Inhibition of eosinophilia in vivo by a small molecule inhibitor of very late antigen (VLA)-4

European Journal of Pharmacology

Volumn 559, Issue 2-3, 2007, Pages 202-209

  Okigami, Hiromi ^a   Takeshita, Keisuke ^a   Tajimi, Masaomi ^a   Komura, Hiroshi ^a   Albers, Markus ^b   Lehmann, Thomas E ^b   Rölle, Thomas ^b   Bacon, Kevin B ^a  

^a BAYER YAKUHIN LTD   (Japan)

^b BAYER AG   (Germany)

Author keywords

Adhesion; Inhibitor; VCAM 1 (Vascular cell adhesion molecule 1); VLA 4 (Very late antigen)

Indexed keywords

3 (2',5' DICHLOROBIPHENYL 4 YL) 2 [[[1 (2 METHOXYBENZOYL)PIPERIDIN 3 YL]CARBONYL]AMINO]PROPANOIC ACID; ANTIINFLAMMATORY AGENT; FIBRONECTIN; MANGANESE; PHORBOL 13 ACETATE 12 MYRISTATE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4; VERY LATE ACTIVATION ANTIGEN 5;

ALLERGIC RHINITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; ASTHMA; ATOPIC DERMATITIS; CELL MIGRATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; EOSINOPHIL; EOSINOPHILIA; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LYMPHOCYTE MIGRATION; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTI-ALLERGIC AGENTS; ANTI-INFLAMMATORY AGENTS; B-LYMPHOCYTES; CELL ADHESION; CHEMOKINES, CC; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILIA; EOSINOPHILS; FEMALE; FIBRONECTINS; HUMANS; INTEGRIN ALPHA4BETA1; INTEGRIN ALPHA5BETA1; INTERLEUKIN-5; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; POLYCHLORINATED BIPHENYLS; SKIN DISEASES; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 33847106380     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.11.065     Document Type: Article

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