Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma

Journal of Experimental Medicine

Volumn 195, Issue 11, 2002, Pages 1433-1444

  Mattes, Joerg ^a   Yang, Ming ^a   Mahalingam, Surendran ^a   Kuehr, Joachim ^b   Webb, Dianne C ^a   Simson, Ljubov ^a   Hogan, Simon P ^a   Koskinen, Aulikki ^a   McKenzie, Andrew N J ^e   Dent, Lindsay A ^c   Rothenberg, Marc E ^d   Matthaei, Klaus I ^a   Young, Ian G ^a   Foster, Pau L S ^a  

^a Biology and Environment   (Australia)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^e MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Allergy; Cytokines; Eosinophils; Inflammation; Lung

Indexed keywords

EOTAXIN; INTERLEUKIN 13; INTERLEUKIN 5;

ALLERGIC DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; EOSINOPHILIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH2 CELL;

ADOPTIVE TRANSFER; ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; CD4-POSITIVE T-LYMPHOCYTES; CHEMOKINES, CC; DISEASE MODELS, ANIMAL; EOSINOPHILIA; EOSINOPHILS; GENE DELETION; HUMANS; INTERLEUKIN-13; INTERLEUKIN-18; INTERLEUKIN-5; MICE; MICE, INBRED BALB C; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPUTUM; TH2 CELLS;

EID: 0037013925     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020009     Document Type: Article

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