메뉴 건너뛰기




Volumn 97, Issue 8, 2010, Pages 917-935

Histone deacetylase inhibitors: Highlight on epigenetic regulation;Inhibiteurs des histone-désacétylases: La régulation épigénétique sort de l'ombre

Author keywords

Epigenetic regulation; Histone deacetylase; Molecular targeted therapy

Indexed keywords

ANTINEOPLASTIC AGENT; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR;

EID: 77956519074     PISSN: 00074551     EISSN: 17696917     Source Type: Journal    
DOI: 10.1684/bdc.2010.1121     Document Type: Review
Times cited : (7)

References (144)
  • 1
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
    • Baylin SH. DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 2000 ; 16 : 168-74.
    • (2000) Trends Genet , vol.16 , pp. 168-174
    • Baylin, S.H.1
  • 2
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • DOI 10.1101/gad.947102
    • Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 2002 ; 16 : 6-21. (Pubitemid 34049633)
    • (2002) Genes and Development , vol.16 , Issue.1 , pp. 6-21
    • Bird, A.1
  • 3
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg AP, Tycko B. The history of cancer epigenetics. Nat Rev Cancer 2004 ; 4 : 143-53.
    • (2004) Nat Rev Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 4
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T, Allis CD. Translating the histone code. Science 2001 ; 293 : 1074-80.
    • (2001) Science , vol.293 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 5
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002 ; 3 : 415-28.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 6
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl BD, Allis CD. The language of covalent histone modifications. Nature 2000 ; 403 : 41-5.
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 7
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in Cancer
    • Esteller M. Epigenetics in Cancer. N Engl J Med 2008 ; 358 : 1148-59.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 8
    • 85015069067 scopus 로고    scopus 로고
    • Controlling the double helix
    • Felsenfeld G, Groudine M. Controlling the double helix. Nature 2003 ; 421 : 448-53.
    • (2003) Nature , vol.421 , pp. 448-453
    • Felsenfeld, G.1    Groudine, M.2
  • 9
    • 0842324785 scopus 로고    scopus 로고
    • The nucleosome: From genomic organization to genomic regulation
    • Khorasanizadeh S. The nucleosome: from genomic organization to genomic regulation. Cell 2004 ; 116 : 259-72.
    • (2004) Cell , vol.116 , pp. 259-272
    • Khorasanizadeh, S.1
  • 10
    • 0036527775 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
    • Johnstone RW. Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov 2002 ; 1 : 287-99.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 287-299
    • Johnstone, R.W.1
  • 11
    • 0029693220 scopus 로고    scopus 로고
    • The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation
    • Van Lint C, Emiliani S, Verdin E. The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation. Gene Expr 1996 ; 5 : 245-53. (Pubitemid 126682821)
    • (1996) Gene Expression , vol.5 , Issue.4-5
    • Van Lint, C.1    Emiliani, S.2    Verdin, E.3
  • 12
    • 1842830815 scopus 로고    scopus 로고
    • Microarray profiling of effects of histone deacetylase inhibitors on gene expression in cancer cell lines
    • Gray SG, Qian CN, Furge K, et al. Microarray profiling of effects of histone deacetylase inhibitors on gene expression in cancer cell lines. Int J Oncol 2004 ; 24 : 773-95.
    • (2004) Int J Oncol , vol.24 , pp. 773-795
    • Gray, S.G.1    Qian, C.N.2    Furge, K.3
  • 13
    • 38649114059 scopus 로고    scopus 로고
    • Histone acetylation is not an accurate predictor of gene expression following treatment with histone deacetylase inhibitors
    • Ellis DJP, Lawman ZK, Bonham K. Histone acetylation is not an accurate predictor of gene expression following treatment with histone deacetylase inhibitors. Biochem Biophys Res Commun 2008 ; 367 : 656-62.
    • (2008) Biochem Biophys Res Commun , vol.367 , pp. 656-662
    • Ellis, D.J.P.1    Lawman, Z.K.2    Bonham, K.3
  • 14
  • 15
    • 36048958965 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Overview and perspectives
    • DOI 10.1158/1541-7786.MCR-07-0324
    • Dokmanovic M, Clarke C, Marks PA. Histone deacetylase inhibitors: overview and perspectives. Mol Cancer Res 2007 ; 5 : 981-9. (Pubitemid 350080267)
    • (2007) Molecular Cancer Research , vol.5 , Issue.10 , pp. 981-989
    • Dokmanovic, M.1    Clarke, C.2    Marks, P.A.3
  • 16
    • 49349107518 scopus 로고    scopus 로고
    • Lysine acetylation: Codified crosstalk with other posttranslational modifications
    • Yang XJ, Seto E. Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell 2008 ; 31 : 449-61.
    • (2008) Mol Cell , vol.31 , pp. 449-461
    • Yang, X.J.1    Seto, E.2
  • 17
    • 56049090769 scopus 로고    scopus 로고
    • Acetylation of non-histone proteins modulates cellular signalling at multiple levels
    • Spange S, Wagner T, Heinzel T, Kramer OH. Acetylation of non-histone proteins modulates cellular signalling at multiple levels. Int J Biochem Cell Biol 2009 ; 41 : 185-98.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 185-198
    • Spange, S.1    Wagner, T.2    Heinzel, T.3    Kramer, O.H.4
  • 19
    • 0024996768 scopus 로고
    • Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin a
    • Yoshida M, Kijima M, Akita M, Beppu T. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin. A. J Biol Chem 1990 ; 265 : 17174-9. (Pubitemid 20334262)
    • (1990) Journal of Biological Chemistry , vol.265 , Issue.28 , pp. 17174-17179
    • Yoshida, M.1    Kijima, M.2    Akita, M.3    Beppu, T.4
  • 20
    • 33751113602 scopus 로고    scopus 로고
    • Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction
    • Haigis MC, Guarente LP. Mammalian sirtuins-emerging roles in physiology, aging, and calorie restriction. Genes Dev 2006 ; 20 : 2913-21.
    • (2006) Genes Dev , vol.20 , pp. 2913-2921
    • Haigis, M.C.1    Guarente, L.P.2
  • 21
    • 39749127166 scopus 로고    scopus 로고
    • The Rpd3/Hda1 family of lysine deacetylases: From bacteria and yeast to mice and men
    • DOI 10.1038/nrm2346, PII NRM2346
    • Yang XJ, Seto E. The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol 2008 ; 9 : 206-18. (Pubitemid 351301825)
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , Issue.3 , pp. 206-218
    • Yang, X.-J.1    Seto, E.2
  • 22
    • 0033306577 scopus 로고    scopus 로고
    • Transcriptional repression by REST: Recruitment of Sin3A and histone deacetylase to neuronal genes
    • DOI 10.1038/13165
    • Huang Y, Myers SJ, Dingledine R. Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes. Nat Neurosci 1999 ; 2 : 867-72. (Pubitemid 30602598)
    • (1999) Nature Neuroscience , vol.2 , Issue.10 , pp. 867-872
    • Huang, Y.1    Myers, S.J.2    Dingledine, R.3
  • 23
    • 8344261349 scopus 로고    scopus 로고
    • Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
    • Vega RB, Matsuda K, Oh J, Barbosa AC, Yang X, Meadows E, et al. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 2004 ; 119 : 555-66.
    • (2004) Cell , vol.119 , pp. 555-566
    • Vega, R.B.1    Matsuda, K.2    Oh, J.3    Barbosa, A.C.4    Yang, X.5    Meadows, E.6
  • 24
    • 0037728615 scopus 로고    scopus 로고
    • HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis
    • DOI 10.1016/S1074-7613(03)00109-2
    • Dequiedt F, Kasler H, Fischle W, Kiermer V, Weinstein M, Herndier BG, et al. HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity 2003 ; 18 : 687-98. (Pubitemid 36588585)
    • (2003) Immunity , vol.18 , Issue.5 , pp. 687-698
    • Dequiedt, F.1    Kasler, H.2    Fischle, W.3    Kiermer, V.4    Weinstein, M.5    Herndier, B.G.6    Verdin, E.7
  • 27
    • 22844432021 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: A novel basis for antileukemia activity of histone deacetylase inhibitors
    • Bali P, Pranpat M, Bradner J, Balasis M, Fiskus W, Guo F, et al. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors. J Biol Chem 2005 ; 280 : 26729-34.
    • (2005) J Biol Chem , vol.280 , pp. 26729-26734
    • Bali, P.1    Pranpat, M.2    Bradner, J.3    Balasis, M.4    Fiskus, W.5    Guo, F.6
  • 28
    • 49649108912 scopus 로고    scopus 로고
    • Role of acetylation and extracellular location of heat shock protein 90 alpha in tumor cell invasion
    • Yang Y, Rao R, Shen J, Tang Y, Fiskus W, Nechtman J, et al. Role of acetylation and extracellular location of heat shock protein 90 alpha in tumor cell invasion. Cancer Res 2008 ; 68 : 4833-42.
    • (2008) Cancer Res , vol.68 , pp. 4833-4842
    • Yang, Y.1    Rao, R.2    Shen, J.3    Tang, Y.4    Fiskus, W.5    Nechtman, J.6
  • 29
    • 0034578389 scopus 로고    scopus 로고
    • Aggresomes, inclusion bodies and protein aggregation
    • Kopito RR. Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 2000 ; 10 : 524-30.
    • (2000) Trends Cell Biol , vol.10 , pp. 524-530
    • Kopito, R.R.1
  • 30
    • 34250183177 scopus 로고    scopus 로고
    • HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
    • Pandey UB. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 2007 ; 447 : 859-63.
    • (2007) Nature , vol.447 , pp. 859-863
    • Pandey, U.B.1
  • 31
    • 0346020435 scopus 로고    scopus 로고
    • The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
    • DOI 10.1016/S0092-8674(03)00939-5
    • Kawaguchi Y. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 2003 ; 115 : 727-38. (Pubitemid 38030301)
    • (2003) Cell , vol.115 , Issue.6 , pp. 727-738
    • Kawaguchi, Y.1    Kovacs, J.J.2    McLaurin, A.3    Vance, J.M.4    Ito, A.5    Yao, T.-P.6
  • 32
    • 67949102053 scopus 로고    scopus 로고
    • Recent progress in the biology and physiology of sirtuins
    • Finkel T, Deng CX, Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 2009 ; 460 : 587-91.
    • (2009) Nature , vol.460 , pp. 587-591
    • Finkel, T.1    Deng, C.X.2    Mostoslavsky, R.3
  • 34
    • 33646354640 scopus 로고    scopus 로고
    • A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition
    • Ropero S, Fraga MF, Ballestar E, Hamelin R, Yamamoto H, Boix-Chornet M, et al. A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Nat Genet 2006 ; 38 : 566-9.
    • (2006) Nat Genet , vol.38 , pp. 566-569
    • Ropero, S.1    Fraga, M.F.2    Ballestar, E.3    Hamelin, R.4    Yamamoto, H.5    Boix-Chornet, M.6
  • 35
    • 46249115065 scopus 로고    scopus 로고
    • Transforming pathways unleashed by a HDAC2 mutation in human cancer
    • DOI 10.1038/onc.2008.31, PII ONC200831
    • Ropero S, Ballestar E, Alaminos M, Arango D, Schwartz Jr. S, Esteller M. Transforming pathways unleashed by a HDAC2 mutation in human cancer. Oncogene 2008 ; 27 : 4008-12. (Pubitemid 351913637)
    • (2008) Oncogene , vol.27 , Issue.28 , pp. 4008-4012
    • Ropero, S.1    Ballestar, E.2    Alaminos, M.3    Arango, D.4    Schwartz Jr., S.5    Esteller, M.6
  • 37
    • 38549157208 scopus 로고    scopus 로고
    • Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: A retrospective analysis
    • Weichert W, Roske A, Gekeler V, Beckers T, Ebert MP, Pross M, et al. Association of patterns of class I histone deacetylase expression with patient prognosis in gastric cancer: a retrospective analysis. Lancet Oncol 2008 ; 9 : 139-48.
    • (2008) Lancet Oncol , vol.9 , pp. 139-148
    • Weichert, W.1    Roske, A.2    Gekeler, V.3    Beckers, T.4    Ebert, M.P.5    Pross, M.6
  • 38
    • 2342603414 scopus 로고    scopus 로고
    • Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis
    • DOI 10.1016/S1535-6108(04)00114-X, PII S153561080400114X
    • Zhu P, Martin E, Mengwasser J, Schlag P, Janssen KP, Gottlicher M. Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis. Cancer Cell 2004 ; 5 : 455-63. (Pubitemid 38610247)
    • (2004) Cancer Cell , vol.5 , Issue.5 , pp. 455-463
    • Zhu, P.1    Martin, E.2    Mengwasser, J.3    Schlag, P.4    Janssen, K.-P.5    Gottlicher, M.6
  • 39
    • 50049108874 scopus 로고    scopus 로고
    • Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma
    • Marquard L, Gjerdrum LM, Christensen IJ, Jensen PB, Sehested M, Ralfkiaer E. Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma. Histopathology 2008 ; 53 : 267-77.
    • (2008) Histopathology , vol.53 , pp. 267-277
    • Marquard, L.1    Gjerdrum, L.M.2    Christensen, I.J.3    Jensen, P.B.4    Sehested, M.5    Ralfkiaer, E.6
  • 40
    • 41549159879 scopus 로고    scopus 로고
    • Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: Specific role of class I histone deacetylases in vitro and in vivo
    • Weichert W, Roske A, Niesporek S, Noske A, Buckendahl AC, Dietel M, et al. Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin Cancer Res 2008 ; 14 : 1669-77.
    • (2008) Clin Cancer Res , vol.14 , pp. 1669-1677
    • Weichert, W.1    Roske, A.2    Niesporek, S.3    Noske, A.4    Buckendahl, A.C.5    Dietel, M.6
  • 41
    • 38949086502 scopus 로고    scopus 로고
    • Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
    • Weichert W, Roske A, Gekeler V, Beckers T, Stephan C, Jung K, et al. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. Br J Cancer 2008 ; 98 : 604-10.
    • (2008) Br J Cancer , vol.98 , pp. 604-610
    • Weichert, W.1    Roske, A.2    Gekeler, V.3    Beckers, T.4    Stephan, C.5    Jung, K.6
  • 42
    • 16844385708 scopus 로고    scopus 로고
    • Histone deacetylase-1 and -3 protein expression in human breast cancer: A tissue microarray analysis
    • Krusche CA, Wulfing P, Kersting C, Vloet A, Bocker W, Kiesel L, et al. Histone deacetylase-1 and -3 protein expression in human breast cancer: a tissue microarray analysis. Cancer Res Treat 2005 ; 90 : 15-23.
    • (2005) Cancer Res Treat , vol.90 , pp. 15-23
    • Krusche, C.A.1    Wulfing, P.2    Kersting, C.3    Vloet, A.4    Bocker, W.5    Kiesel, L.6
  • 43
    • 40449132791 scopus 로고    scopus 로고
    • Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling
    • Bicaku E, Marchion DC, Schmitt ML, Munster PN. Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer Res 2008 ; 68 : 1513-9.
    • (2008) Cancer Res , vol.68 , pp. 1513-1519
    • Bicaku, E.1    Marchion, D.C.2    Schmitt, M.L.3    Munster, P.N.4
  • 44
    • 18744375998 scopus 로고    scopus 로고
    • Regulation and destabilization of HIF-1 alpha by ARD1-mediated acetylation
    • Jeong JW, Bae MK, Ahn MY, Kim SH, Sohn TK, Bae MH, et al. Regulation and destabilization of HIF-1 alpha by ARD1-mediated acetylation. Cell 2002 ; 111 : 709-20.
    • (2002) Cell , vol.111 , pp. 709-720
    • Jeong, J.W.1    Bae, M.K.2    Ahn, M.Y.3    Kim, S.H.4    Sohn, T.K.5    Bae, M.H.6
  • 45
    • 34547864236 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Molecular mechanisms of action
    • Xu WS, Parmigiani RB, Marks PA. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene 2007 ; 37 : 5541-52.
    • (2007) Oncogene , vol.37 , pp. 5541-5552
    • Xu, W.S.1    Parmigiani, R.B.2    Marks, P.A.3
  • 46
    • 67650296574 scopus 로고    scopus 로고
    • Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities
    • Dedes KJ, Dedes I, Imesch P, et al. Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities. Anticancer Drugs 2009 ; 20 : 321-33.
    • (2009) Anticancer Drugs , vol.20 , pp. 321-333
    • Dedes, K.J.1    Dedes, I.2    Imesch, P.3
  • 47
    • 12444321545 scopus 로고    scopus 로고
    • Phase I clinical trial of histone deacatylase inhibitor: Suberoylanilide hydroxamic acid administered intravenously
    • Kelly WK, Richon VM, O'Connor O, et al. Phase I clinical trial of histone deacatylase inhibitor: suberoylanilide hydroxamic acid administered intravenously. Clin Cancer Res 2003 ; 9 : 3578-88.
    • (2003) Clin Cancer Res , vol.9 , pp. 3578-3588
    • Kelly, W.K.1    Richon, V.M.2    O'Connor, O.3
  • 48
    • 21244464349 scopus 로고    scopus 로고
    • Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer
    • Kelly WK, O'Connor O, Krug LM, Chiao JH, Heaney M, Curley T, et al. Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer. J Clin Oncol 2005 ; 23 : 3923-31.
    • (2005) J Clin Oncol , vol.23 , pp. 3923-3931
    • Kelly, W.K.1    O'Connor, O.2    Krug, L.M.3    Chiao, J.H.4    Heaney, M.5    Curley, T.6
  • 49
    • 33845996135 scopus 로고    scopus 로고
    • Phase II trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
    • Duvic M, Talpur R, Ni X, Zhang C, Hazarika P, Kelly C, et al. Phase II trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 2007 ; 109 : 31-9.
    • (2007) Blood , vol.109 , pp. 31-39
    • Duvic, M.1    Talpur, R.2    Ni, X.3    Zhang, C.4    Hazarika, P.5    Kelly, C.6
  • 50
    • 34547683194 scopus 로고    scopus 로고
    • Phase IIB multicenter trial of vorinostat in patients with persistent, progressive or treatment refractory cutaneous T-cell lymphoma
    • Olsen EA, Kim YH, Kuzel TM, Pacheco TR, Foss FM, Parker S, et al. Phase IIB multicenter trial of vorinostat in patients with persistent, progressive or treatment refractory cutaneous T-cell lymphoma. J Clin Oncol 2007 ; 25 : 3109-15.
    • (2007) J Clin Oncol , vol.25 , pp. 3109-3115
    • Olsen, E.A.1    Kim, Y.H.2    Kuzel, T.M.3    Pacheco, T.R.4    Foss, F.M.5    Parker, S.6
  • 51
    • 38949096781 scopus 로고    scopus 로고
    • Phase I study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid, [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
    • Garcia-Manero G, Yang H, Buesos-Ramos C, Al E. Phase I study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid, [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes. Blood 2008 ; 111 : 1060-6.
    • (2008) Blood , vol.111 , pp. 1060-1066
    • Garcia-Manero, G.1    Yang, H.2    Buesos-Ramos, C.3    Al, E.4
  • 52
    • 79951840479 scopus 로고    scopus 로고
    • A phase II study of vorinostat (suberoylanilide hydroxamic acid, SAHA) in relapsed or refractory indolent non-hodgkin's lymphoma. A California Cancer Consortium study
    • abstract
    • Kirschbaum MH, Popplewell L, Nademanee A, Pullakart V, Delioukina M, Zain J, et al. A phase II study of vorinostat (suberoylanilide hydroxamic acid, SAHA) in relapsed or refractory indolent non-hodgkin's lymphoma. A California Cancer Consortium study [abstract]. Haematologica 2009 ; 94(Suppl 2) : 0409.
    • (2009) Haematologica , vol.94 , Issue.SUPPL. 2 , pp. 0409
    • Kirschbaum, M.H.1    Popplewell, L.2    Nademanee, A.3    Pullakart, V.4    Delioukina, M.5    Zain, J.6
  • 53
    • 67649399669 scopus 로고    scopus 로고
    • Vorinostat (NSC# 701852) in patients with relapsed non-small lung cancer: A Wisconsin Oncology Network phase II study
    • Traynor AM, Dubey S, Eickhoff JC, Kolesar JM, Schell K, Huie MS, et al. Vorinostat (NSC# 701852) in patients with relapsed non-small lung cancer: a Wisconsin Oncology Network phase II study. J Thorac Oncol 2009 ; 4 : 522-6.
    • (2009) J Thorac Oncol , vol.4 , pp. 522-526
    • Traynor, A.M.1    Dubey, S.2    Eickhoff, J.C.3    Kolesar, J.M.4    Schell, K.5    Huie, M.S.6
  • 54
    • 50249095068 scopus 로고    scopus 로고
    • Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer
    • Vansteenkiste J, Van Custem E, Dumez H, Chen C, Ricker JL, Randolph SS, et al. Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer. Invest New Drugs 2008 ; 26 : 483-8.
    • (2008) Invest New Drugs , vol.26 , pp. 483-488
    • Vansteenkiste, J.1    Van Custem, E.2    Dumez, H.3    Chen, C.4    Ricker, J.L.5    Randolph, S.S.6
  • 55
    • 58149387609 scopus 로고    scopus 로고
    • Lack of therapeutic effect of the histone deacetylase inhibitor vorinostat in patients with metastatic radioiodine-refractory thyroid carcinoma
    • Woyach JA, Kloos RT, Ringel MD, Arbogast D, Collamore M, Zwiebel JA, et al. Lack of therapeutic effect of the histone deacetylase inhibitor vorinostat in patients with metastatic radioiodine-refractory thyroid carcinoma. J Clin Endocinol Metab 2009 ; 94 : 164-70.
    • (2009) J Clin Endocinol Metab , vol.94 , pp. 164-170
    • Woyach, J.A.1    Kloos, R.T.2    Ringel, M.D.3    Arbogast, D.4    Collamore, M.5    Zwiebel, J.A.6
  • 56
    • 65349141942 scopus 로고    scopus 로고
    • Phase II trial of vorinostat in recurrent gliblastoma multiforme: A north central cancer treatment group study
    • Galanis E, Jaeckle KA, Maurer MJ, Reid JM, Ames MM, Hardwick JS, et al. Phase II trial of vorinostat in recurrent gliblastoma multiforme: a north central cancer treatment group study. J Clin Oncol 2009 ; 27 : 2052-8.
    • (2009) J Clin Oncol , vol.27 , pp. 2052-2058
    • Galanis, E.1    Jaeckle, K.A.2    Maurer, M.J.3    Reid, J.M.4    Ames, M.M.5    Hardwick, J.S.6
  • 57
    • 58149242889 scopus 로고    scopus 로고
    • A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: A California Cancer Consortium study
    • Luu TH, Morgan RJ, Leong L, Lim D, McNamara M, Portnow J, et al. A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California Cancer Consortium study. Clin Cancer Res 2008 ; 14 : 7138-42.
    • (2008) Clin Cancer Res , vol.14 , pp. 7138-7142
    • Luu, T.H.1    Morgan, R.J.2    Leong, L.3    Lim, D.4    McNamara, M.5    Portnow, J.6
  • 58
    • 38149140216 scopus 로고    scopus 로고
    • Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza, suberoylanililide hydroxamic acid, SAHA) in patients with recurrent and/or metastasic head and neck cancer
    • Blumenschein GRJ, Kies MS, Papadimitrakopoulou VA, Lu C, Kumar AJ, Ricker JL, et al. Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza, suberoylanililide hydroxamic acid, SAHA) in patients with recurrent and/or metastasic head and neck cancer. Invest New Drugs 2008 ; 26 : 81-7.
    • (2008) Invest New Drugs , vol.26 , pp. 81-87
    • Blumenschein, G.R.J.1    Kies, M.S.2    Papadimitrakopoulou, V.A.3    Lu, C.4    Kumar, A.J.5    Ricker, J.L.6
  • 59
    • 43049091153 scopus 로고    scopus 로고
    • A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A Gynecologic Oncology Group study
    • Gynecologic Oncology Group
    • Modesitt SC, Sill M, Hoffman JS, Bender DP, Gynecologic Oncology Group. A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 2008 ; 109 : 182-6.
    • (2008) Gynecol Oncol , vol.109 , pp. 182-186
    • Modesitt, S.C.1    Sill, M.2    Hoffman, J.S.3    Bender, D.P.4
  • 60
    • 77956531988 scopus 로고    scopus 로고
    • Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862)
    • 9999 NA
    • Bradley D, Rathkopf D, Dunn R, Stadler WM, Liu G, Smith DC, et al. Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862). Cancer 2009 : 9999 NA.
    • (2009) Cancer
    • Bradley, D.1    Rathkopf, D.2    Dunn, R.3    Stadler, W.M.4    Liu, G.5    Smith, D.C.6
  • 61
    • 38949146399 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors
    • Steele NL, Plumb JA, Vidal L, Tjornelund J, Knoblauch P, Rasmussen A, et al. A phase I pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors. Clin Cancer Res 2008 ; 14 : 804-10.
    • (2008) Clin Cancer Res , vol.14 , pp. 804-810
    • Steele, N.L.1    Plumb, J.A.2    Vidal, L.3    Tjornelund, J.4    Knoblauch, P.5    Rasmussen, A.6
  • 62
    • 49349104503 scopus 로고    scopus 로고
    • A phase I clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced hematological neoplasia
    • Gimsing P, Hansen M, Knudsen LM, Knoblauch P, Christensen IJ, Ooi CE, et al. A phase I clinical trial of the histone deacetylase inhibitor belinostat in patients with advanced hematological neoplasia. Eur J Haematol 2008 ; 81 : 170-6.
    • (2008) Eur J Haematol , vol.81 , pp. 170-176
    • Gimsing, P.1    Hansen, M.2    Knudsen, L.M.3    Knoblauch, P.4    Christensen, I.J.5    Ooi, C.E.6
  • 63
    • 77954872326 scopus 로고    scopus 로고
    • Final results of a phase I study of oral belinostat (PXD101) in patients with solid tumors
    • Meeting Abstracts
    • Kelly WK, DeBono J, Blumenschein G, Lassen U, Zain J, O'Connor O, et al. Final results of a phase I study of oral belinostat (PXD101) in patients with solid tumors. J Clin Oncol 2009 ; 27 : 3531 (Meeting Abstracts).
    • (2009) J Clin Oncol , vol.27 , pp. 3531
    • Kelly, W.K.1    DeBono, J.2    Blumenschein, G.3    Lassen, U.4    Zain, J.5    O'Connor, O.6
  • 64
    • 77955641567 scopus 로고    scopus 로고
    • Final results of a phase I study of oral belinostat (PXD101) in patients with lymphoma
    • Meeting Abstracts
    • Zain JM, Foss F, Kelly WK, DeBono J, Petrylak D, Narwal A, et al. Final results of a phase I study of oral belinostat (PXD101) in patients with lymphoma. J Clin Oncol 2009 ; 27 : 8580 (Meeting Abstracts).
    • (2009) J Clin Oncol , vol.27 , pp. 8580
    • Zain, J.M.1    Foss, F.2    Kelly, W.K.3    DeBono, J.4    Petrylak, D.5    Narwal, A.6
  • 65
    • 76749115128 scopus 로고    scopus 로고
    • Phase II study of the histone deacetylase inhibitor belinostat in thymic malignancies
    • Meeting Abstracts
    • Giaccone G, Rajan A, Carter C, Kelly R, Berman A, Spittler J, et al. Phase II study of the histone deacetylase inhibitor belinostat in thymic malignancies. J Clin Oncol 2009 ; 27 : 7589 (Meeting Abstracts).
    • (2009) J Clin Oncol , vol.27 , pp. 7589
    • Giaccone, G.1    Rajan, A.2    Carter, C.3    Kelly, R.4    Berman, A.5    Spittler, J.6
  • 66
    • 33748063974 scopus 로고    scopus 로고
    • A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies
    • Giles F, Fischer T, Cortes J, Garcia-Manero G, Beck J, Ravandi F, et al. A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies. Clin Cancer Res 2006 ; 12 : 4628-35.
    • (2006) Clin Cancer Res , vol.12 , pp. 4628-4635
    • Giles, F.1    Fischer, T.2    Cortes, J.3    Garcia-Manero, G.4    Beck, J.5    Ravandi, F.6
  • 67
    • 38349187877 scopus 로고    scopus 로고
    • Clinically relevant QTc prolongation is not associated with current dose schedules of LBH589 (panobinostat)
    • discussion 333-4
    • Zhang L, Lebwohl D, Masson E, Laird G, Cooper MR, Prince HM, et al. Clinically relevant QTc prolongation is not associated with current dose schedules of LBH589 (panobinostat). J Clin Oncol 2008 ; 26 : 332-3 (discussion 333-4).
    • (2008) J Clin Oncol , vol.26 , pp. 332-333
    • Zhang, L.1    Lebwohl, D.2    Masson, E.3    Laird, G.4    Cooper, M.R.5    Prince, H.M.6
  • 68
    • 85031339896 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of once-weekly i.v. panobinostat (LBH589)
    • abstract
    • Sharma S, Vogelzang NJ, Beck J. Phase I pharmacokinetic and pharmacodynamic study of once-weekly i.v. panobinostat (LBH589) [abstract]. ECCO Annual Meeting Abstracts 2007.
    • ECCO Annual Meeting Abstracts 2007
    • Sharma, S.1    Vogelzang, N.J.2    Beck, J.3
  • 69
    • 43049088775 scopus 로고    scopus 로고
    • Phase I study of oral LBH589, a novel deacetylase (DAC) inhibitor in advanced solid tumors and non-hodgkin's lymphoma
    • abstract Meeting Abstracts
    • Prince HM, George D, Patnaik A. Phase I study of oral LBH589, a novel deacetylase (DAC) inhibitor in advanced solid tumors and non-hodgkin's lymphoma (abstract). J Clin Oncol 2007 ; 25 (Suppl 18) : 3500 (Meeting Abstracts).
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. 18 , pp. 3500
    • Prince, H.M.1    George, D.2    Patnaik, A.3
  • 70
    • 67449134299 scopus 로고    scopus 로고
    • Phase II trial of oral panobinostat (LBH589) in patients with refractory cutaneous T-cell lymphoma (CTCL) (abstract)
    • Duvic M, Becker JC, Dalle S. Phase II trial of oral panobinostat (LBH589) in patients with refractory cutaneous T-cell lymphoma (CTCL) (abstract). ASH Annual Meeting Abstracts 2008 ; 112 : 1005.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 1005
    • Duvic, M.1    Becker, J.C.2    Dalle, S.3
  • 71
    • 70349194470 scopus 로고    scopus 로고
    • Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin lymphoma
    • Dickinson M, Ritchie D, Deangelo DJ, Spencer A, Ottmann OG, Fischer T, et al. Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin lymphoma. Br J Haematol 2009 ; 147 : 97-101.
    • (2009) Br J Haematol , vol.147 , pp. 97-101
    • Dickinson, M.1    Ritchie, D.2    Deangelo, D.J.3    Spencer, A.4    Ottmann, O.G.5    Fischer, T.6
  • 72
    • 67449125357 scopus 로고    scopus 로고
    • A phase II study of oral panobinostat (LBH589) in adult patients with advanced refractory multiple myeloma
    • abstract
    • Wolf JL, Siegel D, Matous J. A phase II study of oral panobinostat (LBH589) in adult patients with advanced refractory multiple myeloma (abstract). ASH Annual Meeting Abstracts 2008 ; 112 : 2781.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 2781
    • Wolf, J.L.1    Siegel, D.2    Matous, J.3
  • 73
    • 85031332064 scopus 로고    scopus 로고
    • A phase I study of oral panobinostat (LBH589) in Japanese patients with advances solid tumors
    • abstract
    • Okamoto N, Hatake K, Yamamoto N. A phase I study of oral panobinostat (LBH589) in Japanese patients with advances solid tumors (abstract). EORTC-NCI-AACR Annual Meeting 2008.
    • EORTC-NCI-AACR Annual Meeting 2008
    • Okamoto, N.1    Hatake, K.2    Yamamoto, N.3
  • 74
    • 67449109154 scopus 로고    scopus 로고
    • Phase IA/II Study of Oral Panobinostat (LBH589), a novel pan-deacetylase inhibitor (DACi) demonstrating efficacy in patients with advanced heamatologic malignancies
    • abstract
    • Ottmann OG, Spencer A, Prince HM, Bhalla KN, Fischer T, Liu A, et al. Phase IA/II Study of Oral Panobinostat (LBH589), a novel pan-deacetylase inhibitor (DACi) demonstrating efficacy in patients with advanced heamatologic malignancies (abstract). ASH Annual Meeting Abstracts 2008 ; 112 : 958.
    • (2008) ASH Annual Meeting Abstracts , vol.112 , pp. 958
    • Ottmann, O.G.1    Spencer, A.2    Prince, H.M.3    Bhalla, K.N.4    Fischer, T.5    Liu, A.6
  • 75
    • 77956551464 scopus 로고    scopus 로고
    • Panobinostat (LBH589) pharmacokinetics (PK): Implication for clinical safety and efficacy
    • Woo MM, Culver K, Li W, Liu A, Scott JW, Parker K, et al. Panobinostat (LBH589) pharmacokinetics (PK): implication for clinical safety and efficacy. Ann Oncol 2008 ; 18 : 487P.
    • (2008) Ann Oncol , vol.18 , pp. 487
    • Woo, M.M.1    Culver, K.2    Li, W.3    Liu, A.4    Scott, J.W.5    Parker, K.6
  • 76
  • 77
    • 0036735385 scopus 로고    scopus 로고
    • FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases
    • Furumai R, Matsuyama A, Kobashi N, Lee KH, Nishiyama M, Nakajima H, et al. FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res 2002 ; 62 : 4916-21.
    • (2002) Cancer Res , vol.62 , pp. 4916-4921
    • Furumai, R.1    Matsuyama, A.2    Kobashi, N.3    Lee, K.H.4    Nishiyama, M.5    Nakajima, H.6
  • 78
    • 0036301281 scopus 로고    scopus 로고
    • Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms
    • Sandor V, Bakke S, Robey RW, Kang MH, Blagosklonny MV, Bender J, et al. Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms. Clin Cancer Res 2002 ; 8 : 718-28.
    • (2002) Clin Cancer Res , vol.8 , pp. 718-728
    • Sandor, V.1    Bakke, S.2    Robey, R.W.3    Kang, M.H.4    Blagosklonny, M.V.5    Bender, J.6
  • 80
    • 77956522476 scopus 로고    scopus 로고
    • Systematic assessment of potential cardiac effects of the novel histone deacetylase (HDAC) inhibitor romidepsin
    • Meeting Abstracts
    • Cabell C, Bates S, Piekarz R, Whittaker S, Kim Y, Godfrey C, et al. Systematic assessment of potential cardiac effects of the novel histone deacetylase (HDAC) inhibitor romidepsin. J Clin Oncol 2009 ; 27 : 19533 (Meeting Abstracts).
    • (2009) J Clin Oncol , vol.27 , pp. 19533
    • Cabell, C.1    Bates, S.2    Piekarz, R.3    Whittaker, S.4    Kim, Y.5    Godfrey, C.6
  • 81
    • 33746035691 scopus 로고    scopus 로고
    • Cardiotoxicity of histone deacetylase inhibitor depsipeptide in patients with metastatic neuroendocrine tumors
    • Shah MH, Binkley P, Chan K, Xiao J, Arbogast D, Collamore M, et al. Cardiotoxicity of histone deacetylase inhibitor depsipeptide in patients with metastatic neuroendocrine tumors. Clin Cancer Res 2006 ; 12 : 3997-4003.
    • (2006) Clin Cancer Res , vol.12 , pp. 3997-4003
    • Shah, M.H.1    Binkley, P.2    Chan, K.3    Xiao, J.4    Arbogast, D.5    Collamore, M.6
  • 82
    • 33746080897 scopus 로고    scopus 로고
    • Challenges of evaluating the cardiac effects of anticancer agents
    • Bates SE, Rosing DR, Fojo T, Piekarz RL. Challenges of evaluating the cardiac effects of anticancer agents. Clin Cancer Res 2006 ; 12 : 3871-4.
    • (2006) Clin Cancer Res , vol.12 , pp. 3871-3874
    • Bates, S.E.1    Rosing, D.R.2    Fojo, T.3    Piekarz, R.L.4
  • 83
    • 70549105748 scopus 로고    scopus 로고
    • Phase II, two-stage, single-arm trial of the histone deacetylase inhibitor (HDACi) romidepsin in metastatic castration-resistant prostate cancer (CRPC)
    • Molife LR, Attard G, Fong PC, Karavasilis V, Reid AH, Patterson S, et al. Phase II, two-stage, single-arm trial of the histone deacetylase inhibitor (HDACi) romidepsin in metastatic castration-resistant prostate cancer (CRPC). Ann Oncol 2010 ; 21 : 109-13.
    • (2010) Ann Oncol , vol.21 , pp. 109-113
    • Molife, L.R.1    Attard, G.2    Fong, P.C.3    Karavasilis, V.4    Reid, A.H.5    Patterson, S.6
  • 85
    • 68649119641 scopus 로고    scopus 로고
    • Phase II trial of romidepsin (NSC-630176) in previously treated colorectal cancer patients with advanced disease: A Southwest Oncology Group study (S0336)
    • Whitehead RP, Rankin C, Hoff PM, Gold PJ, Billingsley KG, Chapman RA, et al. Phase II trial of romidepsin (NSC-630176) in previously treated colorectal cancer patients with advanced disease: a Southwest Oncology Group study (S0336). Invest New Drugs 2008 ; 27 : 469-75.
    • (2008) Invest New Drugs , vol.27 , pp. 469-475
    • Whitehead, R.P.1    Rankin, C.2    Hoff, P.M.3    Gold, P.J.4    Billingsley, K.G.5    Chapman, R.A.6
  • 86
    • 73949149251 scopus 로고    scopus 로고
    • Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
    • Piekarz RL, Frye R, Turner M, Wright JJ, Allen SL, Kirschbaum MH, et al. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J Clin Oncol 2009 ; 27 : 5410-7.
    • (2009) J Clin Oncol , vol.27 , pp. 5410-5417
    • Piekarz, R.L.1    Frye, R.2    Turner, M.3    Wright, J.J.4    Allen, S.L.5    Kirschbaum, M.H.6
  • 87
    • 34548402425 scopus 로고    scopus 로고
    • Update of the NCI multiinstitutional phase II trial of romidepsin, FK228, for patients with cutaneous or peripheral T-cell lymphoma
    • Meeting Abstracts
    • Piekarz R, Frye R, Wright J, Figg W, Allen S, Kirschbaum M, et al. Update of the NCI multiinstitutional phase II trial of romidepsin, FK228, for patients with cutaneous or peripheral T-cell lymphoma. J Clin Oncol 2007 ; 25 : 8027 (Meeting Abstracts).
    • (2007) J Clin Oncol , vol.25 , pp. 8027
    • Piekarz, R.1    Frye, R.2    Wright, J.3    Figg, W.4    Allen, S.5    Kirschbaum, M.6
  • 88
    • 77954628779 scopus 로고    scopus 로고
    • Pooled analyses of two international, multicenter clinical studies of romidepsin in 167 patients with cutaneous T-cell lymphoma (CTCL)
    • Meeting Abstracts
    • Dermierre M, Whittaker S, Kim Y, Kim E, Piekarz R, Prince M, et al. Pooled analyses of two international, multicenter clinical studies of romidepsin in 167 patients with cutaneous T-cell lymphoma (CTCL). J Clin Oncol 2009 ; 27 : 8546 (Meeting Abstracts).
    • (2009) J Clin Oncol , vol.27 , pp. 8546
    • Dermierre, M.1    Whittaker, S.2    Kim, Y.3    Kim, E.4    Piekarz, R.5    Prince, M.6
  • 89
    • 38949144400 scopus 로고    scopus 로고
    • Tolerability, pharmacodynamics and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes
    • Klimek VM, Fircanis S, Maslak P, Guernah I, Baum M, Wu N, et al. Tolerability, pharmacodynamics and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes. Clin Cancer Res 2008 ; 14 : 826-32.
    • (2008) Clin Cancer Res , vol.14 , pp. 826-832
    • Klimek, V.M.1    Fircanis, S.2    Maslak, P.3    Guernah, I.4    Baum, M.5    Wu, N.6
  • 90
    • 19944432566 scopus 로고    scopus 로고
    • A phase I and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia
    • Byrd JC, Marcucci G, Parthun MR, Xiao JJ, Klisovic RB, Moran M, et al. A phase I and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia. Blood 2005 ; 105 : 959-67.
    • (2005) Blood , vol.105 , pp. 959-967
    • Byrd, J.C.1    Marcucci, G.2    Parthun, M.R.3    Xiao, J.J.4    Klisovic, R.B.5    Moran, M.6
  • 91
    • 76749135579 scopus 로고    scopus 로고
    • Phase II study of depsipeptide (DEP) in radioiodine (RAI)-refractory metastatic nonmedullary thyroid carcinoma
    • abstr 6059
    • Sherman EJ, Fury G, Tuttle RM, Ghossein R, Stambuk H, Baum M, et al. Phase II study of depsipeptide (DEP) in radioiodine (RAI)-refractory metastatic nonmedullary thyroid carcinoma. J Clin Oncol. 2009 ; 27 : (suppl; abstr 6059).
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Sherman, E.J.1    Fury, G.2    Tuttle, R.M.3    Ghossein, R.4    Stambuk, H.5    Baum, M.6
  • 92
    • 50349087906 scopus 로고    scopus 로고
    • Evaluation of the pharmacodynamic effects of MGCD0103 from preclinical models to human using a novel HDAC enzyme assay
    • Bonfils C, Kalita A, Dubay M, Siu LL, Carducci MA, Reid G, et al. Evaluation of the pharmacodynamic effects of MGCD0103 from preclinical models to human using a novel HDAC enzyme assay. Clin Cancer Res 2008 ; 14 : 3441-9.
    • (2008) Clin Cancer Res , vol.14 , pp. 3441-3449
    • Bonfils, C.1    Kalita, A.2    Dubay, M.3    Siu, L.L.4    Carducci, M.A.5    Reid, G.6
  • 93
    • 66349133867 scopus 로고    scopus 로고
    • Isotype-selective histone deacetylase (HDAC) inhibitor MGCD0103 demonstrates clinical activity and safety in patients with relapsed/refractory classical Hodgkin lymphoma (HL)
    • Meeting Abstracts
    • Bociek RG, Kuruvilla J, Pro B, Wedgwood A, Li Z, Drouin M, et al. Isotype-selective histone deacetylase (HDAC) inhibitor MGCD0103 demonstrates clinical activity and safety in patients with relapsed/refractory classical Hodgkin lymphoma (HL). J Clin Oncol 2008 ; 20 : 8507 (Meeting Abstracts).
    • (2008) J Clin Oncol , vol.20 , pp. 8507
    • Bociek, R.G.1    Kuruvilla, J.2    Pro, B.3    Wedgwood, A.4    Li, Z.5    Drouin, M.6
  • 94
    • 30344443991 scopus 로고    scopus 로고
    • In vivo synergy between topoisomerase II and histone deacatylase inhibitors: Predictive correlates
    • Marchion DC, Bicaku E, Daud A, Sullivan DM, Munster PN. In vivo synergy between topoisomerase II and histone deacatylase inhibitors: predictive correlates. Mol Cancer Ther 2005 ; 4 : 1993-2000.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1993-2000
    • Marchion, D.C.1    Bicaku, E.2    Daud, A.3    Sullivan, D.M.4    Munster, P.N.5
  • 95
    • 33846327942 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances gemcitabine-induced cell death in pancreatic cancer
    • Arnold NB, Arkus N, Gunn J, Korc M. The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances gemcitabine-induced cell death in pancreatic cancer. Clin Cancer Res 2007 ; 13 : 18-26.
    • (2007) Clin Cancer Res , vol.13 , pp. 18-26
    • Arnold, N.B.1    Arkus, N.2    Gunn, J.3    Korc, M.4
  • 96
    • 70350443118 scopus 로고    scopus 로고
    • Phase I/II: The oral isotype-selective HDAC inhibitor MGCD0103 in combination with gemcitabine (Gem) in patients (pts) with refractory solid tumors
    • Meeting Abstracts abstr 4625
    • Hurwitz H, Nelson B, O'Dwyer PJ, Chiorean EG, Gabrail N, Li Z, et al. Phase I/II: The oral isotype-selective HDAC inhibitor MGCD0103 in combination with gemcitabine (Gem) in patients (pts) with refractory solid tumors. J Clin Oncol (Meeting Abstracts) 2008 ; 26 : abstr 4625.
    • (2008) J Clin Oncol , vol.26
    • Hurwitz, H.1    Nelson, B.2    O'Dwyer, P.J.3    Chiorean, E.G.4    Gabrail, N.5    Li, Z.6
  • 97
    • 77956538685 scopus 로고    scopus 로고
    • Belinostat (Bel) down-regulates thymidylate synthase (TS) in tumor tissue: A dose-escalation study of belinostat alone and in combination with 5-fluorouracil (5-FU)
    • abstract
    • Northfelt DW, Bonnem E, Fagerberg J, Von Hoff D, Grem J. Belinostat (Bel) down-regulates thymidylate synthase (TS) in tumor tissue: a dose-escalation study of belinostat alone and in combination with 5-fluorouracil (5-FU) (abstract). Gastrointestinal Cancers Symposium 2009; 333.
    • (2009) Gastrointestinal Cancers Symposium , vol.333
    • Northfelt, D.W.1    Bonnem, E.2    Fagerberg, J.3    Von Hoff, D.4    Grem, J.5
  • 98
    • 65249141665 scopus 로고    scopus 로고
    • Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: Phase I/II trial of valproic acid and epirubicin/FEC
    • Munster P, Marchion D, Bicaku E, Lacevic M, Kim J, Centeno B, et al. Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: phase I/II trial of valproic acid and epirubicin/FEC. Clin Cancer Res 2009 ; 15 : 2488-96.
    • (2009) Clin Cancer Res , vol.15 , pp. 2488-2496
    • Munster, P.1    Marchion, D.2    Bicaku, E.3    Lacevic, M.4    Kim, J.5    Centeno, B.6
  • 99
    • 0242610850 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA
    • Kim MS, Blake M, Baek JH, Kohlhagen G, Pommier Y, Carrier F. Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. Cancer Res 2003 ; 63 : 7291-300.
    • (2003) Cancer Res , vol.63 , pp. 7291-7300
    • Kim, M.S.1    Blake, M.2    Baek, J.H.3    Kohlhagen, G.4    Pommier, Y.5    Carrier, F.6
  • 100
    • 77956511800 scopus 로고    scopus 로고
    • Phase IB dose-finding trial of intravenous (i.v.) panobinostat (PAN) with docetaxel (DOC) and prednisone (PRED) in patients (pts) with castration resistant prostate cancer (CRPC)
    • Vaishampayan U, Rathkopf D, Chi KN, et al. Phase IB dose-finding trial of intravenous (i.v.) panobinostat (PAN) with docetaxel (DOC) and prednisone (PRED) in patients (pts) with castration resistant prostate cancer (CRPC). Eur J Cancer Suppl 2009 ; 7 : 413.
    • (2009) Eur J Cancer Suppl , vol.7 , pp. 413
    • Vaishampayan, U.1    Rathkopf, D.2    Chi, K.N.3
  • 101
    • 33845209109 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells
    • Dowdy SC, Jiang S, Zhou XC, Hou X, Jin F, Podratz KC. Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells. Mol Cancer Ther 2006 ; 5 : 2767-76.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2767-2776
    • Dowdy, S.C.1    Jiang, S.2    Zhou, X.C.3    Hou, X.4    Jin, F.5    Podratz, K.C.6
  • 102
    • 34250696097 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies
    • Ramalingam SS, Parise RA, Ramanathan RK, Lagattuta TF, Musguire LA, Stoller RG, et al. Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies. Clin Cancer Res 2007 ; 13 : 3605-10.
    • (2007) Clin Cancer Res , vol.13 , pp. 3605-3610
    • Ramalingam, S.S.1    Parise, R.A.2    Ramanathan, R.K.3    Lagattuta, T.F.4    Musguire, L.A.5    Stoller, R.G.6
  • 103
    • 71749104145 scopus 로고    scopus 로고
    • Vorinostat increases carboplatin and paclitaxel activity in non-small cell lung cancer cells
    • Owonikoko TK, Ramalingam SS, Kanterewicz B, et al. Vorinostat increases carboplatin and paclitaxel activity in non-small cell lung cancer cells. Int J Cancer 2009.
    • (2009) Int J Cancer
    • Owonikoko, T.K.1    Ramalingam, S.S.2    Kanterewicz, B.3
  • 104
    • 77956225157 scopus 로고    scopus 로고
    • Randomized, double blind phase II/III study of first-line paclitaxel (P) plus carboplatin (C) in combination with vorinostat or placebo in patients with advanced non-small cell lung cancer (NSCLC)
    • abstract
    • Belani C, Ramalingam S, Kalemkerian G, Mok T, Rosell R, Ahn MJ, et al. Randomized, double blind phase II/III study of first-line paclitaxel (P) plus carboplatin (C) in combination with vorinostat or placebo in patients with advanced non-small cell lung cancer (NSCLC) (abstract). Eur J Cancer Suppl 2009 ; 7 : 507.
    • (2009) Eur J Cancer Suppl , vol.7 , pp. 507
    • Belani, C.1    Ramalingam, S.2    Kalemkerian, G.3    Mok, T.4    Rosell, R.5    Ahn, M.J.6
  • 105
    • 73949140461 scopus 로고    scopus 로고
    • Carboplatin and paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small cell lung cancer
    • Ramalingam SS, Maitland ML, Frankel P, Argiris AE, Koczywas M, Gitlitz B, et al. Carboplatin and paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small cell lung cancer. J Clin Oncol 2010 ; 28 : 56-62.
    • (2010) J Clin Oncol , vol.28 , pp. 56-62
    • Ramalingam, S.S.1    Maitland, M.L.2    Frankel, P.3    Argiris, A.E.4    Koczywas, M.5    Gitlitz, B.6
  • 106
    • 34447315913 scopus 로고    scopus 로고
    • Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, suberoylanilide hydroxamic acid
    • Rikiishi H, Shinohara F, Sato T, Suzuki M, Echigo S. Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, suberoylanilide hydroxamic acid. Int J Oncol 2007 ; 30 : 1181-8.
    • (2007) Int J Oncol , vol.30 , pp. 1181-1188
    • Rikiishi, H.1    Shinohara, F.2    Sato, T.3    Suzuki, M.4    Echigo, S.5
  • 107
    • 75149160568 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells
    • Dong G, Luo J, Kumar V, Dong Z. Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells. Am J Physiol Renal Physiol 2009 ; 298 : 293-300.
    • (2009) Am J Physiol Renal Physiol , vol.298 , pp. 293-300
    • Dong, G.1    Luo, J.2    Kumar, V.3    Dong, Z.4
  • 108
    • 69249236216 scopus 로고    scopus 로고
    • Phase I trial of vorinostat (V) in combination with pemetrexed (Pem) and cisplatin (CDDP) in patients with advanced cancer
    • Meeting Abstracts
    • Chen L, Vogelzang NJ, Blumenschein G, Robert F, Pluda JM, Frankel SR, et al. Phase I trial of vorinostat (V) in combination with pemetrexed (Pem) and cisplatin (CDDP) in patients with advanced cancer. J Clin Oncol 2007 ; 25 : 18088 (Meeting Abstracts).
    • (2007) J Clin Oncol , vol.25 , pp. 18088
    • Chen, L.1    Vogelzang, N.J.2    Blumenschein, G.3    Robert, F.4    Pluda, J.M.5    Frankel, S.R.6
  • 109
    • 77956553840 scopus 로고    scopus 로고
    • Phase I dose-escalation study of vorinostat in combination with gemcitabine and cisplatinum in patients with advanced non-small cell lung cancer (NSCLC)
    • Teixeira L, Descourt R, Moro-Sibilot D, Misset JL, Gachard E, Rizvi S, et al. Phase I dose-escalation study of vorinostat in combination with gemcitabine and cisplatinum in patients with advanced non-small cell lung cancer (NSCLC). Eur J Cancer Suppl 2009 ; 7 : 554.
    • (2009) Eur J Cancer Suppl , vol.7 , pp. 554
    • Teixeira, L.1    Descourt, R.2    Moro-Sibilot, D.3    Misset, J.L.4    Gachard, E.5    Rizvi, S.6
  • 110
    • 67349237892 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor induced modulation of anti-estrogen therapy
    • Thomas S, Munster PN. Histone deacetylase inhibitor induced modulation of anti-estrogen therapy. Cancer Lett 2009 ; 280 : 184-91.
    • (2009) Cancer Lett , vol.280 , pp. 184-191
    • Thomas, S.1    Munster, P.N.2
  • 111
    • 76649088181 scopus 로고    scopus 로고
    • Phase II trial of the histone deacetylase inhibitor, vorinostat, to restore hormone sensitivity to the antiestrogen tamoxifen in patients with advanced breast cancer who progressed on prior hormone therapy
    • Meeting Abstracts
    • Munster PN, Lacevic M, Thomas S, Christian C, Ismail-Khan R, Melisko M, et al. Phase II trial of the histone deacetylase inhibitor, vorinostat, to restore hormone sensitivity to the antiestrogen tamoxifen in patients with advanced breast cancer who progressed on prior hormone therapy. J Clin Oncol 2009 ; 27 : 1075 (Meeting Abstracts).
    • (2009) J Clin Oncol , vol.27 , pp. 1075
    • Munster, P.N.1    Lacevic, M.2    Thomas, S.3    Christian, C.4    Ismail-Khan, R.5    Melisko, M.6
  • 112
    • 77956549226 scopus 로고    scopus 로고
    • Phase I trial of vorinostat in combination with erlotinib for advanced non-small cell lung cancer (NSCLC) patients (pts) with EGFR mutations after erlotinib progression (NCT00503971): The TARZO trial
    • Reguart N, Isla D, Cardona AF, Palmero R, Cardenal F, Rolfo C, et al. Phase I trial of vorinostat in combination with erlotinib for advanced non-small cell lung cancer (NSCLC) patients (pts) with EGFR mutations after erlotinib progression (NCT00503971): the TARZO trial. Eur J Cancer Suppl 2009 ; 7 : 550.
    • (2009) Eur J Cancer Suppl , vol.7 , pp. 550
    • Reguart, N.1    Isla, D.2    Cardona, A.F.3    Palmero, R.4    Cardenal, F.5    Rolfo, C.6
  • 113
    • 77955564027 scopus 로고    scopus 로고
    • Results from a phase I safety lead-in study investigating the combination of erlotinib and the histone deacetylase inhibitor entinostat in patients with advanced NSCLC
    • abstract Meeting Abstracts
    • Konduri K, Spira AI, Jotte RM, Boyd T, Gaffar YA, Reynolds C, et al. Results from a phase I safety lead-in study investigating the combination of erlotinib and the histone deacetylase inhibitor entinostat in patients with advanced NSCLC (abstract). J Clin Oncol 2009 ; 27 : 14545 (Meeting Abstracts).
    • (2009) J Clin Oncol , vol.27 , pp. 14545
    • Konduri, K.1    Spira, A.I.2    Jotte, R.M.3    Boyd, T.4    Gaffar, Y.A.5    Reynolds, C.6
  • 114
    • 24344473755 scopus 로고    scopus 로고
    • Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of HER2
    • Bali P, Pranpat M, Swaby R, Fiskus W, Yamaguchi H, Balasis M, et al. Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of HER2. Clin Cancer Res 2005 ; 11 : 6382-9.
    • (2005) Clin Cancer Res , vol.11 , pp. 6382-6389
    • Bali, P.1    Pranpat, M.2    Swaby, R.3    Fiskus, W.4    Yamaguchi, H.5    Balasis, M.6
  • 115
    • 76649109445 scopus 로고    scopus 로고
    • Phase I trial of panobinostat (LBH589) in combination with trastuzumab in pretreated HER2-positive metastatic breast cancer (mBC): Preliminary safety and tolerability results
    • Meeting Abstracts
    • Conte P, Campone M, Pronzato P, Amadori D, Frank R, Schuetz F, et al. Phase I trial of panobinostat (LBH589) in combination with trastuzumab in pretreated HER2-positive metastatic breast cancer (mBC): Preliminary safety and tolerability results. J Clin Oncol 2009 ; 27 : 1081S (Meeting Abstracts).
    • (2009) J Clin Oncol , vol.27
    • Conte, P.1    Campone, M.2    Pronzato, P.3    Amadori, D.4    Frank, R.5    Schuetz, F.6
  • 116
    • 77956555435 scopus 로고    scopus 로고
    • Phase I/II trial of the histone deacetylase inhibitor vorinostat in combination with bevacizumab in patients with renal cell carcinoma: Phase I safety and pharmacokinetic/pharmacodynamic results
    • Edition
    • Pili R, Wilky B, Salumbides B, Hammers H, Holleran JL, Egorin MJ, et al. Phase I/II trial of the histone deacetylase inhibitor vorinostat in combination with bevacizumab in patients with renal cell carcinoma: phase I safety and pharmacokinetic/pharmacodynamic results. In Genitourinary Cancers Symposium, Edition 2008; 371S.
    • (2008) Genitourinary Cancers Symposium , vol.371 S
    • Pili, R.1    Wilky, B.2    Salumbides, B.3    Hammers, H.4    Holleran, J.L.5    Egorin, M.J.6
  • 117
    • 33645737411 scopus 로고    scopus 로고
    • Aggresome disruption: A novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells
    • Nawrocki ST, Carew JS, Pino MS, et al. Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. Cancer Res 2006 ; 66 : 3773-81.
    • (2006) Cancer Res , vol.66 , pp. 3773-3781
    • Nawrocki, S.T.1    Carew, J.S.2    Pino, M.S.3
  • 118
    • 2542523228 scopus 로고    scopus 로고
    • Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors
    • Pei XY, Dai Y, Grant S. Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors. Clin Cancer Res 2004 ; 10 : 3839-52.
    • (2004) Clin Cancer Res , vol.10 , pp. 3839-3852
    • Pei, X.Y.1    Dai, Y.2    Grant, S.3
  • 119
    • 64749110754 scopus 로고    scopus 로고
    • Vorinostat plus bortezomib for the treatment of relapsed/ refractory multiple myeloma: Early clinical experience
    • ASH Annual Meeting Abstracts
    • Weber D, Badros AZ, Jagannath S, Siegel D, Richon V, Rizvi S, et al. Vorinostat plus bortezomib for the treatment of relapsed/ refractory multiple myeloma: early clinical experience. Blood 2008 ; 112 : 871 (ASH Annual Meeting Abstracts).
    • (2008) Blood , vol.112 , pp. 871
    • Weber, D.1    Badros, A.Z.2    Jagannath, S.3    Siegel, D.4    Richon, V.5    Rizvi, S.6
  • 120
    • 67649179529 scopus 로고    scopus 로고
    • Phase I trial of vorinostat plus bortezomib (bort) in relapsed/refractory multiple myeloma (mm) patients (pts)
    • Meeting Abstracts
    • Badros AZ, Philip S, Niesvizk R, Goloubeva O, Harris C, Zweibel J, et al. Phase I trial of vorinostat plus bortezomib (bort) in relapsed/refractory multiple myeloma (mm) patients (pts). J Clin Oncol 2008 ; 26 : 8548 (Meeting Abstracts).
    • (2008) J Clin Oncol , vol.26 , pp. 8548
    • Badros, A.Z.1    Philip, S.2    Niesvizk, R.3    Goloubeva, O.4    Harris, C.5    Zweibel, J.6
  • 121
    • 77955566014 scopus 로고    scopus 로고
    • A phase II study of a 1-hour infusion of romidepsin combined with bortezomib for multiple myeloma (MM) patients with relapsed or refractory disease
    • Meeting Abstracts
    • Berenson JR, Yellin O, Mapes R, Eades B, Abaya CD, Strayer A, et al. A phase II study of a 1-hour infusion of romidepsin combined with bortezomib for multiple myeloma (MM) patients with relapsed or refractory disease. J Clin Oncol 2009 ; 27 : 19508 (Meeting Abstracts).
    • (2009) J Clin Oncol , vol.27 , pp. 19508
    • Berenson, J.R.1    Yellin, O.2    Mapes, R.3    Eades, B.4    Abaya, C.D.5    Strayer, A.6
  • 122
    • 0345734267 scopus 로고    scopus 로고
    • Coadministration of the heat shock protein 90 antagonist 17-allylamino-17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells
    • Rahmani M, Yu C, Dai Y, Reese E, Ahmed W, Dent P, et al. Coadministration of the heat shock protein 90 antagonist 17-allylamino-17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells. Cancer Res 2003 ; 63 : 8420-7.
    • (2003) Cancer Res , vol.63 , pp. 8420-8427
    • Rahmani, M.1    Yu, C.2    Dai, Y.3    Reese, E.4    Ahmed, W.5    Dent, P.6
  • 123
    • 13444274622 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
    • Insinga A, Monestiroli S, Ronzoni S, Gelmetti V, Marchesi F, Viale A, et al. Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nat Med 2005 ; 11 : 71-6.
    • (2005) Nat Med , vol.11 , pp. 71-76
    • Insinga, A.1    Monestiroli, S.2    Ronzoni, S.3    Gelmetti, V.4    Marchesi, F.5    Viale, A.6
  • 124
    • 49649098602 scopus 로고    scopus 로고
    • Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist
    • Frew AJ, Lindemann RK, Martin BP, Clarke CJ, Sharkey J, Anthony DA, et al. Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist. Proc Natl Acad Sci U S A 2008 ; 105 : 11317-22.
    • (2008) Proc Natl Acad Sci U S a , vol.105 , pp. 11317-11322
    • Frew, A.J.1    Lindemann, R.K.2    Martin, B.P.3    Clarke, C.J.4    Sharkey, J.5    Anthony, D.A.6
  • 125
    • 33748997409 scopus 로고    scopus 로고
    • Sequential valproic acid/all-trans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemia
    • Cimino G, Lo-Coco F, Fenu S, Travaglini L, Finolezzi E, Mancini M, et al. Sequential valproic acid/all-trans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemia. Cancer Res 2006 ; 66 : 8903-11.
    • (2006) Cancer Res , vol.66 , pp. 8903-8911
    • Cimino, G.1    Lo-Coco, F.2    Fenu, S.3    Travaglini, L.4    Finolezzi, E.5    Mancini, M.6
  • 126
    • 29744454120 scopus 로고    scopus 로고
    • The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia
    • Kuendgen A, Schmid M, Schlenk R, Knipp S, Hildebrandt B, Steidl C, et al. The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia. Cancer 2006 ; 106 : 112-9.
    • (2006) Cancer , vol.106 , pp. 112-119
    • Kuendgen, A.1    Schmid, M.2    Schlenk, R.3    Knipp, S.4    Hildebrandt, B.5    Steidl, C.6
  • 127
    • 34948845116 scopus 로고    scopus 로고
    • Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome
    • Soriano AO, Yang H, Faderl S, Estrov Z, Giles F, Ravandi F, et al. Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome. Blood 2007 ; 110 : 2302-8.
    • (2007) Blood , vol.110 , pp. 2302-2308
    • Soriano, A.O.1    Yang, H.2    Faderl, S.3    Estrov, Z.4    Giles, F.5    Ravandi, F.6
  • 128
    • 34548529948 scopus 로고    scopus 로고
    • Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia
    • Blum W, Klisovic RB, Hackanson B, Liu Z, Liu S, Devine H, et al. Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia. J Clin Oncol 2007 ; 25 : 3884-91.
    • (2007) J Clin Oncol , vol.25 , pp. 3884-3891
    • Blum, W.1    Klisovic, R.B.2    Hackanson, B.3    Liu, Z.4    Liu, S.5    Devine, H.6
  • 129
    • 76749107392 scopus 로고    scopus 로고
    • Interim analysis of a phase II trial of 5-azacitidine (5AC) and entinostat (SNDX-275) in relapsed advanced lung cancer (NSCLC)
    • Meeting Abstracts
    • Juergens RA, Vendetti F, Coleman B, Sebree RS, Rudek MA, Belinsky S, et al. Interim analysis of a phase II trial of 5-azacitidine (5AC) and entinostat (SNDX-275) in relapsed advanced lung cancer (NSCLC). J Clin Oncol 2009 ; 27 : 8055 (Meeting Abstracts).
    • (2009) J Clin Oncol , vol.27 , pp. 8055
    • Juergens, R.A.1    Vendetti, F.2    Coleman, B.3    Sebree, R.S.4    Rudek, M.A.5    Belinsky, S.6
  • 130
    • 53149153902 scopus 로고    scopus 로고
    • Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells
    • Dejligbjerg M, Grauslund M, Litman T, Collins L, Qian X, Jeffers M, et al. Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells. Mol Cancer 2008 ; 7 : 70.
    • (2008) Mol Cancer , vol.7 , pp. 70
    • Dejligbjerg, M.1    Grauslund, M.2    Litman, T.3    Collins, L.4    Qian, X.5    Jeffers, M.6
  • 131
    • 45549083112 scopus 로고    scopus 로고
    • Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma
    • Fantin VR, Loboda A, Paweletz CP, Hendrickson RC, Pierce JW, Roth JA, et al. Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma. Cancer Res 2008 ; 68 : 3785-94.
    • (2008) Cancer Res , vol.68 , pp. 3785-3794
    • Fantin, V.R.1    Loboda, A.2    Paweletz, C.P.3    Hendrickson, R.C.4    Pierce, J.W.5    Roth, J.A.6
  • 132
    • 51649126841 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma
    • Ellis L, Pan Y, Smyth GK, George DJ, McCormack C, Williams-Truax R, et al. Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. Clin Cancer Res 2008 ; 14 : 4500-10.
    • (2008) Clin Cancer Res , vol.14 , pp. 4500-4510
    • Ellis, L.1    Pan, Y.2    Smyth, G.K.3    George, D.J.4    McCormack, C.5    Williams-Truax, R.6
  • 133
    • 58049208190 scopus 로고    scopus 로고
    • Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis
    • Fotheringham S, Epping MT, Stimson L, Khan O, Wood V, Pezzella F, et al. Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis. Cancer Cell 2009 ; 15 : 57-66.
    • (2009) Cancer Cell , vol.15 , pp. 57-66
    • Fotheringham, S.1    Epping, M.T.2    Stimson, L.3    Khan, O.4    Wood, V.5    Pezzella, F.6
  • 134
    • 51049090194 scopus 로고    scopus 로고
    • Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: Development of a molecular predictive model
    • Miyanaga A, Gemma A, Noro R, Kataoka K, Matsuda K, Nara M, et al. Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model. Mol Cancer Ther 2008 ; 7 : 1923-30.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1923-1930
    • Miyanaga, A.1    Gemma, A.2    Noro, R.3    Kataoka, K.4    Matsuda, K.5    Nara, M.6
  • 135
    • 59149098431 scopus 로고    scopus 로고
    • A phase I trial of romidepsin in combination with gemcitabine in patients with pancreatic and other advanced solid tumors
    • Meeting Abstracts
    • Doss HH, Jones SF, Infante JR, Spigel DR, Willcutt N, Lamar R, et al. A phase I trial of romidepsin in combination with gemcitabine in patients with pancreatic and other advanced solid tumors. J Clin Oncol 2008 ; 26 : 2567S (Meeting Abstracts).
    • (2008) J Clin Oncol , vol.26
    • Doss, H.H.1    Jones, S.F.2    Infante, J.R.3    Spigel, D.R.4    Willcutt, N.5    Lamar, R.6
  • 136
    • 58149223747 scopus 로고    scopus 로고
    • A phase I/II study of the safety and anti-cancer activity of i.v. administered belinostat (PXD101) plus carboplatin (C) or paclitaxel (P), or both in patients with advanced solid tumors
    • Meeting Abstracts
    • Sinha R, Moliffe R, Scurr M, Vidal L, Engelholm SA, Buhl Jensen P, et al. A phase I/II study of the safety and anti-cancer activity of i.v. administered belinostat (PXD101) plus carboplatin (C) or paclitaxel (P), or both in patients with advanced solid tumors. J Clin Oncol 2007 ; 25 : 3574 (Meeting Abstracts).
    • (2007) J Clin Oncol , vol.25 , pp. 3574
    • Sinha, R.1    Moliffe, R.2    Scurr, M.3    Vidal, L.4    Engelholm, S.A.5    Buhl Jensen, P.6
  • 137
    • 67349278924 scopus 로고    scopus 로고
    • Phase II multicenter trial of the histone deactylase inhibitor (HDACi) belinostat, carboplatin and paclitaxel (BelCaP) in patients (pts) with relapsed epithelial ovarian cancer (EOC)
    • Meeting Abstracts
    • Finkler NJ, Dizon DS, Braly P, Micha J, Lassen U, Celano P, et al. Phase II multicenter trial of the histone deactylase inhibitor (HDACi) belinostat, carboplatin and paclitaxel (BelCaP) in patients (pts) with relapsed epithelial ovarian cancer (EOC). J Clin Oncol 2008 ; 26 : 5519 (Meeting Abstracts).
    • (2008) J Clin Oncol , vol.26 , pp. 5519
    • Finkler, N.J.1    Dizon, D.S.2    Braly, P.3    Micha, J.4    Lassen, U.5    Celano, P.6
  • 138
    • 67449125357 scopus 로고    scopus 로고
    • A phase IB, multicenter, open-label, dose-escalation study of oral panobinostat (LBH589) and i.v. bortezomib in patients with relapsed multiple myeloma
    • ASH Annual Meeting Abstracts
    • Siegel D, Sezer O, San Miguel JF, Mateos MV, Prosser I, Cavo M, et al. A phase IB, multicenter, open-label, dose-escalation study of oral panobinostat (LBH589) and i.v. bortezomib in patients with relapsed multiple myeloma. Blood 2008 ; 112 : 2781 (ASH Annual Meeting Abstracts).
    • (2008) Blood , vol.112 , pp. 2781
    • Siegel, D.1    Sezer, O.2    San Miguel, J.F.3    Mateos, M.V.4    Prosser, I.5    Cavo, M.6
  • 139
    • 67449148094 scopus 로고    scopus 로고
    • High response rates with the combination of bortezomib, dexamethasone and the pan-histone deacetylase inhibitor romidepsin in patients with relapsed or refractory multiple myeloma in a phase I/II clinical trial
    • ASH Annual Meeting Abstracts
    • Harrison SJ, Quach H, Yuen K, Strayer A, Copeman MC, Peinert S, et al. High response rates with the combination of bortezomib, dexamethasone and the pan-histone deacetylase inhibitor romidepsin in patients with relapsed or refractory multiple myeloma in a phase I/II clinical trial. Blood 2008 ; 112 : 3698 (ASH Annual Meeting Abstracts).
    • (2008) Blood , vol.112 , pp. 3698
    • Harrison, S.J.1    Quach, H.2    Yuen, K.3    Strayer, A.4    Copeman, M.C.5    Peinert, S.6
  • 140
    • 73849120547 scopus 로고    scopus 로고
    • Panobinostat plus lenalidomide and dexamethasone phase I trial in multiple myeloma (MM)
    • Meeting Abstracts
    • Spencer A, Taylor K, Lonial S, Mateos MV, Jalaluddin M, Hazell K, et al. Panobinostat plus lenalidomide and dexamethasone phase I trial in multiple myeloma (MM). J Clin Oncol 2009 ; 27 : 8542 (Meeting Abstracts).
    • (2009) J Clin Oncol , vol.27 , pp. 8542
    • Spencer, A.1    Taylor, K.2    Lonial, S.3    Mateos, M.V.4    Jalaluddin, M.5    Hazell, K.6
  • 141
    • 52949085309 scopus 로고    scopus 로고
    • A phase I/II study of vorinostat, an oral histone deacetylase inhibitor, in combination with azacitidine in patients with the myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Initial results of the phase I trial: A New York Cancer Consortium
    • Meeting Abstracts
    • Silverman LR, Verma A, Odchimar-Reissig R. A phase I/II study of vorinostat, an oral histone deacetylase inhibitor, in combination with azacitidine in patients with the myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Initial results of the phase I trial: a New York Cancer Consortium. J Clin Oncol 2008 ; 26 : 7000 (Meeting Abstracts).
    • (2008) J Clin Oncol , vol.26 , pp. 7000
    • Silverman, L.R.1    Verma, A.2    Odchimar-Reissig, R.3
  • 142
    • 38949088834 scopus 로고    scopus 로고
    • Phase I/II study of a novel oral isotype-selective histone deacetylase (HDAC) inhibitor MGCD0103 in combination with azacitidine in patients (pts) with high-risk myelodysplatic syndrome (MDS) or acute leukemia (AML)
    • Meeting Abstracts
    • Garcia-Manero G, Yang AS, Klimek V. Phase I/II study of a novel oral isotype-selective histone deacetylase (HDAC) inhibitor MGCD0103 in combination with azacitidine in patients (pts) with high-risk myelodysplatic syndrome (MDS) or acute leukemia (AML). J Clin Oncol 2007 ; 25 : 7062 (Meeting Abstracts).
    • (2007) J Clin Oncol , vol.25 , pp. 7062
    • Garcia-Manero, G.1    Yang, A.S.2    Klimek, V.3
  • 143
    • 34848819070 scopus 로고    scopus 로고
    • Combines methyltransferase/ histone deacetylase inhibition with 5-azacitidine and MS-275 in patients with MDS, CMMol and AML: Clinical response, histone acetylation and DNA damage
    • Gore SD, Jiemjit A, Silverman LB. Combines methyltransferase/ histone deacetylase inhibition with 5-azacitidine and MS-275 in patients with MDS, CMMol and AML: clinical response, histone acetylation and DNA damage. ASH Annual Meeting Abstracts 2006 ; 108 : 517.
    • (2006) ASH Annual Meeting Abstracts , vol.108 , pp. 517
    • Gore, S.D.1    Jiemjit, A.2    Silverman, L.B.3
  • 144
    • 33750530675 scopus 로고    scopus 로고
    • Phase I/II study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia
    • Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B, Yang H, Rosner G, Verstovsek S, et al. Phase I/II study of the combination of 5-aza-2′- deoxycytidine with valproic acid in patients with leukemia. Blood 2006 ; 108 : 3271-9.
    • (2006) Blood , vol.108 , pp. 3271-3279
    • Garcia-Manero, G.1    Kantarjian, H.M.2    Sanchez-Gonzalez, B.3    Yang, H.4    Rosner, G.5    Verstovsek, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.