Histone deacetylase inhibition by sodium valproate regulates polarization of macrophage subsets

DNA and Cell Biology

Volumn 31, Issue 4, 2012, Pages 592-599

  Wu, Chenming ^a   Li, Ang ^a   Leng, Ye ^a   Li, Yuan ^a   Kang, Jiuhong ^a  

^a TONGJI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA INTERFERON; HISTONE DEACETYLASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; VALPROIC ACID;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EXPOSURE; EFFECTOR CELL; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION REGULATION; IMMUNOMODULATION; IMMUNOREGULATION; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; T LYMPHOCYTE ACTIVATION; TH2 CELL;

ANIMALS; CELL LINE; CELL POLARITY; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE INHIBITORS; MACROPHAGES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRAZOLIUM SALTS; THIAZOLES; TUMOR NECROSIS FACTOR-ALPHA; VALPROIC ACID;

EID: 84859771693     PISSN: 10445498     EISSN: 15577430     Source Type: Journal    
DOI: 10.1089/dna.2011.1401     Document Type: Article

References (34)

1. Duffield, J.S. (2003). The inflammatory macrophage: a story of Jekyll and Hyde. Clin Sci 104, 27-38.
2. Goerdt, S., and Orfanos, C.E. (1999). Other functions, other genes: alternative activation of antigen-presenting cells. Immunity 10, 137-142.
3. Gordon, S. (2003). Alternative activation of macrophages. Nat Rev Immunol 3, 23-35.
4. Gordon, S., and Taylor, P.R. (2005). Monocyte and macrophage heterogeneity. Nat Rev Immunol 5, 953-964.
5. Huang, Q., Brogdon, J.L., Xu, Y.Y., Szabo, S.J., An, S.J., Buxton, F., and Cohen, D. (2007). Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function. Blood 109, 1123-1130.
6. Johnstone, R.W. (2002). Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov 1, 287-299.
7. Krausgruber, T., Blazek, K., Smallie, T., Alzabin, S., Lockstone, H., Sahgal, N., Hussell, T., Feldmann, M., and Udalova, I.A. (2011). IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol 12, 231-238.
8. Li, M.O., and Flavell, R.A. (2008). Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. Immunity 28, 468-476.
9. Livak, K.J., and Schmittgen, T.D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T))Method. Methods 25, 402-408.
10. Mantovani, A., Martinez, F.O., Sica, A., and Locati, M. (2008). Macrophage activation and polarization. Front Biosci 13, 453-461.
11. Mantovani, A., Sica, A., Sozzani, S., Allavena, P., Vecchi, A., and Locati, M. (2004). The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25, 677-686.
12. Marks, P.A., Rifkind, R.A., Richon, V.M., Breslow, R., Miller, T., and Kelly, W.K. (2001). Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer 1, 194-202.
13. Medzhitov, R., Foster, S.L., and Hargreaves, D.C. (2007). Genespecific control of inflammation by TLR-induced chromatin modifications. Nature 447, 972-978.
14. Medzhitov, R., and Horng, T. (2009). Transcriptional control of the inflammatory response. Nat Rev Immunol 9, 692-703.
15. Mills, C.D., Kincaid, K., Alt, J.M., Heilman, M.J., and Hill, A.M. (2000). M-1/M-2 macrophages and the Th1/Th2 paradigm. J Immunol 164, 6166-6173.
16. Mishra, N., Reilly, C.M., Brown, D.R., Ruiz, P., and Gilkeson, G.S. (2003). Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. J Clin Invest 111, 539-552.
17. Moore, K.W., de Waal Malefyt, R., Coffman, R.L., and O'Garra, A. (2001). Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 19, 683-765.
18. Mosser, D.M., and Edwards, J.P. (2008). Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8, 958-969
19. Mosser, D.M., Zhang, X., and Edwards, J.P. (2006). Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription. J Immunol 177, 1282-1288.
20. Napolitani, G., Rinaldi, A., Bertoni, F., Sallusto, F., and Lanzavecchia, A. (2005). Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 6, 769-776.
21. Narlikar, G.J., Fan, H.Y., and Kingston, R.E. (2002). Cooperation between complexes that regulate chromatin structure and transcription. Cell 108, 475-487.
22. Pollard, J.W. (2009). Trophic macrophages in development and disease. Nat Rev Immunol 9, 259-270.
23. Postigo, J., Genre, F., Iglesias, M., Fernandez-Rey, M., Buelta, L., Carlos Rodriguez-Rey, J., Merino, J., and Merino, R. (2011). Exacerbation of type II collagen-induced arthritis in apolipoprotein E-deficient mice in association with the expansion of Th1 and Th17 cells. Arthritis Rheum 63, 971-980.
24. Reddy, P., Maeda, Y., Hotary, K., Liu, C., Reznikov, L.L., Dinarello, C.A., and Ferrara, J.L. (2004). Histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces acute graftversus-host disease and preserves graft-versus-leukemia effect. Proc Natl Acad Sci U S A 101, 3921-3926.
25. Reddy, P., Sun, Y., Toubai, T., Duran-Struuck, R., Clouthier, S.G., Weisiger, E., Maeda, Y., Tawara, I., Krijanovski, O., Gatza, E., et al. (2008). Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice. J Clin Invest 118, 2562-2573.
26. Rothlin, C.V., and Lemke, G. (2010). TAM receptor signaling and autoimmune disease. Curr Opin Immunol 22, 740-746.
27. Rubtsov, Y.P., Rasmussen, J.P., Chi, E.Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W.R., Jr., et al. (2008). Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity 28, 546-558.
28. Sica, A., Larghi, P., Mancino, A., Rubino, L., Porta, C., Totaro, M.G., Rimoldi, M., Biswas, S.K., Allavena, P., and Mantovani, A. (2008). Macrophage polarization in tumour progression. Semin Cancer Biol 18, 349-355.
29. Skov, S., Rieneck, K., Bovin, L.F., Skak, K., Tomra, S., Michelsen, B.K., and Odum, N. (2003). Histone deacetylase inhibitors: a new class of immunosuppressors targeting a novel signal pathway essential for CD154 expression. Blood 101, 1430-1438.
30. Stout, R.D., and Suttles, J. (2005). Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes. Immunol Rev 205, 60-71.
31. Weischenfeldt, J., and Porse, B. (2008). Bone marrow-derived macrophages (BMM): isolation and applications. CSH Protoc 2008, pdb prot5080.
32. Yi, T., Chen, Y., Wang, L., Du, G., Huang, D., Zhao, D., Johnston, H., Young, J., Todorov, I., Umetsu, D.T., et al. (2009). Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood 114, 3101-3112.
33. Zhang, W., Xu, W., and Xiong, S. (2011). Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/ Akt-ERK signaling Pathway conferred by serum amyloid P component. J Immunol 187, 1764-1777.
34. Zhu, Z.L., Wu, X.M., Gao, H., Ke, W.X., and Giese, R.W. (2011). The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation. J Clin Invest 121, 2599-2613.