-
1
-
-
4544304222
-
Defining a link with asthma in mice congenitally deficient in eosinophils
-
Lee, J. J. et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 305, 1773-1776 (2004).
-
(2004)
Science
, vol.305
, pp. 1773-1776
-
-
Lee, J.J.1
-
2
-
-
4544274172
-
A critical role for eosinophils in allergic airways remodeling
-
Humbles, A. A. et al. A critical role for eosinophils in allergic airways remodeling. Science 305, 1776-1779 (2004).
-
(2004)
Science
, vol.305
, pp. 1776-1779
-
-
Humbles, A.A.1
-
3
-
-
81455155725
-
Reslizumab for poorly controlled, eosinophilic asthma: A randomized, placebo-controlled study
-
Castro, M. et al. Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am. J. Respir. Crit. Care Med. 184, 1125-1132 (2011).
-
(2011)
Am. J. Respir. Crit. Care Med.
, vol.184
, pp. 1125-1132
-
-
Castro, M.1
-
4
-
-
61849086181
-
Mepolizumab and exacerbations of refractory eosinophilic asthma
-
Haldar, P. et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N. Engl. J. Med. 360, 973-984 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 973-984
-
-
Haldar, P.1
-
5
-
-
84868608435
-
The expanding role(s) of eosinophils in health and disease
-
Jacobsen, E. A., Helmers, R. A., Lee, J. J. & Lee, N. A. The expanding role(s) of eosinophils in health and disease. Blood 120, 3882-3890 (2012).
-
(2012)
Blood
, vol.120
, pp. 3882-3890
-
-
Jacobsen, E.A.1
Helmers, R.A.2
Lee, J.J.3
Lee, N.A.4
-
6
-
-
77949349992
-
Eosinophils in health and disease: The LIAR hypothesis
-
Lee, J. J., Jacobsen, E. A., McGarry, M. P., Schleimer, R. P. & Lee, N. A. Eosinophils in health and disease: the LIAR hypothesis. Clin. Exp. Allergy 40, 563-575 (2010).
-
(2010)
Clin. Exp. Allergy
, vol.40
, pp. 563-575
-
-
Lee, J.J.1
Jacobsen, E.A.2
McGarry, M.P.3
Schleimer, R.P.4
Lee, N.A.5
-
7
-
-
0019766379
-
Tumour-associated eosinophilia: A review
-
Lowe, D., Jorizzo, J. & Hutt, M. S. Tumour-associated eosinophilia: a review. J. Clin. Pathol. 34, 1343-1348 (1981).
-
(1981)
J. Clin. Pathol.
, vol.34
, pp. 1343-1348
-
-
Lowe, D.1
Jorizzo, J.2
Hutt, M.S.3
-
8
-
-
33746931253
-
Pivotal advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response
-
Cormier, S. A. et al. Pivotal advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response. J. Leukoc. Biol. 79, 1131-1139 (2006).
-
(2006)
J. Leukoc. Biol.
, vol.79
, pp. 1131-1139
-
-
Cormier, S.A.1
-
9
-
-
33947689316
-
Regulation of carcinogenesis by IL-5 and CCL11: A potential role for eosinophils in tumor immune surveillance
-
Simson, L. et al. Regulation of carcinogenesis by IL-5 and CCL11: a potential role for eosinophils in tumor immune surveillance. J. Immunol. 178, 4222-4229 (2007).
-
(2007)
J. Immunol.
, vol.178
, pp. 4222-4229
-
-
Simson, L.1
-
10
-
-
78751627318
-
Eosinophils are required for the maintenance of plasma cells in the bone marrow
-
Chu, V. T. et al. Eosinophils are required for the maintenance of plasma cells in the bone marrow. Nature Immunol. 12, 151-159 (2011).
-
(2011)
Nature Immunol.
, vol.12
, pp. 151-159
-
-
Chu, V.T.1
-
11
-
-
84855211272
-
Immunization induces activation of bone marrow eosinophils required for plasma cell survival
-
Chu, V. T. & Berek, C. Immunization induces activation of bone marrow eosinophils required for plasma cell survival. Eur. J. Immunol. 42, 130-137 (2012).
-
(2012)
Eur. J. Immunol.
, vol.42
, pp. 130-137
-
-
Chu, V.T.1
Berek, C.2
-
12
-
-
82555169564
-
Escalating incidence of eosinophilic esophagitis: A 20-year prospective, population-based study in Olten County, Switzerland
-
Hruz, P. et al. Escalating incidence of eosinophilic esophagitis: a 20-year prospective, population-based study in Olten County, Switzerland. J. Allergy Clin. Immunol. 128, 1349-1350 (2011).
-
(2011)
J. Allergy Clin. Immunol.
, vol.128
, pp. 1349-1350
-
-
Hruz, P.1
-
13
-
-
84863776515
-
Mucosal eosinophilia: Prevalence and racial/ethnic differences in symptoms and endoscopic findings in adults over 10 years in an urban hospital
-
Bohm, M. et al. Mucosal eosinophilia: prevalence and racial/ethnic differences in symptoms and endoscopic findings in adults over 10 years in an urban hospital. J. Clin. Gastroenterol. 46, 567-574 (2011).
-
(2011)
J. Clin. Gastroenterol.
, vol.46
, pp. 567-574
-
-
Bohm, M.1
-
14
-
-
60549104442
-
Identification of the human eosinophil lineage-committed progenitor: Revision of phenotypic definition of the human common myeloid progenitor
-
Mori, Y. et al. Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor. J. Exp. Med. 206, 183-193 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 183-193
-
-
Mori, Y.1
-
15
-
-
22344443951
-
Identification of eosinophil lineage-committed progenitors in the murine bone marrow
-
Iwasaki, H. et al. Identification of eosinophil lineage-committed progenitors in the murine bone marrow. J. Exp. Med. 201, 1891-1897 (2005).
-
(2005)
J. Exp. Med.
, vol.201
, pp. 1891-1897
-
-
Iwasaki, H.1
-
16
-
-
0030831869
-
+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation
-
+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation. J. Clin. Invest. 100, 2466-2475 (1997).
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 2466-2475
-
-
Sehmi, R.1
-
17
-
-
42249088428
-
Eosinophils: Biological properties and role in health and disease
-
Hogan, S. P. et al. Eosinophils: biological properties and role in health and disease. Clin. Exp. Allergy 38, 709-750 (2008).
-
(2008)
Clin. Exp. Allergy
, vol.38
, pp. 709-750
-
-
Hogan, S.P.1
-
18
-
-
8644255894
-
Eosinophil degranulation status in allergic rhinitis: Observations before and during seasonal allergen exposure
-
Ahlstrom-Emanuelsson, C. A., Greiff, L., Andersson, M., Persson, C. G. & Erjefalt, J. S. Eosinophil degranulation status in allergic rhinitis: observations before and during seasonal allergen exposure. Eur. Respir. J. 24, 750-757 (2004).
-
(2004)
Eur. Respir. J.
, vol.24
, pp. 750-757
-
-
Ahlstrom-Emanuelsson, C.A.1
Greiff, L.2
Andersson, M.3
Persson, C.G.4
Erjefalt, J.S.5
-
19
-
-
0020071965
-
Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma
-
Filley, W. V., Holley, K. E., Kephart, G. M. & Gleich, G. J. Identification by immunofluorescence of eosinophil granule major basic protein in lung tissues of patients with bronchial asthma. Lancet 2, 11-16 (1982).
-
(1982)
Lancet
, vol.2
, pp. 11-16
-
-
Filley, W.V.1
Holley, K.E.2
Kephart, G.M.3
Gleich, G.J.4
-
20
-
-
76349125983
-
Marked deposition of eosinophil-derived neurotoxin in adult patients with eosinophilic esophagitis
-
Kephart, G. M. et al. Marked deposition of eosinophil-derived neurotoxin in adult patients with eosinophilic esophagitis. Am. J. Gastroenterol. 105, 298-307 (2010).
-
(2010)
Am. J. Gastroenterol.
, vol.105
, pp. 298-307
-
-
Kephart, G.M.1
-
21
-
-
0026609027
-
Tissue eosinophilia and eosinophil degranulation in syndromes associated with fibrosis
-
Noguchi, H., Kephart, G. M., Colby, T. V. & Gleich, G. J. Tissue eosinophilia and eosinophil degranulation in syndromes associated with fibrosis. Am. J. Pathol. 140, 521-528 (1992).
-
(1992)
Am. J. Pathol.
, vol.140
, pp. 521-528
-
-
Noguchi, H.1
Kephart, G.M.2
Colby, T.V.3
Gleich, G.J.4
-
22
-
-
0032864516
-
Deposition of eosinophil-granule major basic protein and expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in the mucosa of the small intestine in infants with cow's milk-sensitive enteropathy
-
Chung, H. L. et al. Deposition of eosinophil-granule major basic protein and expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in the mucosa of the small intestine in infants with cow's milk-sensitive enteropathy. J. Allergy Clin. Immunol. 103, 1195-1201 (1999).
-
(1999)
J. Allergy Clin. Immunol.
, vol.103
, pp. 1195-1201
-
-
Chung, H.L.1
-
23
-
-
0029887638
-
Effect of eosinophil peroxidase on airway epithelial permeability in the guinea pig
-
Brottman, G. M., Regelmann, W. E., Slungaard, A. & Wangensteen, O. D. Effect of eosinophil peroxidase on airway epithelial permeability in the guinea pig. Pediatr. Pulmonol. 21, 159-166 (1996).
-
(1996)
Pediatr. Pulmonol.
, vol.21
, pp. 159-166
-
-
Brottman, G.M.1
Regelmann, W.E.2
Slungaard, A.3
Wangensteen, O.D.4
-
24
-
-
0018639632
-
Cytotoxic properties of the eosinophil major basic protein
-
Gleich, G. J., Frigas, E., Loegering, D. A., Wassom, D. L. & Steinmuller, D. Cytotoxic properties of the eosinophil major basic protein. J. Immunol. 123, 2925-2927 (1979).
-
(1979)
J. Immunol.
, vol.123
, pp. 2925-2927
-
-
Gleich, G.J.1
Frigas, E.2
Loegering, D.A.3
Wassom, D.L.4
Steinmuller, D.5
-
25
-
-
0020327601
-
Toxic effects of human eosinophil products on isolated rat heart cells in vitro
-
Tai, P. C., Hayes, D. J., Clark, J. B. & Spry, C. J. Toxic effects of human eosinophil products on isolated rat heart cells in vitro. Biochem. J. 204, 75-80 (1982).
-
(1982)
Biochem. J.
, vol.204
, pp. 75-80
-
-
Tai, P.C.1
Hayes, D.J.2
Clark, J.B.3
Spry, C.J.4
-
26
-
-
47749113698
-
Eosinophil-derived neurotoxin/RNase 2: Connecting the past, the present and the future
-
Rosenberg, H. F. Eosinophil-derived neurotoxin/RNase 2: connecting the past, the present and the future. Curr. Pharm. Biotechnol. 9, 135-140 (2008).
-
(2008)
Curr. Pharm. Biotechnol.
, vol.9
, pp. 135-140
-
-
Rosenberg, H.F.1
-
27
-
-
0031596883
-
Recombinant human eosinophil-derived neurotoxin/RNase 2 functions as an effective antiviral agent against respiratory syncytial virus
-
Domachowske, J. B., Dyer, K. D., Bonville, C. A. & Rosenberg, H. F. Recombinant human eosinophil-derived neurotoxin/RNase 2 functions as an effective antiviral agent against respiratory syncytial virus. J. Infect. Dis. 177, 1458-1464 (1998).
-
(1998)
J. Infect. Dis.
, vol.177
, pp. 1458-1464
-
-
Domachowske, J.B.1
Dyer, K.D.2
Bonville, C.A.3
Rosenberg, H.F.4
-
28
-
-
0027056728
-
Eosinophil cationic protein alters proteoglycan metabolism in human lung fibroblast cultures
-
Hernnas, J. et al. Eosinophil cationic protein alters proteoglycan metabolism in human lung fibroblast cultures. Eur. J. Cell Biol. 59, 352-363 (1992).
-
(1992)
Eur. J. Cell Biol.
, vol.59
, pp. 352-363
-
-
Hernnas, J.1
-
29
-
-
84864775656
-
Eosinophil crystalloid granules: Structure, function, and beyond
-
Muniz, V. S., Weller, P. F. & Neves, J. S. Eosinophil crystalloid granules: structure, function, and beyond. J. Leukoc. Biol. 92, 281-288 (2012).
-
(2012)
J. Leukoc. Biol.
, vol.92
, pp. 281-288
-
-
Muniz, V.S.1
Weller, P.F.2
Neves, J.S.3
-
30
-
-
0029972142
-
Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes
-
Meagher, L. C., Cousin, J. M., Seckl, J. R. & Haslett, C. Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. J. Immunol. 156, 4422-4428 (1996).
-
(1996)
J. Immunol.
, vol.156
, pp. 4422-4428
-
-
Meagher, L.C.1
Cousin, J.M.2
Seckl, J.R.3
Haslett, C.4
-
31
-
-
0141927331
-
Glucocorticoid-induced apoptosis in human eosinophils: Mechanisms of action
-
Druilhe, A., Letuve, S. & Pretolani, M. Glucocorticoid-induced apoptosis in human eosinophils: mechanisms of action. Apoptosis 8, 481-495 (2003).
-
(2003)
Apoptosis
, vol.8
, pp. 481-495
-
-
Druilhe, A.1
Letuve, S.2
Pretolani, M.3
-
32
-
-
0026315499
-
Eosinophil hematopoietins antagonize the programmed cell death of eosinophils. Cytokine and glucocorticoid effects on eosinophils maintained by endothelial cell-conditioned medium
-
Her, E., Frazer, J., Austen, K. F. & Owen, W. F. Jr. Eosinophil hematopoietins antagonize the programmed cell death of eosinophils. Cytokine and glucocorticoid effects on eosinophils maintained by endothelial cell-conditioned medium. J. Clin. Invest. 88, 1982-1987 (1991).
-
(1991)
J. Clin. Invest.
, vol.88
, pp. 1982-1987
-
-
Her, E.1
Frazer, J.2
Austen, K.F.3
Owen Jr., W.F.4
-
33
-
-
63349097828
-
Imatinib has limited therapeutic activity for hypereosinophilic syndrome patients with unknown or negative PDGFRα mutation status
-
Jain, N. et al. Imatinib has limited therapeutic activity for hypereosinophilic syndrome patients with unknown or negative PDGFRα mutation status. Leuk. Res. 33, 837-839 (2009).
-
(2009)
Leuk. Res.
, vol.33
, pp. 837-839
-
-
Jain, N.1
-
34
-
-
71249101922
-
Hypereosinophilic syndrome: A multicenter, retrospective analysis of clinical characteristics and response to therapy
-
Ogbogu, P. U. et al. Hypereosinophilic syndrome: a multicenter, retrospective analysis of clinical characteristics and response to therapy. J. Allergy Clin. Immunol. 124, 1319-1325 (2009).
-
(2009)
J. Allergy Clin. Immunol.
, vol.124
, pp. 1319-1325
-
-
Ogbogu, P.U.1
-
35
-
-
0032873662
-
Anti-interleukin 5 but not anti-IgE prevents airway inflammation and airway hyperresponsiveness
-
Hamelmann, E. et al. Anti-interleukin 5 but not anti-IgE prevents airway inflammation and airway hyperresponsiveness. Am. J. Respir. Crit. Care Med. 160, 934-941 (1999).
-
(1999)
Am. J. Respir. Crit. Care Med.
, vol.160
, pp. 934-941
-
-
Hamelmann, E.1
-
36
-
-
40949146020
-
Treatment of patients with the hypereosinophilic syndrome with mepolizumab
-
Rothenberg, M. E. et al. Treatment of patients with the hypereosinophilic syndrome with mepolizumab. N. Engl. J. Med. 358, 1215-1228 (2008).
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 1215-1228
-
-
Rothenberg, M.E.1
-
37
-
-
33750494433
-
Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis
-
Stein, M. L. et al. Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis. J. Allergy Clin. Immunol. 118, 1312-1319 (2006).
-
(2006)
J. Allergy Clin. Immunol.
, vol.118
, pp. 1312-1319
-
-
Stein, M.L.1
-
38
-
-
84865145614
-
Mepolizumab for severe eosinophilic asthma (DREAM): A multicentre, double-blind, placebo-controlled trial
-
Pavord, I. D. et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 380, 651-659 (2012).
-
(2012)
Lancet
, vol.380
, pp. 651-659
-
-
Pavord, I.D.1
-
39
-
-
68249124539
-
CCR3 antagonists: A survey of the patent literature
-
Gong, L. & Wilhelm, R. S. CCR3 antagonists: a survey of the patent literature. Expert Opin. Ther. Pat. 19, 1109-1132 (2009).
-
(2009)
Expert Opin. Ther. Pat.
, vol.19
, pp. 1109-1132
-
-
Gong, L.1
Wilhelm, R.S.2
-
41
-
-
0029909376
-
2+-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein
-
2+-mobilization, actin reorganization, and CD11b upregulation in human eosinophils via a pertussis toxin-sensitive heterotrimeric guanine nucleotide-binding protein. Blood 88, 3195-3199 (1996).
-
(1996)
Blood
, vol.88
, pp. 3195-3199
-
-
Tenscher, K.1
Metzner, B.2
Schopf, E.3
Norgauer, J.4
Czech, W.5
-
42
-
-
0034653460
-
Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases
-
Kampen, G. T. et al. Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 95, 1911-1917 (2000).
-
(2000)
Blood
, vol.95
, pp. 1911-1917
-
-
Kampen, G.T.1
-
43
-
-
34249798763
-
Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling
-
Fulkerson, P. C., Fischetti, C. A. & Rothenberg, M. E. Eosinophils and CCR3 regulate interleukin-13 transgene-induced pulmonary remodeling. Am. J. Pathol. 169, 2117-2126 (2006).
-
(2006)
Am. J. Pathol.
, vol.169
, pp. 2117-2126
-
-
Fulkerson, P.C.1
Fischetti, C.A.2
Rothenberg, M.E.3
-
44
-
-
33750811888
-
A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation
-
Fulkerson, P. C. et al. A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Proc. Natl Acad. Sci. USA 103, 16418-16423 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 16418-16423
-
-
Fulkerson, P.C.1
-
45
-
-
58149179172
-
Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis
-
Ahrens, R. et al. Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis. J. Immunol. 181, 7390-7399 (2008).
-
(2008)
J. Immunol.
, vol.181
, pp. 7390-7399
-
-
Ahrens, R.1
-
46
-
-
79956218487
-
+ inflammatory monocyte/macrophage-derived CCL11
-
+ inflammatory monocyte/macrophage-derived CCL11. J. Immunol. 186, 5993-6003 (2011).
-
(2011)
J. Immunol.
, vol.186
, pp. 5993-6003
-
-
Waddell, A.1
-
47
-
-
0031445441
-
Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells
-
Ying, S. et al. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur. J. Immunol. 27, 3507-3516 (1997).
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 3507-3516
-
-
Ying, S.1
-
48
-
-
33846074487
-
Effects of a low-molecular-weight CCR-3 antagonist on chronic experimental asthma
-
Wegmann, M. et al. Effects of a low-molecular-weight CCR-3 antagonist on chronic experimental asthma. Am. J. Respir. Cell. Mol. Biol. 36, 61-67 (2007).
-
(2007)
Am. J. Respir. Cell. Mol. Biol.
, vol.36
, pp. 61-67
-
-
Wegmann, M.1
-
49
-
-
77249130857
-
A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in mice
-
Komai, M. et al. A novel CC-chemokine receptor 3 antagonist, Ki19003, inhibits airway eosinophilia and subepithelial/peribronchial fibrosis induced by repeated antigen challenge in mice. J. Pharmacol. Sci. 11 2, 203-213 (2010).
-
(2010)
J. Pharmacol. Sci.
, vol.112
, pp. 203-213
-
-
Komai, M.1
-
50
-
-
9144248460
-
Bertilimumab Cambridge antibody technology group
-
Ding, C., Li, J. & Zhang, X. Bertilimumab Cambridge Antibody Technology Group. Curr. Opin. Investig. Drugs 5, 1213-1218 (2004).
-
(2004)
Curr. Opin. Investig. Drugs
, vol.5
, pp. 1213-1218
-
-
Ding, C.1
Li, J.2
Zhang, X.3
-
51
-
-
32444443951
-
Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis
-
Blanchard, C. et al. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J. Clin. Invest. 116, 536-547 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 536-547
-
-
Blanchard, C.1
-
52
-
-
77956203100
-
IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent il-13rα2-inhibited pathway
-
Zuo, L. et al. IL-13 induces esophageal remodeling and gene expression by an eosinophil-independent, IL-13Rα2-inhibited pathway. J. Immunol. 185, 660-669 (2010).
-
(2010)
J. Immunol.
, vol.185
, pp. 660-669
-
-
Zuo, L.1
-
53
-
-
0037013925
-
Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma
-
Mattes, J. et al. Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J. Exp. Med. 195, 1433-1444 (2002).
-
(2002)
J. Exp. Med.
, vol.195
, pp. 1433-1444
-
-
Mattes, J.1
-
54
-
-
0028345697
-
Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue
-
Nakajima, H., Sano, H., Nishimura, T., Yoshida, S. & Iwamoto, I. Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. J. Exp. Med. 179, 1145-1154 (1994).
-
(1994)
J. Exp. Med.
, vol.179
, pp. 1145-1154
-
-
Nakajima, H.1
Sano, H.2
Nishimura, T.3
Yoshida, S.4
Iwamoto, I.5
-
55
-
-
0031573520
-
Blockade of CD49d (α4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma
-
Henderson, W. R. Jr et al. Blockade of CD49d (α4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma. J. Clin. Invest. 100, 3083-3092 (1997).
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 3083-3092
-
-
Henderson Jr., W.R.1
-
56
-
-
33847106380
-
Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4
-
Okigami, H. et al. Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4. Eur. J. Pharmacol. 559, 202-209 (2007).
-
(2007)
Eur. J. Pharmacol.
, vol.559
, pp. 202-209
-
-
Okigami, H.1
-
57
-
-
82955235691
-
Hypereosinophilia in patients with multiple sclerosis treated with natalizumab
-
Abbas, M. et al. Hypereosinophilia in patients with multiple sclerosis treated with natalizumab. Neurology 77, 1561-1564 (2011).
-
(2011)
Neurology
, vol.77
, pp. 1561-1564
-
-
Abbas, M.1
-
58
-
-
0022388825
-
Role of human basophils and mast cells in the pathogenesis of allergic diseases
-
Schleimer, R. P. et al. Role of human basophils and mast cells in the pathogenesis of allergic diseases. J. Allergy Clin. Immunol. 76, 369-374 (1985).
-
(1985)
J. Allergy Clin. Immunol.
, vol.76
, pp. 369-374
-
-
Schleimer, R.P.1
-
59
-
-
49749119253
-
The role of the prostaglandin D2 receptor, D P, in eosinophil trafficking
-
Schratl, P. et al. The role of the prostaglandin D2 receptor, D P, in eosinophil trafficking. J. Immunol. 179, 4792-4799 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 4792-4799
-
-
Schratl, P.1
-
60
-
-
35748943481
-
A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst
-
Royer, J. F. et al. A novel antagonist of CRTH2 blocks eosinophil release from bone marrow, chemotaxis and respiratory burst. Allergy 62, 1401-1409 (2007).
-
(2007)
Allergy
, vol.62
, pp. 1401-1409
-
-
Royer, J.F.1
-
61
-
-
0035862329
-
Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2
-
Hirai, H. et al. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J. Exp. Med. 193, 255-261 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 255-261
-
-
Hirai, H.1
-
62
-
-
79958162505
-
Role of prostaglandin D2 receptor CRTH2 in sustained eosinophil accumulation in the airways of mice with chronic asthma
-
Kagawa, S. et al. Role of prostaglandin D2 receptor CRTH2 in sustained eosinophil accumulation in the airways of mice with chronic asthma. Int. Arch. Allergy Immunol. 155 (Suppl. 1), 6-11 (2011).
-
(2011)
Int. Arch. Allergy Immunol.
, vol.155
, Issue.SUPPL. 1
, pp. 6-11
-
-
Kagawa, S.1
-
63
-
-
0037407693
-
δ12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis
-
Heinemann, A., Schuligoi, R., Sabroe, I., Hartnell, A. & Peskar, B. A. δ12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis. J. Immunol. 170, 4752-4758 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 4752-4758
-
-
Heinemann, A.1
Schuligoi, R.2
Sabroe, I.3
Hartnell, A.4
Peskar, B.A.5
-
64
-
-
0037382497
-
An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro
-
Sugimoto, H. et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. J. Pharmacol. Exp. Ther. 305, 347-352 (2003).
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.305
, pp. 347-352
-
-
Sugimoto, H.1
-
65
-
-
77953598665
-
CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases
-
Schuligoi, R. et al. CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases. Pharmacology 85, 372-382 (2010).
-
(2010)
Pharmacology
, vol.85
, pp. 372-382
-
-
Schuligoi, R.1
-
66
-
-
84655167630
-
A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma
-
Barnes, N. et al. A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma. Clin. Exp. Allergy 42, 38-48 (2012).
-
(2012)
Clin. Exp. Allergy
, vol.42
, pp. 38-48
-
-
Barnes, N.1
-
67
-
-
0037202790
-
Asthma exacerbations and sputum eosinophil counts: A randomised controlled trial
-
Green, R. H. et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 360, 1715-1721 (2002).
-
(2002)
Lancet
, vol.360
, pp. 1715-1721
-
-
Green, R.H.1
-
68
-
-
84873404923
-
856 treatment of eosinophilic esophagitis with the CRTH2-antagonist Oc000459: A novel therapeutic principle
-
Straumann, A. et al. 856 treatment of eosinophilic esophagitis with the CRTH2-antagonist Oc000459: a novel therapeutic principle. Gastroenterology 142 (Suppl. 1), 147 (2012).
-
(2012)
Gastroenterology
, vol.142
, Issue.SUPPL. 1
, pp. 147
-
-
Straumann, A.1
-
69
-
-
0036978843
-
Identification of a histamine H4 receptor on human eosinophils-role in eosinophil chemotaxis
-
O'Reilly, M. et al. Identification of a histamine H4 receptor on human eosinophils-role in eosinophil chemotaxis. J. Recept. Signal Transduct. Res. 22, 431-448 (2002).
-
(2002)
J. Recept. Signal Transduct. Res.
, vol.22
, pp. 431-448
-
-
O'Reilly, M.1
-
70
-
-
2542530713
-
Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation
-
Ling, P. et al. Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br. J. Pharmacol. 142, 161-171 (2004).
-
(2004)
Br. J. Pharmacol.
, vol.142
, pp. 161-171
-
-
Ling, P.1
-
71
-
-
84855440025
-
4 receptor small molecule antagonist with anti-inflammatory pain and anti-pruritic functions
-
4 receptor small molecule antagonist with anti-inflammatory pain and anti-pruritic functions. Eur. J. Pharmacol. 675, 47-56 (2012).
-
(2012)
Eur. J. Pharmacol.
, vol.675
, pp. 47-56
-
-
Shin, N.1
-
72
-
-
67149084970
-
The role of histamine H4 receptor in immune and inflammatory disorders
-
Zampeli, E. & Tiligada, E. The role of histamine H4 receptor in immune and inflammatory disorders. Br. J. Pharmacol. 157, 24-33 (2009).
-
(2009)
Br. J. Pharmacol.
, vol.157
, pp. 24-33
-
-
Zampeli, E.1
Tiligada, E.2
-
73
-
-
38349062989
-
Antigen inhalation induces mast cells and eosinophils infiltration in the guinea pig esophageal epithelium involving histamine-mediated pathway
-
Yu, S., Stahl, E., Li, Q. & Ouyang, A. Antigen inhalation induces mast cells and eosinophils infiltration in the guinea pig esophageal epithelium involving histamine-mediated pathway. Life Sci. 82, 324-330 (2008).
-
(2008)
Life Sci.
, vol.82
, pp. 324-330
-
-
Yu, S.1
Stahl, E.2
Li, Q.3
Ouyang, A.4
-
74
-
-
37749048627
-
The role of histamine H1 and H4 receptors in allergic inflammation: The search for new antihistamines
-
Thurmond, R. L., Gelfand, E. W. & Dunford, P. J. The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nature Rev. Drug Discov. 7, 41-53 (2008).
-
(2008)
Nature Rev. Drug Discov.
, vol.7
, pp. 41-53
-
-
Thurmond, R.L.1
Gelfand, E.W.2
Dunford, P.J.3
-
75
-
-
77949897036
-
Importance of cytokines in murine allergic airway disease and human asthma
-
Finkelman, F. D., Hogan, S. P., Hershey, G. K., Rothenberg, M. E. & Wills-Karp, M. Importance of cytokines in murine allergic airway disease and human asthma. J. Immunol. 184, 1663-1674 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 1663-1674
-
-
Finkelman, F.D.1
Hogan, S.P.2
Hershey, G.K.3
Rothenberg, M.E.4
Wills-Karp, M.5
-
76
-
-
79959830634
-
Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies
-
Sherrill, J. D. & Rothenberg, M. E. Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies. J. Allergy Clin. Immunol. 128, 23-32 (2011).
-
(2011)
J. Allergy Clin. Immunol.
, vol.128
, pp. 23-32
-
-
Sherrill, J.D.1
Rothenberg, M.E.2
-
77
-
-
0034769498
-
IL-13 induces eosinophil recruitment into the lung by an IL-5-and eotaxin-dependent mechanism
-
Pope, S. M. et al. IL-13 induces eosinophil recruitment into the lung by an IL-5-and eotaxin-dependent mechanism. J. Allergy Clin. Immunol. 108, 594-601 (2001).
-
(2001)
J. Allergy Clin. Immunol.
, vol.108
, pp. 594-601
-
-
Pope, S.M.1
-
78
-
-
17144362809
-
Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation
-
Pope, S. M. et al. Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation. J. Biol. Chem. 280, 13952-13961 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 13952-13961
-
-
Pope, S.M.1
-
79
-
-
36849017952
-
IL-13 involvement in eosinophilic esophagitis: Transcriptome analysis and reversibility with glucocorticoids
-
Blanchard, C. et al. IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids. J. Allergy Clin. Immunol. 120, 1292-1300 (2007).
-
(2007)
J. Allergy Clin. Immunol.
, vol.120
, pp. 1292-1300
-
-
Blanchard, C.1
-
80
-
-
0029038120
-
IL-13 expression at the sites of allergen challenge in patients with asthma
-
Huang, S. K. et al. IL-13 expression at the sites of allergen challenge in patients with asthma. J. Immunol. 155, 2688-2694 (1995).
-
(1995)
J. Immunol.
, vol.155
, pp. 2688-2694
-
-
Huang, S.K.1
-
81
-
-
0033856743
-
Increased interleukin-13 mRNA expression in bronchoalveolar lavage cells of atopic patients with mild asthma after repeated low-dose allergen provocations
-
Prieto, J. et al. Increased interleukin-13 mRNA expression in bronchoalveolar lavage cells of atopic patients with mild asthma after repeated low-dose allergen provocations. Respir. Med. 94, 806-814 (2000).
-
(2000)
Respir. Med.
, vol.94
, pp. 806-814
-
-
Prieto, J.1
-
82
-
-
79954583416
-
Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma
-
Gauvreau, G. M. et al. Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma. Am. J. Respir. Crit. Care Med. 183, 1007-1014 (2011).
-
(2011)
Am. J. Respir. Crit. Care Med.
, vol.183
, pp. 1007-1014
-
-
Gauvreau, G.M.1
-
83
-
-
80053084755
-
Lebrikizumab treatment in adults with asthma
-
Corren, J. et al. Lebrikizumab treatment in adults with asthma. N. Engl. J. Med. 365, 1088-1098 (2011).
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 1088-1098
-
-
Corren, J.1
-
84
-
-
80053568990
-
The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge
-
Nicholson, G. C. et al. The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge. J. Allergy Clin. Immunol. 128, 800-807 (2011).
-
(2011)
J. Allergy Clin. Immunol.
, vol.128
, pp. 800-807
-
-
Nicholson, G.C.1
-
85
-
-
0035340763
-
A murine IL-4 receptor antagonist that inhibits IL-4-and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness
-
Tomkinson, A. et al. A murine IL-4 receptor antagonist that inhibits IL-4-and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness. J. Immunol. 166, 5792-5800 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 5792-5800
-
-
Tomkinson, A.1
-
86
-
-
44449167278
-
Distinct roles for IL-13 and IL-4 via IL-13 receptor α1 and the type II IL-4 receptor in asthma pathogenesis
-
Munitz, A., Brandt, E. B., Mingler, M., Finkelman, F. D. & Rothenberg, M. E. Distinct roles for IL-13 and IL-4 via IL-13 receptor α1 and the type II IL-4 receptor in asthma pathogenesis. Proc. Natl Acad. Sci. USA 105, 7240-7245 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 7240-7245
-
-
Munitz, A.1
Brandt, E.B.2
Mingler, M.3
Finkelman, F.D.4
Rothenberg, M.E.5
-
87
-
-
77953039047
-
A randomized, controlled, phase 2 study of AMG 317, an IL-4Rα antagonist, in patients with asthma
-
Corren, J. et al. A randomized, controlled, phase 2 study of AMG 317, an IL-4Rα antagonist, in patients with asthma. Am. J. Respir. Crit. Care Med. 181, 788-796 (2010).
-
(2010)
Am. J. Respir. Crit. Care Med.
, vol.181
, pp. 788-796
-
-
Corren, J.1
-
88
-
-
35348909044
-
Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: Results of two phase 2a studies
-
Wenzel, S., Wilbraham, D., Fuller, R., Getz, E. B. & Longphre, M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 370, 1422-1431 (2007).
-
(2007)
Lancet
, vol.370
, pp. 1422-1431
-
-
Wenzel, S.1
Wilbraham, D.2
Fuller, R.3
Getz, E.B.4
Longphre, M.5
-
89
-
-
61849155730
-
Mepolizumab for prednisone-dependent asthma with sputum eosinophilia
-
Nair, P. et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N. Engl. J. Med. 360, 985-993 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 985-993
-
-
Nair, P.1
-
90
-
-
80055022680
-
Monoclonal antibodies for the treatment of asthma
-
Catley, M. C., Coote, J., Bari, M. & Tomlinson, K. L. Monoclonal antibodies for the treatment of asthma. Pharmacol. Ther. 132, 333-351 (2011).
-
(2011)
Pharmacol. Ther.
, vol.132
, pp. 333-351
-
-
Catley, M.C.1
Coote, J.2
Bari, M.3
Tomlinson, K.L.4
-
92
-
-
82355162913
-
Interleukin-5 and IL-5 receptor in health and diseases
-
Takatsu, K. Interleukin-5 and IL-5 receptor in health and diseases. Proc. Jpn Acad. Ser. B Phys. Biol. Sci. 87, 463-485 (2011).
-
(2011)
Proc. Jpn Acad. Ser. B Phys. Biol. Sci.
, vol.87
, pp. 463-485
-
-
Takatsu, K.1
-
93
-
-
84860010929
-
Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor
-
Molfino, N. A., Gossage, D., Kolbeck, R., Parker, J. M. & Geba, G. P. Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor. Clin. Exp. Allergy 42, 712-737 (2012).
-
(2012)
Clin. Exp. Allergy
, vol.42
, pp. 712-737
-
-
Molfino, N.A.1
Gossage, D.2
Kolbeck, R.3
Parker, J.M.4
Geba, G.P.5
-
94
-
-
70449490403
-
Functional extracellular eosinophil granules: Novel implications in eosinophil immunobiology
-
Neves, J. S. & Weller, P. F. Functional extracellular eosinophil granules: novel implications in eosinophil immunobiology. Curr. Opin. Immunol. 21, 694-699 (2009).
-
(2009)
Curr. Opin. Immunol.
, vol.21
, pp. 694-699
-
-
Neves, J.S.1
Weller, P.F.2
-
95
-
-
0026580593
-
Apoptosis in human eosinophils. Programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5
-
Stern, M., Meagher, L., Savill, J. & Haslett, C. Apoptosis in human eosinophils. Programmed cell death in the eosinophil leads to phagocytosis by macrophages and is modulated by IL-5. J. Immunol. 148, 3543-3549 (1992).
-
(1992)
J. Immunol.
, vol.148
, pp. 3543-3549
-
-
Stern, M.1
Meagher, L.2
Savill, J.3
Haslett, C.4
-
96
-
-
0025769977
-
Effects of IL-5, granulocyte/macrophage colony-stimulating factor (GM-CSF) and IL-3 on the survival of human blood eosinophils in vitro
-
Tai, P. C., Sun, L. & Spry, C. J. Effects of IL-5, granulocyte/macrophage colony-stimulating factor (GM-CSF) and IL-3 on the survival of human blood eosinophils in vitro. Clin. Exp. Immunol. 85, 312-316 (1991).
-
(1991)
Clin. Exp. Immunol.
, vol.85
, pp. 312-316
-
-
Tai, P.C.1
Sun, L.2
Spry, C.J.3
-
97
-
-
0025723962
-
Analysis of the survival of mature human eosinophils: Interleukin-5 prevents apoptosis in mature human eosinophils
-
Yamaguchi, Y. et al. Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils. Blood 78, 2542-2547 (1991).
-
(1991)
Blood
, vol.78
, pp. 2542-2547
-
-
Yamaguchi, Y.1
-
98
-
-
80054871141
-
An antibody against IL-5 reduces numbers of esophageal intraepithelial eosinophils in children with eosinophilic esophagitis
-
Assa'ad, A. H. et al. An antibody against IL-5 reduces numbers of esophageal intraepithelial eosinophils in children with eosinophilic esophagitis. Gastroenterology 141, 1593-1604 (2011).
-
(2011)
Gastroenterology
, vol.141
, pp. 1593-1604
-
-
Assa'Ad, A.H.1
-
99
-
-
73449140151
-
Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: A randomised, placebo-controlled, double-blind trial
-
Straumann, A. et al. Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial. Gut 59, 21-30 (2010).
-
(2010)
Gut
, vol.59
, pp. 21-30
-
-
Straumann, A.1
-
100
-
-
80055080497
-
Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis
-
Gevaert, P. et al. Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis. J. Allergy Clin. Immunol. 128, 989-995 (2011).
-
(2011)
J. Allergy Clin. Immunol.
, vol.128
, pp. 989-995
-
-
Gevaert, P.1
-
101
-
-
84856458622
-
Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial
-
Spergel, J. M. et al. Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial. J. Allergy Clin. Immunol. 129, 456-463.e3 (2012).
-
(2012)
J. Allergy Clin. Immunol.
, vol.129
-
-
Spergel, J.M.1
-
102
-
-
0038643527
-
Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: A pilot study
-
Kips, J. C. et al. Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am. J. Respir. Crit. Care Med. 167, 1655-1659 (2003).
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.167
, pp. 1655-1659
-
-
Kips, J.C.1
-
103
-
-
77952733788
-
MEDI-563, a humanized anti-IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function
-
Kolbeck, R. et al. MEDI-563, a humanized anti-IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J. Allergy Clin. Immunol. 125, 1344-1353 (2010).
-
(2010)
J. Allergy Clin. Immunol.
, vol.125
, pp. 1344-1353
-
-
Kolbeck, R.1
-
104
-
-
77952683218
-
Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor α antibody, in a phase i study of subjects with mild asthma
-
Busse, W. W. et al. Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor α antibody, in a phase I study of subjects with mild asthma. J. Allergy Clin. Immunol. 125, 1237-1244 (2010).
-
(2010)
J. Allergy Clin. Immunol.
, vol.125
, pp. 1237-1244
-
-
Busse, W.W.1
-
105
-
-
80054978390
-
TPI ASM8 reduces eosinophil progenitors in sputum after allergen challenge
-
Imaoka, H. et al. TPI ASM8 reduces eosinophil progenitors in sputum after allergen challenge. Clin. Exp. Allergy 41, 1740-1746 (2011).
-
(2011)
Clin. Exp. Allergy
, vol.41
, pp. 1740-1746
-
-
Imaoka, H.1
-
106
-
-
84856431819
-
RNA therapeutics: Beyond RNA interference and antisense oligonucleo-tides
-
Kole, R., Krainer, A. R. & Altman, S. RNA therapeutics: beyond RNA interference and antisense oligonucleo-tides. Nature Rev. Drug Discov. 11, 125-140 (2012).
-
(2012)
Nature Rev. Drug Discov.
, vol.11
, pp. 125-140
-
-
Kole, R.1
Krainer, A.R.2
Altman, S.3
-
107
-
-
84856389509
-
RNA-based therapeutics: Current progress and future prospects
-
Burnett, J. C. & Rossi, J. J. RNA-based therapeutics: current progress and future prospects. Chem. Biol. 19, 60-71 (2012).
-
(2012)
Chem. Biol.
, vol.19
, pp. 60-71
-
-
Burnett, J.C.1
Rossi, J.J.2
-
108
-
-
45749096229
-
An endogenous TNF-α antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models
-
Graziewicz, M. A. et al. An endogenous TNF-α antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models. Mol. Ther. 16, 1316-1322 (2008).
-
(2008)
Mol. Ther.
, vol.16
, pp. 1316-1322
-
-
Graziewicz, M.A.1
-
109
-
-
58849167243
-
Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors
-
Bochner, B. S. Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors. Clin. Exp. Allergy 39, 317-324 (2009).
-
(2009)
Clin. Exp. Allergy
, vol.39
, pp. 317-324
-
-
Bochner, B.S.1
-
110
-
-
0038044928
-
Ligation of Siglec-8: A selective mechanism for induction of human eosinophil apoptosis
-
Nutku, E., Aizawa, H., Hudson, S. A. & Bochner, B. S. Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis. Blood 101, 5014-5020 (2003).
-
(2003)
Blood
, vol.101
, pp. 5014-5020
-
-
Nutku, E.1
Aizawa, H.2
Hudson, S.A.3
Bochner, B.S.4
-
111
-
-
34248376987
-
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils
-
Zhang, M. et al. Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood 109, 4280-4287 (2007).
-
(2007)
Blood
, vol.109
, pp. 4280-4287
-
-
Zhang, M.1
-
112
-
-
49249130983
-
Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils
-
Zimmermann, N. et al. Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils. Allergy 63, 1156-1163 (2008).
-
(2008)
Allergy
, vol.63
, pp. 1156-1163
-
-
Zimmermann, N.1
-
113
-
-
63249123223
-
Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model
-
Song, D. J. et al. Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model. Clin. Immunol. 131, 157-169 (2009).
-
(2009)
Clin. Immunol.
, vol.131
, pp. 157-169
-
-
Song, D.J.1
-
114
-
-
84864483273
-
Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions
-
Kiwamoto, T., Kawasaki, N., Paulson, J. C. & Bochner, B. S. Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions. Pharmacol. Ther. 135, 327-336 (2012).
-
(2012)
Pharmacol. Ther.
, vol.135
, pp. 327-336
-
-
Kiwamoto, T.1
Kawasaki, N.2
Paulson, J.C.3
Bochner, B.S.4
-
115
-
-
0034907372
-
Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma
-
Busse, W. et al. Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J. Allergy Clin. Immunol. 108, 184-190 (2001).
-
(2001)
J. Allergy Clin. Immunol.
, vol.108
, pp. 184-190
-
-
Busse, W.1
-
116
-
-
0034881877
-
The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics
-
Soler, M. et al. The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics. Eur. Respir. J. 18, 254-261 (2001).
-
(2001)
Eur. Respir. J.
, vol.18
, pp. 254-261
-
-
Soler, M.1
-
117
-
-
11144356805
-
Efficacy and safety of a recombinant anti-immunoglobulin e antibody (omalizumab) in severe allergic asthma
-
Holgate, S. T. et al. Efficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthma. Clin. Exp. Allergy 34, 632-638 (2004).
-
(2004)
Clin. Exp. Allergy
, vol.34
, pp. 632-638
-
-
Holgate, S.T.1
-
118
-
-
17744376022
-
Anti-immunoglobulin e treatment with omalizumab in allergic diseases: An update on anti-inflammatory activity and clinical efficacy
-
Holgate, S. T., Djukanovic, R., Casale, T. & Bousquet, J. Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy. Clin. Exp. Allergy 35, 408-416 (2005).
-
(2005)
Clin. Exp. Allergy
, vol.35
, pp. 408-416
-
-
Holgate, S.T.1
Djukanovic, R.2
Casale, T.3
Bousquet, J.4
-
119
-
-
4444232912
-
Effects of treatment with anti-immunoglobulin e antibody omalizumab on airway inflammation in allergic asthma
-
Djukanovic, R. et al. Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am. J. Respir. Crit. Care Med. 170, 583-593 (2004).
-
(2004)
Am. J. Respir. Crit. Care Med.
, vol.170
, pp. 583-593
-
-
Djukanovic, R.1
-
120
-
-
73749083569
-
Effect of omalizumab on peripheral blood eosinophilia in allergic asthma
-
Massanari, M. et al. Effect of omalizumab on peripheral blood eosinophilia in allergic asthma. Respir. Med. 104, 188-196 (2010).
-
(2010)
Respir. Med.
, vol.104
, pp. 188-196
-
-
Massanari, M.1
-
121
-
-
33646914451
-
Effect of omalizumab treatment on peripheral eosinophil and T-lymphocyte function in patients with allergic asthma
-
Noga, O. et al. Effect of omalizumab treatment on peripheral eosinophil and T-lymphocyte function in patients with allergic asthma. J. Allergy Clin. Immunol. 117, 1493-1499 (2006).
-
(2006)
J. Allergy Clin. Immunol.
, vol.117
, pp. 1493-1499
-
-
Noga, O.1
-
122
-
-
34548257315
-
Anti-IgE treatment of eosinophil-associated gastrointestinal disorders
-
Foroughi, S. et al. Anti-IgE treatment of eosinophil-associated gastrointestinal disorders. J. Allergy Clin. Immunol. 120, 594-601 (2007).
-
(2007)
J. Allergy Clin. Immunol.
, vol.120
, pp. 594-601
-
-
Foroughi, S.1
-
123
-
-
0034613151
-
Immune inhibitory receptors
-
Ravetch, J. V. & Lanier, L. L. Immune inhibitory receptors. Science 290, 84-89 (2000).
-
(2000)
Science
, vol.290
, pp. 84-89
-
-
Ravetch, J.V.1
Lanier, L.L.2
-
124
-
-
49249110953
-
Inhibition of immune cell function
-
Cooper, M. D. Inhibition of immune cell function. Immunol. Rev. 224, 7-10 (2008).
-
(2008)
Immunol. Rev.
, vol.224
, pp. 7-10
-
-
Cooper, M.D.1
-
125
-
-
34249798165
-
Inhibitory receptors on eosinophils: A direct hit to a possible Achilles heel?
-
Munitz, A. & Levi-Schaffer, F. Inhibitory receptors on eosinophils: a direct hit to a possible Achilles heel? J. Allergy Clin. Immunol. 119, 1382-1387 (2007).
-
(2007)
J. Allergy Clin. Immunol.
, vol.119
, pp. 1382-1387
-
-
Munitz, A.1
Levi-Schaffer, F.2
-
126
-
-
72049132624
-
Inhibitory receptors on myeloid cells: New targets for therapy?
-
Munitz, A. Inhibitory receptors on myeloid cells: new targets for therapy? Pharmacol. Ther. 125, 128-137 (2010).
-
(2010)
Pharmacol. Ther.
, vol.125
, pp. 128-137
-
-
Munitz, A.1
-
127
-
-
33344478875
-
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils
-
Munitz, A. et al. The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils. Blood 107, 1996-2003 (2006).
-
(2006)
Blood
, vol.107
, pp. 1996-2003
-
-
Munitz, A.1
-
128
-
-
80052688904
-
SIRPα/CD172a regulates eosinophil homeostasis
-
Verjan, G. N. et al. SIRPα/CD172a regulates eosinophil homeostasis. J. Immunol. 187, 2268-2277 (2011).
-
(2011)
J. Immunol.
, vol.187
, pp. 2268-2277
-
-
Verjan, G.N.1
-
129
-
-
47049125345
-
A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils
-
Munitz, A., McBride, M. L., Bernstein, J. S. & Rothenberg, M. E. A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils. Blood 111, 5694-5703 (2008).
-
(2008)
Blood
, vol.111
, pp. 5694-5703
-
-
Munitz, A.1
McBride, M.L.2
Bernstein, J.S.3
Rothenberg, M.E.4
-
130
-
-
33646908000
-
Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a
-
Bachelet, I., Munitz, A. & Levi-Schaffer, F. Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a. J. Allergy Clin. Immunol. 117, 1314-1320 (2006).
-
(2006)
J. Allergy Clin. Immunol.
, vol.117
, pp. 1314-1320
-
-
Bachelet, I.1
Munitz, A.2
Levi-Schaffer, F.3
-
131
-
-
0034605037
-
Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor
-
Park, L. S. et al. Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: formation of a functional heteromeric complex requires interleukin 7 receptor. J. Exp. Med. 192, 659-670 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 659-670
-
-
Park, L.S.1
-
132
-
-
0036301998
-
Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP
-
Soumelis, V. et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nature Immunol. 3, 673-680 (2002).
-
(2002)
Nature Immunol.
, vol.3
, pp. 673-680
-
-
Soumelis, V.1
-
133
-
-
18244387204
-
Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells
-
Rimoldi, M. et al. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nature Immunol. 6, 507-514 (2005).
-
(2005)
Nature Immunol.
, vol.6
, pp. 507-514
-
-
Rimoldi, M.1
-
134
-
-
84864283017
-
Functions of thymic stromal lymphopoietin in immunity and disease
-
Zhang, Y. & Zhou, B. Functions of thymic stromal lymphopoietin in immunity and disease. Immunol. Res. 52, 211-223 (2012).
-
(2012)
Immunol. Res.
, vol.52
, pp. 211-223
-
-
Zhang, Y.1
Zhou, B.2
-
135
-
-
1642459383
-
Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis
-
Osborn, M. J. et al. Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis. Blood 103, 843-851 (2004).
-
(2004)
Blood
, vol.103
, pp. 843-851
-
-
Osborn, M.J.1
-
136
-
-
77956633109
-
Thymic stromal lymphopoietin induces chemotactic and prosurvival effects in eosinophils: Implications in allergic inflammation
-
Wong, C. K., Hu, S., Cheung, P. F. & Lam, C. W. Thymic stromal lymphopoietin induces chemotactic and prosurvival effects in eosinophils: implications in allergic inflammation. Am. J. Respir. Cell Mol. Biol. 43, 305-315 (2010).
-
(2010)
Am. J. Respir. Cell Mol. Biol.
, vol.43
, pp. 305-315
-
-
Wong, C.K.1
Hu, S.2
Cheung, P.F.3
Lam, C.W.4
-
137
-
-
84865032686
-
Thymic stromal lymphopoietin stimulates the formation of eosinophil extracellular traps
-
Morshed, M., Yousefi, S., Stockle, C., Simon, H. U. & Simon, D. Thymic stromal lymphopoietin stimulates the formation of eosinophil extracellular traps. Allergy 67, 1127-1137 (2012).
-
(2012)
Allergy
, vol.67
, pp. 1127-1137
-
-
Morshed, M.1
Yousefi, S.2
Stockle, C.3
Simon, H.U.4
Simon, D.5
-
138
-
-
61349089164
-
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
-
Gudbjartsson, D. F. et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genet. 41, 342-347 (2009).
-
(2009)
Nature Genet.
, vol.41
, pp. 342-347
-
-
Gudbjartsson, D.F.1
-
139
-
-
77950297532
-
Common variants at 5q22 associate with pediatric eosinophilic esophagitis
-
Rothenberg, M. E. et al. Common variants at 5q22 associate with pediatric eosinophilic esophagitis. Nature Genet. 42, 289-291 (2010).
-
(2010)
Nature Genet.
, vol.42
, pp. 289-291
-
-
Rothenberg, M.E.1
-
140
-
-
2542494041
-
Familial eosinophilia: A benign disorder?
-
Klion, A. D. et al. Familial eosinophilia: a benign disorder? Blood 103, 4050-4055 (2004).
-
(2004)
Blood
, vol.103
, pp. 4050-4055
-
-
Klion, A.D.1
-
141
-
-
77953641765
-
Human airway eosinophils respond to chemoattractants with greater eosinophil-derived neurotoxin release, adherence to fibronectin, and activation of the Ras-ERK pathway when compared with blood eosinophils
-
Bates, M. E. et al. Human airway eosinophils respond to chemoattractants with greater eosinophil-derived neurotoxin release, adherence to fibronectin, and activation of the Ras-ERK pathway when compared with blood eosinophils. J. Immunol. 184, 7125-7133 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 7125-7133
-
-
Bates, M.E.1
-
142
-
-
0026485410
-
Comparison of airway and blood eosinophil function after in vivo antigen challenge
-
Sedgwick, J. B. et al. Comparison of airway and blood eosinophil function after in vivo antigen challenge. J. Immunol. 149, 3710-3718 (1992).
-
(1992)
J. Immunol.
, vol.149
, pp. 3710-3718
-
-
Sedgwick, J.B.1
-
143
-
-
0030742813
-
Granulocyte signal transduction and priming: Cause without effect?
-
Coffer, P. J. & Koenderman, L. Granulocyte signal transduction and priming: cause without effect? Immunol. Lett. 57, 27-31 (1997).
-
(1997)
Immunol. Lett.
, vol.57
, pp. 27-31
-
-
Coffer, P.J.1
Koenderman, L.2
-
144
-
-
33646453518
-
The eosinophil: The cell and its weapons, the cytokines, its locations
-
Kariyawasam, H. H. & Robinson, D. S. The eosinophil: the cell and its weapons, the cytokines, its locations. Semin. Respir. Crit. Care Med. 27, 117-127 (2006).
-
(2006)
Semin. Respir. Crit. Care Med.
, vol.27
, pp. 117-127
-
-
Kariyawasam, H.H.1
Robinson, D.S.2
-
145
-
-
44649103777
-
Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels
-
Stein, M. L. et al. Anti-IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels. J. Allergy Clin. Immunol. 121, 1473-1483.e4 (2008).
-
(2008)
J. Allergy Clin. Immunol.
, vol.121
-
-
Stein, M.L.1
-
146
-
-
61849117309
-
Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33
-
Pecaric-Petkovic, T., Didichenko, S. A., Kaempfer, S., Spiegl, N. & Dahinden, C. A. Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. Blood 113, 1526-1534 (2009).
-
(2009)
Blood
, vol.113
, pp. 1526-1534
-
-
Pecaric-Petkovic, T.1
Didichenko, S.A.2
Kaempfer, S.3
Spiegl, N.4
Dahinden, C.A.5
-
147
-
-
44649129170
-
A novel IL-1 family cytokine, IL-33, potently activates human eosinophils
-
Cherry, W. B., Yoon, J., Bartemes, K. R., Iijima, K. & Kita, H. A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J. Allergy Clin. Immunol. 121, 1484-1490 (2008).
-
(2008)
J. Allergy Clin. Immunol.
, vol.121
, pp. 1484-1490
-
-
Cherry, W.B.1
Yoon, J.2
Bartemes, K.R.3
Iijima, K.4
Kita, H.5
-
148
-
-
78649878351
-
IL-33 exacerbates eosinophil-mediated airway inflammation
-
Stolarski, B., Kurowska-Stolarska, M., Kewin, P., Xu, D. & Liew, F. Y. IL-33 exacerbates eosinophil-mediated airway inflammation. J. Immunol. 185, 3472-3480 (2010).
-
(2010)
J. Immunol.
, vol.185
, pp. 3472-3480
-
-
Stolarski, B.1
Kurowska-Stolarska, M.2
Kewin, P.3
Xu, D.4
Liew, F.Y.5
-
149
-
-
84855765388
-
Anti-IL-33 antibody has a therapeutic effect in a murine model of allergic rhinitis
-
Kim, Y. H. et al. Anti-IL-33 antibody has a therapeutic effect in a murine model of allergic rhinitis. Allergy 67, 183-190 (2012).
-
(2012)
Allergy
, vol.67
, pp. 183-190
-
-
Kim, Y.H.1
-
150
-
-
67649207586
-
Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma
-
Liu, X. et al. Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma. Biochem. Biophys. Res. Commun. 386, 181-185 (2009).
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.386
, pp. 181-185
-
-
Liu, X.1
-
151
-
-
84865632852
-
Adenovirus-mediated delivery of soluble ST2 attenuates ovalbumin-induced allergic asthma in mice
-
Yin, H. et al. Adenovirus-mediated delivery of soluble ST2 attenuates ovalbumin-induced allergic asthma in mice. Clin. Exp. Immunol. 170, 1-9 (2012).
-
(2012)
Clin. Exp. Immunol.
, vol.170
, pp. 1-9
-
-
Yin, H.1
-
152
-
-
35848969549
-
Regulation of functional phenotypes of cord blood derived eosinophils by γ-secretase inhibitor
-
Kang, J. H. et al. Regulation of functional phenotypes of cord blood derived eosinophils by γ-secretase inhibitor. Am. J. Respir. Cell Mol. Biol. 37, 571-577 (2007).
-
(2007)
Am. J. Respir. Cell Mol. Biol.
, vol.37
, pp. 571-577
-
-
Kang, J.H.1
-
153
-
-
63849314570
-
Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation
-
Radke, A. L. et al. Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation. Blood 113, 3092-3101 (2009).
-
(2009)
Blood
, vol.113
, pp. 3092-3101
-
-
Radke, A.L.1
-
154
-
-
0033617522
-
Notch signaling: Cell fate control and signal integration in development
-
Artavanis-Tsakonas, S., Rand, M. D. & Lake, R. J. Notch signaling: cell fate control and signal integration in development. Science 284, 770-776 (1999).
-
(1999)
Science
, vol.284
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
Rand, M.D.2
Lake, R.J.3
-
155
-
-
1842785211
-
Notch 1 signaling regulates peripheral T cell activation
-
Eagar, T. N. et al. Notch 1 signaling regulates peripheral T cell activation. Immunity 20, 407-415 (2004).
-
(2004)
Immunity
, vol.20
, pp. 407-415
-
-
Eagar, T.N.1
-
156
-
-
27644553827
-
Eosinophilic differentiation is promoted by blockage of Notch signaling with a γ-secretase inhibitor
-
Kang, J. H. et al. Eosinophilic differentiation is promoted by blockage of Notch signaling with a γ-secretase inhibitor. Eur. J. Immunol. 35, 2982-2990 (2005).
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 2982-2990
-
-
Kang, J.H.1
-
157
-
-
33645013015
-
Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease
-
Siemers, E. R. et al. Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease. Neurology 66, 602-604 (2006).
-
(2006)
Neurology
, vol.66
, pp. 602-604
-
-
Siemers, E.R.1
-
158
-
-
0034141996
-
Evidence for local eosinophil differentiation within allergic nasal mucosa: Inhibition with soluble IL-5 receptor
-
Cameron, L. et al. Evidence for local eosinophil differentiation within allergic nasal mucosa: inhibition with soluble IL-5 receptor. J. Immunol. 164, 1538-1545 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 1538-1545
-
-
Cameron, L.1
-
159
-
-
0032615710
-
+ cells in the bronchial mucosa in asthma: Potential airway eosinophil progenitors
-
+ cells in the bronchial mucosa in asthma: potential airway eosinophil progenitors. Am. J. Respir. Cell Mol. Biol. 20, 9-13 (1999).
-
(1999)
Am. J. Respir. Cell Mol. Biol.
, vol.20
, pp. 9-13
-
-
Robinson, D.S.1
-
160
-
-
59449093130
-
+ hemopoietic progenitor cells are potent effectors of allergic inflammation
-
+ hemopoietic progenitor cells are potent effectors of allergic inflammation. J. Allergy Clin. Immunol. 123, 472-478 (2009).
-
(2009)
J. Allergy Clin. Immunol.
, vol.123
, pp. 472-478
-
-
Allakhverdi, Z.1
-
161
-
-
0037393468
-
Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics
-
Menzies-Gow, A. et al. Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics. J. Allergy Clin. Immunol. 111, 714-719 (2003).
-
(2003)
J. Allergy Clin. Immunol.
, vol.111
, pp. 714-719
-
-
Menzies-Gow, A.1
-
162
-
-
84858754351
-
Evaluation and differential diagnosis of marked, persistent eosinophilia
-
Mejia, R. & Nutman, T. B. Evaluation and differential diagnosis of marked, persistent eosinophilia. Semin. Hematol. 49, 149-159 (2012).
-
(2012)
Semin. Hematol.
, vol.49
, pp. 149-159
-
-
Mejia, R.1
Nutman, T.B.2
-
163
-
-
77954089699
-
Refining the definition of hypereosinophilic syndrome
-
Simon, H. U. et al. Refining the definition of hypereosinophilic syndrome. J. Allergy Clin. Immunol. 126, 45-49 (2010).
-
(2010)
J. Allergy Clin. Immunol.
, vol.126
, pp. 45-49
-
-
Simon, H.U.1
-
164
-
-
77950342602
-
Glucocorticoid-regulated genes in eosinophilic esophagitis: A role for FKBP51
-
Caldwell, J. M. et al. Glucocorticoid-regulated genes in eosinophilic esophagitis: a role for FKBP51. J. Allergy Clin. Immunol. 125, 879-888 (2010).
-
(2010)
J. Allergy Clin. Immunol.
, vol.125
, pp. 879-888
-
-
Caldwell, J.M.1
-
165
-
-
78649897499
-
A striking local esophageal cytokine expression profile in eosinophilic esophagitis
-
Blanchard, C. et al. A striking local esophageal cytokine expression profile in eosinophilic esophagitis. J. Allergy Clin. Immunol. 127, 208-217 (2011).
-
(2011)
J. Allergy Clin. Immunol.
, vol.127
, pp. 208-217
-
-
Blanchard, C.1
-
166
-
-
70349432266
-
Biology and treatment of eosinophilic esophagitis
-
Rothenberg, M. E. Biology and treatment of eosinophilic esophagitis. Gastroenterology 137, 1238-1249 (2009).
-
(2009)
Gastroenterology
, vol.137
, pp. 1238-1249
-
-
Rothenberg, M.E.1
-
167
-
-
84867098836
-
Diagnostic utility of major basic protein, eotaxin-3, and leukotriene enzyme staining in eosinophilic esophagitis
-
Dellon, E. S., Chen, X., Miller, C. R., Woosley, J. T. & Shaheen, N. J. Diagnostic utility of major basic protein, eotaxin-3, and leukotriene enzyme staining in eosinophilic esophagitis. Am. J. Gastroenterol. 107, 1503-1511 (2012).
-
(2012)
Am. J. Gastroenterol.
, vol.107
, pp. 1503-1511
-
-
Dellon, E.S.1
Chen, X.2
Miller, C.R.3
Woosley, J.T.4
Shaheen, N.J.5
-
168
-
-
84865701899
-
Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes
-
Valent, P. et al. Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. J. Allergy Clin. Immunol. 130, 607-612 (2012).
-
(2012)
J. Allergy Clin. Immunol.
, vol.130
, pp. 607-612
-
-
Valent, P.1
-
169
-
-
77954089655
-
Practical approach to the patient with hypereosinophilia
-
Roufosse, F. & Weller, P. F. Practical approach to the patient with hypereosinophilia. J. Allergy Clin. Immunol. 126, 39-44 (2010).
-
(2010)
J. Allergy Clin. Immunol.
, vol.126
, pp. 39-44
-
-
Roufosse, F.1
Weller, P.F.2
-
170
-
-
70449704424
-
How i treat hypereosinophilic syndromes
-
Klion, A. D. How I treat hypereosinophilic syndromes. Blood 114, 3736-3741 (2009).
-
(2009)
Blood
, vol.114
, pp. 3736-3741
-
-
Klion, A.D.1
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