A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture

Hepatology

Volumn 29, Issue 3, 1999, Pages 858-867

  Niki, Toshiro ^a,e   Rombouts, Krista ^a   De Bleser, Pieter ^a   De Smet, Karen ^a   Rogiers, Vera ^a   Schuppan, Detlef ^b   Yoshida, Minoru ^c   Gabbiani, Giulio ^d   Geerts, Albert ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF GENEVA   (Switzerland)

^e NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHOXYCOUMARIN DEETHYLASE; ALBUMIN; ALPHA ACTIN; BUTYRIC ACID; COLLAGEN TYPE 1; COLLAGEN TYPE 3; EPOXIDE HYDROLASE; HISTONE DEACETYLASE; HISTONE H4; LACTATE DEHYDROGENASE; PROTEIN; THYMIDINE; TRICHOSTATIN A; TRITON X 100; UREA;

ACETYLATION; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LIVER CELL; MYOFIBROBLAST; NONHUMAN; NORTHERN BLOTTING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; STELLATE CELL;

EID: 0033055983     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510290328     Document Type: Article

References (15)

1. Felsenfeld G. Chromatin as an essential part of the transcriptional mechanism. Nature 1992;355:219-224.
2. Wolffe AP. Transcription: in tune with the histones. Cell 1994;77:13-16.
3. Kornberg RD, Lorch Y. Interplay between chromatin structure and transcription. Curr Opin Cell Biol 1995;7:371-375.
4. Csordas A. On the biological role of histone acetylation. Biochem J 1990;265:23-38.
5. Kruh J. Effects of sodium butyrate, a new pharmacological agent, on cells in culture. Mol Cell Biochem 1982;42:65-82.
6. Yoshida M, Kijima M, Akita M, Beppu T. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 1990;265:17174-17179.
7. Kijima M, Yoshida M, Sugita K, Horinouchi S, Beppu T. Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase. J Biol Chem 1993;268:22429-22435.
8. Darkin-Rattray SJ, Gurnett AM, Myers RW, Dulski PM, Crumley TM, Allocco JJ, Cannova C, et al. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci U S A 1996;93:13143-13147.
9. Jung M, Hoffmann K, Brosch G, Loidl P. Analogues of trichostatin A and trapoxin B as histone deacetylase inhibitors. Bioorg Med Chem Lett 1997;7:1655-1658.
10. Richon V, Emiliani S, Verdin E, Webb Y, Breslow R. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A 1998;95:3003-3007.
11. Kwon H, Owa T, Hassig C, Shimada J, Schreiber S. Depudecin induces morphological reversion of transformed fibroblasts via inhibition of histone deacetylase. Proc Natl Acad Sci U S A 1998;95:3356-3361.
12. Newmark H, Lupton J, Young C. Butyrate as a differentiating agent: pharmacokinetics, analogues and current status. Cancer Lett 1994; 78:1-5.
13. Tsutsumi T, Ido A, Nakao K, Hamasaki K, Kato Y, Ohtsuru A. Reciprocal regulation of alpha-fetoprotein and albumin gene expression by butyrate in human hepatoma cells. Gastroenterology 1994;107:499-504.
14. Heerdt B, Houston M, Augenlicht L. Potentiation by specific short-chain fatty acids of differentiation ana apoptosis in human colonic carcinoma cell lines. Cancer Res 1994;54:3288-3294.
15. Hague A, Manning A, Hanlon K, Huschtscha L, Hart D, Paraskeva C. Sodium butyrate induces apoptosis in human colonic tumor cell lines in a p53-independent pathway: implications for possible role of dietary fibre in the prevention of large bowel cancer. Int J Cancer 1993;55:498-505.