A genomewide scan for type 1-diabetes susceptibility in scandinavian families: Identification of new loci with evidence of interactions

American Journal of Human Genetics

Volumn 69, Issue 6, 2001, Pages 1301-1313

  Holm, P ^a   Julier, C ^a   Kockum, I ^a   Senee, V ^a   Blanc, H ^a   Papp, J ^a   Akesson K ^a   Bartsocas, C ^a   De Leiva, A ^a   Dahlquist, G ^a   Ronningen K S ^a   Lathrop, M ^a   Luthman, H ^a   Pociot, F ^a   Nerup, J ^a  

^a STENO DIABETES CENTER   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; INSULIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CHROMOSOME 16P; CHROMOSOME 2P; CHROMOSOME 5Q; CHROMOSOME 6Q; ENVIRONMENTAL FACTOR; GENE LOCUS; GENETIC LINKAGE; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOME; GENOTYPE; HEREDITY; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; NORWAY; PHENOTYPE; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

EID: 0035212224     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/324341     Document Type: Article

References (66)

1. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus
2. Male predominance of type 1 (insulin-dependent) diabetes mellitus in young adults: Results from a 5-year prospective nationwide study of the 15-34 year age group in Sweden
3. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus
4. Two-locus maximum lod score analysis of a multifactorial trait: Joint considerations of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes
5. Investigation of linkage of chromosome 8 to type 1 diabetes: Multipoint analysis and exclusion mapping of human chromosome 8 in 593 affected sib-pair families from the U.K. and U.S.
6. The epidemiology of diabetes in Swedish children 0-14 years - A six-year prospective study
7. The incidence of diabetes mellitus in Swedish children 0-14 years of age
8. Childhood onset diabetes - Time trends and climatological factors
9. Analysis of 20 years of prospective registration of childhood onset diabetes - Time trends and birth cohort effects
10. Saturation multipoint linkage mapping of chromosome 6q in type 1 diabetes
11. A genome-wide search for human type 1 diabetes susceptibility genes
12. Insulin dependent diabetes mellitus in twins: Differences between monozygotic and dizygotic twins may need to be taken into account
13. Diabetes mellitus among first- and second degree relatives of early diabetes
14. EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome
15. Evidence of a non-MHC susceptibility locus in type 1 diabetes linked to HLA on chromosome 6
16. Secular trends in incidence of childhood IDDM in 10 countries
17. A test statistic to detect errors in sib-pair relationships
18. Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on chromosome 14q24.3-q31
19. Allegro, a new computer program for multipoint linkage analysis
20. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q
21. Affected-sib-pair interval mapping and exclusion for complex genetic traits: Sampling conciderations
22. Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility
23. Multiple DNA variant association analysis: Application to the insulin gene region in type 1 diabetes
24. Concordance for type 1 (insulin-dependent) and type 2 (non-insulin-dependent) diabetes mellitus in a population-based cohort of twins in Finland
25. Complete multipoint sib-pair analysis of qualitative and quantitative traits
26. North-American twins with IDDM: Genetic, etiological, and clinical significance of disease concordance according to age, zygosity, and the interval after diagnosis in first twin
27. A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine Eae2
28. Concordance rates of insulin dependent diabetes mellitus: A population based study of young Danish twins
29. Construction of multilocus genetic linkage maps in humans
30. Title IDDM12 (CTLA4) on 2q33 and IDDM13 on 2q34 in genetic susceptibility to type 1 diabetes (insulin-dependent)
31. Long-term risk for IDDM in first-degree relatives of patients with IDDM
32. Predictions of IDDM recurrence risk in offspring of Danish DDM patients
33. Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene associated VNTR
34. Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8
35. Intrafamilial and case-control association analysis of D2S152 in insulin-dependent diabetes
36. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
37. A search for type 1 diabetes susceptibility genes in families from the United Kingdom
38. A simple salting out procedure for extracting DNA from human nucleated cells
39. Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus
40. Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele
41. Incidence of insulin-dependent diabetes mellitus in age groups over 30 years in Denmark
42. HL-A antigens and diabetes mellitus
43. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes
44. All LODs are not created equal
45. The Swedish childhood diabetes study: An analysis of the temporal variation in diabetes incidence 1978-1987
46. PedCheck: A program for identification of genotype incompatibilities in linkage analysis
47. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation
48. DR "low-resolution" PCR-SSP typing - A correction and an update
49. The significance of concordance rate for type 1 (insulin-dependent) diabetes in identical twins
50. Epidemiology of diabetes mellitus in Sweden: Results of the first year of a prospective study in the population age group 15-34 years
51. Linkage and association analysis of susceptibility regions on chromosome 5 and 6 in 106 Scandinavian sibling pair families with multiple sclerosis
52. The HOXD8 locus (2q31) is linked to type I diabetes: Interaction with chromosome 6 and 11 disease susceptibility genes
53. Sex of affected sibpairs and genetic linkage to type 1 diabetes
54. Insulin-dependent diabetes mellitus - A polygenic disorder?
55. A nationwide population-based study of the familial aggregation of type 1 (insulin-dependent) diabetes mellitus in Denmark
56. Evidence for a type 1 diabetes susceptibility locus (IDDM10) on human chromosome 10p11-q11
57. Assessing the role of HLA-linked and unlinked determinants of disease
58. A genome screen of autism: Evidence for a multilocus etiology
59. Replication of linkage studies of complex traits: An examination of variation in location estimates
60. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22
61. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (DDM)
62. A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic loci
63. Age-corrected empirical genetic risk estimates for first-degree relatives of IDDM patients
64. Record-high incidence of type 1 (insulin-dependent) diabetes mellitus in Finnish children
65. Evidence for oligogenic inheritance of type 1 diabetes in a large Bedouin Arab family
66. Preliminary experience with predictive testing for insulin-dependent diabetes mellitus