Histone deacetylase inhibitors: A new mode for inhibition of cholesterol metabolism

BMC Genomics

Volumn 9, Issue , 2008, Pages

  Chittur, Sridar V ^a   Sangster Guity, Niquiche ^b   McCormick, Paulette J ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SREBF2; TRAPOXIN A; TRICHOSTATIN A; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT; CHOLESTEROL; ENZYME INHIBITOR; HYDROXAMIC ACID; HYPOCHOLESTEROLEMIC AGENT; SREBF2 PROTEIN, HUMAN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

ANIMAL CELL; ARTICLE; CELL STRAIN HEPG2; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; EMBRYO; EMBRYONAL CARCINOMA; ENZYME INHIBITION; FATTY ACID SYNTHESIS; GENE CONTROL; GENE EXPRESSION REGULATION; GENE REPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; METABOLIC REGULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; UNINDEXED SEQUENCE; ACETYLATION; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM;

EUKARYOTA;

ACETYLATION; ANTICHOLESTEREMIC AGENTS; CELL LINE; CHOLESTEROL; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; METABOLIC NETWORKS AND PATHWAYS; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

EID: 58149307916     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-9-507     Document Type: Article

References (45)

1. Monneret C Histone deacetylase inhibitors Eur J Med Chem 2005, 40:1-13. 15642405
2. Sakajiri S Kumagai T Kawamata N Saitoh T Said JW Koeffler HP Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines Exp Hematol 2005, 33:53-61. 15661398
3. Burton GR Nagarajan R Peterson CA McGehee RE Jr Microarray analysis of differentiation-specific gene expression during 3T3-L1 adipogenesis Gene 2004, 329:167-85. 15033539
4. Dannenberg LO Edenberg HJ Epigenetics of gene expression in human hepatoma cells: Expression profiling the response to inhibition of DNA methylation and histone deacetylation BMC Genomics 2006, 7:181. 1574318 16854234
5. Marks PA Richon VM Miller T Kelly WK Histone deacetylase inhibitors Adv Cancer Res 2004, 91:137-68. 15327890
6. Mehnert JM Kelly WK Histone deacetylase inhibitors: Biology and mechanism of action Cancer J 2007, 13:23-9. 17464243
7. Gottlicher M Minucci S Zhu P Kramer OH Schimpf A Giavara S Sleeman JP Lo Coco F Nervi C Pelicci PG et al.: Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells Embo J 2001, 20:6969-78. 125788 11742974
8. Kelly WK O'Connor OA Marks PA Histone deacetylase inhibitors: From target to clinical trials Expert Opin Investig Drugs 2002, 11:1695-713. 12457432
9. Yoshida M Furumai R Nishiyama M Komatsu Y Nishino N Horinouchi S Histone deacetylase as a new target for cancer chemotherapy Cancer Chemother Pharmacol 2001, 48(Suppl 1):S20-6. 11587361
10. Kijima M Yoshida M Sugita K Horinouchi S Beppu T Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase J Biol Chem 1993, 268:22429-35. 8226751
11. Yoshida M Horinouchi S Beppu T Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function Bioessays 1995, 17:423-30. 7786288
12. Kim MS Son MW Kim WB In Park Y Moon A Apicidin, an inhibitor of histone deacetylase, prevents H-ras-induced invasive phenotype Cancer Lett 2000, 157:23-30. 10893438
13. Nakajima H Kim YB Terano H Yoshida M Horinouchi S FR90 a potent antitumor antibiotic, is a novel histone deacetylase inhibitor Exp Cell Res 1998, 241(1):126-133. 9633520
14. Suzuki T Ando T Tsuchiya K Fukazawa N Saito A Mariko Y Yamashita T Nakanishi O Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives J Med Chem 1999, 42:3001-3. 10425110
15. Saito A Yamashita T Mariko Y Nosaka Y Tsuchiya K Ando T Suzuki T Tsuruo T Nakanishi O A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors Proc Natl Acad Sci USA 1999, 96:4592-7. 16377 10200307
16. Nervi C Borello U Fazi F Buffa V Pelicci PG Cossu G Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity Cancer Res 2001, 61:1247-9. 11245412
17. Marks P Rifkind RA Richon VM Breslow R Miller T Kelly WK Histone deacetylases and cancer: Causes and therapies Nat Rev Cancer 2001, 1:194-202. 11902574
18. Sangster-Guity N Yu LM McCormick P Molecular profiling of embryonal carcinoma cells following retinoic acid or histone deacetylase inhibitor treatment Cancer Biol Ther 2004, 3:1109-20. 15467438
19. Doniger SW Salomonis N Dahlquist KD Vranizan K Lawlor SC Conklin BR MAPPFinder: Using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data Genome Biol 2003, 4:R7. 151291 12540299
20. Dahlquist KD Salomonis N Vranizan K Lawlor SC Conklin BR GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways Nat Genet 2002, 31:19-20. 11984561
21. Williamson RA Yea CM Robson PA Curnock AP Gadher S Hambleton AB Woodward K Bruneau JM Hambleton P Moss D et al.: Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound J Biol Chem 1995, 270:22467-72. 7673235
22. Greene S Watanabe K Braatz-Trulson J Lou L Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide Biochem Pharmacol 1995, 50:861-7. 7575649
23. Fairbanks LD Bofill M Ruckemann K Simmonds HA Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors J Biol Chem 1995, 270:29682-9. 8530356
24. Breedveld FC New insights in the pathogenesis of rheumatoid arthritis J Rheumatol Suppl 1998, 53:3-7. 9666411
25. Chung YL Lee MY Wang AJ Yao LF A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis Mol Ther 2003, 8:707-17. 14599803
26. Arend WP Dayer JM Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis Arthritis Rheum 1995, 38:151-60. 7848304
27. Young DA Lakey RL Pennington CJ Jones D Kevorkian L Edwards DR Cawston TE Clark IM Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption Arthritis Res Ther 2005, 7:R503-12. 1174946 15899037
28. Leoni F Zaliani A Bertolini G Porro G Pagani P Pozzi P Dona G Fossati G Sozzani S Azam T et al.: The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines Proc Natl Acad Sci USA 2002, 99:2995-3000. 122461 11867742
29. Miller NE Coronary atherosclerosis and plasma lipoproteins: Epidemiology and pathophysiologic considerations J Cardiovasc Pharmacol 1982, 4(Suppl 2):S190-5. 6177955
30. Sakakura Y Shimano H Sone H Takahashi A Inoue N Toyoshima H Suzuki S Yamada N Sterol regulatory element-binding proteins induce an entire pathway of cholesterol synthesis Biochem Biophys Res Commun 2001, 286:176-83. 11485325
31. Brown MS Goldstein JL The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor Cell 1997, 89:331-40. 9150132
32. Sone H Shimano H Sakakura Y Inoue N Amemiya-Kudo M Yahagi N Osawa M Suzuki H Yokoo T Takahashi A et al.: Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status Am J Physiol Endocrinol Metab 2002, 282:E222-30. 11739104
33. Shechter I Dai P Huo L Guan G IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: Evidence that IDH1 may regulate lipogenesis in hepatic cells J Lipid Res 2003, 44:2169-80. 12923220
34. Ekins S Mankowski DC Hoover DJ Lawton MP Treadway JL Harwood HJ Jr Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors Drug Metab Dispos 2007, 35:493-500. 17194716
35. Kastelein JJ The future of best practice Atherosclerosis 1999, 143(Suppl 1):S17-21. 10382834
36. Munro JM Cotran RS The pathogenesis of atherosclerosis: Atherogenesis and inflammation Lab Invest 1988, 58:249-61. 3279259
37. Iso H Jacobs DR Jr Wentworth D Neaton JD Cohen JD Serum cholesterol levels and six-year mortality from stroke in 350,977 men screened for the multiple risk factor intervention trial N Engl J Med 1989, 320:904-10. 2619783
38. Kannel WB Castelli WP Gordon T McNamara PM Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study Ann Intern Med 1971, 74:1-12. 5539274
39. Ranade VV Significance of cholesterol in health and disease Int J Clin Pharmacol Ther Toxicol 1993, 31:276-84. 8335424
40. Klag MJ Ford DE Mead LA He J Whelton PK Liang KY Levine DM Serum cholesterol in young men and subsequent cardiovascular disease N Engl J Med 1993, 328:313-8. 8419817
41. Rashid S Curtis DE Garuti R Anderson NN Bashmakov Y Ho YK Hammer RE Moon YA Horton JD Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9 Proc Natl Acad Sci USA 2005, 102:5374-9. 556275 15805190
42. Wrenn SM Jr Parks JS Immermann FW Rudel LL ACAT inhibitors CL 283,546 and CL 283,796 reduce LDL cholesterol without affecting cholesterol absorption in African green monkeys J Lipid Res 1995, 36:1199-210. 7665998
43. Rudel LL Lee RG Parini P ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia Arterioscler Thromb Vasc Biol 2005, 25:1112-8. 15831806
44. Ferguson M Henry PA Currie RA Histone deacetylase inhibition is associated with transcriptional repression of the Hmga2 gene Nucleic Acids Res 2003, 31:3123-33. 162237 12799440
45. Bell TA 3rd Kelley K Wilson MD Sawyer JK Rudel LL Dietary fat-induced alterations in atherosclerosis are abolished by ACAT2-deficiency in ApoB100 only, LDLr-/- mice Arterioscler Thromb Vasc Biol 2007, 27:1396-402. 17431188