CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation

Journal of Allergy and Clinical Immunology

Volumn 123, Issue 2, 2009, Pages

  Allakhverdi, Zoulfia ^a   Comeau, Michael R ^b   Smith, Dirk E ^b   Toy, Dean ^b   Endam, Leandra Mfuna ^c   Desrosiers, Martin ^c   Liu, Yong Jun ^d   Howie, Karen J ^e   Denburg, Judah A ^e   Gauvreau, Gail M ^e   Delespesse, Guy ^a  

^a NOTRE DAME HOSPITAL   (Canada)

^b AMGEN INC   (United States)

^c CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e MCMASTER UNIVERSITY   (Canada)

Author keywords

airway epithelial cells; allergen inhalation challenge; asthma; Blood CD34+ cells; chemokines; IL 33; rhinosinusitis; TH2 cytokines; TSLP

Indexed keywords

ALLERGEN; CD34 ANTIBODY; CHEMOKINE; CYTOKINE; INTERLEUKIN 13; INTERLEUKIN 33; INTERLEUKIN 5; INTERLEUKIN RECEPTOR; THYMIC STROMAL LYMPHOPOIETIN;

ALLERGIC DISEASE; ARTICLE; ASTHMA; CELL ACTIVATION; CELL FUNCTION; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; EPITHELIUM CELL; EXPLANT; HUMAN; HUMAN CELL; INHALATION; NOSE MUCOSA; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURIFICATION; RESPIRATORY EPITHELIUM; RHINOSINUSITIS; SPUTUM ANALYSIS; SUPERNATANT; TH2 CELL;

EID: 59449093130     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2008.10.022     Document Type: Article

References (31)

1. Holgate S.T. The epithelium takes centre stage in asthma and atopic dermatitis. Trends Immunol 28 (2007) 248-251
2. Kato A., and Schleimer R.P. Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity. Curr Opin Immunol 19 (2007) 711-720
3. Liu Y.J. Thymic stromal lymphopoietin: master switch for allergic inflammation. J Exp Med 203 (2006) 269-273
4. Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., et al. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med 204 (2007) 253-258
5. Angkasekwinai P., Park H., Wang Y.H., Wang Y.H., Chang S.H., Corry D.B., et al. Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med 204 (2007) 1509-1517
6. Schmitz J., Owyang A., Oldham E., Song Y., Murphy E., McClanahan T.K., et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23 (2005) 479-490
7. Cameron L., Christodoulopoulos P., Lavigne F., Nakamura Y., Eidelman D., McEuen A., et al. Evidence for local eosinophil differentiation within allergic nasal mucosa: inhibition with soluble IL-5 receptor. J Immunol 164 (2000) 1538-1545
8. Denburg J.A., Telizyn S., Messner H., Lim B., Jamal N., Ackerman S.J., et al. Heterogeneity of human peripheral blood eosinophil-type colonies: evidence for a common basophil-eosinophil progenitor. Blood 66 (1985) 312-318
9. Cyr M.M., and Denburg J.A. Systemic aspects of allergic disease: the role of the bone marrow. Curr Opin Immunol 13 (2001) 727-732
10. Massberg S., Schaerli P., Knezevic-Maramica I., Kollnberger M., Tubo N., Moseman E.A., et al. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell 131 (2007) 994-1008
11. Sehmi R., Wood L.J., Watson R., Foley R., Hamid Q., O'Byrne P.M., et al. Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects: a novel marker of progenitor cell commitment towards eosinophilic differentiation. J Clin Invest 100 (1997) 2466-2475
12. Mastrandrea F., Cadario G., Nicotra M.R., and Natali P.G. Hemopoietic progenitor cells in atopic dermatitis skin lesions. J Investig Allergol Clin Immunol 9 (1999) 386-391
13. Dorman S.C., Efthimiadis A., Babirad I., Watson R.M., Denburg J.A., Hargreave F.E., et al. Sputum CD34+IL-5Ralpha+ cells increase after allergen: evidence for in situ eosinophilopoiesis. Am J Respir Crit Care Med 169 (2004) 573-577
14. Otsuka H., Dolovich J., Richardson M., Bienenstock J., and Denburg J.A. Metachromatic cell progenitors and specific growth and differentiation factors in human nasal mucosa and polyps. Am Rev Respir Dis 136 (1987) 710-717
15. Kim Y.K., Uno M., Hamilos D.L., Beck L., Bochner B., Schleimer R., et al. Immunolocalization of CD34 in nasal polyposis: effect of topical corticosteroids. Am J Respir Cell Mol Biol 20 (1999) 388-397
16. Asosingh K., Swaidani S., Aronica M., and Erzurum S.C. Th1- and Th2-dependent endothelial progenitor cell recruitment and angiogenic switch in asthma. J Immunol 178 (2007) 6482-6494
17. Schmidt M., Sun G., Stacey M.A., Mori L., and Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol 171 (2003) 380-389
18. Allakhverdi Z., Smith D.E., Comeau M.R., and Delespesse G. Cutting edge: the ST2 ligand IL-33 potently activates and drives maturation of human mast cells. J Immunol 179 (2007) 2051-2054
19. O'Byrne P.M., Dolovich J., and Hargreave F.E. Late asthmatic responses. Am Rev Respir Dis 136 (1987) 740-751
20. Pizzichini E., Pizzichini M.M., Efthimiadis A., Evans S., Morris M.M., Squillace D., et al. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. Am J Respir Crit Care Med 154 (1996) 308-317
21. Liu Y.J., Soumelis V., Watanabe N., Ito T., Wang Y.H., Malefyt Rde W., et al. TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol 25 (2007) 193-219
22. Chackerian A.A., Oldham E.R., Murphy E.E., Schmitz J., Pflanz S., and Kastelein R.A. IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol 179 (2007) 2551-2555
23. Da Silva C.A., Reber L., and Frossard N. Stem cell factor expression, mast cells and inflammation in asthma. Fundam Clin Pharmacol 20 (2006) 21-39
24. Von Luttichau I., Notohamiprodjo M., Wechselberger A., Peters C., Henger A., Seliger C., et al. Human adult CD34- progenitor cells functionally express the chemokine receptors CCR1, CCR4, CCR7, CXCR5, and CCR10 but not CXCR4. Stem Cells Dev 14 (2005) 329-336
25. Kato A., Favoreto Jr. S., Avila P.C., and Schleimer R.P. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J Immunol 179 (2007) 1080-1087
26. Leckie M.J., ten Brinke A., Khan J., Diamant Z., O'Connor B.J., Walls C.M., et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356 (2000) 2144-2148
27. Menzies-Gow A., Flood-Page P., Sehmi R., Burman J., Hamid Q., Robinson D.S., et al. Anti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmatics. J Allergy Clin Immunol 111 (2003) 714-719
28. Cancelas J.A., and Williams D.A. Stem cell mobilization by beta2-agonists. Nat Med 12 (2006) 278-279
29. Spiegel A., Shivtiel S., Kalinkovich A., Ludin A., Netzer N., Goichberg P., et al. Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling. Nat Immunol 8 (2007) 1123-1131
30. Baatjes A.J., Sehmi R., Saito H., Cyr M.M., Dorman S.C., Inman M.D., et al. Anti-allergic therapies: effects on eosinophil progenitors. Pharmacol Ther 95 (2002) 63-72
31. Godot V., Arock M., Garcia G., Capel F., Flys C., Dy M., et al. H4 histamine receptor mediates optimal migration of mast cell precursors to CXCL12. J Allergy Clin Immunol 120 (2007) 827-834