An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro

Journal of Pharmacology and Experimental Therapeutics

Volumn 305, Issue 1, 2003, Pages 347-352

  Sugimoto, Hiromi ^a   Shichijo, Michitaka ^a   Iino, Takashi ^a   Manabe, Yoshihisa ^a   Watanabe, Akihiko ^a   Shimazaki, Makoto ^a   Gantner, Florian ^a   Bacon, Kevin B ^a  

^a BAYER YAKUHIN LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 3 BENZYL 5 (6 CARBOXYHEXYL) 1 (2 CYCLOHEXYL 2 HYDROXYETHYLAMINO)HYDANTOIN; CELL PROTEIN; CHEMOATTRACTANT RECEPTOR ANTAGONIST; CRTH2 ANTAGONIST; G PROTEIN COUPLED CHEMOATTRACTANT RECEPTOR HOMOLOGOUS MOLECULE; G PROTEIN COUPLED RECEPTOR; INDOMETACIN; PERTUSSIS TOXIN; PROSTAGLANDIN D2; PROSTAGLANDIN D2 RECEPTOR; PROSTAGLANDIN RECEPTOR; PROTEIN CRTH2; RAMATROBAN; THROMBOXANE A2 RECEPTOR; UNCLASSIFIED DRUG;

ALLERGIC RHINITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN DETECTION; ARTICLE; ATTENUATION; BASOPHIL; BRONCHUS HYPERREACTIVITY; CELL MIGRATION; CELL SPECIFICITY; CONTROLLED STUDY; DISEASE COURSE; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG EFFICACY; DRUG MARKETING; DRUG RECEPTOR BINDING; EOSINOPHIL; GUINEA PIG; HUMAN; HUMAN CELL; INFLAMMATION; INHIBITION KINETICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; RAT; TH2 CELL;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; CALCIUM; CARBAZOLES; CELL MOVEMENT; DRUG INTERACTIONS; EOSINOPHILS; HUMANS; PLATELET AGGREGATION INHIBITORS; PROSTAGLANDIN D2; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; SULFONAMIDES; TRANSFECTION;

EID: 0037382497     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.046748     Document Type: Article

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