-
1
-
-
37849019672
-
Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors
-
Khan N, Jeffers M, Kumar S, et al. Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors. Biochem J. 2008 409 : 581 589.
-
(2008)
Biochem J.
, vol.409
, pp. 581-589
-
-
Khan, N.1
Jeffers, M.2
Kumar, S.3
-
2
-
-
43049129992
-
Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors
-
Varghese S, Senanayake T, Murray-Stewart T, et al. Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors. J Med Chem. 2008 51 : 2447 2456.
-
(2008)
J Med Chem.
, vol.51
, pp. 2447-2456
-
-
Varghese, S.1
Senanayake, T.2
Murray-Stewart, T.3
-
3
-
-
33846813964
-
Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells
-
Baradari V, Huether A, Hopfner M, et al. Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal neuroendocrine tumor cells. Endocr Relat Cancer. 2006 13 : 1237 1250.
-
(2006)
Endocr Relat Cancer.
, vol.13
, pp. 1237-1250
-
-
Baradari, V.1
Huether, A.2
Hopfner, M.3
-
4
-
-
20444446595
-
Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis
-
Camelo S, Iglesias AH, Hwang D, et al. Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis. J Neuroimmunol. 2005 164 : 10 21.
-
(2005)
J Neuroimmunol.
, vol.164
, pp. 10-21
-
-
Camelo, S.1
Iglesias, A.H.2
Hwang, D.3
-
5
-
-
33845810433
-
Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: The essential role of the mitochondria-mediated caspase activation cascade
-
Reddy RM, Yeow WS, Chua A, et al. Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. Apoptosis. 2007 12 : 55 71.
-
(2007)
Apoptosis.
, vol.12
, pp. 55-71
-
-
Reddy, R.M.1
Yeow, W.S.2
Chua, A.3
-
6
-
-
33751100367
-
TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome
-
Taghiyev AF, Guseva NV, Glover RA, et al. TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome. Cancer Biol Ther. 2006 5 : 1199 1205.
-
(2006)
Cancer Biol Ther.
, vol.5
, pp. 1199-1205
-
-
Taghiyev, A.F.1
Guseva, N.V.2
Glover, R.A.3
-
7
-
-
34247227700
-
Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients
-
Huber LC, Brock M, Hemmatazad H, et al. Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients. Arthritis Rheum. 2007 56 : 1087 1093.
-
(2007)
Arthritis Rheum.
, vol.56
, pp. 1087-1093
-
-
Huber, L.C.1
Brock, M.2
Hemmatazad, H.3
-
8
-
-
34047210698
-
Anti- rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents
-
Lin HS, Hu CY, Chan HY, et al. Anti- rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents. Br J Pharmacol. 2007 150 : 862 872.
-
(2007)
Br J Pharmacol.
, vol.150
, pp. 862-872
-
-
Lin, H.S.1
Hu, C.Y.2
Chan, H.Y.3
-
9
-
-
33750496904
-
Targeting histone deacetylases for the treatment of cancer and inflammatory diseases
-
Huang L. Targeting histone deacetylases for the treatment of cancer and inflammatory diseases. J Cell Physiol. 2006 209 : 611 616.
-
(2006)
J Cell Physiol.
, vol.209
, pp. 611-616
-
-
Huang, L.1
-
10
-
-
13544265432
-
Histone deacetylase inhibitors: New drugs for the treatment of inflammatory diseases
-
Blanchard F, Chipoy C. Histone deacetylase inhibitors: new drugs for the treatment of inflammatory diseases Drug Discov Today. 2005 10 : 197 204.
-
(2005)
Drug Discov Today.
, vol.10
, pp. 197-204
-
-
Blanchard, F.1
Chipoy, C.2
-
11
-
-
0038607422
-
Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells
-
Chakrabarti SK, Francis J, Ziesmann SM, et al. Covalent histone modifications underlie the developmental regulation of insulin gene transcription in pancreatic beta cells. J Biol Chem. 2003 278 : 23617 23623.
-
(2003)
J Biol Chem.
, vol.278
, pp. 23617-23623
-
-
Chakrabarti, S.K.1
Francis, J.2
Ziesmann, S.M.3
-
12
-
-
4544233448
-
Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1
-
Mosley AL, Corbett JA, Ozcan S. Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1. Mol Endocrinol. 2004 18 : 2279 2290.
-
(2004)
Mol Endocrinol.
, vol.18
, pp. 2279-2290
-
-
Mosley, A.L.1
Corbett, J.A.2
Ozcan, S.3
-
13
-
-
0038820063
-
Glucose regulates insulin gene transcription by hyperacetylation of histone H4
-
Mosley AL, Ozcan S. Glucose regulates insulin gene transcription by hyperacetylation of histone H4. J Biol Chem. 2003 278 : 19660 19666.
-
(2003)
J Biol Chem.
, vol.278
, pp. 19660-19666
-
-
Mosley, A.L.1
Ozcan, S.2
-
14
-
-
33847676166
-
Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells
-
Larsen L, Tonnesen M, Ronn SG, et al. Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells. Diabetologia. 2007 50 : 779 789.
-
(2007)
Diabetologia.
, vol.50
, pp. 779-789
-
-
Larsen, L.1
Tonnesen, M.2
Ronn, S.G.3
-
15
-
-
54149099810
-
Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells
-
Susick L, Veluthakal R, Suresh MV, et al. Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells. J Cell Mol Med. 2008 12 : 1571 1583.
-
(2008)
J Cell Mol Med.
, vol.12
, pp. 1571-1583
-
-
Susick, L.1
Veluthakal, R.2
Suresh, M.V.3
-
16
-
-
26444441453
-
Alkyl-substituted polyaminohydroxamic acids: A novel class of targeted histone deacetylase inhibitors
-
Varghese S, Gupta D, Baran T, et al. Alkyl-substituted polyaminohydroxamic acids: a novel class of targeted histone deacetylase inhibitors. J Med Chem. 2005 48 : 6350 6365.
-
(2005)
J Med Chem.
, vol.48
, pp. 6350-6365
-
-
Varghese, S.1
Gupta, D.2
Baran, T.3
-
17
-
-
33947301430
-
Biologically active lipids promote trafficking and membrane association of Rac1 in insulin-secreting INS 832/13 cells
-
McDonald P, Veluthakal R, Kaur H, et al. Biologically active lipids promote trafficking and membrane association of Rac1 in insulin-secreting INS 832/13 cells. Am J Physiol Cell Physiol. 2007 292 : C1216 20.
-
(2007)
Am J Physiol Cell Physiol.
, vol.292
, pp. 1216-1220
-
-
McDonald, P.1
Veluthakal, R.2
Kaur, H.3
-
18
-
-
33847042302
-
Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells
-
Veluthakal R, Kaur H, Goalstone M, et al. Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells. Diabetes. 2007 56 : 204 210.
-
(2007)
Diabetes
, vol.56
, pp. 204-210
-
-
Veluthakal, R.1
Kaur, H.2
Goalstone, M.3
-
19
-
-
0141888306
-
Novel roles for palmitoylation of Ras in IL-1 beta-induced nitric oxide release and caspase 3 activation in insulin-secreting beta cells
-
Chen HQ, Tannous M, Veluthakal R, et al. Novel roles for palmitoylation of Ras in IL-1 beta-induced nitric oxide release and caspase 3 activation in insulin-secreting beta cells. Biochem Pharmacol. 2003 66 : 1681 1694.
-
(2003)
Biochem Pharmacol.
, vol.66
, pp. 1681-1694
-
-
Chen, H.Q.1
Tannous, M.2
Veluthakal, R.3
-
20
-
-
0035584412
-
Positive modulation by Ras of interleukin-1beta-mediated nitric oxide generation in insulin-secreting clonal beta (HIT-T15) cells
-
Tannous M, Amin R, Popoff MR, et al. Positive modulation by Ras of interleukin-1beta-mediated nitric oxide generation in insulin-secreting clonal beta (HIT-T15) cells. Biochem Pharmacol. 2001 62 : 1459 1468.
-
(2001)
Biochem Pharmacol.
, vol.62
, pp. 1459-1468
-
-
Tannous, M.1
Amin, R.2
Popoff, M.R.3
-
22
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976 72 : 248 254.
-
(1976)
Anal Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
23
-
-
0035668779
-
A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis
-
Eizirik DL, Mandrup-Poulsen T. A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia. 2001 44 : 2115 2133.
-
(2001)
Diabetologia.
, vol.44
, pp. 2115-2133
-
-
Eizirik, D.L.1
Mandrup-Poulsen, T.2
-
24
-
-
0029817047
-
The role of interleukin-1 in the pathogenesis of IDDM
-
Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia. 1996 39 : 1005 1029.
-
(1996)
Diabetologia.
, vol.39
, pp. 1005-1029
-
-
Mandrup-Poulsen, T.1
-
25
-
-
0032523104
-
Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus
-
Rabinovitch A, Suarez-Pinzon WL. Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Biochem Pharmacol. 1998 55 : 1139 1149.
-
(1998)
Biochem Pharmacol.
, vol.55
, pp. 1139-1149
-
-
Rabinovitch, A.1
Suarez-Pinzon, W.L.2
-
26
-
-
0036211013
-
Histone acetylation: A switch between repressive and permissive chromatin. Second in review series on chromatin dynamics
-
Eberharter A, Becker PB. Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics. EMBO Rep. 2002 3 : 224 229.
-
(2002)
EMBO Rep.
, vol.3
, pp. 224-229
-
-
Eberharter, A.1
Becker, P.B.2
-
27
-
-
0037072601
-
Molecular biology. Chromatin higher order folding-wrapping up transcription
-
Horn PJ, Peterson CL. Molecular biology. Chromatin higher order folding-wrapping up transcription. Science. 2002 297 : 1824 1827.
-
(2002)
Science
, vol.297
, pp. 1824-1827
-
-
Horn, P.J.1
Peterson, C.L.2
-
28
-
-
78651162036
-
Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis
-
Allfrey VG, Faulkner R, Mirsky AE. Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis. Proc Natl Acad Sci U S A. 1964 51 : 786 794.
-
(1964)
Proc Natl Acad Sci U S A.
, vol.51
, pp. 786-794
-
-
Allfrey, V.G.1
Faulkner, R.2
Mirsky, A.E.3
-
29
-
-
15744385061
-
Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation
-
Wang R, Cherukuri P, Luo J. Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation. J Biol Chem. 2005 280 : 11528 11534.
-
(2005)
J Biol Chem.
, vol.280
, pp. 11528-11534
-
-
Wang, R.1
Cherukuri, P.2
Luo, J.3
-
30
-
-
12244251445
-
Stat3 dimerization regulated by reversible acetylation of a single lysine residue
-
Yuan ZL, Guan YJ, Chatterjee D, et al. Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science. 2005 307 : 269 273.
-
(2005)
Science
, vol.307
, pp. 269-273
-
-
Yuan, Z.L.1
Guan, Y.J.2
Chatterjee, D.3
-
31
-
-
36849002449
-
The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression
-
Zhang Y, Sif S, DeWille J. The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression. J Cell Biochem. 2007 102 : 1256 1270.
-
(2007)
J Cell Biochem.
, vol.102
, pp. 1256-1270
-
-
Zhang, Y.1
Sif, S.2
Dewille, J.3
-
32
-
-
33750309635
-
Regulation of inducible nitric oxide synthase expression by viral A238L-mediated inhibition of p65/RelA acetylation and p300 transactivation
-
Granja AG, Sabina P, Salas ML, et al. Regulation of inducible nitric oxide synthase expression by viral A238L-mediated inhibition of p65/RelA acetylation and p300 transactivation. J Virol. 2006 80 : 10487 10496.
-
(2006)
J Virol.
, vol.80
, pp. 10487-10496
-
-
Granja, A.G.1
Sabina, P.2
Salas, M.L.3
-
33
-
-
34447509891
-
Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: Comparison with tumor necrosis factor alpha
-
Horion J, Gloire G, El Mjiyad N, et al. Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha. J Biol Chem. 2007 282 : 15383 15393.
-
(2007)
J Biol Chem.
, vol.282
, pp. 15383-15393
-
-
Horion, J.1
Gloire, G.2
El Mjiyad, N.3
-
34
-
-
13944274571
-
Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding
-
Hu J, Colburn NH. Histone deacetylase inhibition down-regulates cyclin D1 transcription by inhibiting nuclear factor-kappaB/p65 DNA binding. Mol Cancer Res. 2005 3 : 100 109.
-
(2005)
Mol Cancer Res.
, vol.3
, pp. 100-109
-
-
Hu, J.1
Colburn, N.H.2
-
35
-
-
0026755720
-
Interleukin-1 beta induces the expression of an isoform of nitric oxide synthase in insulin-producing cells, which is similar to that observed in activated macrophages
-
Eizirik DL, Cagliero E, Bjorklund A, et al. Interleukin-1 beta induces the expression of an isoform of nitric oxide synthase in insulin-producing cells, which is similar to that observed in activated macrophages. FEBS Lett. 1992 308 : 249 252.
-
(1992)
FEBS Lett.
, vol.308
, pp. 249-252
-
-
Eizirik, D.L.1
Cagliero, E.2
Bjorklund, A.3
-
36
-
-
0029665049
-
Cytokines activate the nuclear factor kappa B (NF-kappa B) and induce nitric oxide production in human pancreatic islets
-
Flodstrom M, Welsh N, Eizirik DL. Cytokines activate the nuclear factor kappa B (NF-kappa B) and induce nitric oxide production in human pancreatic islets. FEBS Lett. 1996 385 : 4 6.
-
(1996)
FEBS Lett.
, vol.385
, pp. 4-6
-
-
Flodstrom, M.1
Welsh, N.2
Eizirik, D.L.3
-
37
-
-
1642576221
-
Spatial distribution and temporal onset of NF-kB activation and inducible nitric oxide synthase within pancreatic islets in the pre-diabetic stage of genetic, diabetic-prone BB rats: Attenuation by drug intervention decreases inflammatory cell infiltration and incidence of diabetes
-
Pieper CM, Roza AM, Henderson JD, Jr., et al. Spatial distribution and temporal onset of NF-kB activation and inducible nitric oxide synthase within pancreatic islets in the pre-diabetic stage of genetic, diabetic-prone BB rats: attenuation by drug intervention decreases inflammatory cell infiltration and incidence of diabetes. Inflamm Res. 2004 53 : 22 30.
-
(2004)
Inflamm Res.
, vol.53
, pp. 22-30
-
-
Pieper, C.M.1
Roza, A.M.2
Henderson Jr., J.D.3
-
38
-
-
0036067845
-
Histone deacetylases augment cytokine induction of the iNOS gene
-
Yu Z, Zhang W, Kone BC. Histone deacetylases augment cytokine induction of the iNOS gene. J Am Soc Nephrol. 2002 13 : 2009 2017.
-
(2002)
J Am Soc Nephrol.
, vol.13
, pp. 2009-2017
-
-
Yu, Z.1
Zhang, W.2
Kone, B.C.3
-
39
-
-
35348974994
-
Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes
-
Wang J, Mahmud SA, Bitterman PB, et al. Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes. J Biol Chem. 2007 282 : 28408 28418.
-
(2007)
J Biol Chem.
, vol.282
, pp. 28408-28418
-
-
Wang, J.1
Mahmud, S.A.2
Bitterman, P.B.3
-
40
-
-
33644862022
-
Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells
-
Yu Z, Kone BC. Targeted histone H4 acetylation via phosphoinositide 3-kinase- and p70s6-kinase-dependent pathways inhibits iNOS induction in mesangial cells. Am J Physiol Renal Physiol. 2006 290 : F496 502.
-
(2006)
Am J Physiol Renal Physiol.
, vol.290
, pp. 496-502
-
-
Yu, Z.1
Kone, B.C.2
|