9
Ochs, H.D.10
-
90
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori, S., Nomura, T. and Sakaguchi, S. (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science 299, 1057-1061
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
91
-
-
0037385330
-
Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells
-
Fontenot, J. D., Gavin, M. A. and Rudensky, A. Y. (2003) Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat. Immunol. 4, 330-336
-
(2003)
Nat. Immunol.
, vol.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
92
-
-
0037385314
-
An essential role for Scurfin in CD4+ CD25+ T regulatory cells
-
Khattri, R., Cox, T., Yasayko, S. A. and Ramsdell, F. (2003) An essential role for Scurfin in CD4+ CD25+ T regulatory cells. Nat. Immunol. 4, 337-342
-
(2003)
Nat. Immunol.
, vol.4
, pp. 337-342
-
-
Khattri, R.1
Cox, T.2
Yasayko, S.A.3
Ramsdell, F.4
-
93
-
-
73449117582
-
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells
-
Wang, L., de Zoeten, E. F., Greene, M. I. and Hancock, W. W. (2009) Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells. Nat. Rev. Drug Discovery 8, 969-981
-
(2009)
Nat. Rev. Drug Discovery
, vol.8
, pp. 969-981
-
-
Wang, L.1
de Zoeten, E.F.2
Greene, M.I.3
Hancock, W.W.4
-
94
-
-
35948980739
-
Deacetylase inhibition promotes the generation and function of regulatory T cells
-
Tao, R., de Zoeten, E. F., Ozkaynak, E., Chen, C., Wang, L., Porrett, P. M., Li, B., Turka, L. A., Olson, E. N., Greene, M. I. et al. (2007) Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat. Med. 13, 1299-1307
-
(2007)
Nat. Med.
, vol.13
, pp. 1299-1307
-
-
Tao, R.1
de Zoeten, E.F.2
Ozkaynak, E.3
Chen, C.4
Wang, L.5
Porrett, P.M.6
Li, B.7
Turka, L.A.8
Olson, E.N.9
Greene, M.I.10
-
95
-
-
75449114277
-
Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice
-
de Zoeten, E. F., Wang, L., Sai, H., Dillmann, W. H. and Hancock, W. W. (2010) Inhibition of HDAC9 increases T regulatory cell function and prevents colitis in mice. Gastroenterology 138, 583-594
-
(2010)
Gastroenterology
, vol.138
, pp. 583-594
-
-
de Zoeten, E.F.1
Wang, L.2
Sai, H.3
Dillmann, W.H.4
Hancock, W.W.5
-
96
-
-
50849102708
-
The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice
-
Reilly, C. M., Thomas, M., Gogal, Jr, R., Olgun, S., Santo, A., Sodhi, R., Samy, E. T., Peng, S. L., Gilkeson, G. S. and Mishra, N. (2008) The histone deacetylase inhibitor trichostatin A upregulates regulatory T cells and modulates autoimmunity in NZB/W F1 mice. J. Autoimmun. 31, 123-130
-
(2008)
J. Autoimmun.
, vol.31
, pp. 123-130
-
-
Reilly, C.M.1
Thomas, M.2
Gogal Jr., R.3
Olgun, S.4
Santo, A.5
Sodhi, R.6
Samy, E.T.7
Peng, S.L.8
Gilkeson, G.S.9
Mishra, N.10
-
97
-
-
70349385423
-
Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis
-
Saouaf, S. J., Li, B., Zhang, G., Shen, Y., Furuuchi, N., Hancock, W. W. and Greene, M. I. (2009) Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis. Exp. Mol. Pathol. 87, 99-104
-
(2009)
Exp. Mol. Pathol.
, vol.87
, pp. 99-104
-
-
Saouaf, S.J.1
Li, B.2
Zhang, G.3
Shen, Y.4
Furuuchi, N.5
Hancock, W.W.6
Greene, M.I.7
-
98
-
-
13244252362
-
Trichostatin A attenuates airway inflammation in mouse asthma model
-
Choi, J. H., Oh, S. W., Kang, M. S., Kwon, H. J., Oh, G. T. and Kim, D. Y. (2005) Trichostatin A attenuates airway inflammation in mouse asthma model. Clin. Exp. Allergy 35, 89-96
-
(2005)
Clin. Exp. Allergy
, vol.35
, pp. 89-96
-
-
Choi, J.H.1
Oh, S.W.2
Kang, M.S.3
Kwon, H.J.4
Oh, G.T.5
Kim, D.Y.6
-
99
-
-
0037330279
-
Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse
-
Mishra, N., Reilly, C. M., Brown, D. R., Ruiz, P. and Gilkeson, G. S. (2003) Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. J. Clin. Invest. 111, 539-552
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 539-552
-
-
Mishra, N.1
Reilly, C.M.2
Brown, D.R.3
Ruiz, P.4
Gilkeson, G.S.5
-
100
-
-
33645775726
-
Histone hyperacetylation is associated with amelioration of experimental colitis in mice
-
Glauben, R., Batra, A., Fedke, I., Zeitz, M., Lehr, H. A., Leoni, F., Mascagni, P., Fantuzzi, G., Dinarello, C. A. and Siegmund, B. (2006) Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J. Immunol. 176, 5015-5022
-
(2006)
J. Immunol.
, vol.176
, pp. 5015-5022
-
-
Glauben, R.1
Batra, A.2
Fedke, I.3
Zeitz, M.4
Lehr, H.A.5
Leoni, F.6
Mascagni, P.7
Fantuzzi, G.8
Dinarello, C.A.9
Siegmund, B.10
-
101
-
-
5644239630
-
Histone deacetylase inhibitor suppression of autoantibody-mediated arthritis in mice via regulation of p16INK4a and p21WAF1/Cip1 expression
-
Nishida, K., Komiyama, T., Miyazawa, S., Shen, Z. N., Furumatsu, T., Doi, H., Yoshida, A., Yamana, J., Yamamura, M., Ninomiya, Y. et al. (2004) Histone deacetylase inhibitor suppression of autoantibody-mediated arthritis in mice via regulation of p16INK4a and p21WAF1/Cip1 expression. Arthritis Rheum. 50, 3365-3376
-
(2004)
Arthritis Rheum
, vol.50
, pp. 3365-3376
-
-
Nishida, K.1
Komiyama, T.2
Miyazawa, S.3
Shen, Z.N.4
Furumatsu, T.5
Doi, H.6
Yoshida, A.7
Yamana, J.8
Yamamura, M.9
Ninomiya, Y.10
-
102
-
-
34047210698
-
Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents
-
Lin, H. S., Hu, C. Y., Chan, H. Y., Liew, Y. Y., Huang, H. P., Lepescheux, L., Bastianelli, E., Baron, R., Rawadi, G. and Clement-Lacroix, P. (2007) Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents. Br. J. Pharmacol. 150, 862-872
-
(2007)
Br. J. Pharmacol.
, vol.150
, pp. 862-872
-
-
Lin, H.S.1
Hu, C.Y.2
Chan, H.Y.3
Liew, Y.Y.4
Huang, H.P.5
Lepescheux, L.6
Bastianelli, E.7
Baron, R.8
Rawadi, G.9
Clement-Lacroix, P.10
-
103
-
-
1642415712
-
Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect
-
Reddy, P., Maeda, Y., Hotary, K., Liu, C., Reznikov, L. L., Dinarello, C. A. and Ferrara, J. L. (2004) Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect. Proc. Natl. Acad. Sci. U.S. A. 101, 3921-3926
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 3921-3926
-
-
Reddy, P.1
Maeda, Y.2
Hotary, K.3
Liu, C.4
Reznikov, L.L.5
Dinarello, C.A.6
Ferrara, J.L.7
-
104
-
-
42449130607
-
HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen
-
Li, N., Zhao, D., Kirschbaum, M., Zhang, C., Lin, C. L., Todorov, I., Kandeel, F., Forman, S. and Zeng, D. (2008) HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen. Proc. Natl. Acad. Sci. U.S. A. 105, 4796-4801
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 4796-4801
-
-
Li, N.1
Zhao, D.2
Kirschbaum, M.3
Zhang, C.4
Lin, C.L.5
Todorov, I.6
Kandeel, F.7
Forman, S.8
Zeng, D.9
-
105
-
-
33750496904
-
Targeting histone deacetylases for the treatment of cancer and inflammatory diseases
-
Huang, L. (2006) Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. J. Cell. Physiol. 209, 611-616
-
(2006)
J. Cell. Physiol.
, vol.209
, pp. 611-616
-
-
Huang, L.1
-
106
-
-
70349443224
-
Transcriptional control of the inflammatory response
-
Medzhitov, R. and Horng, T. (2009) Transcriptional control of the inflammatory response. Nat. Rev. Immunol. 9, 692-703
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 692-703
-
-
Medzhitov, R.1
Horng, T.2
-
107
-
-
77949971595
-
Selective transcription in response to an inflammatory stimulus
-
Smale, S. T. (2010) Selective transcription in response to an inflammatory stimulus. Cell 140, 833-844
-
(2010)
Cell
, vol.140
, pp. 833-844
-
-
Smale, S.T.1
-
108
-
-
84867652835
-
Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages
-
Chen, X., Barozzi, I., Termanini, A., Prosperini, E., Recchiuti, A., Dalli, J., Mietton, F., Matteoli, G., Hiebert, S. and Natoli, G. (2012) Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages. Proc. Natl. Acad. Sci. U.S. A. 109, E2865-E2874
-
(2012)
Proc. Natl. Acad. Sci. U. S. A.
, vol.109
-
-
Chen, X.1
Barozzi, I.2
Termanini, A.3
Prosperini, E.4
Recchiuti, A.5
Dalli, J.6
Mietton, F.7
Matteoli, G.8
Hiebert, S.9
Natoli, G.10
-
109
-
-
84860529747
-
HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats
-
Usui, T., Okada, M., Mizuno, W., Oda, M., Ide, N., Morita, T., Hara, Y. and Yamawaki, H. (2012) HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. Am. J. Physiol. Heart. Circ. Physiol. 302, H1894-H1904
-
(2012)
Am. J. Physiol. Heart. Circ. Physiol.
, vol.302
-
-
Usui, T.1
Okada, M.2
Mizuno, W.3
Oda, M.4
Ide, N.5
Morita, T.6
Hara, Y.7
Yamawaki, H.8
-
110
-
-
84857233842
-
Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay
-
Grabiec, A. M., Korchynskyi, O., Tak, P. P. and Reedquist, K. A. (2012) Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay. Ann. Rheum. Dis. 71, 424-431
-
(2012)
Ann. Rheum. Dis.
, vol.71
, pp. 424-431
-
-
Grabiec, A.M.1
Korchynskyi, O.2
Tak, P.P.3
Reedquist, K.A.4
-
111
-
-
84859771693
-
Histone deacetylase inhibition by sodium valproate regulates polarization of macrophage subsets
-
Wu, C., Li, A., Leng, Y., Li, Y. and Kang, J. (2012) Histone deacetylase inhibition by sodium valproate regulates polarization of macrophage subsets. DNA Cell Biol. 31, 592-599
-
(2012)
DNA Cell Biol
, vol.31
, pp. 592-599
-
-
Wu, C.1
Li, A.2
Leng, Y.3
Li, Y.4
Kang, J.5
-
112
-
-
0037022598
-
The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
-
Leoni, F., Zaliani, A., Bertolini, G., Porro, G., Pagani, P., Pozzi, P., Dona, G., Fossati, G., Sozzani, S., Azam, T. et al. (2002) The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines. Proc. Natl. Acad. Sci. U.S.A. 99, 2995-3000
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 2995-3000
-
-
Leoni, F.1
Zaliani, A.2
Bertolini, G.3
Porro, G.4
Pagani, P.5
Pozzi, P.6
Dona, G.7
Fossati, G.8
Sozzani, S.9
Azam, T.10
-
113
-
-
0033863238
-
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
-
Segain, J. P., Raingeard de la Bletiere, D., Bourreille, A., Leray, V., Gervois, N., Rosales, C., Ferrier, L., Bonnet, C., Blottiere, H. M. and Galmiche, J. P. (2000) Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease. Gut 47, 397-403
-
(2000)
Gut
, vol.47
, pp. 397-403
-
-
Segain, J.P.1
Raingeard de la Bletiere, D.2
Bourreille, A.3
Leray, V.4
Gervois, N.5
Rosales, C.6
Ferrier, L.7
Bonnet, C.8
Blottiere, H.M.9
Galmiche, J.P.10
-
114
-
-
0036212170
-
Butyrate inhibits NF-κB activation in lamina propria macrophages of patients with ulcerative colitis
-
Luhrs, H., Gerke, T., Muller, J. G., Melcher, R., Schauber, J., Boxberge, F., Scheppach, W. and Menzel, T. (2002) Butyrate inhibits NF-κB activation in lamina propria macrophages of patients with ulcerative colitis. Scand. J. Gastroenterol. 37, 458-466
-
(2002)
Scand. J. Gastroenterol.
, vol.37
, pp. 458-466
-
-
Luhrs, H.1
Gerke, T.2
Muller, J.G.3
Melcher, R.4
Schauber, J.5
Boxberge, F.6
Scheppach, W.7
Menzel, T.8
-
115
-
-
79957933972
-
Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat)
-
Furlan, A., Monzani, V., Reznikov, L. L., Leoni, F., Fossati, G., Modena, D., Mascagni, P. and Dinarello, C. A. (2011) Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat). Mol. Med. 17, 353-362
-
(2011)
Mol. Med.
, vol.17
, pp. 353-362
-
-
Furlan, A.1
Monzani, V.2
Reznikov, L.L.3
Leoni, F.4
Fossati, G.5
Modena, D.6
Mascagni, P.7
Dinarello, C.A.8
-
116
-
-
0035862199
-
The human histone deacetylase family
-
Gray, S. G. and Ekstrom, T. J. (2001) The human histone deacetylase family. Exp. Cell Res. 262, 75-83
-
(2001)
Exp. Cell Res.
, vol.262
, pp. 75-83
-
-
Gray, S.G.1
Ekstrom, T.J.2
-
117
-
-
0035212224
-
A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions
-
Nerup, J. and Pociot, F. (2001) A genomewide scan for type 1-diabetes susceptibility in Scandinavian families: identification of new loci with evidence of interactions. Am. J. Hum. Genet. 69, 1301-1313
-
(2001)
Am. J. Hum. Genet.
, vol.69
, pp. 1301-1313
-
-
Nerup, J.1
Pociot, F.2
-
118
-
-
0037692891
-
A genome-wide scan in type 2 diabetes mellitus provides independent replication of a susceptibility locus on 18p11 and suggests the existence of novel loci on 2q12 and 19q13
-
van Tilburg, J. H., Sandkuijl, L. A., Strengman, E., van Someren, H., Rigters-Aris, C. A., Pearson, P. L., van Haeften, T. W. and Wijmenga, C. (2003) A genome-wide scan in type 2 diabetes mellitus provides independent replication of a susceptibility locus on 18p11 and suggests the existence of novel loci on 2q12 and 19q13. J. Clin. Endocrinol. Metab. 88, 2223-2230
-
(2003)
J. Clin. Endocrinol. Metab.
, vol.88
, pp. 2223-2230
-
-
van Tilburg, J.H.1
Sandkuijl, L.A.2
Strengman, E.3
van Someren, H.4
Rigters-Aris, C.A.5
Pearson, P.L.6
van Haeften, T.W.7
Wijmenga, C.8
-
119
-
-
0038820063
-
Glucose regulates insulin gene transcription by hyperacetylation of histone h4
-
Mosley, A. L. and Ozcan, S. (2003) Glucose regulates insulin gene transcription by hyperacetylation of histone h4. J. Biol. Chem. 278, 19660-19666
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19660-19666
-
-
Mosley, A.L.1
Ozcan, S.2
-
120
-
-
0038607422
-
Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic β cells
-
Chakrabarti, S. K., Francis, J., Ziesmann, S. M., Garmey, J. C. and Mirmira, R. G. (2003) Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic β cells. J. Biol. Chem. 278, 23617-23623
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 23617-23623
-
-
Chakrabarti, S.K.1
Francis, J.2
Ziesmann, S.M.3
Garmey, J.C.4
Mirmira, R.G.5
-
121
-
-
79957944601
-
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus
-
Christensen, D. P., Dahllof, M., Lundh, M., Rasmussen, D. N., Nielsen, M. D., Billestrup, N., Grunnet, L. G. and Mandrup-Poulsen, T. (2011) Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Mol. Med. 17, 378-390
-
(2011)
Mol. Med.
, vol.17
, pp. 378-390
-
-
Christensen, D.P.1
Dahllof, M.2
Lundh, M.3
Rasmussen, D.N.4
Nielsen, M.D.5
Billestrup, N.6
Grunnet, L.G.7
Mandrup-Poulsen, T.8
-
122
-
-
4544233448
-
Glucose regulation of insulin gene expression requires the recruitment of p300 by the β-cell-specific transcription factor Pdx-1
-
Mosley, A. L., Corbett, J. A. and Ozcan, S. (2004) Glucose regulation of insulin gene expression requires the recruitment of p300 by the β-cell-specific transcription factor Pdx-1. Mol. Endocrinol. 18, 2279-2290
-
(2004)
Mol. Endocrinol.
, vol.18
, pp. 2279-2290
-
-
Mosley, A.L.1
Corbett, J.A.2
Ozcan, S.3
-
123
-
-
33847393267
-
Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets
-
Evans-Molina, C., Garmey, J. C., Ketchum, R., Brayman, K. L., Deng, S. and Mirmira, R. G. (2007) Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets. Diabetes 56, 827-835
-
(2007)
Diabetes
, vol.56
, pp. 827-835
-
-
Evans-Molina, C.1
Garmey, J.C.2
Ketchum, R.3
Brayman, K.L.4
Deng, S.5
Mirmira, R.G.6
-
124
-
-
0036134978
-
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47
-
Qiu, Y., Guo, M., Huang, S. and Stein, R. (2002) Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol. Cell. Biol. 22, 412-420
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 412-420
-
-
Qiu, Y.1
Guo, M.2
Huang, S.3
Stein, R.4
-
125
-
-
0031943003
-
p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene
-
Qiu, Y., Sharma, A. and Stein, R. (1998) p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol. Cell. Biol. 18, 2957-2964
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 2957-2964
-
-
Qiu, Y.1
Sharma, A.2
Stein, R.3
-
126
-
-
11144237178
-
The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose
-
Mosley, A. L. and Ozcan, S. (2004) The pancreatic duodenal homeobox-1 protein (Pdx-1) interacts with histone deacetylases Hdac-1 and Hdac-2 on low levels of glucose. J. Biol. Chem. 279, 54241-54247
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 54241-54247
-
-
Mosley, A.L.1
Ozcan, S.2
-
127
-
-
80755168896
-
Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9
-
Lenoir, O., Flosseau, K., Ma, F. X., Blondeau, B., Mai, A., Bassel-Duby, R., Ravassard, P., Olson, E. N., Haumaitre, C. and Scharfmann, R. (2011) Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9. Diabetes 60, 2861-2871
-
(2011)
Diabetes
, vol.60
, pp. 2861-2871
-
-
Lenoir, O.1
Flosseau, K.2
Ma, F.X.3
Blondeau, B.4
Mai, A.5
Bassel-Duby, R.6
Ravassard, P.7
Olson, E.N.8
Haumaitre, C.9
Scharfmann, R.10
-
128
-
-
84862726998
-
Inhibition of histone deacetylase 3 protects β cells from cytokine-induced apoptosis
-
Chou, D. H., Holson, E. B., Wagner, F. F., Tang, A. J., Maglathlin, R. L., Lewis, T. A., Schreiber, S. L. and Wagner, B. K. (2012) Inhibition of histone deacetylase 3 protects β cells from cytokine-induced apoptosis. Chem. Biol. 19, 669-673
-
(2012)
Chem. Biol.
, vol.19
, pp. 669-673
-
-
Chou, D.H.1
Holson, E.B.2
Wagner, F.F.3
Tang, A.J.4
Maglathlin, R.L.5
Lewis, T.A.6
Schreiber, S.L.7
Wagner, B.K.8
-
129
-
-
79957949655
-
The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro
-
Lewis, E. C., Blaabjerg, L., Storling, J., Ronn, S. G., Mascagni, P., Dinarello, C. A. and Mandrup-Poulsen, T. (2011) The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro. Mol. Med. 17, 369-377
-
(2011)
Mol. Med.
, vol.17
, pp. 369-377
-
-
Lewis, E.C.1
Blaabjerg, L.2
Storling, J.3
Ronn, S.G.4
Mascagni, P.5
Dinarello, C.A.6
Mandrup-Poulsen, T.7
-
130
-
-
70349152864
-
A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells
-
Susick, L., Senanayake, T., Veluthakal, R., Woster, P. M. and Kowluru, A. (2009) A novel histone deacetylase inhibitor prevents IL-1β induced metabolic dysfunction in pancreatic β-cells. J. Cell. Mol. Med. 13, 1877-1885
-
(2009)
J. Cell. Mol. Med.
, vol.13
, pp. 1877-1885
-
-
Susick, L.1
Senanayake, T.2
Veluthakal, R.3
Woster, P.M.4
Kowluru, A.5
-
131
-
-
77953860649
-
The role of epigenetics in the pathology of diabetic complications
-
Villeneuve, L. M. and Natarajan, R. (2010) The role of epigenetics in the pathology of diabetic complications. Am. J. Physiol. Renal. Physiol. 299, F14-F25
-
(2010)
Am. J. Physiol. Renal. Physiol.
, vol.299
-
-
Villeneuve, L.M.1
Natarajan, R.2
-
132
-
-
77955896784
-
Inhibition of histone deacetylase protects the retina from ischemic injury
-
Crosson, C. E., Mani, S. K., Husain, S., Alsarraf, O. and Menick, D. R. (2010) Inhibition of histone deacetylase protects the retina from ischemic injury. Invest. Ophthalmol. Visual Sci. 51, 3639-3645
-
(2010)
Invest. Ophthalmol. Visual Sci.
, vol.51
, pp. 3639-3645
-
-
Crosson, C.E.1
Mani, S.K.2
Husain, S.3
Alsarraf, O.4
Menick, D.R.5
-
133
-
-
79955384015
-
Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation
-
Zhang, J., Henagan, T. M., Gao, Z. and Ye, J. (2011) Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. Endocrinology 152, 1829-1838
-
(2011)
Endocrinology
, vol.152
, pp. 1829-1838
-
-
Zhang, J.1
Henagan, T.M.2
Gao, Z.3
Ye, J.4
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