Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-x(L), c-Jun, and p21(CIP1), but independent of p53

Oncogene

Volumn 18, Issue 50, 1999, Pages 7016-7025

  Vrana, J A ^a   Decker, R H ^a   Johnson, C R ^a   Wang, Z ^a   Jarvis, W D ^a   Richon, V M ^b   Ehinger, M ^c   Fisher, P B ^d   Grant, S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d Columbia Univ Coll of Phys and S ^*  (United States)

Author keywords

Apoptosis; Differentiation; HMBA; Leukemia; p53; SAHA

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CASPASE 3; HYDROXAMIC ACID DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; MYC PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN C JUN; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; VORINOSTAT;

APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL STRAIN U937; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME DEGRADATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL;

EID: 0033604457     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1203176     Document Type: Article

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