Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis

Journal of Clinical Investigation

Volumn 116, Issue 2, 2006, Pages 536-547

  Blanchard, Carine ^a   Wang, Ning ^a   Stringer, Keith F ^a   Mishra, Anil ^a   Fulkerson, Patricia C ^a   Abonia, J Pablo ^a   Jameson, Sean C ^a   Kirby, Cassie ^a   Konikoff, Michael R ^a   Collins, Margaret H ^a   Cohen, Mitchell B ^a   Akers, Rachel ^a   Hogan, Simon P ^a   Assa'ad, Amal H ^a   Putnam, Philip E ^a   Aronow, Bruce J ^a   Rothenberg, Marc E ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CCR3; EOTAXIN; EOTAXIN 3; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; EOSINOPHIL; EOSINOPHILIA; ESOPHAGITIS; ESOPHAGUS BIOPSY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE INDUCTION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC CONSERVATION; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN GENOME; HUMAN TISSUE; MASTOCYTOSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM; TISSUE SECTION;

ANIMALS; BIOPSY; CHEMOKINES, CC; CHILD; EOSINOPHILIA; ESOPHAGITIS; FEMALE; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; MASTOCYTOSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 32444443951     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI26679     Document Type: Article

References (65)

1. Fox, V.L., Nurko, S., and Furuta, G.T. 2002. Eosinophilic esophagitis: it's not just kid's stuff. Gastrointest. Endosc. 56:260-270.
2. Straumann, A., et al. 2003. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology. 125:1660-1669.
3. Orenstein, S.R., et al. 2000. The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 children. Am. J. Gastroenterol. 95:1422-1430.
4. Cheung, K.M., Oliver, M.R., Cameron, D.J., Catto-Smith, A.G., and Chow, C.W. 2003. Esophageal eosinophilia in children with dysphagia. J. Pediatr. Gastroenterol. Nutr. 37:498-503.
5. Noel, R.J., Putnam, P.E., and Rothenberg, M.E. 2004. Eosinophilic esophagitis. N. Engl. J. Med. 351:940-941.
6. Kelly, K.J., et al. 1995. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology. 109:1503-1512.
7. Walsh, S.V., et al. 1999. Allergic esophagitis in children: a clinicopathological entity. Am. J. Surg. Pathol. 23:390-396.
8. Rothenberg, M.E. 2004. Eosinophilic gastrointestinal disorders (EGID) [review]. J. Allergy Clin. Immunol. 113:11-28.
9. Sant'Anna, A.M., Rolland, S., Fournet, J.C., Yazbeck, S., and Drouin, E. 2004. Eosinophilic esophagitis in children: symptoms, histology and pH probe results. J. Pediatr. Gastroenterol. Nutr. 39:373-377.
10. Lim, J.R., et al. 2004. White specks in the esophageal mucosa: an endoscopic manifestation of non-reflux eosinophilic esophagitis in children. Gastrointest. Endosc. 59:835-838.
11. Ruchelli, E., Wenner, W., Voytek, T., Brown, K., and Liacouras, C. 1999. Severity of esophageal eosinophilia predicts response to conventional gastroesophageal reflux therapy. Pediatr. Dev. Pathol. 2:15-18.
12. Attwood, S.E., et al. 2003. Eosinophilic oesophagitis: a novel treatment using Montelukast. Gut. 52:181-185.
13. Teitelbaum, J.E., et al. 2002. Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate. Gastroenterology. 122:1216-1225.
14. Mishra, A., Hogan, S.P., Lee, J.J., Foster, P.S., and Rothenberg, M.E. 1999. Fundamental signals that regulate eosinophil homing to the gastrointestinal tract. J. Clin. Invest. 103:1719-1727.
15. Rothenberg, M.E., Mishra, A., Brandt, E.B., and Hogan, S.P. 2001. Gastrointestinal eosinophils. Immunol. Rev. 179:139-155.
16. Mishra, A., Hogan, S.P., Brandt, E.B., and Rothenberg, M.E. 2001. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J. Clin. Invest. 107:83-90.
17. Mishra, A., Hogan, S.P., Brandt, E.B., and Rothenberg, M.E. 2002. IL-5 promotes eosinophil trafficking to the esophagus. J. Immunol. 168:2464-2469.
18. Straumann, A., Bauer, M., Fischer, B., Blaser, K., and Simon, H.U. 2001. Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response. J. Allergy Clin. Immunol. 108:954-961.
19. Mishra, A., and Rothenberg, M.E. 2003. Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism. Gastroenterology. 125:1419-1427.
20. Garrett, J.K., et al. 2004. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J. Allergy Clin. Immunol. 113:115-119.
21. Schmid-Grendelmeier, P., et al. 2002. Eosinophils express functional IL-13 in eosinophilic inflammatory diseases. J. Immunol. 169:1021-1027.
22. Komiya, A., et al. 2003. Concerted expression of eotaxin-1, eotaxin-2, and eotaxin-3 in human bronchial epithelial cells. Cell. Immunol. 225:91-100.
23. Ying, S., et al. 1999. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (Intrinsic) asthmatics. J. Immunol. 163:6321-6329.
24. Rankin, S.M., Conroy, D.M., and Williams, T.J. 2000. Eotaxin and eosinophil recruitment: implications for human disease. Mol. Med. Today. 6:20-27.
25. Gerard, C., and Rollins, B.J. 2001. Chemokines and disease. Nat. Immunol. 2:108-115.
26. Al-Tubuly, A.A., Spijker, R., Pignatelli, M., Kirkland, S.C., and Ritter, M.A. 1997. Inhibition of growth and enhancement of differentiation of colorectal carcinoma cell lines by MAb MR6 and IL-4. Int. J. Cancer. 71:605-611.
27. Gordon, D., and Finch, S.J. 2005. Factors affecting statistical power in the detection of genetic association. J. Clin. Invest. 115:1408-1418. doi:10.1172/JCI24756.
28. Shah, U., and Walker, W.A. 2002. Pathophysiology of intestinal food allergy. Adv. Pediatr. 49:299-316.
29. Humbert, M., et al. 1996. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am. J. Respir. Crit. Care Med. 154:1497-1504.
30. Kitaura, M., et al. 1999. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980.
31. Kagami, S., et al. 2005. Interleukin-4 and interleukin-13 enhance CCL26 production in a human keratinocyte cell line, HaCaT cells. Clin. Exp. Immunol. 141:459-466.
32. Atasoy, U., et al. 2003. Regulation of eotaxin gene expression by TNF-alpha and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR. J. Immunol. 171:4369-4378.
33. Stellato, C., et al. 1999. Differential regulation of epithelial-derived C-C chemokine expression by IL-4 and the glucocorticoid budesonide. J. Immunol. 163:5624-5632.
34. Heller, N.M., et al. 2004. Interferon-gamma inhibits STAT6 signal transduction and gene expression in human airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 31:573-582.
35. Hoffjan, S., Nicolae, D., and Ober, C. 2003. Association studies for asthma and atopic diseases: a comprehensive review of the literature. Respir. Res. 4:14.
36. Chae, S.C., Park, Y.R., Oh, G.J., Lee, J.H., and Chung, H.T. 2005. The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis. Immunogenetics. 56:760-764.
37. Chae, S.C., et al. 2004. Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil. Biochem. Biophys. Res. Commun. 320:131-137.
38. Akey, J.M., Zhang, G., Zhang, K., Jin, L., and Shriver, M.D. 2002. Interrogating a high-density SNP map for signatures of natural selection. Genome Res. 12:1805-1814.
39. Austen, K.F., and Boyce, J.A. 2001. Mast cell lineage development and phenotypic regulation. Leuk. Res. 25:511-518.
40. Romagnani, P., et al. 1999. Tryptase-chymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines. Am. J. Pathol. 155:1195-1204.
41. de Paulis, A., et al. 2001. Expression of the chemokine receptor CCR3 on human mast cells. Int. Arch. Allergy Immunol. 124:146-150.
42. Ochi, H., et al. 1999. T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. J. Exp. Med. 190:267-280.
43. Zimmermann, N., et al. 2003. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J. Clin. Invest. 111:1863-1874. doi:10.1172/JCI24756.
44. Nomura, I., et al. 2003. Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis. J. Allergy Clin. Immunol. 112:1195-1202.
45. Noel, R.J., et al. 2004. Clinical and immunopathologic effects of swallowed fluticasone for eosinophilic esophagitis. Clin. Gastroenterol. Hepatol. 2:568-575.
46. Gleich, G.J. 2000. Mechanisms of eosinophil-associated inflammation. J. Allergy Clin. Immunol. 105:651-663.
47. Weller, P.F. 1997. Human eosinophils. J. Allergy Clin. Immunol. 100:283-287.
48. Tai, I.T., Dai, M., and Chen, L.B. 2005. Periostin induction in tumor cell line explants and inhibition of in-vitro cell growth by anti-periostin antibodies. Carcinogenesis. 26:908-915.
49. Shao, R., and Guo, X. 2004. Human microvascular endothelial cells immortalized with human telomerase catalytic protein: a model for the study of in vitro angiogenesis. Biochem. Biophys. Res. Commun. 321:788-794.
50. Haendler, B., Kratzschmar, J., Theuring, F., and Schleuning, W.D. 1993. Transcripts for cysteine-rich secretory protein-1 (CRISP-1; DE/AEG) and the novel related CRISP-3 are expressed under androgen control in the mouse salivary gland. Endocrinology. 133:192-198.
51. Carey, M.A., et al. 2003. Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1-/- but not cyclooxygenase-2-/-mice. Am. J. Respir. Crit. Care Med. 167:1509-1515.
52. Sheng, G.G., et al. 1997. A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells. Gastroenterology. 113:1883-1891.
53. Cao, T.V., La, M., Getting, S.J., Day, A.J., and Perretti, M. 2004. Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo. Microcirculation. 11:615-624.
54. Szanto, S., Bardos, T., Gal, I., Glant, T.T., and Mikecz, K. 2004. Enhanced neutrophil extravasation and rapid progression of proteoglycan-induced arthritis in TSG-6-knockout mice. Arthritis Rheum. 50:3012-3022.
55. Getting, S.J., et al. 2002. The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha-inhibitor-independent manner. J. Biol. Chem. 277:51068-51076.
56. Ogilvie, P., Paoletti, S., Clark-Lewis, I., and Uguccioni, M. 2003. Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes. Blood. 102:789-794.
57. Petkovic, V., Moghini, C., Paoletti, S., Uguccioni, M., and Gerber, B. 2004. Eotaxin-3/CCL26 is a natural antagonist for CC chemokine receptors 1 and 5. A human chemokine with a regulatory role. J. Biol. Chem. 279:23357-23363.
58. Humbles, A.A., et al. 2002. The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness. Proc. Natl. Acad. Sci. U. S. A. 99:1479-1484.
59. Beaulieu, S., et al. 2002. Expression of a functional eotaxin (CC chemokine ligand 11) receptor CCR3 by human dendritic cells. J. Immunol. 169:2925-2936.
60. Dennis, G., Jr., et al. 2003. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 4:P3.
61. Hosack, D.A., Dennis, G., Jr., Sherman, B.T., Lane, H.C., and Lempicki, R.A. 2003. Identifying biological themes within lists of genes with EASE. Genome Biol. 4:R70.
62. Blanchard, C., et al. 2005. Eotaxin-3/CCL26 gene expression in intestinal epithelial cells is up-regulated by interleukin-4 and interleukin-13 via the signal transducer and activator of transcription 6. Int. J. Biochem. Cell Biol. 37:2559-2573.
63. Ott, J. 2005. Linkage utility programs for human genetics. http://linkage.rockefeller.edu/ott/linkutil.htm.
64. TDT/S-TDT. http://genomics.med.upenn.edu/ spielman/TDT.htm.
65. Spielman, R.S., and Ewens, W.J. 1998. A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. Am. J. Hum. Genet. 62:450-458.