Effect of a new immunosuppressant histon deacetylase (HDAC) inhibitor FR276457 in a rat cardiac transplant model

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 9, 2008, Pages 1723-1726

  Kinugasa, Fumitaka ^a   Yamada, Toshiko ^a   Noto, Takahisa ^b   Matsuoka, Hideaki ^a   Mori, Hiroaki ^a   Sudo, Yuji ^a   Mutoh, Seitaro ^a  

^a ASTELLAS PHARMA INC   (Japan)

^b ASTELLAS PHARMA GLOBAL DEVELOPMENT   (United States)

Author keywords

Combination therapy; Histone deacetylase inhibitor; Rat cardiac transplant model; Tacrolimus

Indexed keywords

CONCANAVALIN A; FR 276457; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; ISOENZYME; TACROLIMUS; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME SPECIFICITY; EXPERIMENTAL MODEL; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HEART MUSCLE; HEART TRANSPLANTATION; HETEROTOPIC TRANSPLANTATION; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INTERSTITIUM; MALE; MONOTHERAPY; NONHUMAN; RAT; SPLEEN CELL; SURVIVAL TIME; TRANSCRIPTION REGULATION;

ANIMALS; CELL PROLIFERATION; FEMALE; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; IMMUNOSUPPRESSIVE AGENTS; ISOENZYMES; MYOCARDIUM; RATS; RATS, INBRED LEW; T-LYMPHOCYTES; TACROLIMUS;

EID: 51449120215     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.1723     Document Type: Article

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