Second-generation histone deacetylase 6 inhibitors enhance the immunosuppressive effects of Foxp3+ T-regulatory cells

Journal of Medicinal Chemistry

Volumn 55, Issue 2, 2012, Pages 639-651

  Kalin, Jay H ^a   Butler, Kyle V ^a   Akimova, Tatiana ^b   Hancock, Wayne W ^b   Kozikowski, Alan P ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(2 (3 AMINO 3 OXOPROPYL) 3,4 DIHYDRO 1H PYRIDO(4,3 B)INDOL 5 (2H) YL)METHYL] N HYDROXYBENZAMIDE; 4 [(2 (3 AMINO 3 OXOPROPYL) 3,4 DIHYDRO 1H PYRIDO[4,3 B)INDOL 5 (2H) YL)METHYL] N HYDROXYBENZAMIDE; 4 [(2 ALLYL 3,4 DIHYDRO 1H PYRIDO(4,3 B]INDOL 5 (2H) YL)METHYL] N HYDROXYBENZAMIDE; 4 [(2 ALLYL 3,4 DIHYDRO 1H PYRIDO[4,3 B)INDOL 5 (2H) YL)METHYL] N HYDROXYBENZAMIDE; 4 [(2 BENZYL 3,4 DIHYDRO 1H PYRIDO(3,4 B)INDOL 9 (2H) YL)METHYL] N HYDROXYBENZAMIDE; 4 [(2 ETHYL 3,4 DIHYDRO 1H PYRIDO(4,3 B]INDOL 5 (2H) YL)METHYL] N HYDROXYBENZAMIDE; 4 [(2(4 AMINO 4 OXOBUTYL) 3,4 DIHYDRO 1H PYRIDO(4,3 B)INDOL 5 (2H) YL)METHYL] N HYDROXYBENZAMIDE; 4 [(2,6 DIMETHYL 3,4 DIHYDRO 1H PYRIDO(4,3 B)INDOL 5 (2H) YL) METHYL] N HYDROXYBENZAMIDE; 4 [(2,7 DIMETHYL 3,4 DIHYDRO 1H PYRIDO(4,3 B)INDOL 5 (2H) YL) METHYL] N HYDROXYBENZAMIDE; 4 [(2,8 DIMETHYL 3,4 DIHYDRO 1H PYRIDO(4,3 B)INDOL 5 (2H) YL) METHYL] N HYDROXYBENZAMIDE; 4 [(3,4 DIHYDRO 1H PYRIDO(3,4 B]INDOL 9 (2H) YL)METHYL] N HYDROXYBENAZAMIDE; 4 [(3,4 DIHYDRO 1H PYRIDO(4,3 B)INDOL 5 (2H) YL)METHYL] N HYDROXYBENZAMIDE; 4 [(8 BROMO 2 METHYL 3,4 DIHYDRO 1H PYRIDO(4,3 B)INDOL 5 (2H) YL)METHYL] N HYDROXYBENZAMIDE; 4 [(8 CHLORO 2 METHYL 3,4 DIHYDRO 1H PYRIDO[4,3 B]INDOL 5 (2H) YLMETHYL] N HYDROXYBENZAMIDE; 4 [(8 TERT BUTYL 2 METHYL 3,4 DIHYDRO 1H PYRIDO(4,3 B)INDOL 5 (2H) YL)METHYL] N HYDROXYBANZAMIDE; CARBOLINE DERIVATIVE; HISTONE DEACETYLASE INHIBITOR; IMMUNOSUPPRESSIVE AGENT; N HYDROXY 4 [(2 (3 METHOXYBENZYL) 3,4 DIHYDRO 1H PYRIDO(4,3 B)INDOL 5 (2H) YL)METHYL]BENZAMIDE; N HYDROXY 4 [(2 (4 METHOXYBENZYL) 3,4 DIHYDRO 1H PYRIDO[4,3 B)INDOL 5 (2H) YL)METHYL]BENZAMIDE; N HYDROXY 4 [(2 (PYRIDIN 4 YLMETHYL) 3,4 DIHYDRO 1H PYRIDO(4,3 B)INDOL 5 (2H) YL)METHYL]BENZAMIDE; N HYDROXY 4 [(2 ISOPROPYL 3,4 DIHYDRO 1H PYRIDO(4,3 B)INDOL 5 (2H) YL)METHYL]BENZAMIDE; N HYDROXY 4 [(2 METHYL 3,4 DIHYDRO 1H PYRIDO(3,4 B)INDOL 9 (2H) YL)METHYL]BENZAMIDE; N HYDROXY 4 [(2,7,9 TRIMETHYL 3,4 DIHYDRO 1H PYRID(4,3 B)INDOL 5 (2H) YL)METHYL]BENZAMIDE; N HYDROXY 4 [(8 METHOXY 2 METHYL 3,4 DIHYDRO 1H PYRIDO(4,3 B)INDOL 5 (2H) YL)METHYL]BENZAMIDE; TERT BUTYL 5 [4 (HYDROXYCARBAMOYL)BENZYL] 3,4 DIHYDRO 1HPYRIDO[4,3 B]INDOLE 2 (5H) CARBOXYLATE; TRANSCRIPTION FACTOR FOXP3; TUBASTATIN A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MITOSIS; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; SUBSTITUTION REACTION;

ANIMALS; ANTIGENS, CD4; CARBOLINES; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; INDOLES; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MICE; MICE, INBRED C57BL; MITOSIS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 84856390338     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200773h     Document Type: Article

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